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Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
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Articles 321 Documents
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The Role of Omega-3/Omega-6 Ratio on Appetite in Pulmonary Multidrug-Resistant Tuberculosis Patients Fattrias Handayani Jayaatmaja; Nurul Ratna Mutu Manikam; Inge Permadhi; Neni Sawitri; Budi Rahayu; Adityo Wibowo; Fariz Nurwidya
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.7-11

Abstract

Introduction: Tumour necrosis factor-alpha (TNF-α) levels, pro-inflammatory cytokines that suppress appetite, were discovered to be much higher in multidrug-resistant tuberculosis (MDR-TB) than in drug-sensitive TB. Research on the omega-3/omega-6 (êž·-3/êž·-6) polyunsaturated fatty acids (PUFAs) intake, which can support appetite in patients with MDR-TB, has never been performed. This study aimed to examine the relationship between êž·-3/êž·-6 PUFAs intake ratio and appetite mediated by TNF-α in pulmonary MDR-TB patients. Methods: This was a cross-sectional study conducted on 46 male and female adults with MDR-TB undergoing intensive phase therapy. Data were collected through questionnaires, 1x24 hours food recall, anthropometric measurements, 100 mm visual analogue appetite scale, and venous blood collection. Results: Correlation analysis used the Pearson and Spearman tests. The findings revealed the ratio of êž·-3/êž·-6 PUFAs intake of 0.11 ± 0.05, the median value of TNF-α 7.49(1.66-447.62) pg/mL, and an average appetite of 58.72 ± 26.7. There was no relationship between êž·-3/êž·-6 PUFAs intake ratio and TNF-α (r = 0.016; p = 0.91), likewise between êž·-3/êž·-6 PUFAs intake ratio with appetite (r = -0.1; p = 0.54), but there was a relationship between TNF-α and appetite (r = 0.031; p = 0.04). Conclusion: There was no relationship between êž·-3/êž·-6 PUFAs intake ratio and TNF-α and appetite in pulmonary MDR-TB patients. However, there was a relationship between TNF-α and appetite. This study is the first to determine the correlation between êž·-3/êž·-6 PUFAs intake ratio and appetite in pulmonary MDR-TB patients.
Final Condition of HIV Patients Infected with COVID-19 after Receiving Hospital Treatment: A Systematic Review Elin Hidayat; Abu Bakar; Nursalam Nursalam; Retno Indarwati; Herminia Maria
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.56-63

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) can attack anyone, including those who have human immunodeficiency virus (HIV) due to low immune systems. This study aimed to evaluate the final condition of people living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (PLWHA) who received treatment at the hospital. Methods: A literature investigation of the last three years (2020-2022) were inquired. Electronic databases (Science Direct, Scopus, ProQuest) with case series or case report designs were examined. The titles, abstracts, and full texts were screened to obtain relevant studies. Data tabulation and narrative analysis were conducted, resulting in 14 studies that met the inclusion criteria. Most of them were case series and case report methods. Each study had different numbers of patients and criteria discussing COVID-19 infection in HIV patients. Results: A total of 14 reviewed studies revealed that HIV patients with COVID-19 could recover from the infection if proper treatments were performed. Some articles also stated that self-isolation at home can manage HIV-infected patients who are not yet severe. In the case of patients with severe infections, intensive care is performed using supplemental oxygen or a ventilator to prevent respiratory failure or acute respiratory distress. Conclusion: COVID-19 can worsen the condition of patients with HIV if not appropriately treated. Otherwise, if the proper treatment is properly performed, it can cure the infection.
Doege-Potter Syndrome: A Rare Paraneoplastic Syndrome of Solid Fibrous Tumors Reported in Indonesia Jahja Teguh Widjaja; Peter Syarief; Evelyn Nathania; Ayunda Prameswari; Yumilia Hoo
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.37-43

