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YARSI Medical Journal

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Published by Universitas Yarsi

ISSN : 08541159 EISSN : 24609382 DOI : -

Core Subject : Health,

Medicine & Pharmacology

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Articles 232 Documents

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PENGARUH PERLAKUAN BIPEDAL PADA KEPADATAN JARINGAN KOLAGEN PADA TEMPAT PERLEKATAN OTOT PADA TULANG PANJANG SELAMA PERTUMBUHAN Boer, H. Ardiyan
Jurnal Kedokteran YARSI Vol 17, No 3 (2009): SEPTEMBER - DESEMBER 2009
Publisher : Lembaga Penelitian Universitas YARSI

Penelitian ini dimaksudkan untuk mengetahui hubungan antara kepadatan jaringan kolagen pada perlekatan otot pada tulang panjang dengan perlakuan bipedal selama pertumbuhan. Sebagai hewan percobaan dipakai 120 ekor tikus jantan (Rattus norvegicus), umur 6 minggu, berat rata-rata 70 gram. Secara randomisasi 120 ekor tikus dibagi 2 kelompok, (1) kontrol, (2) bipedal, dan kelompok bipedal diberi perlakuan selama 6 bulan dan dikorbankan pada umur 2 bulan perlakuan dan umur 6 bulan perlakuan. Tempat perlekatan m.pectineus pada femur bagian proximal dan m.rectus femoris yang melekat pada tibia bagian proximal, dipotong pada perlakuan 2 bulan dan 6 bulan, dan dibuat preparat histologisnya dengan pewarnaan Mallory-azan. Nilai rerata kepadatan jaringan kolagen pada perlakuan 2 bulan dan 6 bulan diuji dengan Fisher Exact atau Chi-kuadrat. Pengukuran kepadatan jaringan kolagen m.pectineus antara perlakuan 2 bulan dan 6 bulan lebih besar secara bermakna pada kelompok kontrol dan lebih besar secara tidak bermakna pada kelompok bipedal. Terdapat perbedaan nilai kepadatan jaringan kolagen pada perlekatan m.rectus femoris pada tibia bagian proximal antara perlakuan 2 bulan dan 6 bulan yaitu lebih besar secara bermakna pada kelompok bipedal, dan lebih besar secara tidak bermakna pada kelompok kontrol. Selama migrasi antara 2 bulan dan 6 bulan nilai kepadatan jaringan kolagen pada sebagian besar otot bertambah secara tidak bermakna.

IDENTIFIKASI KALSIUM YANG TERLARUT DALAM FRAKSI ETIL ASETAT DAN AIR DARI DAUN DUDUK (DESMODIUM TRIQUETRUM (L) DC) SECARA IN VITRO DENGAN TEHNIK AKTIVASI NEUTRON CEPAT Kamal, Zainul; Yazid, M.; Sapto Aji, Rani
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

The study on the solubility of calcium kidney stone in the ethyl acetate and water fraction of Duduk leaves was intended to investigate the efectiveness of the kidney stone solubility. The kidney stone was obtained after surgery, and analyzed applaying the infrared spectrophotometer to identify qualitatively the type of kidney stone. The study was performed by dissolving the calcium kidney stone 100 mg in 10 ml fraction of ethyl acetate and water Duduk leaves respectively. The mixtures were shaken and incubated at 370C for 4 hours in a waterbath and were then filtered. The solubility of calcium was determined by the rapid neutron activation tehnique. The result indicated that calcium solubilitty in the water fraction was better than that in the ethyl acetate fraction.

