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Medica Hospitalia

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Published by RSUP Dr. Kariadi Semarang

ISSN : 23014369 EISSN : 26857898 DOI : https://doi.org/10.36408/mhjcm

Core Subject : Health,

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.

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Articles 584 Documents

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Pengaruh Ekstrak Daun Wungu Terhadap Luas Islet Pankreas Tikus Wistar Diabetes Melitus Excelinda, Tifanni; Istiadi, Hermawan; Retnoningrum, Dwi; Hendrianingtyas, Meita
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang : Diabetes melitus merupakan kumpulan gejala gangguan metabolik dengan prevalensi penyandang yang masih terus meningkat. Faktor lingkungan, gaya hidup, maupun genetik dapat menyebabkan kerusakan sel pankreas maupun resistensi insulin yang kemudian bermanifestasi sebagai diabetes melitus. Daun wungu (Graphytophyllum pictum (L.) Griff) mengandung metabolit aktif seperti flavonoid yang merupakan antioksidan untuk mencegah destruksi dan meregenerasi sel pankreas penderita diabetes melitus. Tujuan : Membuktikan adanya perbedaan ukuran luas islet pankreas tikus Wistar diabetes melitus yang mendapatkan ekstrak daun wungu (Graphtophyllum pictum (L.) Griff) setelah perlakuan dengan kontrol. Metode : Penelitian true experimental dengan menggunakan desain Post-Test Only Control Group Design. Sampel 24 ekor tikus Wistar jantan dengan kriteria tertentu dibagi secara acak menjadi 4 kelompok. Kontrol negatif (K-1) diberikan aloksan dan kelompok perlakuan 1 (K-2), perlakuan 2 (K-3), dan perlakuan 3 (K-4) masing-masing diberikan aloksan dan ekstrak daun wungu 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Glukosa darah diperiksa pada hari ke-4 untuk memastikan tikus sudah diabetes melitus dan dilanjutkan perlakuan selama 14 hari. Terminasi dan pengambilan organ dilakukan pada hari ke-15. Data berupa luas islet pankreas kemudian dianalisis menggunakan uji Kruskal-Wallis dan uji Mann-Whitney. Hasil: Berdasarkan uji Kruskal-Wallis didapatkan perbedaan luas islet pankreas yang bermakna (p = 0,000) antar kelompok. Pada uji Mann-Whitney didapatkan peningkatan luas islet pankreas yang signifikan (p = 0,000) pada seluruh kelompok perlakuan terhadap kontrol negatif. Rerata luas islet pankreas berbanding lurus dengan peningkatan dosis pemberian ekstrak daun wungu. Kesimpulan : Terdapat perbedaan ukuran luas islet pankreas yang signifikan pada seluruh kelompok perlakuan terhadap kontrol negatif. Kata Kunci : Daun wungu; luas islet pankreas; diabetes melitus

Efek Protektif Methylprednisolone pada Testis Kontralateral Tikus Wistar yang dilakukan Torsio-Detorsio: Ditinjau dari variabel pemeriksaan Histopatologi Johnsen score, jumlah lapis sel tubulus seminiferus, jumlah sel nekrosis, dan derajat adhesi neutrofil Wibisono, Dimas Sindhu; Nugroho, Leonardo Cahyo; Muhammad, Krisna; Fauzi, Ardi; Putra, Adityas Mahendra; Hidayat, Afif Iman
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Testicular torsion is an emergency situation and requires immediate surgery. Testicular torsion accounts for 13-54% of cases of acute pediatric scrotal disease and occurs in 1 in 4,000 men aged <25 years and 1 in 160 men over 25 years. Even though the intervention was carried out for less than 6 hours, post-detortion testicular tissue mortality was still high, due to reperfusion ischemic injury due to excessive production of ROS (Reactive Oxygen Species). The contralateral testis is often affected after torsion-detortion due to the effects of ROS. The provision of additional therapy after detortion is an urgent need to be found because it can reduce the death of testicular tissue due to reperfusion ischemic injury. Methods: It is an experimental study with a randomized controlled study design with post test only control group design. The research sample was 18 Wistar rats divided into 3 groups. Torsion of the ipsilateral testis is performed, then detortion and intravenous therapy are administered. The apoptotic index (infertility) was observed on the Johnsen score variable, the number of seminiferous tubular cell layers, neutrophil adhesion and the number of necrotic cells in the Eosin Hematoxyline in the contralateral testis. Furthermore, statistical analysis is carried out, the results are presented in tables and figures. Results: There was a significant difference between the Methylprednisolone group and the Torsion Detortion group with p = 0.008 in the Johnsen score variable and the number of seminiferous tubular cell layers. Discussion: Methylprednisolone as an anti-inflammatory has been proven in its function to reduce ROS so that it can reduce reperfusion ischemic injuries.

