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Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
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Articles 321 Documents
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Depression in Patients with Lung Cancer during the COVID-19 Pandemic Afladhia, Hanna Lianti; Andarini, Sita
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.15-21

Abstract

Introduction: The coronavirus disease (COVID-19) pandemic has caused significant disruptions in various aspects of life, leading to psychological distress and an increase in mental health disorders, particularly in vulnerable populations such as lung cancer patients. This study investigated the depression levels among lung cancer patients during the COVID-19 pandemic. Methods: A cross-sectional study was conducted at the Thoracic Oncology Outpatient Clinic of Persahabatan National Respiratory Referral Hospital, Jakarta. Depression levels were evaluated using the Patient Health Questionnaire-9 (PHQ-9) in Indonesian. Sociodemographic and clinical characteristics and COVID-19-related stress factors (such as concerns about treatment delays, access to healthcare, psychological pressure, and interpersonal relationships) were also assessed. Results: Out of 42 patients, 42.9% were found to have depression during the pandemic. Factors significantly associated with depression included being female, having a lower economic status, poor performance status, undergoing chemotherapy, and experiencing higher levels of psychological pressure related to COVID-19. Conclusion: This study highlighted a high prevalence of depression among lung cancer patients during the COVID-19 pandemic. Psychological assessment and interventions are crucial to prevent further deterioration in mental health and quality of life, which could negatively affect patients' prognoses.
How to Manage Lung Injury Related to Cancer Therapy? Haryati, Haryati; Saputra, Muhammad Hendi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.83-92

Abstract

Modern technology has improved our understanding of cancer biology, especially anti-cancer medicines from cytotoxic chemotherapy, radiotherapy, targeted therapy, and immunotherapy. Nevertheless, these treatments can result in significant pulmonary toxicities, including interstitial lung disease (ILD) and radiation-induced lung injury (RILI), which can result in a high rate of morbidity and mortality despite being less severe than injuries to other organ systems. Lung injury mechanisms occur through various pathways, such as immune-mediated damage and oxidative stress. Through clinical history and examination, imaging techniques such as high-resolution computed tomography (HRCT), and the necessity of eliminating other possibilities of respiratory symptoms, lung injuries due to cancer therapies can be identified. The management strategies are based on the severity of the condition and may include discontinuing the responsible agent, corticosteroid treatment, and supportive care. The challenge is early identification and management of these lung injuries due to the variability in patient responses and the lack of comprehensive guidelines. Therefore, awareness is needed to monitor lung health in cancer patients undergoing therapy.
Lung Aging and Lung Function Assessment in Elderly Wesnawa, Made Agustya Darma Putra; Subagiarta, I Made; Nathania, Evelyn
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.93-100

Abstract

The lung is one of the organs that experiences the most frequent decline in function among the elderly. Reduced lung function associated with aging is a physiological condition. The lungs transform both their cellular composition and their functional capabilities. The lungs of an aging population may show structural changes to the respiratory muscles, chest wall, lung parenchyma, and upper and lower respiratory tracts. The elderly are more susceptible to reduced lung perfusion, respiratory mechanics, infection, and weaker respiratory muscles because of aging. The body plethysmograph, oscillometer, spirometry, and carbon monoxide (CO) diffusing lung capacity are techniques used to assess lung function in the elderly. For elderly people, lung function testing might be challenging due to frailty and cognitive decline. Consequently, choosing the best lung function test method for the elderly and offering an accurate and suitable interpretation of the test findings are crucial. Early detection of changes in lung function and accurate assessment of lung function can help identify lung function abnormalities in the elderly and give the appropriate treatment and intervention. This review focused on lung aging, the potential benefits and drawbacks of different lung function tests in the elderly, and the proper way to interpret specific lung function tests.
Double-Lumen vs Small-Bore Pigtail Catheter for Pleural Effusion: Which is Superior? Siagian, Novi Andriani; Soeroso, Noni Novisari; Bihar, Syamsul; Ashar, Taufik
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.39-46