PENENTUAN JENIS DENGAN ANALISIS GEN 16SRRNA DAN UJI DAYA REDUKSI BAKTERI RESISTEN MERKURI YANG DIISOLASI DARI FESES PASIEN DENGAN TAMBALAN AMALGAM MERKURI DI PUSKESMAS BAHU MANADO Umar, Fatimawali
Jurnal Kedokteran YARSI Vol 23, No 1 (2015): JANUARI - APRIL 2015
Publisher : Lembaga Penelitian Universitas YARSI

Paparan merkuri secara kontinyu dalam saluran pencernaan, dapat menyebabkan kresistensi bakteri terhadap merkuri. Bakteri resisten merkuri bermanfaat pada proses detoksifikasi merkuri anorganik dengan mereduksinya menjadi logam merkuri yang tidak toksik. Penelitian ini bertujuan untuk menganalisis gen 16SrRNA dan menguji daya reduksinya terhadap merkuri HgCl2 dari bakteri resisten merkuri anorganik Isolat F2.1 dan F2.2 yang diisolasi dari feses pasien dengan tambalan amalgam gigi di Puskesmas Bahu Manado. Analisis Gen 16SrRNA menggunakan metode Polymerase chain reaction (PCR) dan kadar merkuri dianalisis dengan menggunakan metode Cold-Vapor Atomic Absorption Spectrophotometry (CV-AAS). Hasil BLAST urutan nukleotida gen 16SrRNA menunjukkan bahwa kedua isolat bakteri tersebut mempunyai kemiripan 100% terhadap gen 16SrRNA bakteri Escherichia coli yang terdapat pada GenBank. Hasil analisis daya reduksi merkuri diperoleh bahwa dalam waktu 1, 12, dan 24 jam dapat menurunkan kadar merkuri dalam media berturut-turut untuk isolat F2.1: 82,2%, 87,1% dan 99,2% dan untuk isolat F2.2: 79,5%, 89,2% dan 99,3%.Hasil penelitian menunjukkan bahwa bakteri isolat F2.1 dan F2.2 yang diisolasi dari feses ialah bakteri Escherichia coli dan dapat mereduksikan HgCl2 hampir 100% dalam waktu 24 jam sehingga bakteri tersebut dapat digunakan pada penelitian selanjutnya untuk proses detoksifikasi merkuri organik.Continuous exposure to mercury in the digestive tract, can cause mercury-resistance bacteria. Mercury resistance bacteria are useful in detoxifying processes of inorganic mercury to the reduct form of non toxic metallic mercury.This study aims to analyze 16SrRNA gene and test for mercury reduction ability of inorganic mercury resistant bacteria isolates F2.1 and F2.2, isolated from feces of patients with tooth amalgam at Puskesmas Bahu in Manado. 16SrRNA gene analysis was done using polymerase chain reaction (PCR) and mercury levels were analyzed by using the method of Cold - Vapor Atomic Absorption Spectrophotometry (CV - AAS). BLAST results of nucleotide sequence of 16SrRNA gene showed that both the bacterial isolates had 100% similarity to the 16SrRNA gene of Escherichia coli bacteria found in GenBank. The results of the analysis showed that the reduction ability of mercury in 1 , 12 , and 24 hours can reduce levels of mercury in a row for a media F2.1 isolates: 82.2%, 87.1% and 99.2% and for isolates F2.2: 79.5%, 89.2% and 99.3%. The results showed that the bacterial isolates F2.1 and F2.2 isolated from fecal is Escherichia coli bacteria and may reduce the HgCl2 almost 100% within 24 hours so that the bacteria can be used in future studies to inorganic mercury detoxification process.

ENVIRONMENTAL FACTORS OF THE HOME AFFECT THE DENSITY OF AEDES AEGYPTI (DIPTERA: CULICIDAE) Satoto, Tri Baskoro Tunggul; Diptyanusa, Ajib; Setiawan, Yohanes Didik; Alvira, Nur
Jurnal Kedokteran YARSI Vol 25, No 1 (2017): JANUARI - APRIL 2017
Publisher : Lembaga Penelitian Universitas YARSI