Korelasi Antara Jumlah Cd4 Dengan Global Longitudinal Strain Ventrikel Kiri Pada Penderita Human Immunodeficiency Virus Pratama, Yanuar Surya; Chairunnisa, Andita; Bahrudin, Udin; Uddin, Ilham; Nugroho, Mochamad Arif; Sofro, Muchlis Achsan Udji; Kristina, Tri Nur
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang: Jumlah CD4 merupakan parameter penting pada penderita HIV dan berhubungan dengan peningkatan risiko disfungsi sistolik. Hingga saat ini, korelasi antara jumlah CD4 dengan parameter global longitudinal strain (GLS) sebagai indikator fungsi sistolik subklinis masih belum jelas. Metode: Penelitian ini merupakan studi observasional dengan metode belah lintang. GLS ventrikel kiri diperiksa menggunakan ekokardiografi dua dimensi. Jumlah CD4 baseline dan nadir diperoleh dari rekam medis sedangkan jumlah CD4 aktual dan CD4 percentage (CD4%) diperiksa menggunakan metode flow cytometry. Hasil: Total 37 pasien HIV asimptomatik mengikuti penelitian dengan rerata umur 31,95± 7,54 tahun dan median durasi penggunaan ARV adalah 34 bulan. Median CD4 baseline dan CD4 nadir adalah 272 sel/uL dan 223 sel/uL, sedangkan rerata CD4 aktual dan CD4% adalah 516,08±252,03 sel/uL dan 19,66±7,97 %. Semua subyek penelitian memiliki fungsi sistolik normal. Rerata GLS ventrikel kiri adalah 17,02±0,71. GLS ventrikel kiri berkorelasi positif dengan CD4 aktual (r=0,43; p=0,008) dan CD4% (r=0,349; p=0,034). Penderita HIV dengan jumlah CD4 aktual ?400 sel/uL memiliki GLS ventrikel kiri yang lebih baik dibandingkan dengan yang <400 sel/uL (p=0,022). Kesimpulan: Jumlah CD4, terutama CD4 aktual dan CD4 percentage berkorelasi dengan disfungsi sistolik subklinis yang diukur dengan global longitudinal strain pada penderita HIV asimtomatik. Hal ini mungkin dapat menjelaskan peran CD4 terhadap patogenesis gagal jantung pada penderita HIV.

