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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol. 47 No. 3 (2024): MKA July 2024" : 11 Documents clear
Korelasi Positif antara Tumor Associated Macrophage dengan Stadium Klinis pada Adenokarsinoma Kolorektal Ramadhan, Ryan Surya
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p289-300.2024

Abstract

Latar Belakang: Tingginya angka kejadian kanker kolorektal mendorong perkembangan pengetahuan mengenai kanker kolorektal, salah satunya mengenai tumor associated macrophage (TAM). TAM merupakan makrofag yang ditemukan dalam lingkungan mikro tumor dan dibagi menjadi 2 sub tipe M1 dan M2. Infiltrasi TAM akan mempengaruhi pertumbuhan ukuran serta akan berdampak pada stadium kanker yang lebih lanjut sehingga dicanangkan menjadi indikator prognosis pada kanker kolorektal. Tujuan: Mengetahui hubungan tumor associated macrophage dengan ukuran dan stadium kanker pada pasien adenokarsinoma kolorektal. Metode: Analitik observasional dengan pendekatan cross sectional menggunakan data sekunder. Sampel penelitian ini adalah 37 pasien adenokarsinoma kolorektal. Analisis statistik dengan uji Spearman. Hasil: Hasil dari analisis SPSS 25.0 didapatkan nilai sebesar 0,768 (p>0,05) untuk hubungan TAM dan klasifikasi “T” dan nilai sebesar 0,026 (p<0,05) untuk hubungan TAM dan stadium klinis. Kesimpulan: Tidak terdapat hubungan yang signifikan antara TAM dan klasifikasi “T” dan terdapat korelasi positif antara TAM dengan stadium klinis pada adenokarsinoma kolorektal.
Derajat Ekspresi Fibroblast Activation Protein Pada Cancer-Associated Fibroblast Karsinoma Kolorektal Amalia, Vonny
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p308-314.2024

Abstract

Objective: to determine the degree of expression of Fibroblast Activation Protein in Cancer Associated Fibroblasts of colorectal carcinoma. Methods: descriptive study with a cross sectional research design. Using 36 paraffin blocks of CRC cases that met the inclusion criteria. FAP expression was assessed through immunohistochemical staining with anti-FAP and histopathological data were recorded in the form of depth invasion, degree of differentiation, lymphovascular invasion and lymph node metastatic status. Results: FAP in CAFs showed a high expression in most cases (52.8%). High-grade expression of FAP more common at T3-T4 depth of invasion, low-grade differentiation, CRC without lymphovascular invasion and CRC without lymph node metastases. Conclusion: there are variations in the expression of FAP as a marker of CAFs in colorectal carcinoma histopathology features.
Hubungan Gejala Klinis dengan Neutrofil-Limfosit Rasio (NLR) pada Anak dengan Covid-19 di Rumah Sakit H.Abdul Manap Kota Jambi Hutabarat, Okto Dolin; Farah, Fransiska
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p260-264.2024

Abstract

Latar belakang: Neutrophil-to-Lymphocyte Ratio (NLR) dipertimbangkan sebagai penanda inflamasi untuk menilai derajat klinis COVID-19 pada anak, namun data lokal masih terbatas.Objektif: Menilai hubungan antara gejala/derajat klinis dengan NLR pada anak dengan COVID-19.Metode: Studi analitik korelatif dengan desain potong lintang menggunakan data rekam medis sekunder pasien pediatrik terkonfirmasi COVID-19 yang dirawat di ruang isolasi RS H. Abdul Manap, Kota Jambi, Januari–Juli 2021. Variabel utama: derajat klinis dan NLR (cut-off 3,13). Analisis menggunakan uji korelasi serta estimasi kekuatan hubungan.Hasil: Mayoritas pasien berjenis kelamin laki-laki (55,1%), berderajat klinis ringan (87,7%), dan memiliki NLR <3,13 (98%). Terdapat korelasi lemah namun bermakna antara derajat klinis (ringan–sedang) dan NLR (r=0,386; p=0,006).Kesimpulan: Derajat klinis COVID-19 pada anak berkorelasi lemah tetapi signifikan dengan NLR, dengan sebagian besar kasus ringan menunjukkan NLR <3,13. NLR berpotensi sebagai penanda pendukung stratifikasi klinis; diperlukan penelitian prospektif dengan ukuran sampel memadai untuk memvalidasi temuan ini.      
Bedah Basis Kranii Hipofisektomi Tahap Kedua dengan Pendekatan Endoskopi Transfenoid pada Adenoma Hipofisis Danuwirya, Muhammad Reko; Irfandy, Dolly
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p362-370.2024