The transmission of Dengue Hemorrhagic Fever (DHF) by Aedes aegypti and Aedes albopictus mosquitoes is influenced by climate change and several environmental factors, namely light intensity, CO2, temperature, humidity, housing condition, drainage, and vegetation. This study aims to identify the relationship between environmental factors and dengue vector population density. This research applies an observational analytic study with a cross-sectional design. The study was conducted in 2012, in the city of Yogyakarta, Indonesia, in 39 houses in the Kricak Village and in 50 houses in the Prenggan Village. Data were collected by observation, interview, and completing checklists, as well as by measuring environmental variables. The differential effect of various factors influencing mosquito density was tested using an independent sample t-test for physical environmental factors and chi-square test for the variable physical condition of the house, biologically relevant environmental factors, drainage, residential density, and the distance between houses. The probability value was p 0.05. The results showed that differences in the physical environment, the physical condition of the house, residential density, and vegetation, all affect the density of dengue vector mosquitoes in the villages of Kricak and Prenggan. The need of raising public awareness about healthy living and care for the environment, along with advocacy to stakeholders, is important for vector density control.

CYTOTOXICITY AND ANTIOXIDANT ACTIVITY OF ZINGIBER OFFICINALE AND 6-GINGEROL ON HEPG2 CELLS Hanif, Harliansyah; Azian Murad, Noor; Wan Ngah, Wan Zurinah; Anum Mohd Yusof, Yasmin
Jurnal Kedokteran YARSI Vol 16, No 1 (2008): JANUARI - APRIL 2008
Publisher : Lembaga Penelitian Universitas YARSI

The present study was designed to compare the effects of ethanolic extract of ginger (Zingiber officinale) and its phenolic component [6]-Gingerol on viability, antiproliferation and apoptotic levels of human hepatoma cell lines (HepG2) and its antioxidant activity. HepG2 cells were cultured in Eagle?s minimum essential medium (EMEM) and the percentage of cell cytotoxicity was evaluated by tetrazolium salt (MTS) assay. Antiproliferation and apoptotic levels were measured by 5?Bromo-2?deoxyuridine (BrdU) colorimetry. Antioxidant capacity was studied by 1.1-diphenyl-2-picryl-hydrazyl radical (DPPH) using spectrophotometry. We found that cytotoxicity and antiproliferative effect of ginger extract and [6]-Gingerol could be associated with induction of apoptosis. The ginger ethanol extract and [6]-Gingerol also showed remarkable antioxidant activities in comparison with ascorbic acid and N-acetyl-L-cysteine.

PERANAN BIDAN DESA DALAM MENANGANI DAN MERUJUK KASUS BAYI BARU LAHIR ASFIKSIA DI KABUPATEN CIREBON Umniyati, Helwiah
Jurnal Kedokteran YARSI Vol 15, No 3 (2007): SEPTEMBER-DESEMBER 2007
Publisher : Lembaga Penelitian Universitas YARSI

Each year 3 million newborns die during the first seven days of life, accounting for 75% of all neonatal deaths. At least 1 million babies die during their first 24 hours of life. Three major causes of neonatal death are infections (pneumonia, diarrhea, and tetanus) 36%, preterm birth 28% and asphyxia 23%. Causes of death vary between the early and late neonatal periods, with deaths caused by preterm birth, asphyxia and congenital defects occur predominantly during the frst week of life and infection is the major cause of neonatal deaths thereafter. In Indonesia based on 2001 Household Health Survey (SKRT 2001) neonatal death caused by asphyxia was 27% which was the second cause of neonatal death after low birth weight. The objective of this study was to learn the role of midwives in handling and referring birth asphyxia in Cirebon District by using qualitative method. The result showed that many people living in villages in Cirebon district did not understand the causes of asphyxia. They thought that babies could not cry because of bad spirit or devil. The midewives were capable of handling the asphyxia babies according to their knowledges obtained from training about asphyxia management. Sometimes however, the midwives encountered some constrains in practice such as low birth weight babies (only 1,4 Kg) and oversize concave cover for resuscitation. Other limiting factors occurred when the midwives would like to refer the babies to the hospital. The families might refuse with some reasons such as, no trust in the medical staff, shortage of money or difficulty in finding transportation. Lack of incubator in the hospital was also another obstacle.