Ekspresi Reseptor Estrogen Dan Reseptor Progesteron Pada Pasien Dengan Leiomioma Uteri Finot, Finot; Puspasari, Dik; Wijaya, Indra
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang: Leiomioma uteri merupakan tumor jinak dengan prevalensi yang cukup tinggi dan perkembangannya sangat dipengaruhi oleh hormon steroid. Sementara itu masih terdapat pertentangan pada penelitian mengenai ekspresi reseptor estrogen (ER) dan reseptor progesteron (PR) pada leiomioma uteri, serta belum dipahami tentang etiologi dan patogenesis leiomioma uteri. Objektif: Penelitian ini bertujuan untuk mengetahui ekspresi ER dan PR pada leiomioma uteri. Metoda: Penelitian ini merupakan analitik observasional dengan rancangan case control design, dilakukan di Laboratorium Patologi anatomi RSUP Dr. Kariadi, Semarang. Populasi penelitian adalah blok histopatologi dengan diagnosa leiomioma uteri pada tahun 2017. Pengambilan sampel dilakukan secara acak sederhana, setelah memenuhi kriteria inklusi. Hasil: Berdasarkan karakteristik usia pada kelompok leiomioma uteri, yang terbanyak adalah kelompok usia > 40 tahun. Dari segi karakteristik Indeks Massa Tubuh (IMT), pada kelompok Leiomioma uteri IMT yang paling banyak pada normoweight, tetapi terdapat kecendrungan kasus Leiomioma uteri meningkat pada IMT yang lebih tinggi, dengan jumlah kumulatif pada IMT overweight dan obese adalah sebanyak 6 kasus (40%). Karakteristik paritas pada kelompok Leiomioma uteri yang terbanyak adalah nullipara yaitu 7 kasus (46,7%). Seluruh kelompok leiomioma uteri mengeskpresikan ER dengan rerata skor 7,20 ± 0,78 dan PR dengan rerata skor 7,47 ± 0,74. pengujian dengan uji korelasi spearman’s terhadap ekspresi ER dan PR dihubungkan dengan karakteristik, didapatkan hasil yang tidak signifikan juga. Sehingga tidak bermakna hubungan antara ekspresi ER dan PR terhadap karakteristik dan multiparitas. Pembahasan: Pada pengujian Mann-whitney terdapat perbedaan yang bermakna pada ekspresi ER antara jaringan leiomioma uteri dan miometrium normal (p = 0,045). Dan terdapat perbedaan yang bermakna pada ekspresi PR antara jaringan Leiomioma uteri dan miometrium normal (p = 0.022). Kata kunci: Leiomioma uteri, miometrium, reseptor estrogen, reseptor progesteron ABSTRACT Background: Leiomyoma is a benign tumor with a fairly high prevalence and its development is strongly influenced by steroid hormones. While it is still related to research on estrogen receptors and progesterone receptors in uterine leiomyomas, and has not been understood about the etiology and pathogenesis of uterine leiomyomas. Objective: This study aims to determine the expression of estrogen receptors and progesterone receptors in uterine leiomyomas. Method: This study is an observational analytic with a case control design, carried out at the Anatomical Pathology Laboratory Dr. General Hospital. Kariadi, Semarang. The study population was histopathological block with diagnosis of uterine leiomyoma and myometrium in 2017. Sampling was done in a simple randomized manner, after fulfilling the inclusion criteria. Results: Based on the age characteristics in the uterine leiomyoma group, the most were the age group> 40 years. In terms of characteristics of the Body Mass Index (BMI), in the uterine Leiomioma group the most BMI was normoweight, but there was a tendency for cases of uterine Leiomyoma to increase in higher BMI, with a cumulative number of overweight and obese BMI of 6 cases (40%) . The most characteristic parity in the uterine Leiomioma group was nullipara which was 7 cases (46.7%). All uterine leiomyoma groups expressed estrogen receptors with a mean score of 7.20 ± 0.78 and progesterone receptors with a mean score of 7.47 ± 0.74. testing with the spearman correlation test on the expression of ER and PR is related to the characteristics, which results are not significant as well. So there is no meaningful relationship between ER and PR expression on characteristics and multiparity. Discussion: In the Mann-Whitney test there were significant differences in the expression of estrogen receptors between uterine leiomyoma and normal myometrium (p = 0.045). And there are significant differences in the expression of progesterone receptors between uterine leiomyoma and normal myometrium (p = 0.022). Keywords: Uterine leiomyoma, myometrium, estrogen receptor, progesterone receptor

