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Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
Arjuna Subject : -
Articles 321 Documents
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Prevalence and Affecting Factors of Arrhythmias in Stable Chronic Obstructive Pulmonary Disease at a Tertiary Hospital in Indonesia Gozali, Achmad; Wicaksono, Muhammad Bimo Adi; Yunus, Faisal; Ratnawati, Ratnawati; Basalamah, Muhammad Abbas; Amien, Bagus Radityo
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.131-139

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) represents an increasing global health burden. Among its significant comorbidities, cardiovascular complications, particularly arrhythmias, are of significant concern. Chronic obstructive pulmonary disease and arrhythmias share common risk factors, including advanced age and smoking. This study investigated the prevalence and contributing factors of arrhythmias in stable COPD patients. Methods: This cross-sectional study was conducted among stable COPD patients attending the Asthma-COPD Clinic at Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia, from January to April 2018. The inclusion criteria encompassed a clinical diagnosis of COPD and voluntary participation with written informed consent. Each participant underwent laboratory evaluation, electrocardiography (ECG), blood pressure measurement, and a structured interview. Patients were excluded if they had experienced acute COPD exacerbations during the assessment, had a history of other chronic lung diseases, suffered a recent myocardial infarction, had structural heart disease, were diagnosed with fibrillation, or declined to participate. Results: The prevalence of arrhythmias in stable COPD patients was 24.1%. The types included sinus bradycardia (2.41%), premature atrial contractions/PACs (3.61%), premature ventricular contractions/PVCs (8.43%), and sinus tachycardia (9.64%). The majority of arrhythmic patients were males, with an average age of 68 years old. These patients also had a history of heart disease, exhibited severe COPD symptoms, and demonstrated significant airflow obstruction (average pCO₂ of 36 mmHg). Conclusion: Decreased chloride levels were associated with an increased incidence of arrhythmias. However, no significant associations were observed with airflow limitation, sex, age, bronchodilator use, or arterial blood gas parameters.
Prognosis of Tyrosine Kinase Inhibitor Therapy for Non-Small Cell Lung Cancer Santoso, Agus Andreas; Pratiwi, Suryanti Dwi; Sugiri, Yani Jane; Al Rasyid, Harun; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.140-146

Abstract

Introduction: Non-small cell lung cancer (NSCLC) was the primary cause of death in lung cancer. Tyrosine kinase inhibitors (TKIs) were one of the management options for NSCLC. Meanwhile, serum carcinoembryonic antigen (CEA) plays a crucial role in the diagnosis and prognosis of NSCLC patients. This study aimed to determine the effectiveness of epidermal growth factor receptor (EGFR)-TKI based on progression-free survival (PFS) and overall survival (OS) in NSCLC patients with common EGFR mutations. Methods: This retrospective cohort study used a total sampling method. The serum CEA level was measured before the initial treatment. Tyrosine kinase inhibitors therapy was monitored with PFS and OS. Statistical analysis for comparing prognosis in NSCLC among TKI groups used Kruskal-Wallis, analysis of variance (ANOVA), Mann-Whitney, and Spearman’s rho tests. A significant analysis referred to a p-value of <0.05. Results: The participants were 189 patients, consisting of 106 on gefitinib, 43 on erlotinib, and 40 on afatinib. The average PFS values in the gefitinib, erlotinib, and afatinib groups were 9.9±5.25, 8.77±4.53, and 12.83±7.02 months, respectively (p=0.016). Furthermore, there were no significant OS among the gefitinib (14.91±7.61 months), erlotinib (14.54±7.64 months), and afatinib group (15.51±8.13 months, p=0.867). There was a significant correlation between CEA levels and PFS (r=0.146; p=0.046) and between CEA levels and OS (r=0.223; p=0.004). Conclusion: Although afatinib may prolong PFS compared with gefitinib and erlotinib, it did not significantly impact OS. Increased serum CEA levels before treatment significantly improved PFS and OS. However, elevated CEA levels are usually associated with a poor prognosis in NSCLC.
The Effectiveness of Lactobacillus rhamnosus Administration on the Growth of Klebsiella pneumoniae in Mice (Mus musculus) Ahmad, Izhar Fitrah; Wiriansya, Edward Pandu; Anggita, Dwi; Basri, Rezky Pratiwi Lambang; Sodiqah, Yani; Nurmadilla, Nesyana
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.147-152