Abstract

Introduction: Solitary fibrous tumors (SFT) is a rare group of tumor. Even rarer, it is associated with Doege-Potter syndrome (DPS), which manifests as hypoglycemia due to paraneoplastic syndrome. From searching through national reports and articles, this was the first case of DPS in Indonesia. Case: A 60-year-old woman was admitted to the emergency department with dyspnea and unconscious. The patient's glucose level showed 21mg/dL. A solid mass on the patient's right lung was shown on the chest X-ray. A previous biopsy concluded that the patient had a solid fibrous tumor with a history of profound hypoglycemia. The patient underwent tumor resection and got a biopsy of the tumor. After resection, the patient showed no sign of hypoglycemia, and the blood glucose level was stable. We concluded that the patient had DPS, a paraneoplastic syndrome associated with the solid fibrous tumor. Conclusion: Performing an adequate examination and giving prompt treatments can increase the patient's quality of life, even though it is a rare disease and hard to diagnose. The patient's condition, evaluated from a clinical condition, chest X-ray, and blood glucose, was better than before getting radical resection.
Profile of Exon 20 T790M Mutation Incidence Rate with Plasma ctDNA in Lung Adenocarcinoma Patients Receiving EGFR-TKI Treatment Muhammad Harbi Praditya; Noni Novisari Soeroso; Setia Putra Tarigan; Taufik Ashar; Darren Wan-Teck Lim
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.12-17

Abstract

Introduction: Patients with lung adenocarcinoma following epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment will develop acquired resistance after 7 to 16 months of starting the medication, indicated by the emergence of exon 20 T790M mutations. This study aimed to identify the clinical and demographical profile of acquired resistance in patients with lung adenocarcinoma receiving EGFR-TKI therapy through plasma circulating tumor deoxyribonucleic acid (ctDNA) examination. Methods: This was a descriptive study with a retrospective cross-sectional design involving 108 lung adenocarcinoma patients who received EGFR-TKI for more than six months. Exon 20 T790M EGFR mutations were identified as a sign of acquired resistance using the digital droplet polymerase chain reaction (ddPCR) approach to examine plasma ctDNA Utilizing the Statistical Package for the Social Sciences, statistical tests were used to examine the data (SPSS). The data were analyzed by statistical tests using the Statistical Package for the Social Sciences (SPSS). Results: A total of 31 patients were recruited as study participants. The majority of the research subjects were female (64.5%), aged 20-69 years old (58%), and non-smokers (67.7%). Exon 19 deletions were the most prevalent EGFR mutation (58.1%). The incidence of acquired resistance was found in 10 subjects (32.3%). Patients with acquired resistance were predominately female (70%), non-smokers (80%), and with gefitinib therapy (90%). The average time for EGFR-TKI treatment until acquired resistance occurred was 12.6 months. Conclusion: The incidence of acquired resistance was mainly found in women without a smoking history after 12.6 months of treatment with EGFR-TKI.
Hematologic Paraneoplastic Syndrome in Newly Diagnosed Patients with Lung Cancer Andika Chandra Putra; Steven Jonathan; Wira Winardi; Elisna Syahruddin
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.18-29

Abstract

Introduction: Lung cancer could have signs and symptoms generated by paraneoplastic syndromes. This study aimed to describe and analyze hematologic paraneoplastic syndrome in patients with lung cancer in Indonesia. Methods: This was a cross-sectional analytic study conducted in Persahabatan National Respiratory Referral Hospital, Jakarta, between September 2018 and February 2019, on all newly diagnosed patients with lung cancer whose diagnosis was established and who fulfilled the inclusion and exclusion criteria. Results: The mean age of subjects was 56.7 ± 11.4 years old. Most subjects were male, had normal nutritional status (42.6%), had a smoking history (75%), and had a moderate Brinkman Index (BI) value (52%). The most common type of histology was squamous cell carcinoma (SCC) (39.7%), with advanced stage (83.8%) and performance status <2 (94.1%). Paraneoplastic anemia was 40.4%, associated with poor nutritional status and commonly normocytic normochromic anemia. The proportion of paraneoplastic leukocytosis was 39%, associated with males and smoking history. The proportion of paraneoplastic neutrophilia was 51.5%, and it was related to males, smoking history, and SCC histology type. Paraneoplastic hypereosinophilia and thrombocytosis proportions were 2.9% and 18.4%, respectively. The proportion of paraneoplastic hypercoagulability was 91.2%, which was caused by the elevated D-dimer level. Conclusion: The most common hematologic paraneoplastic syndromes in patients with lung cancer were hypercoagulability, neutrophilia, and anemia. The low hemoglobin (Hb) level of paraneoplastic anemia was associated with low body mass index (BMI). Male and smoking history in lung cancer patients were associated with paraneoplastic leukocytosis and/or neutrophilia.
COVID-19 Severity based on Deep Convolutional Neural Networks Chest X-Ray Image in Aceh, Indonesia Budi Yanti; Yudha Nurdin; Teuku Geumpana
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.30-36