Perbandingan Terapi Antibiotik Ceftriakson Rute Intervena Bolus dan Intravena Drip terhadap Penurunan Kadar Procalcitonin dan Asam Laktat Pasien Sepsis Jainuri Erik Pratama; Heri Sutanto
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang: Ceftriaxone merupakan antibiotika golongan bakterisida dan termasuk dalam golongan antibiotic time dependent. Efek bakterisidal yang optimal dari obat ini memerlukan waktu paparan yang lebih lama dibandingkan dengan konsentrasi obat yang tinggi dalam darah (T > MIC). Penelitian ini bertujuan untuk mengkaji perbandingan penurunan kadar procalcitonin dan asam laktat pada pasien sepsis yang mendapat terapi antibiotik ceftriaxone rute intravena bolus dan rute intravena drip. Metode: Desain penelitian ini merupakan penelitian prospektif cohort, dengan analisa data menggunakan metode analisis komparatif tidak berpasangan. Pengamatan penanda infeksi procalcitonin dan asam laktat pada masing-masing kelompok dilakukan sebanyak tiga kali, yakni berupa data baseline, hari ke 3 dan 5 setelah terapi ceftriaxone diberikan. Hasil: Nilai rata-rata kadar procalcitonin dan asam laktat sebelum pemberian terapi ceftriaxone pada 15 pasien dengan rute intravena bolus adalah sebesar 23,50 ± 5,59 ng/ml dan 7,17 ± 1,3 mmol/L, sedangkan kadar procalcitonin dan asam laktat pada 15 pasien dengan pemberian ceftriaxone rute intravena drip adalah sebesar 12,98 ± 2,75 ng/ml dan 4,18 ± 1,2 mmol/L. Pada hari ke 3 setelah terapi diberikan, terjadi penurunan kadar procalcitonin dan asam laktat menjadi 14,18 ± 3,21 ng/ml dan 4,68 ± 1,1 mmol/L dengan rute pemberian intravena bolus, sedangkan pada kelompok rute intravena drip menjadi 9,78 ± 2,00 ng/ml dan 3,35 ± 1,7 mmol/L. Pada hari ke 5 setelah pemberian terapi ceftriaxone, kadar procalditonin dan asam laktat menurun menjadi 8,70 ± 2,54 ng/ml dan 2,39 ± 0,14 mmol/L dengan rute intravena bolus, sedangkan dengan rute intravena drip menurun menjadi 5,78 ± 1,38 ng/ml dan 2,85 ± 0,5 mmol/L. Namun, tidak ada perbedaan penurunan procalcitonin dan asam laktat yang bermakna antara kedua kelompok (p>0,05). Simpulan: Tidak terdapat perbedaan penurunan kadar procalcitonin dan asam laktat pada pasien dengan terapi ceftriaxone rute pemberian intravena bolus ataupun intravena drip. Kata kunci : ceftriaxone, intravena bolus, intravena drip, procalcitonin, asam laktat. Abstract Background : Ceftriaxone is a bactericidal group antibiotic and includes in the time dependent antibiotic class. The optimal bactericidal effect of this drug needs longer exposure time compared to high drug concentrations in the blood (T>MIC). This study aims to analyze procalcitonin and lactic acid levels in septic patients receiving therapy with ceftriaxone with an intravenous bolus and with intravenous drip route. Methods : This study is a prospective cohort design, data was analysed using unpaired comparative analysis methods. Observation of procalcitonin and lactic acid levels in each group were carried out three times involving baseline, day 3, and day 5 of ceftriaxone administration. Result : Before treatment, the average value of procalcitonin and lactic acid in 15 patients with ceftriaxone intravenous bolus therapy was 23,50 ± 5,59 ng/ml and 7,17 ± 1,3 mmol/L, whereas in 15 patients with intravenous drip route is 12,98 ± 2,75 ng/ml and 4,18 ± 1,2 mmol/L. On the 3rd and 5th day of ceftriaxone administration, there was a significant reduction (p < 0,05) of procalcitonin and lactic acid levels. There was no significant (p> 0,05) differences of procalcitonin and lactic acid levels between groups. Conclusion : There is no difference in the reduction of procalcitonin and lactic acid levels among those receiving ceftriaxone intravenous bolus nor intravenous drip administration. Key word : Ceftriaxone, intravenous bolus, intravenous drip, procalcitonin, lactic acid.

