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Hirowati Ali
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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 792 Documents
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Efek Pemberian Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) terhadap Gambaran Histologi Pankreas Hewan Model Diabetes Melitus Tipe 1 Endrinaldi Endrinaldi; Tofrizal Tofrizal; Elmatris Elmatris; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1704-1711.2024

Abstract

Objective: This study was conducted to determine the effect of administering Mesenchymal Stem Cell Wharton Jelly (MSC-WJ) on the histological appearance of the pancreas of rat in a type 1 diabetes mellitus model. Methods: This research is an experimental research with a Posttest-Only Control Group Design. The sample consisted of 3 groups (Normal, T1DM, T1DM + MSC-WJ). The treatment group was treated with MSC-WJ for 4 weeks. Data analysis used One Way ANOVA and Post Hoc Bonferroni tests. Results: WJ-MSC can increase the mean diameter and area of the islets of Langerhans in the T1DM rat group from 98.08 mm – 126.85 mm and from 4911.95 mm2 – 8995.35 mm2, but this difference is not yet significant (p > 0.05). Conclusion This research shows that there is improvement in pancreatic damage by administering WJ-MSC to diabetic rat due to alloxan induction.
The Role of Microbiota and Early Detection in Colorectal Cancer Through Fecal Screening Muhammad Iqbal
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1303-1318.2024

Abstract

Objective: This literature review explores the link between gut microbiota and colorectal cancer, emphasizing early detection through fecal screening. Method: We conducted a comprehensive literature review, using Google Scholar and PubMed, with key search terms including "Microbiota," "Colorectal cancer," and "Fecal screening." Results: The gut microbiota plays a vital role in colorectal cancer development, involving specific bacterial strains such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, Streptococcus bovis, Enterococcus faecalis, and Peptostreptococcus anaerobius. These strains contribute to cancer through various mechanisms. Fecal microbiota screening, often employing advanced techniques like next-generation sequencing, shows promise for early detection. Combining fecal microbiota data with other non-invasive screening methods can enhance colorectal cancer detection sensitivity and efficiency. Understanding this microbiota-cancer relationship is pivotal for cancer prevention and early diagnosis. Conclusion: The intricate microbiota- colorectal cancer connection, driven by specific bacterial strains and inflammation, presents opportunities for early detection. Fecal microbiota screening, combined with non-invasive methods, may reduce colorectal cancer mortality, advancing oncology prevention and diagnosis.
Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Sri Oktavia; Arni Amir; Fatma Sri Wahyuni; Hasmiwati Hasmiwati
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1174-1179.2023

Abstract

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).
Korelasi antara Diameter Limpa dengan Jumlah Trombosit pada Pasien Sirosis Hati Alya Nadia Andini Harahap
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1579-1591.2024

Abstract

Tujuan: Mengetahui korelasi antara diameter limpa dengan jumlah trombosit pada pasien sirosis hati; Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Subjek penelitian berjumlah 96 pasien sirosis hati pada RSUP Dr. M. Djamil Padang tahun 2019–2021. Pengambilan sampel dilakukan dengan teknik simple random sampling. Data dikumpulkan dalam bentuk data sekunder yaitu data diameter limpa dan jumlah trombosit pasien yang diperoleh melalui rekam medis. Korelasi antara diameter limpa dengan jumlah trombosit pada pasien sirosis hati dianalisis dengan uji korelasi Pearson; Hasil: Terdapat sebanyak 85,4% pasien mengalami pembesaran limpa dengan nilai rerata diameter limpa 13,88 ± 2,24 cm dan sebanyak 64,2% mengalami trombositopenia dengan nilai rerata jumlah trombosit 132.365 ± 66.296/mm3. Pada hasil uji korelasi Pearson antara diameter limpa dengan jumlah trombosit pada pasien sirosis hati, didapatkan nilai koefisien korelasi (r) = -0,564 dengan signifikansi (p) = 0,001 (p < 0,05); Kesimpulan: Terdapat korelasi yang bermakna antara diameter limpa dengan jumlah trombosit pada pasien sirosis hati dengan arah korelasi negatif dan nilai koefisien korelasi yang kuat.
Bedah Basis Kranii Hipofisektomi Tahap Kedua dengan Pendekatan Endoskopi Transfenoid pada Adenoma Hipofisis Muhammad Reko Danuwirya; Dolly Irfandy
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1128-1136.2023

