cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Hirowati Ali
Contact Email
hirowatiali@med.unand.ac.id
Phone
+6281276163526
Journal Mail Official
mka@med.unand.ac.id
Editorial Address
Faculty of Medicine, Universitas Andalas
Location
Kota padang,
Sumatera barat
INDONESIA
Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 792 Documents
 58   59   60   61   62 
EKSPRESI GEN MIRO1 DAN P53 PADA CO-CULTURE WHARTON’S JELLY-MESENCHYMAL STEM CELL DAN JANTUNG TIKUS NEONATUS DIINDUKSI DOXORUBICIN Ariliusra, Zikril
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1469-1481.2024

Abstract

Transfer mitokondria interseluler diduga dapat menjadi mekanisme terapi mesenchymal stem cell (MSC) terhadap berbagai penyakit yang diakibatkan oleh gangguan atau kerusakan pada mitokondria, salah satunya kardiomiopati akibat doxorubicin. Tujuan penelitian ini adalah untuk mengetahui peran transfer mitokondria interseluler sebagai mekanisme protektif MSC. Penelitian ex vivo ini menggunakan jantung tikus neonatus yang diberikan doxorubicin dan MSC dengan metode whole organ culture. Pengukuran ekspresi gen Miro1 digunakan sebagai indikator aktivitas transfer mitokondria interseluler dan ekspresi gen p53 sebagai indikator stres sel. Ekspresi gen p53 pada kelompok yang diberikan doxorubicin 20µM selama 30 menit meningkat singnifikan (p<0,05) dibanding kelompok kontrol. Penambahan wharthon’s jelly(WJ)-MSC sebanyak 1x105  atau 1x106 pada menit ke-10 menyebabkan ekspresi gen p53 pada menit ke-30 lebih rendah signifikan (p<0,05) dibanding kelompok perlakuan tanpa penambahan WJ-MSC. Tidak ditemukan korelasi yang signifikan antara ekspresi gen Miro1 dan gen p53 pada kelompok yang mendapatkan WJ-MSC. Pada penelitian ini disimpulkan bahwa transfer mitokondria interseluler tidak berperan signifikan dalam mekanisme terapi WJ-MSC tanpa rekayasa genetik.
Effect of Topical Application of Black Seed Oil (Nigella Sativa) on Wound Healing in Diabetic Rat Ulcer Model Eliza Arman; Almahdy A; Putri Dafiriani; Dedy Almasdy
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1417-1425.2024

Abstract

Objective : This study aims to evaluate the use of topical black seed oil on wound healing in a diabetic rat model. Method:10 experimental rats were induced with streptozotocin at a dose of 55 mg/kg BW. Diabetic rats were anesthetized and then the wound was made with a biopsy push with a diameter of 10 mm. The rats were divided into 2 groups, namely the untreated group and the topical treatment group with 1 ml of 100% Black Seed Oil every day for 14 days. Wound healing evaluation was carried out on days 7 and 14. Gene expression analysis was performed using molecular technique RT PCR an histopathologically using He staining. Data analysis used T test. Result: On day 7 there was a decrease in TNF expression with p <0.05, while on day 14 it also showed a decrease in TNF alpha expression with p <0.01. Histopathological showed positive development by showing better wound healing with complete epithelialization, granulation with lower inflammatory cells, higher fibroblasts and collagen compared to the control group. Conclusion :Black seed oil can increase the speed of wound healing in diabetic rat models by inhibiting TNF alpha expression.
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
Nutrient content in dadiah pudding, a potential source of probiotics from Minangkabau, West Sumatra Zuhrah Taufiqa; Dian Novita Chandra; Nur Indrawaty Lipoeto; Badriul Hegar
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1289-1302.2024

Abstract

Introduction: Dadiah is a fermented milk product derived from the milk of West Sumatran swamp buffaloes.  Methods: The manufacture of dadiah pudding used dadiah fermented milk obtained from Bukittinggi, West Sumatra. Levels of carbohydrate, protein, fat, calcium, zinc, and iron were measured according to the Indonesian National Standard, then total calories were determined using 4:4:9 kcal/g conversion. Inoculation of samples on de Man, Rogosa, and Sharpe agar was performed to determine total lactic acid bacteria counts, and Gram staining was done for further morphological confirmation. Results: The result revealed that 100 g dadiah pudding contained 6.49 g of carbohydrates, 6.12 g of protein, 23.31 g of fat, 260.23 kcal of calories, 276.61 mg of calcium, 3.75 mg of zinc, 6.60 mg of iron, and 6.1 × 10⁹ CFU/ml of lactic acid bacteria assuming that modification of the liquid into pudding form has been shown to impact macronutrient, micronutrients, total calories, and total lactic acid bacteria. Conclusion: The nutrient content in dadiah pudding revealed in this study indicates that this dairy product can be used as a nutritious local food source and a potential probiotic.
Gangguan Ginjal Akut akibat Keracunan Jengkol Idha Yulfiwanti; Aumas Pabuti; Fitrisia Amelin; Ronaldi Noor
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1238-1246.2023

