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Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
Arjuna Subject : -
Articles 334 Documents
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Persistent Pneumothorax in Neurofibromatosis Type-1 Simamora, Hustorio Aliongko; Djajalaksana, Susanthy; Chozin, Iin Noor; Erawati, Dini Rachma; Yudhanto, Hendy Setyo; Damanik, Gracelia Ruth Elisabeth; Dani, Adinda Amalia; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.64-70

Abstract

Introduction: Neurofibromatosis type 1 (NF-1) is a rare autosomal dominant disorder. While typically recognized by its cutaneous features, pulmonary involvement, including apical cysts and basal interstitial fibrosis consistent with interstitial lung disease (ILD), can occur in up to 20% of patients. These manifestations create a predisposition to complications such as spontaneous pneumothorax. While this is relatively uncommon, occurring in approximately 1.5% of patients with NF-1, it represents a serious and potentially life-threatening complication when it does occur. Case: A 52-year-old male with a 20-pack-year smoking history and active pulmonary tuberculosis (TB) presented with acute chest pain and dyspnea. Dermatological examination and skin biopsy confirmed the diagnosis of NF-1. A high-resolution computed tomography (HRCT) scan of the chest revealed multiple subpleural pulmonary cysts consistent with NF-1-related ILD, alongside findings suggestive of active TB. The patient was diagnosed with a secondary spontaneous pneumothorax (SSP), which proved to be persistent despite initial chest tube drainage, ultimately requiring surgical intervention. Conclusion: This case highlights that NF-1 is a significant underlying risk factor for persistent pneumothorax, particularly when co-existing with other conditions like active TB and a history of smoking. The chronic inflammation and parenchymal destruction associated with these comorbidities can exacerbate the inherent structural lung abnormalities in NF-1, leading to complex, difficult-to-manage clinical scenarios. Early recognition of pulmonary manifestations in patients with NF-1 is crucial for anticipating and managing severe complications.
The Potential of Ethanol Extract Tamarillo (Solanum betaceum) on B-Cell Lymphoma 2 Expression in Mice (Mus musculus) Lungs Exposed to Lead Acetate Iswandi, Cantika Marcellin Princess; Setiawan, Herley Windo; Fatimah, Nurmawati; I’tishom, Reny; A'yuni, Mila Qurotul
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.44-51

Abstract

Introduction: Lead acetate, a toxic heavy metal compound, induces cellular and tissue injury primarily through oxidative stress. Exposure via inhalation or ingestion enables systemic absorption and distribution to target organs, particularly the lungs. One of the key anti-apoptotic proteins involved in maintaining cell survival is B-cell lymphoma 2 (Bcl-2). The administration of exogenous antioxidants represents a preventive approach to counteract the cytotoxic effects of lead, including the use of ethanol extract of tamarillo fruit. This study investigated the potential influence of tamarillo (Solanum betaceum) ethanol extract, known for its antioxidant content. Specifically, it examined its effect on Bcl-2 expression in the lung tissue of male mice exposed to lead acetate. Methods: This study used a true experimental design in a controlled laboratory setting. The specimens were divided into five groups: K0 served as the negative control, while K1 acted as the positive control and was treated with lead acetate at a dose of 0.075 g/kgBW. Group P1, P2, and P3 received lead acetate combined with ethanol extract of tamarillo at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively. Results: The findings showed that tamarillo ethanol extract significantly increased lung Bcl-2 expression in lead-exposed mice (p<0.05). B-cell lymphoma 2 expression increased progressively with higher extract doses compared with the positive control group. Conclusion: Administration of the tamarillo ethanol extract at 100 mg/kgBW was the most effective and provided protective effects on lung tissue.
Predicting Prolonged Hospitalization in Pneumonia: The Role of Lung Injury Score Putri, Mayandra Alif Anggita; Marhana, Isnin Anang; Hakim, Arief Rakhman; Bakhtiar, Arief; Syafa'ah, Irmi
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.27-34

Abstract

Introduction: Pneumonia is a lung infection with a high prevalence and is associated with prolonged length of stay (LOS). An excessive LOS increases the risk of complications, while a short LOS may lead to inadequate treatment. The lung injury score (LIS), which assesses the severity of lung injury and respiratory dysfunction, is expected to be an accurate predictor of LOS in patients with pneumonia. This study aimed to determine the correlation between LIS and LOS in hospitalized patients with pneumonia. Methods: This retrospective cohort study included adult patients hospitalized at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, with a diagnosis of pneumonia between January and December 2023. The LIS component scores (chest X-ray findings, arterial partial pressure of oxygen-to-fractional inspired oxygen ratio, positive end-expiratory pressure (PEEP), and static lung compliance) were obtained from electronic medical records and used to calculate LIS values. The correlation between LIS and LOS was analyzed using the Spearman test, while the cut-off point was determined using receiver operating characteristic (ROC) curve analysis. Results: A total of 152 patients fulfilled the inclusion criteria. The mean LIS was 1.82±0.89, while the mean LOS was 10.23±6.27 days. A statistically significant correlation was found between LIS and LOS (p<0.001) with a correlation coefficient of 0.317. Receiver operating characteristic curve analysis identified the optimal LIS cut-off point for an LOS of 10 days as 1.75. Conclusion: There was a statistically significant correlation between LIS and LOS in patients with pneumonia. The LIS cut-off point of 1.75 for an LOS of 10 days was statistically significant.
Ki-67 Expression and Histopathological Type, Metastatic Status, and Risk Factors in Lung Cancer Khairani, Muhammad; Munir, Sri Melati; Darmawi, Darmawi; Yovi, Indra; Esha, Indi; Fauzi, Zarfiardy Aksa; Zahtamal, Zahtamal
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.35-43

Abstract

Introduction: Lung cancer remains a leading cause of cancer-related morbidity and mortality worldwide. In Indonesia, the incidence and death rates associated with this disease remain alarmingly high. Ki-67 is a potential biomarker for assessing cellular proliferation and metastatic potential. However, its clinical application in lung cancer remains inconsistent. This study aimed to analyze the association between Ki-67 expression and histopathological subtype, metastatic status, and clinical risk factors in patients with lung cancer. Methods: This study enrolled 42 patients diagnosed with lung cancer at Arifin Achmad General Hospital, Pekanbaru, Indonesia. Statistical analysis used the Chi-square or Fisher’s exact test (non-parametric tests) for categorical data and the Kolmogorov-Smirnov test, depending on the data characteristics. Participants were selected based on predefined inclusion criteria, complete medical documentation, and available Ki-67 immunohistochemistry results. Results: Among the 42 patients analyzed, 34 (80.9%) exhibited metastasis. The findings revealed a significant correlation between Ki-67 expression and metastasis (p=0.0038), whereas no significant associations were observed with age, sex, smoking status, or histopathological classification. Most patients (approximately 69%) had low Ki-67 expression. Conclusion: Ki-67 expression was associated with metastatic status in patients with lung cancer and might serve as a prognostic biomarker. Further studies with larger sample sizes are needed to validate these findings.

Page 34 of 34 | Total Record : 334

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