Abstract

Latar Belakang: Teknik operasi bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan kualitas visualisasi lapang pandang operasi lebih baik dibanding menggunakan mikroskop dan morbiditas lebih rendah dibanding teknik lainnya. Selama dua dekade terakhir bedah endoskopik telah mendapatkan dukungan sebagai pendekatan utama untuk lesi sellar dan parasellar termasuk adenoma hipofisis. Laporan Kasus: Dilaporkan satu kasus seorang laki-laki 34 tahun dengan keluhan penurunan penglihatan dan didiagnosis dengan adenoma hipofisis. Pada pasien dilakukan tindakan reseksi tumor oleh ahli bedah saraf dengan pendekatan endoskopi transfenoid berkolaborasi dengan ahli THT-KL. Kesimpulan: Bedah basis kranii pendekatan endoskopi transfenoid adalah tindakan bedah yang menjadi pilihan utama untuk lesi basis kranii. Tindakan ini memberikan visualisasi struktur anatomi yang baik, lapang pandang operasi yang lebih luas, manipulasi struktur neurovaskular minimal, meminimalisir morbiditas dan meningkatkan kualitas hidup pasien, memiliki tingkat keberhasilan yang cukup tinggi dan memberikan hasil yang memuaskan.
Potensi Probiotik dalam Peningkatan Kesehatan Lanjut Usia Angriani, Winda; Thamrin, Silvia; Desmawati, Desmawati
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1471-1484.2024

Abstract

Tren demografi menggambarkan bahwa jumlah orang lanjut usia (lansia) terus meningkat secara dramatis. Semakin bertambahnya usia, tubuh semakin rentan mengalami gangguan kesehatan dikarenakan menurunnya berbagai fungsi organ. Investigasi faktor yang mendasari penyakit pada lansia mengungkapkan peran mikrobiota usus. Studi menunjukkan bahwa gut-brain axis (GBA) yaitu rute komunikasi dua arah antara saluran pencernaan dan sistem saraf pusat memainkan peran penting dalam fisiologi dan penyakit inang.  Tujuan: Mengetahui peran probiotik dalam meningkatkan status kesehatan lansia; Metode: Artikel ini ditulis dengan metode studi kepustakaan yang berhubungan dengan probiotik dan kesehatan lansia ; Hasil: Mikrobiota usus memainkan peran penting dalam kesehatan karena terlibat dalam proses metabolisme yang memengaruhi kognisi, dan fungsi imunitas, yang penting untuk mencapai penuaan yang sehat. Intervensi tepat waktu untuk lansia harus dilakukan untuk memperbaiki komposisi mikrobiota usus selama proses penuaan, termasuk suplementasi probiotik. Probiotik adalah mikroorganisme hidup yang bila diberikan dalam jumlah yang cukup akan memberikan manfaat pada inangnya. Penelitian mengenai peran probiotik terhadap kesehatan lansia menunjukkan manfaat probiotik pada lansia, antara lain terhadap imunitas, neurodegeneratif, kardiovaskuler, dan sistem tubuh lainnya ; Kesimpulan: Probiotik bermanfaat terhadap berbagai sistem organ dan dapat meningkatkan kesehatan lanjut usia.
Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1361-1375.2024

Abstract

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.
Hubungan Ekspresi PD-L1 dengan Stadium Patologis dan Grading Karsinoma Urotelial Kandung Kemih Rina Addina
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1625-1634.2024