Abstract

Introduction: Klebsiella pneumoniae is a bacterium from the Enterobacteriaceae family and is considered one of the most dangerous pathogens. Antibiotics are crucial for treating acute bacterial infections. Using probiotics has become one of the supportive and curative efforts in managing the growth of K. pneumoniae. One probiotic derived from microorganisms is Lactobacillus rhamnosus. This study aimed to determine the effectiveness of L. rhamnosus on the growth of K. pneumoniae in mice (Mus musculus). Methods: This was an experimental post-test study. The study population consisted of mice aged 3 to 4 months, weighing 20 to 40 grams, determined using Federer’s formula. Mice were given standard feed and sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The distribution colony count test was used for evaluation. Results: Among the five groups studied, probiotic intervention in the group receiving a combination of L. rhamnosus and the antibiotic ceftriaxone showed effective results (p<0.05), as did the group given only the probiotic L. rhamnosus (p<0.05). In contrast, the other groups did not show effective results (p>0.05). Conclusion: The administration of L. rhamnosus is effective as a supportive and curative treatment, but it is not effective as a preventive measure against the growth of K. pneumoniae in mice.
Pulmonary Empyema with Possible Tuberculosis Infection: A Case Report Putra, I Gusti Putu Adietha Chandra; Santoso, Resyana; Putra, Wayan Wahyu Semara; Putra, I Wayan Ardyan Sudharta
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.166-173

Abstract

Introduction: Pulmonary empyema is an infectious disease with mortality and morbidity rates ranging between 3% and 33%. It occurs in approximately 8.9% of patients with tuberculosis (TB), and the associated mortality rate is approximately 20%. If not treated promptly following diagnosis, empyema may result in a poor prognosis. Therefore, this case report presented a patient with pulmonary empyema caused by a possible TB infection. Case: A 57-year-old female presented with a two-week history of coughing up yellow phlegm and a three-day history of fever. The patient reported an untreated dental cavity in the right lower tooth for the past three weeks. Physical examination revealed decreased vesicular breath sounds in the right hemithorax’s fifth to sixth intercostal space (ICS). Chest X-ray examination suggested pneumonia and right pleural effusion. Laboratory examinations revealed leukocytosis, thrombocytosis, and an increased neutrophil-to-lymphocyte ratio (NLR). The adenosine deaminase (ADA) level was 89 U/L. Ultrasonography (USG) of the right hemithorax confirmed right pleural effusion. A pleural puncture was performed, and a thoracic drainage was inserted. The procedure yielded approximately 1,700 cc of cloudy brown pus. The patient was diagnosed with right pulmonary empyema caused by tuberculous pleurisy. She received antibiotic therapy and a four-drug fixed-dose combination (FDC) of anti-TB therapy. After nine days of treatment, the patient’s symptoms showed improvement. Conclusion: Empyema is a complex disease with diverse etiologies and multifactorial pathogenesis. Early detection and prompt treatment are essential to minimize the risk of further complications.
Front Matter Vol 11 No 2, 2025 Matter, Front
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

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Back Matter Vol 11 No 2, 2025 Matter, Back
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

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A Big Data to Discovery: Network Analysis of COPD Research Collaborations from 2000 to 2023 Ogasawara, Naruaki
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.276-284

Abstract

Introduction: Collaborative research is critical for advancing knowledge of chronic obstructive pulmonary disease (COPD). Over the last two decades, understanding the structure and evolution of research networks can provide insights into key contributors and trends in international cooperation. This study aimed to analyze the structure and evolution of collaborative networks in COPD research from 2000 to 2023, identifying key researchers and trends in international cooperation using co-authorship network analysis. Methods:  A dataset of 74,024 COPD-related publications indexed in the Web of Science (WoS) Core Collection was analyzed using Python (Version 3.10.5) in PyCharm (Version 2022.1.3). Macro-level metrics (network density, clustering coefficient, components, average path length) and micro-level metrics (degree centrality, closeness centrality, betweenness centrality) were calculated to evaluate collaboration intensity and researcher roles. Results: The analysis revealed progressive growth in network density (from 0.00023 in 2000-2009 to 0.00020 in 2020-2023) and clustering coefficient (from 0.885 to 0.893), reflecting strengthened collaboration. Notable researchers, including P.J. Barnes (2000-2009), E.K. Silverman (2010-2019), and R.G. Barr (2020-2023), were identified as central figures. Despite improvements, network fragmentation remains a challenge. Many isolated components exist, and average distances between research groups remain infinite across all periods. Conclusion: Chronic obstructive pulmonary disease research collaboration has grown significantly over the past two decades, driven by key contributors and increasingly cohesive local networks. However, the persistent fragmentation of the global network highlights the need for further integration to enhance knowledge dissemination and innovation. These findings underscore the importance of fostering broader, more inclusive international collaborations.
E-Cigarette or Vaping Use-Associated Lung Injury (EVALI): A Literature Review Brahmantyo, Adhimas; Esha, Indi; Yunus, Faisal
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.285-297