KADAR SUPEROKSIDA DISMUTASE MAHASISWA PEROKOK DI PROGRAM STUDI PENDIDIKAN DOKTER UNIVERSITAS SRIWIJAYA Albasyam, Subandrate; Safyudin, Safyudin; Arifin, Mutmainah; Oktalisa, Wenni
Jurnal Kedokteran YARSI Vol 23, No 2 (2015): MEI - AGUSTUS 2015
Publisher : Lembaga Penelitian Universitas YARSI

Merokok merupakan suatu masalah kesehatan pada masyarakat Indonesia dan ancaman besar bagi kesehatan di dunia. Asap rokok mengandung komponen gas dan partikel yang berpotensi untuk menimbulkan radikal bebas, peroksidasi lipid (MDA) dan menurunkan kadar antioksidan endogen (SOD). Penelitian ini bertujuan untuk mengetahui kadar superoksida dismutase mahasiswa perokok di Program Studi Pendidikan Dokter FK Unsri. Penelitian ini adalah penelitian analitik observasional dengan pendekatan potong lintang yang dilakukan dari bulan April sampai Desember 2014. Jumlah sampel yang didapat di dalam penelitian ini adalah 20 mahasiswa perokok dan 10 mahasiswa bukan perokok. Kadar superoksida dismutase darah ditentukan secara biokimia menggunakan kit RanSOD®. Hasil penelitian ini menunjukkan bahwa rata-rata kadar SOD subjek penelitian yang merokok adalah 0,76 u/mL dan yang tidak merokok adalah 0,87 u/mL. Hasil uji statistik kadar SOD menunjukkan nilai signifikansi p=0,860. Kadar SOD mahasiswa perokok Program Pendidikan Dokter FK Unsri lebih rendah daripada kadar SOD mahasiswa nonperokok. Pada mahasiswa Program Pendidikan Dokter FK, merokok tidak berpengaruh signifikan terhadap penurunan kadar SOD.Smoking is a public health problem in the world. Cigarette smoke contains gas and particle which leads to generate free radicals, lipid peroxidation (MDA) and reduced levels of endogenous antioxidants (SOD). This study aimed to determine the levels of superoxide dismutase of smoker student in Medical Education of Sriwijaya University. We used a cross sectional study from April to December 2014. Subject of this study consisted of 20 smoker students and 10 nonsmoker students. Blood levels of superoxide dismutase was determined biochemically using RanSOD® kit. The results showed that average of SOD level in smokers was 0.76 U/mL and nonsmokers was 0.87 U/mL (p= 0.860). SOD levels of smoker students were lower than nonsmoker students. In Medical Education of Sriwijaya University, smoking had no significant effect on reducing the levels of SOD.

ATROPINE 0.01% AS A POTENTIAL MYOPIA PREVENTION IN CHILDREN WITH DOSAGE EFFECTIVITY COMPARISON: A LITERATURE REVIEW Ivan, Ignatius; Stella, Maureen Miracle; Santosa, Mariani
Jurnal Kedokteran YARSI Vol 27, No 3 (2019): SEPTEMBER - DESEMBER 2019
Publisher : Lembaga Penelitian Universitas YARSI

Myopia (long-sightedness) is one of the many problems of vision disorder occurring around the world and being 1 in 5 eye conditions that becoming a priority at the World Health Organization's Global Intitiative for the Elimination of Avoidable Blindness. Many methods of preventing myopia development have been sought. Atropine is an alkaloid derived herbal plant Atropa belladonna which acts as a muscarinic acetylcholine receptor antagonist that has a strong nonselective competitive affinity on the five types of muskarinic acetylcholine receptors (M1-M5) that weaken the muscles of the ciliary and iris and causes the reduction of accommodation and the occurrence of pupil dilation. Recent research found that with the use of low dose atropine (0.01%), in addition to the side effects inflicted more minimal, effectiveness in the long time period shows better results. Until now, the mechanism of atropine is still experiencing debate whether working on an accommodating or non-accommodating pathway. But recent research suggests the possibility of working mechanism of this drug is through a non-accommodating pathway i.e. on GABAergic, dopaminergic as well as involving nitric oxide (NO) role to help inhibit the progression of myopia. In research and advanced scientific studies, it can be researched regarding the pathways of atropine mechanism and its advantages and disadvantages at any dose of atropine given to myopia sufferers using the latest literature sources.