Abstract

Objective: To determine the relationship between Programmed Cell Death-Ligand 1 (PD-L1)   expression with histopathological variants, and staging of papillary thyroid carcinoma. Methods: This study is an observational research with a cross-sectional study. The sample consisted of papillary thyroid carcinoma cases from the Pathological Anatomy Laboratory of Dr. M. Djamil Padang General Hospital, spanning from January 2022 to December 2022, totaling 37 cases. Pathological stages of invasive urothelial carcinoma of bladder were assessed based on the TNM system WHO 2022 classification, and grades were evaluated according to the WHO 2022 classification. PD-L1 expression was assessed through immunohistochemical staining. Bivariate analysis was conducted using the Chi-square test, with statistical significance set at p < 0.05. Results: The study revealed a positive PD-L1 expression rate of 32.5%. Statistical analysis showed a significant association between PD-L1 expression and pathological stages of invasive urothelial carcinoma of bladder (p=0.019). High stages exhibited higher levels of PD-L1 expression. However, the study did not find a significant relationship between PD-L1 expression and grades of invasive urothelial carcinoma of bladder (p=0.152). Conclusion: There is an association between PD-L1 expression and pathological stages. PD-L1 expression is not associated with the grades of invasive urothelial carcinoma of bladder.
Deteksi crypstosporidium sp. pada pasien dengan kanker kolorektal Sri Wahyuni Handayani; Nuzulia Irawati; Djong Hon Tjong; Tofrizal Tofrizal; Elli Firdamila
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p%p.2023

Abstract

Cryptosporidium sp. adalah parasit obligat intraseluler yang menyerang sel epitel usus. Infeksinya mengakibatkan diare, malnutrisi, dehidrasi dan cedera usus terutama pada orang dengan gangguan imunitas. Tingginya infeksi Cryptosporidium pada pasien HIV-AIDS pada penelitian  sebelumnya menandakan sumber infeksi yang tinggi di lingkungan. Cryptosporidium dilaporkan memiliki hubungan dengan kanker kolorektal baru-baru ini. Tujuan: tujuan penelitian ini adalah untuk mengetahui prevalensi infeksi Cryptosporidium pada pasien dengan kanker kolorektal. Metode: metode yang digunakan observasional dengan desain cross-sectional study pada 43 pasien kanker kolorektal yang sesuai dengan kriteria yaitu pasien yang baru didiagnosis dan belum mendapatkan terapi onkologis. Pengumpulan sampel feses dilakukan dari bulan April hingga Agustus 2023. Pemeriksaan ookista dilakukan secara mikroskopik dengan pewarnaan tahan asam modifikasi ziehl neelsen. Hasil: hasil penelitian didapatkan 46,5% (20/43) pasien positif terinfeksi Cryptosporidium. Kesimpulan: kesimpulan hasil penelitian, infeksi Cryptosporidium tinggi pada pasien kanker kolorektal, terutama pada lokasi kanker rektum. Penelitian lebih lanjut untuk mengetahui spesies Cryptosporidium diperlukan untuk mengetahui  rute penularan dan sumber infeksi.
Hubungan antara kepatuhan minum obat anti tuberkulosis dan kualitas hidup pasien TB paru Sri Hotnatiury Panjaitan
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1164-1173.2023

Abstract

Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kepatuhan minum obat anti tuberkulosis dan kualitas hidup pasien TB paru di Kecamatan Pontianak Barat Kota Pontianak. Metode: Studi analitik observasional jenis cross sectional. Populasi penelitian adalah pasien TB paru yang menerima pengobatan di Pusat Kesehatan Masyarakat  yang ada di Kecamatan Pontianak Barat Kota Pontianak yang dipilih menggunakan teknik purposive sampling dengan subjek penelitian sebesar 76 orang. Analisis bivariat menggunakan uji korelasi Rank Spearman. Hasil: Hasil uji analisis Rank Spearman didapatkan nilai p sebesar 0,000 (Sig <0,05). Kesimpulan: Terdapat hubungan antara kepatuhan minum obat anti tuberkulosis dan kualitas hidup pasien TB paru di Kecamatan Pontianak Barat Kota Pontianak.Kata kunci: pasien TB paru; kepatuhan minum obat; kualitas hidup

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