Abstract

Electronic cigarettes (e-cigarettes) are electronic tools designed to produce an inhalable aerosol from a liquid solution. Electronic cigarette or vaping use-associated lung injury (EVALI) describes any lung damage linked to the consumption of e-cigarettes or vaping products. The liquids and aerosols from e-cigarettes can include tobacco-related nitrosamines, aldehydes, metals, volatile organic compounds, phenolic compounds, polycyclic aromatic hydrocarbons, tobacco alkaloids from tobacco, flavor additives, and various medicinal compounds. Substantial evidence indicates that substances like propylene glycol, vitamin E acetate (VEA), and heavy metals such as lead and arsenic are significant constituents of e-cigarettes, contributing to lung harm. Patients with EVALI may present with sudden or gradually developing respiratory disease, presenting with non-specific signs, including breathlessness, coughing, chest discomfort, and sometimes coughing up blood. Radiological findings in EVALI are often non-specific. The most commonly observed pattern in EVALI is parenchymal organizing pneumonia (OP), identified in 56% of cases, whereby bilateral dominant ground-glass opacity (GGO) was identified, located in the inferior sections of the lungs or diffusely distributed with varying degrees of consolidation.
The Impact of Viscose Rayon Fiber Exposure on Lung Function Khairani, Muhammad; Esha, Indi; Suyanto, Suyanto
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.298-306

Abstract

Viscose rayon fiber is a semi-synthetic material derived from regenerated cellulose. The cellulose used to make viscose rayon is extracted from natural sources, resulting in fibers that are physically similar to cotton and have characteristics such as softness and high absorbency. The viscose manufacturing process involves chemical modification of cellulose using carbon disulfide (CS2), which is dangerous if exposed to humans. Carbon disulfide residues, along with endotoxin biological agents present on rayon fibers, can be inhaled into the respiratory tract. This causes oxidative protein damage, which then activates the oxidative stress response. This response ultimately results in the release of oxidants that induce inflammatory mediators, triggering acute or chronic inflammatory reactions in the airways and alveoli, resulting in decreased lung function. A systematic approach is essential for gathering and interpreting relevant data. This approach can be organized into seven steps to diagnose occupational lung diseases. The use of personal protective equipment (PPE) represents the final but most important defense. Recommended PPE includes respirator masks with suitable particle filters, protective eyewear to prevent eye irritation, chemical-resistant gloves to protect the skin from direct contact, and full-body work clothing.
Factors Associated with Outcomes of Acinetobacter baumannii Infection in Ventilator-Associated Pneumonia in the ICU of Dr. Moewardi General Hospital, Surakarta Putra, Lutfi Lafil Cahya; Saptawati, Leli; Setijanto, Eko; Maryani, Maryani; Maarif, Athok Shofiudin
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.201-207

Abstract

Introduction: Acinetobacter baumannii is a nosocomial pathogen with high mortality rates in intensive care units (ICUs) and is commonly associated with ventilator-associated pneumonia (VAP). Due to declines in physiological and immune functions, A. baumannii can trigger septic shock complications, thereby increasing mortality risk. This study aimed to identify the risk factors associated with outcomes in VAP patients in the ICU of Dr. Moewardi General Hospital, Surakarta. Methods: This retrospective cohort study was conducted at Dr. Moewardi General Hospital, Surakarta, using patient medical records. Data were analyzed with Chi-square and Mann-Whitney U tests, followed by multiple logistic and linear regression to determine correlations between risk factors and outcomes (recovery, mortality, length of stay/LOS). Results: This study included 80 patients with VAP caused by A. baumannii. Most patients were under 60 years old (52.5%), had good nutritional status (75%), were on ventilators for less than 10 days (63.75%), and had mild comorbidities (51.25%). Moderate-severe comorbidities (p=0.001) and malnutrition (p=0.005) were significantly associated with increased mortality. In addition, ventilator use ≥10 days was significantly associated with LOS (p<0.001). Conclusion: Moderate-severe comorbidities and malnutrition were risk factors for mortality in patients with A. baumannii-related VAP, while ventilator use ≥10 days was a risk factor for prolonged hospitalization. Identifying these factors can help medical personnel manage conditions that worsen VAP outcomes and reduce the risk of A. baumannii-related mortality.

Page 31 of 33 | Total Record : 321

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