Abstract

Jengkolic acid intoxication is one of the causes of acute kidney injury in children. This case report discusses the diagnosis and management of jenkol intoxication in children. We reported a 12-year-old boy with painful urination accompanied by low back pain and urine was initially whitish-colored sand then turned red-colored urine accompanied by reduced urine volume after consuming jengkol. The patient was diagnosed with acute kidney injury due to jenkolic acid intoxication, urinary tract infection, and bilateral hydronephrosis with initial conditions of oliguria, elevated urea, the impression of an estimated glomerular filtration rate (GFR) was stage failure, and planned emergency hemodialysis. The patient was managed with bicarbonate sodium and other symptomatic therapy. During monitoring of patients with increased urine output, decreased ureum and increased estimated GFR, hemodialysis was not performed. The patient was treated for 6 days and recommended for control at the pediatric clinic.
Hubungan Komorbid dengan Outcome Pasien Terkonfirmasi COVID-19 Di RSUP M. Djamil Padang Tahun 2020 Adiiba Turfha Zahira; Ida Rahmah Burhan; Yusticia Katar; Yuniar Lestari; Fenty Anggrainy; Fathiyyatul Khaira
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1592-1600.2024

Abstract

Tujuan : Penelitian bertujuan Untuk mengetahui hubungan komorbid dengan outcome pasien terkonfirmasi COVID-19 di RSUP. M. Djamil Padang tahun 2020. Metode : Penelitian bersifat analitik observasional dengan pendekatan cross sectional. Data dikumpulkan dan diolah dengan menggunakan teknik total sampling , yaitu semua pasien terkonfirmasi COVID-19 yang dirawat di RSUP M.Djamil Padang berdasarkan kriteria inklusi dan ekslusi . Jumlah sampel penelitian sebanyak 468 pasien terkonfimasi COVID-19 yang dirawat pada periode Maret – Desember 2020. Analisis yang digunakan adalah analisis bivariat berupa Chi-Square . Hasil: Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara komorbid dengan outcome pada pasien terkonfirmasi COVID-19 (p=0,010) di RSUP. M.Djamil Padang. Kesimpulan : Berdasarkan hasil penelitian dapat diartikan bahwa terdapat hubungan antara komorbid dengan outcome pada pasien terkonfirmasi COVID-19.
KARAKTERISTIK DAN PROFIL PENGOBATAN PASIEN DIABETES MELLITUS TIPE 2 DI PUSKESMAS I DENPASAR SELATAN Putu Satyakumara Upadhana; Gede Agus Indra Pramana; Putu Restu Pertiwi; I Wayan Dediyana
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1137-1143.2023