Abstract

Introduction: Every area of our lives has been devastated by the worldwide Coronavirus disease 2019 (COVID-19) epidemic. However, the development of artificial intelligence has made it possible to build advanced applications that can fulfill this level of clinical accuracy. This study aimed to create a deep learning model that can detect COVID-19 from a chest image dataset of confirmed patients treated at the provincial hospital in Aceh. Methods: Eight hundred confirmed COVID-19 patients' chest X-ray photos were gathered locally from Dr. Zainoel Abidin General Hospital, Banda Aceh. Performance was evaluated in several ways. First, the dataset was used for training and testing. Second, the data was used to train and test the model. VGG16 is a robust network adapted to an enhanced dataset constructed from a confirmed COVID-19 chest X-ray pool. To artificially produce a huge number of chest X-ray pictures, this study used data augmentation techniques such as random rotation at an angle between 10 and 10°, random noise, and horizontal flips. Results: The experimental results were encouraging: the proposed models classified chest X-ray pictures as normal or COVID-19 with an accuracy of 97.20% for Resnet50, 98.10% for InceptionV3, and 98.30% for VGG16. The results showed the outstanding performance of straightforward COVID-19 diagnosis with the classification of COVID-19 severity, such as mild, severe, and very severe. Conclusion: These made it possible to automate the X-ray image interpretation process accurately and could also be applied when materials and reverse transcription polymerase chain reaction  (RT-PCR) tests are scarce.
Dual Primary Squamous Cell Carcinoma of the Lung and Adenocarcinoma Rectal Sayyid Muhammad Sahil Haikal; Hadi Irawiraman; Aryo Dirgantara Putra
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.44-48

Abstract

Introduction: Lung and colorectal carcinoma are commonly found in cancer and often cause mortality worldwide. Colorectal cancer (CRC) is the third most common cause of death. Although multiple primary cancers can exist, these two malignancies rarely happen simultaneously. This case report shows a patient diagnosed with squamous cell carcinoma of the lung and rectal adenocarcinoma with metastases to the liver, ocular, and cerebrum. Case: A 54-year-old woman came with chest pain accompanied by persistent and progressive breathing difficulty, cough, loss of appetite, and weight loss of almost 15 kg. The patient experienced sudden lower and upper extremities weakness two weeks after being hospitalized. The patient also experienced blurred vision and swelling of the eyes. At that time, the patient had an endoscopy procedure, and the biopsy showed colitis with severe dysplasia. Based on clinical and radiologic findings, the patient had lung and colon cancer. Conclusion: Dual primary carcinoma rarely happens, and metastases from different neoplasms are difficult. Warren and Gates' criteria could be used to diagnose dual primary carcinoma, especially if diagnostic studies could not be performed. Signal that the hedgehog gene is still active when the neonate is born is suspected of causing these carcinomas.
Giant Pleural Hydatid Cyst: A Case Report Sudarto, Sudarto; Belinda, Selli; Fathurrachman, Alif; Andriani, Linda; Pasaribu, Rouly; Rasyid, Ahmad; Ahmad, Zen; Setiawan, Tommy
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.49-55