Abstract

Latar Belakang: Teknik operasi bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan kualitas visualisasi lapang pandang operasi lebih baik dibanding menggunakan mikroskop dan morbiditas lebih rendah dibanding teknik lainnya. Selama dua dekade terakhir bedah endoskopik telah mendapatkan dukungan sebagai pendekatan utama untuk lesi sellar dan parasellar termasuk adenoma hipofisis. Laporan Kasus: Dilaporkan satu kasus seorang laki-laki 34 tahun dengan keluhan penurunan penglihatan dan didiagnosis dengan adenoma hipofisis. Pada pasien dilakukan tindakan reseksi tumor oleh ahli bedah saraf dengan pendekatan endoskopi transfenoid berkolaborasi dengan ahli THT-KL. Kesimpulan: Bedah basis kranii pendekatan endoskopi transfenoid adalah tindakan bedah yang menjadi pilihan utama untuk lesi basis kranii. Tindakan ini memberikan visualisasi struktur anatomi yang baik, lapang pandang operasi yang lebih luas, manipulasi struktur neurovaskular minimal, meminimalisir morbiditas dan meningkatkan kualitas hidup pasien, memiliki tingkat keberhasilan yang cukup tinggi dan memberikan hasil yang memuaskan.
Harnessing the Potential of Synbiotic Therapy for Childhood Malnutrition: A Narrative Review of Onion Inulin Extracts and Probiotic-Rich Dadih Rahmaddiansyah, Refa; Rahmi, Wahida; Arisanty, Dessy; Rita, Rauza Sukma; Rusti, Sukarsi
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p330-340.2024

Abstract

Background: Childhood malnutrition stems from inadequate intake and disease; synbiotics (probiotics+prebiotics) can modulate gut microbiota and immune function, aligning with SDG-3 targets through cost-effective prophylaxis and immunomodulation. Objective: To evaluate onion (Allium cepa Linn.)-derived inulin combined with probiotic-rich Sumatran dadih as supportive therapy for pediatric malnutrition. Methods: Narrative literature review of human and relevant preclinical studies on synbiotics, inulin, dadih, gut microbiota, and immune modulation, with selection based on relevance and methodological quality. Results: Evidence suggests synbiotics improve microbiota diversity, short-chain fatty acid production, nutrient absorption, and reduce inflammation and infection rates. Onion-inulin functions as a fermentable prebiotic; dadih provides robust local lactic-acid bacteria strains. Yet data are heterogeneous, sample sizes small, and dosing/formulation poorly standardized; safety reporting is variable. Conclusion: An onion-inulin + dadih synbiotic is a plausible, context-appropriate adjuvant for managing childhood malnutrition. Rigorous, controlled trials should optimize dose, strain selection, and formulation, and confirm efficacy and safety for scalable implementation.
Analisa Faktor Risiko yang Mempengaruhi Infeksi Scabies di Pondok Pesantren Darunna’Im Yapia Parung Bogor Ramadhani, Isniani
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p245-251.2024

Abstract

Latar belakang: Prevalensi skabies di lingkungan pesantren Indonesia tetap tinggi dan berdampak pada kesehatan serta proses belajar.Objektif: Menilai faktor yang memengaruhi kejadian skabies, kekuatan hubungan masing-masing faktor, dan faktor paling dominan di pesantren.Metode: Studi potong lintang observasional kuantitatif di Pesantren Darunna’im Yapia, Warujaya–Parung, Bogor (2023). Responden santri usia 12–18 tahun (n=74). Analisis menggunakan uji Chi-Square dan regresi logistik biner.Hasil: Terdapat hubungan bermakna antara jenis kelamin (p=0,004; OR 4,4299), tingkat usia (p<0,001; OR 19,556), tingkat pendidikan (p=0,007; OR 4,000), dan personal hygiene (p=0,003; OR 7,931) dengan kejadian skabies. Pada analisis multivariat, tingkat usia merupakan prediktor paling dominan (p=0,036; Exp(B) 11,744). Keempat faktor secara simultan menjelaskan 41,4% variabilitas kejadian skabies.Kesimpulan: Kejadian skabies di pesantren dipengaruhi oleh jenis kelamin, usia, pendidikan, dan personal hygiene; usia adalah faktor paling dominan. Temuan ini menekankan perlunya intervensi terarah pada kelompok usia berisiko, disertai penguatan higiene pribadi dan tata kelola asrama.
Exploring the Therapeutic Landscape: A Systematic Review on the Anti-inflammatory Effects of Probiotics in Colitis-associated Colorectal Cancer Suswita, Rini; Alvarino; Eryati Darwin; Jamsari
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p341-361.2024