Abstract

AbstrakTujuan: Diabetes mellitus tipe 2 (DMT2) merupakan suatu penyakit metabolik kronis dengan hiperglikemi yang persisten. Kondisi ini berhubungan dengan berbagai komplikasi. Studi ini bertujuan untuk mengidentifikasi karakteristik klinis dan profil pengobatan pasien DMT2 di Puskesmas I Denpasar Selatan.  Metode: Studi ini merupakan studi deskrpitif observasional dengan pendekatan potong lintang. Studi ini menggunakan data sekunder dari rekam medis pasien DMT2 yang dirawat di Puskesmas I Denpasar Selatan pada 1 Februari 2023 – 28 Februari 2023, dengan menggunakan total sampling. Hasil: Terdapat 50 pasien dimasukkan pada penelitian ini. Sebagian besar berjenis kelamin perempuan (n=29;58,0%), dengan median usia sebesar 60 tahun. Prevalensi hipertensi adalah sebesar 54,0%. Sebagian besar pasien tergolong tidak mengalami obesitas (n=28;56,0%) dan memiliki kadar gula darah puasa yang tidak terkontrol (n=34;68,0%), dengan median gula darah puasa sebesar 160 mg/dL. Mayoritas pasien memiliki durasi pengobatan DMT2 sebesar >10 bulan (n=26;52,0%). Metformin merupakan obat yang paling banyak diberikan pada bulan Februari 2023 (n=43;86,0%), diikuti dengan glimepiride (n=42;84,0%). Sebagian besar pasien memiliki riwayat penggunaan obat selain obat anti diabetes (n=44;88,0%), meliputi simvastatin (n=29;58,0%), amlodipine (n=26; 52,0%), alopurinol (n=21; 42,0%), dan captofril (n=6; 12,0%). Kesimpulan: Sebagian besar pasien berjenis kelamin perempuan, memiliki kadar gula darah puasa yang tidak terkontrol, dan mendapatkan pengobatan metformin.  
Hubungan Kadar 25-Hidroksivitamin D (25(OH)D) Serum pada Ibu Hamil Trimester III dengan Fetal Outcome Delfina, Delfina; Amir, Arni; Ilmiawati, Cimi
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1444-1451.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar 25(OH)D serum pada ibu hamil trimester III dengan fetal outcome. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cohort terhadap 77 ibu hamil trimester III dan bayi baru lahir, penelitian dilakukan di wilayah kerja Puskesmas Andalas. Pengambilan sampel secara purposive sampling. Pengukuran kadar 25(OH)D serum dilakukan dengan metode ELISA secara dupleks. Data fetal outcome (berat badan, panjang badan, lingkar kepala) didapatkan dari buku Kesehatan Ibu dan Anak. Korelasi antar variabel diuji dengan uji korelasi Pearson atau Spearman. Hasil: Kadar 25(OH)D serum ibu hamil trimester III didapatkan nilai median yaitu 21,10 ng/ml dan 32 ibu hamil yang mengalami defisiensi. Kadar 25(OH)D) serum ibu berkorelasi negatif dengan berat badan bayi lahir (uji Pearson; r=-0,239; p=0,036), namun tidak memiliki korelasi yang bermakna secara statistik dengan panjang badan (uji Spearman; r=-0,106; p=0,360) dan lingkar kepala bayi  (uji Spearman; r=-0,031; p=0,788). Kesimpulan: Disimpulkan bahwa sebagian besar ibu hamil mengalami defisiensi 25(OH)D dan hal ini dapat mempengaruhi fetal outcome.
Hubungan Healthy Eating Index Dengan Kenaikan Berat Badan Ibu Selama Kehamilan Di Sumatera Barat Hrlfina, Riska
Majalah Kedokteran Andalas Vol 46, No 9 (2024): Supplementary Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i9.p1376-1385.2024

Abstract

AbstractObjective: To determine the association between the healthy eating index of pregnant women and maternal weight gain during pregnancy in West Sumatra.Methods: Research with a cross-sectional design in West Sumatra on 110 pregnant women.This research is an analysis of secondary data from the study "Giving Dadiah on pregnancy and birth outcomes in West Sumatra".The study used data from 24-hour recall of pregnant women in the first trimester, second trimester and third trimester and pregnant women's weight data.Results: The study showed that there was a relationship between the HEI of pregnant women and the increase in maternal weight during pregnancy with p = 0.049 with a value of r = 0.188.Conclusion: There is a relationship between the healthy eating index of pregnant women and the increase in maternal weight during pregnancy.Keywords:  healthy eating index; weight gain; pregnant woman
Epidemiological Analysis and Management of Oral and Craniomaxillofacial Trauma in Indonesia: A Systematic Review Fiki Muhammad Ridho; Alfi Syahri; Pulung Dwisari
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1667-1687.2024

Abstract

Objective: This systematic review aims to analyze and review the epidemiological characteristics and management of oral and craniomaxillofacial trauma in patients in Indonesia. Methods: Using PRISMA guidelines, a systematic review of articles published in Scopus, PubMed, ScienceDirect, Google Scholar, and Garuda up to March 2024 was conducted. In selecting studies, inclusion and exclusion criteria were applied. Results: This study included 2,928 cases of oral and craniomaxillofacial trauma obtained from a total of 44 studies consisting of 25 case reports, 11 retrospective studies, 7 cross-sectional studies, and 1 case series. Summary results from pooled data, this study highlights that male patients predominate in all cases with a total of 80.70% and the male/female ratio is 4.2:1. Oral and craniomaxillofacial trauma occurred mostly in the 21-30 year age group (25.51%), followed by 11-20 year olds (24.15%) and 31-40 year olds (16.73%). Based on etiology, most cases occurred due to traffic accidents (87.88%). In the management of trauma cases, open reduction and internal fixation (ORIF) is the most frequently performed with a total of 66.71% of all cases. Conclusion: Oral and craniomaxillofacial trauma in Indonesia is dominated by male patients and in the productive age group with mandibular fractures being the highest cases.