Abstract

Introduction: Echinococcosis is a zoonotic disease caused by the larva stage of a Taeniidae parasite of Echinococcus. Echinococcus granulosus (E. granulosus) causes cystic echinococcus (CE) and is the most common species causing disease in humans. A pleural hydatid cyst should be considered initially with a corresponding chest radiograph. It can develop into fatal complications, including secondary infection, severe bleeding, bronchial rupture and pleural or pericardial cavities. This case report shows a rare case of a pleural hydatid cyst. Case: We reported a 59-year-old woman with shortness of breath and a productive cough for three months. The chest radiography and computed tomography (CT) scan revealed a cystic lesion measuring 14.2 x 18.5 cm with edge calcification thick around 3 mm. The pleural histopathology revealed that the cyst wall was made of fibrocollagen with a red oval echinococcus. The patient received oral albendazole/ABZ (400mg BID) for three months, paracetamol (500mg TID), and n-acetylcysteine (200mg TID). After three months, the patient had no complaints, only shortness of breath with heavy activity. Conclusion: It is important to be aware of this condition to avoid inappropriate and potentially dangerous underdiagnoses and treatment, which could endanger the patient.
Preparation and Findings in Diagnostic and Therapeutic Flexible Fiberoptic Bronchoscopy Procedures in Patients with COVID-19 Irandi Putra Pratomo; Hario Baskoro; Dicky Soehardiman; Prasenohadi Prasenohadi; Tutug Kinasih; Ahmad Fauzi; Ike Maretta; Nachita Putri; Kentaro Tokumo
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.72-79

Abstract

The coronavirus disease 2019 (COVID-19), which has raised concerns about infection control for every clinical procedure, including flexible fiberoptic bronchoscopy (FFB), has drawn the attention of clinicians across the globe. A pulmonologist frequently conducts this procedure to diagnose and treat pulmonary diseases like COVID-19. This procedure involves direct airway observation and generates aerosol from the patient. However, it is considered a double-edged sword, as the risk of infection and instrument contamination always haunts its clinical benefit to the patients and the operators. Therefore, a guideline for preparing and indicating FFB in COVID-19 must be addressed appropriately by emphasizing the importance of infection prevention and control. Fortunately, several recommendations and findings have emerged over the past three years, which should support safe FFB procedures for its operators with controlled infection. This study summarizes the indication, objective, contraindication, risk, preparation, and findings in diagnostic and therapeutic FFB patients with COVID-19.
Implementing Palliative and End-of-Life Care in Lung Cancer: When to Start? Haryati Haryati; Desi Rahmawaty; Tenri Ashari Wanahari
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.64-71

Abstract

Lung cancer is among the most prevalent cancers and the primary cause of cancer-related mortality. Despite advances in treatment, patients often have a poor prognosis, with a limited survival period, particularly in advanced stages. Significant morbidity is linked with lung cancer, and symptoms are frequently inadequately controlled, resulting in a considerable symptom burden for patients and their family caregivers. It is typically accompanied by an overall reduction in one's quality of life (QoL). Palliative care is an established therapy paradigm that successfully enhances symptom management and physical and mental health. It can be initiated as soon as the patient develops symptoms (even in the early stage) or is diagnosed with a late stage. Over the past few decades, palliative care has become a vital part of comprehensive care for people, especially those with advanced diseases. Early palliative care (EPC) integration within the oncology setting is more effective than standard care in enhancing the patient's QoL and length of survival, resulting in less intrusive end-of-life care. When caring for lung cancer patients, medical practitioners must remember their duty to cure occasionally, routinely alleviate, and constantly comfort the patient. Treating physical symptoms, illness comprehension, coping, and psychological and spiritual anguish are all vital components. Intervention strategies by multidisciplinary teams concentrating on the patient and their family and dealing with the circumstances are essential. All health providers should prioritize palliative and end-of-life care to enhance care and assist patients and their families in navigating the final period of life.

Page 20 of 33 | Total Record : 321

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