Hubungan Hemoglobin Terglikosilasi (HbA1c) Dengan Risiko Kardiovaskular Pada Pasien Diabetes Mellitus Widyatmojo, Hadian; Suromo, Lisyani Budipradigda
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang : Diabetes Mellitus (DM) dengan kondisi hiperglikemik kronik dapat mengakibatkan gangguan sistem kardiovaskular dan peningkatan mortalitas. Hemoglobin terglikosilasi (HbA1c) merupakan salah satu parameter untuk pengendalian DM. Tujuan penelitian untuk membuktikan adanya hubungan antara kadar HbA1c serum dengan risiko kardiovaskular pada pasien DM. Metode : Penelitian belah lintang dilakukan pada 42 penderita DM yang dirawat di RSUP Dr. Kariadi Semarang periode Agustus - September 2017. Diagnosis DM didapatkan melalui rekam medis. Dilakukan pemeriksaan HbA1c dan dinilai faktor risiko yang terdapat pada rekam medis menggunakan skor interheart (IHR). Analisa statistik menggunakan uji korelasi Spearman. Hasil : Terdapat hubungan antara HbA1c dengan skor IHR dengan nilai r=0,887, p=0,001. Pasien dengan kategori risiko kardiovaskular tinggi memiliki nilai HbA1c dengan rerata 10,12 ± 2,29, skor kategori sedang 6,62 ± 1,67 dan skor kategori rendah 5,75 ± 0,78. Simpulan :Terdapat hubungan positif kuat antara HbA1c dengan risiko kardiovaskular pada pasien DM. Perlu dilakukan penelitian prospektif dengan sampel yang lebih besar. Kata kunci DM, HbA1c, Skor risiko Interheart

The association between adiponectin level and non alcoholic fatty liver disease (NAFLD) in obese adolescents Mexitalia, Maria; Romadhona, Suci
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Non alcoholic fatty liver disease (NAFLD) has been associated with cytokines and inflammatory mediators. Adiponectin has insulin sensitizing effects and has correlation with severity of NAFLD disease. However, the study about the relationship between adiponectin level and NAFLD is lacking. The objective of the study was to determine the association between adiponectin level and NAFLD in obese adolescents through the role of insulin resistance. Methods: This was a cross-sectional study, that was done in August 2007. The inclusion criteria were obese adolescents aged 11-14 years, and normal weight adolescent as control group. Adiponectin was assessed by using ELISA, insulin resistance was obtained by Homeostasis Model Assessment Insulin Resistance (HOMA-IR). NAFLD was confirmed by abdominal ultrasound, which represented by fatty liver imaging. The comparison of adiponectin level and HOMA-IR among 3 groups were analyzed by Kruskal Wallis test, meanwhile the correlation between adiponectin level and some variables were analyzed by spearman correlation. Result: There were 73 subjects, consisted of 37 obese and 36 non obese. Among obese subjects, 54.1% got NAFLD. All of our obese subjects were insulin resistance, the HOMA-IR level of obese non NAFLD was 6.1 and obese with NAFLD was 6.8. The adiponectin levels in normal children was (5.1mg / ml), obese non NAFLD (4.1mg / ml) and obese with NAFLD (4.0 mg / ml) (p <0.001). There were no association between adiponectin level and other variables. Conclusion: There were significant differences of adiponectin levels and insulin resistance measured by HOMA-IR between normal and obese subjects, but no significant differences between the obese groups with or without NAFLD. Keywords: NAFLD, adiponectin, HOMA-IR, obesity, adolescent.