Abstract

Introduction: Pleural effusion is associated with a high mortality rate. Tube thoracostomy remains the standard treatment. Despite this, double-lumen catheters, typically used for central venous access, are infrequently employed for pleural drainage. This study compared the characteristics of patients undergoing double-lumen catheter versus pigtail catheter placements for pleural effusion. Methods: A retrospective cross-sectional study was conducted on adult patients at Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara Hospital, Haji Adam Malik General Hospital, and St. Elisabeth Hospital, Medan, from September 2022 to April 2024. This study analyzed patient demographics and clinical presentations for those receiving either catheter type. Results: The mean age of patients with double-lumen catheters was 58.21 years old, while those with pigtail catheters averaged 54.9 years old. Patients with double-lumen catheters frequently presented with a combination of shortness of breath, cough, and chest pain, while those with pigtail catheters primarily reported shortness of breath. Both groups predominantly exhibited exudative pleural effusions. Radiological evaluations indicated moderate pleural effusion was most common in both groups, with thoracic ultrasound revealing fluid volumes between 500 and 2,000 cc. Conclusion: Double-lumen catheters are more frequently utilized for moderate to massive pleural effusion, whereas pigtail catheters are typically reserved for moderate cases. The choice of catheter depends on the patient's condition, the underlying cause of the effusion, and radiological findings.
The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Abstract

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.
The Influence of Nigella sativa on the Increase of IFN-γ and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy Mahendra, Reza Aditya; Pratiwi, Suryanti Dwi; Sartono, Teguh Rahayu; Rakhma, Sastia; Setijowati, Nanik
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.31-38

Abstract

Introduction: In vitro and animal model studies have shown that Nigella sativa reduces cancer cell proliferation and improves chemotherapy effectiveness. Cellular activation triggers the production of IFN-γ by natural killer (NK) cells. This study examined the effect of Nigella sativa supplementation on IFN-γ levels and quality of life in lung cancer patients before and after interferon therapy. Methods: This study used a non-equivalent control experimental design involving 21 lung cancer patients undergoing initial chemotherapy at Dr. Saiful Anwar General Hospital, Malang, in 2023. The patients were divided into two groups: one group received standard chemotherapy, and another group received a combination of chemotherapy and Nigella sativa supplementation at a dose of 2x500 mg for nine weeks. The effects of this intervention were assessed by measuring IFN-γ levels using an enzyme-linked immunosorbent assay (ELISA) kit and evaluating quality of life using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life (QLQ-C30) questionnaire before and after the fourth cycle of chemotherapy. Results: The results showed a significant increase in IFN-γ levels in the combination group undergoing chemotherapy and receiving Nigella sativa supplementation (6140.44±2233.89) compared to the standard chemotherapy group (3827.08±1722.79), with a p-value of 0.015. Quality of life improved in both groups, with scores of 53.70±6.05 before and 65.74±14.70 after chemotherapy (p=0.000). Conclusion: This study found that Nigella sativa supplementation can enhance IFN-γ levels and quality of life in lung cancer patients after four chemotherapy treatment cycles. These findings indicated that Nigella sativa could be a beneficial supplement for lung cancer patients.
Anaplastic Lymphoma Kinase (ALK) Rearrangement of Lung Adenocarcinoma among North Sumatera Population Putra, Muhammad Yusuf Adira; Soeroso, Noni Novisari; Syahruddin, Elisna; Suzanna, Evlina; Afiani, Dina; Ashar, Taufik; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.47-53

Abstract

Introduction: Lung cancer is a malignancy of the lung parenchyma or bronchi. Molecular targeted therapy directed at oncogene driver mutations, such as anaplastic lymphoma kinase (ALK), improves the prognosis of patients with non-small cell lung carcinoma (NSCLC). This study aimed to determine the characteristics of lung adenocarcinoma patients and the prevalence of ALK rearrangement among the North Sumatra population. Methods: This descriptive study used data from patients' formalin-fixed paraffin-embedded (FFPE) ALK examination results and medical records. The laboratory analyzed the patient’s FFPE for ALK fusion protein expression using the VENTANA anti-ALK (D5F3) procedure to determine the prevalence of ALK rearrangement. Results: Of the 34 subjects, it was revealed that the characteristics of lung adenocarcinoma patients were 18 patients aged >60 years old (52.9%), 26 male patients (76.4%), and 24 heavy smoker patients (70.6%). Based on the pathological tumor-node-metastasis (pTNM) stage, most samples were classified as stage IVA, with 24 cases (70.6%) showing the highest metastases to the pleura. There were 2 cases of ALK mutations obtained through immunohistochemical examination with a percentage of 5.8%. Conclusion: There are relatively few ALK rearrangement mutations in lung adenocarcinoma patients without screening. Additional research is needed to ascertain the distribution of lung adenocarcinoma patient characteristics associated with a higher prevalence of ALK rearrangement mutations.
Unveiling Risk Factors in a Patient with Silicotuberculosis: A Case Report Sadikim, Rahel Yuana; Hasan, Helmia; Hidayat , Agus; Duta, Garinda Alma; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.62-68

