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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Uji Aktivitas Antibakteri Ekstrak Etanol Daun dan Kulit Batang Sawo (Manilkara zapota (L.) Van Royen) Melzi Octaviani; Syafrina Syafrina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sapodilla (Manilkara zapota (L.) van Royen) is a plant that grows in a tropical climate, fruit all year round and the distribution is in the widespread in Indonesia. The contents of secondary metabolites in the leaves and the bark sapodilla are flavonoids, phenols and saponins are known to inhibit the growth of bacteria. The purpose of this research is to know the antibacterial activity of ethanol extract leaves and bark Sapodilla against Staphylococcus aureus and Propionibacterium acnes bacteria. The study was performed by disc diffusion method with the varyation concentrations of ethanol extract from the leaves and bark with a concentration of 50%, 25%, 12.5%, 6.25% and 3.125% respectively and the positive control is clindamycin and the negative control is DMSO . The diameter of the inhibition zone formed on the ethanol extract test of the leaves sapodilla against Staphylococcus aureus and Propionibacterium acnes at a concentration of 50% was 14.18 ± 0.13 mm and 15.33 ± 0.25 mm, respectively. While the diameter of the inhibition zone formed on the ethanol extract test of the bark against Staphylococcus aureus and Propionibacterium acnes at a concentration of 50% was 14.22±0.15 mm and 18.30±0.23 mm, respectively. The results of the data statistical analysis using oneway ANOVA, it shown a significant difference (p < 0.05) between the variation of the concentration of the extract. The test results shown that the antibacterial activity ethanol extract of the leaves and bark of Sapodilla had activity for inhibit the growth of Staphylococcus aureus and Propionibacterium acnes bacteria.
Pengaruh Iradiasi Sinar Gamma dan Konsentrasi Kitosan terhadap Pembentukan Hidrogel Polivinil Alkohol-Kitosan Zuhelmi Aziz; Gatot Trimulyadi; Trivena Fithriany A
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Chitosan is one of the product from the shrimp disposal. Its medicinal and pharmaceutics application are now developed by pharmaceutical industries, i.e as bioplastics and hydrogel. A research about the effect of gamma radiation and chitosan as a raw material for production of polyvinilalcohol has been carried out. PVA-chitosan hydrogel was made from a mixture of composition of 80% PVA in 10% solution and 20% of chitosan in 0, 1, 2 ,and 3% solution respectively. The mixture was heated in oven at 80°C for two hours and then irradiated with 0, 15, 25, and 35 kGy gamma radiation. The physical characteristic of the gel was determined, e.g. colour, swelling degree and gel fraction. The colour of hydrogel more yellow darker to raising of chitosan concentration and radiation dosage. Swelling degree PVA-chitosan hydrogel increased meanwhile chitosan concentration and radiation dosage decreased. In absolute ethanol medium (96%) PVA-chitosan hydrogel was deswelling. The swelling degree PVAchitosan hydrogel decreased with increased gel fraction.
Sintesis dan Uji Aktivitas Antimalaria Senyawa Turunan 2,4-Difenil-1,10-Fenantrolin RUSLIN HADANU; MUSTAFA MUSTAFA; NAZUDIN NAZUDIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malaria is still the main health problems in subtropical and tropical countries. There are 105 countries in the world at malaria endemic and more than 500 million cases or more than 2.7 million deaths from malaria each year. The traditional remedies are no longer effective and the incidence of malarial by P. falciparum, the most dangerous species of parasite, continues to grow, while some traditional drugs such as chloroquine has been resistance. Synthesis of 2,4-diphenyl-1,10-phenanthroline [5] compounds with benzaldehyde [1], acetophenone [2], t-calcone [3], 8-aminoquinoline [4] as starting material through three steps has been carried out. The results of all steps of the reaction were obtained compounds of [5], (1)-N methyl-7,9-diphenyl-1,10-phenanthrolinium sulfate [6] and (1)-N-ethyl-7,9-diphenyl-1,10-phenanthrolinium sulfate [7]. The results of antiplasmodial activity in vitro testing of the derivatives on chloroquine resistant P. falciparum FCR3 indicated that compound [7] has higher antimalarial activity (IC5O = 0.06±0.05 µM) than the activity of [6] compound (ICSO = 1.27±O.97 µM) and [5] compound (1C50 = 1.66±0.70 µM). Results of similar in vitro testing on chloroquine resistant P. falciparum D10 strain indicated that [7] compound has higher antimalarial activity (IC50 = 0.04±0.04 uM) than the activity of [5] compound (IC50 = 1.13±0.30 µM) and [6] compound (ICSO = 0.81±0.06 µM).