Page 60 of 80 | Total Record : 792

 58   59   60   61   62 

Filter by Year

2008 2025


Reset
Filter By Issues
All Issue Vol. 48 No. 4 (2025): MKA October 2025 Vol. 48 No. 3 (2025): MKA July 2025 Vol. 48 No. 2 (2025): MKA April 2025 Vol. 48 No. 1 (2025): MKA January 2025 Vol 46, No 12 (2024): Online Oktober 2024 Vol 46, No 11 (2024): July 2024 Vol 46, No 10 (2024): Supplementary April 2024 Vol 46, No 10 (2024): Online May 2024 Vol. 47 No. 4 (2024): MKA October 2024 Vol. 47 No. 3 (2024): MKA July 2024 Vol. 47 No. 2 (2024): MKA April 2024 Vol. 47 No. 1 (2024): MKA Januari 2024 Vol 46, No 9 (2024): Supplementary Januari 2024 Vol 46, No 8 (2024): Online Januari 2024 Vol 46, No 7 (2023): Supplementary December 2023 Vol 46, No 5 (2023): Supplementary July 2023 Vol 46, No 4 (2023): Online Juli 2023 Vol. 46 No. 3 (2023): Supplementary July 2023 Vol 46, No 3 (2023): Supplementary May 2023 Vol. 46 No. 3 (2023): Online Juli 2023 Vol 46, No 2 (2023): Online April 2023 Vol 46, No 1 (2023): Online Januari 2023 Vol 46, No 6 (2023): Online Oktober Vol. 46 No. 4 (2023): Online Oktober Vol 45, No 4 (2022): Online October 2022 Vol 45, No 3 (2022): Online July 2022 Vol 45, No 2 (2022): Online April 2022 Vol 45, No 1 (2022): Online Januari 2022 Vol 44, No 7 (2021): Online Desember 2021 Vol 44, No 6 (2021): Online November 2021 Vol 44, No 5 (2021): Online Oktober 2021 Vol 44, No 4 (2021): Online September 2021 Vol 44, No 3 (2021): Online August 2021 Vol 44, No 2 (2021): Online July 2021 Vol 44, No 1 (2021) Vol 43, No 2 (2020): Online Mei 2020 Vol 43, No 1 (2020): Published in January 2020 Vol 42, No 3S (2019): Published in November 2019 Vol 42, No 3 (2019): Published in September 2019 Vol 42, No 2 (2019): Published in May 2019 Vol 42, No 1 (2019): Published in January 2019 Vol 41, No 3 (2018): Published in September 2018 Vol 41, No 2 (2018): Published in May 2018 Vol 41, No 1 (2018): Published in January 2018 Vol 40, No 2 (2017): Published in September 2017 Vol 40, No 1 (2017): Published in May 2017 Vol 39, No 2 (2016): Published in August 2016 Vol 39, No 1 (2016): Published in April 2016 Vol 38, No 3 (2015): Published in December 2015 Vol 38, No 2 (2015): Published in September 2015 Vol 38 (2015): Supplement 1 | Published in September 2015 Vol 38, No 1 (2015): Published in May 2015 Vol 37, No 3 (2014): Published in December 2014 Vol 37, No 2 (2014): Published in September 2014 Vol 37 (2014): Supplement 2 | Published in December 2014 Vol 37 (2014): Supplement 1 | Published in March 2014 Vol 37, No 1 (2014): Published in May 2014 Vol 36, No 2 (2012): Published in August 2012 Vol 36, No 1 (2012): Published in April 2012 Vol 35, No 2 (2011): Published in August 2011 Vol 35, No 1 (2011): Published in April 2011 Vol 34, No 2 (2010): Published in August 2010 Vol 34, No 1 (2010): Published in April 2010 Vol 33, No 2: Agustus 2009 Vol 33, No 1: April 2009 Vol 32, No 2: Agustus 2008 Vol 32, No 1: April 2008 More Issue