Abstract

Introduction: Silicosis, an occupational lung disease caused by crystalline silica dust, is often complicated by tuberculosis (TB). The epidemiological triad suggests disease results from imbalanced interactions between the host, agent, and environment. Case: A 63-year-old underweight man presented with decreased consciousness after consuming drugs, chronic cough, low-grade fever, weight loss, and lower urinary tract symptoms. He was a smoker, drug abuser, and alcoholic. He had worked as a construction worker for 33 years without personal protective equipment (PPE). The patient lived in substandard housing, and three neighbors had a history of TB. Urine toxicology was positive for amphetamine. Abdominal ultrasound showed prostate enlargement. A chest X-ray showed fibroinfiltrates, cavities, and reticulogranular patterns. A high-kV chest X-ray revealed profusion levels of 1/2 S/S and 1/1 P/P. Contrast chest computed tomography (CT) showed tree-in-bud patterns, reticulogranular patterns, small nodules, and fibrosis. Brain CT was normal. GeneXpert sputum confirmed Mycobacterium tuberculosis (MTB), and bronchoalveolar lavage (BAL) spectrophotometric detected 38.90 ppm silica. He was diagnosed with amphetamine intoxication, benign prostatic hyperplasia, and silicotuberculosis. Haloperidol, tamsulosin, and anti-TB therapy were administered, while silicosis had no specific treatment. He was advised to change job to reduce silica exposure and planned to receive housing renovation assistance from the Health Office of Surabaya. The patient was declared cured after completing six months of TB treatment. Conclusion: The host factors included nutritional status, comorbidity, and personal habits; the agent factor was MTB; and the environmental factors included inadequate ventilation, high housing density, close contact with TB patients, and occupational conditions. A holistic identification of host, agent, and environmental risk factors is essential for understanding the development, prevention, and diagnosis of silicotuberculosis.
Primary Pulmonary Myxoid Sarcoma: A Rare and Challenging Diagnosis in Thoracic Oncology Apriyanto, Yudi; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.69-74

Abstract

Introduction: Primary pulmonary myxoid sarcoma (PPMS) is a rare malignant mesenchymal lung tumor, with fewer than 40 cases reported worldwide. This care report presented a case of PPMS with surgical difficulties. Case: A 53-year-old man presented with a six-month history of exertional dyspnea, coughing up blood, right chest pain, anorexia, and weight loss. Thoracic computed tomography (CT) imaging revealed an enhancing solid mass in the middle-posterior mediastinum. Histopathological examination of a core biopsy identified anaplastic lipoblast cells indicative of liposarcoma. Based on the multidisciplinary team (MDT) discussion, the patient was diagnosed with mediastinal liposarcoma, and tumor excision was planned. However, during the surgery, a lung tumor with adhesions to the middle and lower lobes of the right lung was discovered, precluding the complete tumor. An open biopsy was performed instead, revealing a proliferation of anaplastic cells with round to oval spindle nuclei arranged reticularly within a myxoid stroma, along with positive Alcian blue staining. Immunohistochemical analysis demonstrated focal desmin positivity in the cytoplasm of the tumor cells. The diagnosis of PPMS was confirmed based on the criteria by the World Health Organization (WHO) in 2021, including primary lung tumor, spindle-shaped and round tumor cells in a reticular pattern within a myxoid stroma, and immunohistochemical findings that exclude other histologically similar tumors. Conclusion: Although rare, PPMS should be considered in the differential diagnosis of thoracic tumors. Most PPMS patients were treated surgically and had a good prognosis. However, tumor excision could not be performed in this patient due to the adhesion of the tumor mass to the middle and lower lobes of the right lung.
Front Matter Vol 11 No 1, 2025 Matter, Front
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Page 29 of 33 | Total Record : 321

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