cover
Contact Name
Dr. Masdiana C. Padaga, DVM. M App.Sc
Contact Email
vbcj@ub.ac.id
Phone
-
Journal Mail Official
nofanvet@ub.ac.id
Editorial Address
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Location
Kota malang,
Jawa timur
INDONESIA
Veterinary Biomedical and Clinical Journal
Published by Universitas Brawijaya
ISSN : -     EISSN : 26221012     DOI : -
Veterinary Clinical and Biomedical Journal (VBCJ) is periodically peer reviewed journal that publish every January and July per year since 2019. VBCJ accommodate any articles in the field of veterinary medicine, biomedical, as well as veterinary case report.
Arjuna Subject : -
Articles 75 Documents
Front Matter: Front Cover, Editorial Board, Peer Reviewers, Acknowledgments VBCJ
Veterinary Biomedical and Clinical Journal Vol. 7 No. 2 (2025): Vol. 7 No. 2 2025
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2025.007.02

Abstract

Front Matter
Lycopene Supplementation Mitigates Heat Stress-Induced Impairment of Embryonic Development, Survival, and Heart Rate in Zebrafish (Danio rerio) Residiwati, Gretania; Nararya, Winandana Parama; Ainurrahma, Hafidha; Lonameo, Bonick Kartini; Lesmana, Muhammad Arfan; Agustina, Galuh Chandra; Budiono; Hartono, Djoko; Hendrawan, Viski Fitri; Tuska, Habib Syaiful Arif; Sidi, Shehu
Veterinary Biomedical and Clinical Journal Vol. 8 No. 1 (2026): In Press
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2026.008.01.1

Abstract

Fish at any change in aquaculture air temperature can affect fish survival, physiological conditions and immune response. The need to study the reaction of fish to sublethal temperatures (30-40oC) is an impetus because of global warming which can trigger heat stress (HS). Heat stress (HS) and its effects can occur in fish with any changes in the environment (physical or physiological), where heat can change the animal's normal homeostasis. Tomato (Lycopersicum esculentum), has been proven as a fruit that is rich in lycopene, which acts as a natural antioxidant. The purpose of this study was to determine the effect of lycopene supplementation on the process of external fertilization on embryo development, survival rate and heart rate of zebrafish (Danio rerio) at normal temperature (NHS) and with heat exposure (HS). The survival rate data obtained will then be analyzed using SPSS, with ANOVA and LSD tests (P ≤0.05). While the results of the statistical analysis test of heart rate, a non-parametric test was used using Kruskal-Wallis H, to find out whether there was a significant difference in the treatment; and the Mann-Whitney Test, to detect significant differences between groups (P ≤0.05). The effect of lycopene supplementation on the external fertilization process of zebrafish embryos gives a low survival rate and heart vibration of zebrafish embryos, which is thought to be caused by several factors, namely zebrafish genetics; storage method, dosage, and lycopene extraction method used in the research
Front Matter: Front Cover, Editorial Board, Peer Reviewers, Acknowledgments VBCJ
Veterinary Biomedical and Clinical Journal Vol. 8 No. 1 (2026): In Press
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Front Matter
Comparative Benchmark Whole Blood Cholinesterase Inhibition by Dichlorvos in Humans and Ruminants : Whole Blood Cholinesterase Inhibition by Dichlorvos Ramadhan, Maha Ahmed; Mohammad, Fouad Kasim
Veterinary Biomedical and Clinical Journal Vol. 8 No. 1 (2026): In Press
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2026.008.01.2

Abstract

In vitro inhibition of whole blood cholinesterase (WBChE) by the organophosphate insecticide dichlorvos has been used to assess sentinel animal species among ruminants. The aim of the study was to calculate the benchmark dose (BMD) as a sensitive indicator of WBChE inhibition caused by dichlorvos. The BMD sensitivity of WBChE of humans and ruminants (sheep, goats and cattle) was assessed after in vitro dichlorvos 10-min inhibition in the assay mixture. At concentrations of 0 (control), 0.25, 0.5, and 1 µM, dichlorvos significantly, but variably reduced enzyme activity across the four species with IC50 values of about 0.5 µM. These data were used to calculate BMD using the online tool BMDS Online Version: 25.1 software introduced by U.S. Environmental Protection Agency (US EPA). The exponential 3 curve fitting model was recommended by the tool. The resultant plots showed dose-response curves estimated by the model. The BMD levels in humans, sheep, goats and cattle were 0.181, 0.126, 0.343, 0.304 µM, respectively. The goodness-of-fit p-values ranged from 0.757 to 0.983 across the species, which were larger than the predetermined critical p-value of 0.1 used by the US EPA. The data showed that the BMD model appropriately described the observed dose-response pattern of WBChE inhibition by dichlorvos, and showed that this model was a better sensitivity indicator of enzyme inhibition s compared to IC50 determined earlier. Sheep-derived benchmark dose assessment defines this species as the most sensitive (sentinel) one among humans, goats and cattle, with regards to WBChE inhibition threshold. Refining the in vitro dichlorvos toxicity outcome with in vivo studies and risk assessment methods is needed, as this study highlights and further supports the potential of BMD modelling in evaluating health risks posed by OP insecticides.
The Effect of Sulfur and Aloe Vera Gel on Crust Length and Collagen Density in Scabies Nur Indasari, Elly; Armadhaniand, Shafa Rayya; Prasetyo, Dodik
Veterinary Biomedical and Clinical Journal Vol. 8 No. 1 (2026): In Press
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2026.008.01.3

Abstract

Scabies infestation by Sarcoptes scabiei cause crust formation, skin damage, and impaired wound healing. This study evaluated the effectiveness of combined sulfur and aloe vera therapy on crust length and collagen density in scabies-infected white rats. A laboratory experimental study with a completely randomized design was conducted. Twenty-five male Wistar rats were divided into five groups: negative control (healthy, no infection), positive control (infected, no therapy), and three treatment groups (P1, P2, P3) infected and treated with a gel containing sulfur (5%, 10%, and 15%, respectively) in aloe vera gel for 7 days. Crust length was measured using digital calipers, and collagen density was assessed semi-quantitatively (score 0–4) on Hematoxylin-Eosin-stained ear skin sections. Data were analyzed using One-way ANOVA followed by Tukey’s HSD (crust length) and Kruskal-Wallis followed by Mann-Whitney U test (collagen density). Combined therapy significantly reduced crust length (p=0.006) and increased collagen density (p<0.05). The 5% sulfur group (P1) showed the most significant crust reduction (p=0.005) and collagen density improvement (p=0.003) compared to the positive control. In conclusion, the combination gel of aloe vera and 5% sulfur effectively reduces crust length and improves collagen density, accelerating wound healing in scabies-infected rats.