Abstract

Background: Colorectal cancer is closely linked to chronic inflammation; long-standing colitis confers a 2–3-fold higher risk. Modulating the gut–immune axis with probiotics may attenuate the inflammatory microenvironment of colitis-associated colorectal cancer (CAC). Objective:To evaluate the anti-inflammatory effects of probiotics in CAC animal models. Methods: We searched PubMed, ScienceDirect, and Wiley Online Library; 248 records were screened and 9 studies met inclusion. Risk of bias was appraised using SYRCLE RoB. Results: Probiotic treatment consistently reduced clinical severity, down-regulated inflammatory markers, and modulated key signaling pathways in CAC models. Nonetheless, evidence was heterogeneous, sample sizes were small, and dosing, strains, and formulations varied; safety reporting was limited. Conclusions: Probiotics show promise as anti-inflammatory adjuncts in CAC based on animal studies. Rigorous, standardized preclinical work and well-designed trials are needed to define optimal strains, dosing, and formulations, and to confirm efficacy and safety for translation.
The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital Coloay, Yuliany Christy; Purnakarya, Idral; Lipoeto, Indrawaty
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p252-259.2024

Abstract

Breast cancer is a non-communicable disease, the development of cancer cells affects a series of organ functions. Treatment for breast cancer is generally divided into three, namely mastectomy, chemotherapy and radiotherapy. Objective: To determine the relationship between frequency of therapy, food intake and nutritional status with the quality of life of cancer patients. Results: Cancer cell activity in the body is characterized by pain, especially in the cancer area. The frequency of therapy >3 months has an effect on decreasing nutritional status, the therapy undertaken has side effects, both chemotherapy and radiotherapy, resulting in side effects such as nausea and loss of appetite. Conclusion: Patients who undergo therapy for 3 months tend to be underweight, if the food intake they receive according to their needs will reduce the risk and disruption of a series of body system functions. Regulating the types of food with a regular eating pattern increases the body's physical defenses. Maintaining normal nutritional status while undergoing therapy can maintain physical quality that is related to quality of life.The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital
Biscuit Formulation With Substitution Of Mackerel Fish Meal (Rastrelliger Sp.) And Black Rice Flour (Oryza Sativa L. Indica) As An Alternative Snack For Diabetes Mellitus Sufferers Lubis, Rizka Adelia; Syahrial, Syahrial; Elnovriza, Deni
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p265-275.2024

Abstract

Objective: This research aims to develop a biscuit formulation with the substitution of mackerel fish flour and black rice flour as an alternative snack for diabetes mellitus sufferers.Method: This research was an experiment with a Completely Randomized Design (CRD) consisting of four treatments, namely 0% (F0), 25% (F1), 50% (F2), and 75% (F3). Organoleptic tests were carried out on 7 trained panelists. The organoleptic test data was tested for normality using the Shapiro Wilk test. The results of the data distribution are normally distributed, so to determine whether there are real differences in each treatment, the data is processed using the ANOVA test at the 5% level, if it is known that there are significant differences (p value <0.05), followed by the Duncan New Multiple Range Test (DNMRT) at the 5% level to see which treatments are different. Results: The biscuits selected based on organoleptic tests were F1 biscuits with a water content of 3.1%, ash 1.5%, protein 5.2%, fat 3%, magnesium 117 gr, anthocyanin 14.88 mg. Conclusion: Biscuits substituted for mackerel fish flour and black rice flour can be used as an alternative snack for diabetes mellitus sufferers.Keywords: diabetes mellitus, biscuits, mackerel flour, black rice flour 
Gambaran Angka Bakteri Di Laboratorium Mikroskopik Fakultas Kedokteran Universitas Tanjungpura Atirah, Nur -; Mardhia, Mardhia; Liana, Delima Fajar
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p276-288.2024

Abstract

Tujuan: Mengetahui angka dan jenis bakteri udara, lantai, dan meja berdasarkan pewarnaan Gram di laboratorium Mikroskopik Fakultas Kedokteran Universitas Tanjungpura. Metode: Penelitian ini menggunakan metode settling plate, selama 15 menit dengan media agar darah untuk sampel bakteri udara. Sampel lantai dan meja diambil menggunakan swab lidi kapas steril dengan cairan buffer phospate, kemudian digores pada media agar darah. Semua media sampel diinkubasi pada suhu 36℃ selama 24 jam, kemudian dilakukan penghitungan koloni serta pewarnaan Gram untuk melihat variasi jenis bakterinya. Hasil: Angka bakteri udara tertinggi adalah 208,33 CFU/m3, dan yang paling rendah 52,08 CFU/m3.  Dari pewarnaan Gram, bentuk morfologi bakteri udara yaitu kokkus Gram positif dan negatif, serta basil Gram negatif. Sedangkan angka bakteri swab permukaan lantai dan meja yang paling tinggi adalah 200 CFU/m2, terendah adalah 18 CFU/m2. Morfologi bakteri permukaan lantai dan meja yang paling banyak yaitu diplobasil Gram negatif. Kesimpulan: Rata – rata angka bakteri udara laboratorium Mikroskopik adalah 52,08 CFU/m3, dan masih memenuhi standar nilai batas yang ditetapkan. Rata-rata angka bakteri swab permukaan adalah 64 CFU/m2 yang cukup tinggi, melebihi standar nilai batas permukaan dinding dan lantai ruang perawatan yang ditetapkan oleh Kepmenkes.

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