PERAN SERTA MASYARAKAT SECARA MANDIRI DALAM MELESTARIKAN BACILLUS THURINGIENSIS H-14 GALUR LOKAL DALAM BUAH KELAPA UNTUK MENGENDALIKAN JENTIK ANOPHELES SP DI KAMPUNG LAUT KABUPATEN CILACAP Blondine, Ch.P.; Yuniarti, R.A.
Jurnal Kedokteran YARSI Vol 16, No 1 (2008): JANUARI - APRIL 2008
Publisher : Lembaga Penelitian Universitas YARSI

Training for society independent activity has been carried out recently to culture B. thuringiensis H14 local strain in the coconut media. This study was done for the purpose of Anopheles control in Klaces Village, Kampung Laut involving 30 participants. It focused on the culturing process of B. thuringiensis H-14 local strain in the coconut media and its application. The collection result of bacterial culture was then spread to surrounding local pools containing some mosquito larvae. Check list evaluation was applied continually for six times period, with two weeks interval. The result showed that most of the participants ( 80%) were able to do the nine elements perfectly in order. Ninety percent of them were able to prepare the coconut independently and practiced the inoculation of B. thuringiensis H-14 local strain on the coconut media correctly (96,675%). In addition, they could also maintain the main equipments required for the culturing process (100%). Meanwhile, a decrease in density of Anopheles sp (80 ? 100%) after one day culturing of B. thuringiensis H-14 local strain on the coconut media was observed. It is concluded that the results encourage the society to culture B. thuringiensis H-14 local strain in the coconut media independently in order to control Anopheles sp larvae. Further studies are still needed particularly those related with the cost benefit and cost effectiveness

OTOVAKSIN SEBAGAI TERAPI ALTERNATIF INFEKSI MYCOBACTERIUM TUBERCULOSIS PADA TIKUS PUTIH (RATTUS NORVEGICUS) Praseno, Praseno; Nurrokhman, Nurrokhman; Fiatiningsih, Istiana
Jurnal Kedokteran YARSI Vol 15, No 3 (2007): SEPTEMBER-DESEMBER 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v15i3.1077

Tuberculosis (TB) is still an important public health problem, especially in developing countries such as Indonesia. Efforts have been made to overcome the problem, however, number of cases is still high. This is due to various factors which might affect the development of the disease. Increasing number of resistant strains against antimycobacterial drugs is one of the major factors. Therefore, alternative method to control TB is needed.The aim of this study was to evaluate the effectiveness of autogenous vaccine on healing process of infection caused by Mycobacterium tuberculosis in rats. Eighteen Wistar rats (Rattus norvegicus) were infected with 109 colony forming unit of M. tuberculosis subcutaneously. One week after infection, the rats were divided randomly into 2 groups, first group were treated with autogenous vaccine and the other were left untreated (control group). Autogenous vaccine was given subcutaneously with the dose of 108 cfu/0,1 ml every 7 days 3 times. Subcutaneous nodules were evaluated every 3 days and weight gain was evaluated 3 times. Laboratory examinations were done, including acid fast bacilli stain, histopatological feature and serologic test. The result showed that recovery of subcutaneous nodules in autovaccine treated group of rats was faster than that of untreated control group. Acid fast bacilli staining showed that the number of micobacteria found in the lung, liver, spleen and kidney of autovaccine treated group were much lower than those found in the control group. Histopathology features showed that lymphocytes infiltration in the lung and other organs was heavier in the control group than that of treated group. In conclusion, animal study on rats showed that autogenous vaccine had effective therapeutic effect on healing process for M. tuberculosis infection.

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