Pengaruh Kadar Nitrogen dalam Media pada Pembuatan Protease Menggunakan Bacillus megaterium DSM 319 Trismilah Trismilah; Sumaryanto Sumaryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The media components and fermentation conditions play an important role for the result of fermentation processes, for instance nitrogen is one of the element which is influence for the growth of microorganism. Therefore it is needed the available media formulation for the optimal growth of microorganism with high productivity. It was shown in this protease production experiment by using Bacillus megaterium DSM 319 with media of Geolitti Cantoni (G&C) with modified of urea as source of nitrogen. The variation of carbon and nitrogen ratio which are used in this process are 3 : 0.8, 3: 1.5,3 :2,3: 2.5. Fermentation conditions were adjusted : temperature at 37°C, pH 7.5 and agitation of 250 rpm. The result of this process indicated that carbon and nitrogen ratio of 3 : 2 giving highest enzyme activity at 18 hours. The other results such are specific activity 6.552 Unit / protein mg, specific growth rate (u max/h) 0.074, duplication time (t jam) 9.367, coeffisient convert (Yx/s) 0.23.
Sintesis Artemeter dengan Katalis Bifungsional dalam Satu Sistem Reaksi dan Uji Aktivitas Sitotoksik Terhadap Sel Leukimia L1210 LIA NURLIANA; HARMITA HARMITA; SILVESTER S. TURSILOADI; L.B. S KARDONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Artemisinin has been known as herbal medicine from China, which was isolated from the Artemisia annua L. plant. Artemisinin was originally known as antipyretic and antimalarial drug. Artemisinin and its derivatives also have potential as anticancer, due to the sesquiterpene lactone containing a unique peroxide group. This study aimed to modify the structure of artemisinin into artemether using solid catalyst Ni/TiO2-SO4 through the hydrogenation and methylation of the alcohol group in one pot reaction system. The product was then investigated for its cytotoxic activity against L1210 leukemia cells. The solid catalyst in this study was composed of metalic Ni as the active center, TiO2 as a catalyst support and sulphate as the promoter. The modification of artemisinin produced 1.29% artemether white crystalls as a minor product, and 19% dihidroartemisinin as an intermediate compound. The synthesized artemether showed an anticancer activity against L1210 leukimia cells with IC50 value of 3.07 µg / mL. The result suggests that the synthesized artemether has a potency as an anticancer.
Standardization of the Extract of Cultivated Ipomoea reptans Poir. Leaves from Sardonoharjo, Sleman and Its Potency as Antioxidant FARIDA HAYATI; ARI WIBOWO; PINUS JUMARYATNO; ARDE TOGA NUGROHO; DIAN AMALIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Telah dilakukan penelitian untuk mengetahui nilai parameter spesifik dan nonspesifik standardisasi ekstrak kangkung darat hasil budidaya di wilayah Sardonoharjo, Sleman serta potensinya sebagai antioksidan. Sampel yang digunakan dipanen pada saat usia kangkung darat ±25-30 hari setelah penanaman. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Parameter spesifik terdiri dari uji organoleptik, pola kromatografi, kadar senyawa marker dan parameter nonspesifik terdiri dari uji bobot jenis,uji kadar air, uji kadar abu total, uji kadar abu tidak larut asam, uji cemaran logam, uji cemaran mikroba, uji cemaran kapang dan khamir, perkiraan angka koliform, dan uji sisa pelarut etanol. Hasil standardisasi ekstrak menunjukkan nilai pengukuran berturut-turut untuk parameter kadar air 16,45±0,05%, bobot jenis ekstrak 3,26±3,37x10-3 g/mL, kadar abu total 4,52± 0,77%. Tidak terdapat sisa pelarut etanol di dalam ekstrak, serta angka cemaran mikroba, angka kapang dan khamir, angka koliform, serta cemaran logam timbal (Pb) dan kadmium (Cd), di dalam ekstrak di bawah standar batas maksimal yang ditetapkan BPOM. Hasil pengukuran dengan KLT densitometri menunjukkan nilai kadar β-karoten di dalam ekstrak sebesar 5,7% (b/b). Hasil Uji aktivitas antioksidan dengan menggunakan 2,2-diphenyl-1- picrylhydrazyl (DPPH) menunjukkan nilai IC50 ekstrak daun kangkung sebesar 178,3 μg/ mL.
Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis MOCH FUTUCHUL ARIFIN; LILIEK NUR HIDAYATI; SYARMALINA SYARMALINA; RENSY RENSY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Halitosis (bad breath) is the most complained problem among mouth and teeth health. The source of halitosis are volatile sulfur compounds produced by Streptococcus mutans from degradation of food debris. Sirih leaves (Pqaer betle L.) are traditionally used as mouth antiseptic for its volatile oil. The aim of this research was to formulate sirih extract into an edible film. The leaves were macerated with 96% ethanol for 24 hours, resulting to an extract with minimum inhibitory concentration (MIC) on Streptococcus mutans of 8.49x10-3 g/ml. The extract with strength quadruple of the MIC, or equal to 0.92% povidone iodine, was formulated using 23 factorial design. Com starch, hydroxypropyl methylcellulose (HPMC) and sorbitol were independent variables and drying time, moisture, hlm thickness, disintegrating time, and iilrn strength were the dependent ones. The results showed that HPMC significantly fastened the drying time, decreased the moisture, and lengthened the disintegrating time. Sorbitol significantly lengthened the drying time, increased the moisture, and strengthened the film, while corn starch decreased the moisture and lengthened the disintegrating time. Optimation of the formula ingredients using contour plot superimposed cannot be determined due to edible film disintegrating time that was out of comparative interval.
Uji Molecular Docking Annomuricin E dan Muricapentocin pada Aktivitas Antiproliferas ROSA ADELINA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Various natural compounds have been reported to be used as anticancer, however their modes of action have not been clearly defined. One of the plant compounds is acetogenin which can induce apoptosis in in vitro study. Two new acetogenins discovered in Annona muricata are annomuricin E and muricapentocin. Molecular docking is one of in silico model to screen coumponds based on their mechanism to protein. Therefore, the two compounds were docked using PLANTS 1.1 to see the affinity to proliferation protein, Protein Kinase C. The RMSD calculations of the best predicting binding site gave 1.3906 Å. The molecular docking results of native ligand (07u), annomuricin E, and muricapentocin are -71.161; -127.739; and -116.868. It showed that annomuricin E has the best in silico affinity to Protein Kinase C, and has better ability to inhibit proliferation as compared to the native ligand and muricapentocin.
Uji Aktivitas Inhibisi Enzim Tirosinase In-vitro Krim Ekstrak Akar Manis (Glycyrrhiza glabra L.) Siti Umroh Noor; Faridah Faridah; Pamela Magdalena
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.345 KB) | DOI: 10.35814/jifi.v16i2.566

Abstract

Liquorice root extract (Glycyrrhiza glabra L.) contains glabridin, an isoflavone substance that has the ability to inhibit the oxidation of L-tyrosin and L-DOPA in the formation of melanin, therefore it can be used as skin whitening. The aim of the study was to determine the potential of the best skin whitening cream using positive control of kojic acid. Formulated 1 blank formula, 3 cream formulas using various concentrations of ethanol extract 70% liquorice roots of (0.01, 0.11, 1.01)% based on the value of tyrosinase inhibition activity in vitro from extracts of (50, 75, 100)%. Spectrophotometric method is used to measure the absorption of dopacrome by a microplate reader which was incubated at 37°C at λ 490 nm for 20 minutes. Oil in water cream was prepared by mixing extract with cream base at a temperature of 70-75°C at a speed of 400 rpm for 25 minutes. Stability test was carried out for 4 weeks at room temperature storage and a temperature of 40°C, evaluated for physical quality. The results of determination of IC50 of kojic acid was 20.88 µg / mL; IC50 of extract variation were (126.75; 1130.90; and 10092.41) µg / mL respectively. Cream has milky white-yellowish color; smell of flowers; soft texture; homogeneous; there is no separation; has type M/A; plastic thixotropic flow properties; has an increasing value including viscosity, spreadability, globule size, and pH, which are respectively (455000-620000)cPs, (2695.82-3545.83)mm2, (54.66-66.27)μm , and (4.44-5.04); tyrosinase inhibition activity in formula 1, 2 and 3 were stored at weeks 0, 2nd and 4th were respectively (1.78; -25.74; 22.04)%, (6.74; 6, 12; 4.49)%, and (-28.78; 53.06; 20.32)%. It can be concluded that the cream formula containing liquorice root extract with a concentration of 1.01% is the best formula so it can be used as skin whitening.
Mekanisme Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malaria remains the most devastating infectious parasitic disease, inflicting both death and economic losses on at least half the world's population. Numerous attempts have been made to control the disease using vector control measures and/or chemoprophylaxis. Antimalarial drugs have a selective action on the different phases of the parasite life cycle. Mechanism of antimalarial drugs action will be discussed in this article.

Page 35 of 73 | Total Record : 721

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