Hipertensi pada Pasien Kanker Kolorektal Metastatik dengan Terapi Bevacizumab di RSUP Dr. Kariadi Septiantoro, Bayu Prio; Perwitasari, Dyah Aryani; Faridah, Imaniar Noor; Pradipta, Indra
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang: Kanker kolorektal saat ini sudah menjadi penyebab utama ketiga kematian akibat kanker di dunia, penyakit ini membutuhkan terapi yang progresif dimana salah satu terapinya adalah bevacizumab. Namun diketahui bevacizumab dapat menimbulkan hipertensi pada sebagian pasien. Penelitian ini bertujuan untuk untuk mengetahui onset terjadinya hipertensi akibat bevacizumab dengan rejimen kemoterapi apa yang digunakan. Metode: Penelitian ini merupakan sebuah tinjauan deskriptif restrospektif yang dilakukan di RSUP Dr. Kariadi, Semarang. Kriteria inklusi terdiri dari pasien kanker kolorektal metastatik yang berusia ? 18 tahun dengan hipertensi tingkat ?2 berdasarkan NCI CTCAE version 5.0 setelah diberikan terapi bevacizumab 5 mg/kg berat badan di RSUP Dr. Kariadi. Pengambilan data dalam 1 tahun (bulan April 2018 hingga April 2019) melalui peninjauan dari rekam medis, laporan penggunaan obat bevacizumab dan laporan penggunaan obat kardiovaskuler instalasi farmasi. Kriteria ekslusi dalam penelitian ini yaitu hipertensi tingkat ?2 berdasarkan NCI CTCAE version 5.0 yang muncul setelah ?4 kali waktu paruh bevacizumab (t 1/2 = 20 hari) dari kemoterapi yang terakhir. Hasil: Total 95 pasien sesuai kriteria, sebanyak 24 pasien (25,26%) teridentifikasi mengalami hipertensi tingkat ? 2 berdasarkan NCI CTCAE version 5.0. Dengan 20 pasien (83,33%) pasien mendapatkan kemoterapi rejimen FOLFOX4, sedangkan sisanya (16,66%) dengan rejimen de Gramont. Hipertensi ini muncul sebagian besar pada siklus III, diikuti siklus ke II, ke I dan ke VI. Tidak satupun pasien dengan kombinasi FOLFIRI yang terdeteksi mengalami hipertensi ini. Kesimpulan: Penelitian ini menunjukkan onset munculnya hipertensi tingkat ?2 NCI CTCAE version 5.0 paling banyak adalah pada siklus awal terapi yaitu I-III dan dengan rejimen kombinasi FOLFOX4 + bevacizumab. Kata Kunci: Kanker kolorektal, bevacizumab, hipertensi Background: Colorectal cancer nowadays is the third leading cause of cancer deaths in the world, this disease requires progressive therapy where one of the treatments is bevacizumab. But it is known that bevacizumab can cause hypertension in some patients. This study aims to determine the onset of the hypertension with chemotherapy regimen used. Method: This research is a retrospective descriptive review conducted at Dr. Kariadi General Hospital, Semarang. Inclusion criteria consisted of metastatic colorectal cancer patients aged ?18 years old with hypertension level ?2 based on NCI CTCAE version 5.0 after being given bevacizumab therapy dose 5 mg/kg body weight. Retrieval of data in 1 year (April 2018 to April 2019) through a review of medical records, reports on the use of bevacizumab drugs and reports on the use of cardiovascular drugs in Department of Pharmacy. The exclusion criteria in this study were hypertension level on NCI CTCAE version 5.0 which appeared after 4 times the half-life of bevacizumab (t 1/2 = 20 days) from the last chemotherapy. Result: Total 95 patients according to the criteria, 24 patients (25.26%) were identified as having hypertension level ? 2 based on NCI CTCAE version 5.0. With 20 patients (83.33%) patients received FOLFOX4 regimen, while the rest (16.66%) with de Gramont regimen. This hypertension occurs mostly in cycle III, followed by cycle II, to I and to VI. None of the patients with a combination of FOLFIRI. Conclusion: This research shows that the onset of hypertension level ?2 NCI CTCAE version 5.0 mostly in the initial cycle of therapy (I-III) with the FOLFOX4 + bevacizumab combination regimen. Keywords: Colorectal cancer, bevacizumab, hypertension

PERBEDAAN RIWAYAT PENYAKIT TIROID TERDAHULU, METASTASIS DAN ABNORMALITAS PEMERIKSAAN ULTRASONOGRAFI ANTARA PASIEN KARSINOMA TIROID PAPILER KLASIK DAN VARIAN FOLIKULER DI RSUP Dr. KARIADI SEMARANG Firdauzi Putri, Nabila Zenska; Istiadi, Hermawan; Wikanta, Edmond Rukmana; Miranti, Ika Pawitra
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Papillary thyroid carcinoma (PTC) is the most common carcinoma, accounting for more than 90% of all malignancies, where the most variants are classic papillary thyroid carcinoma and follicular variant papillary thyroid carcinoma (PTCVF). The characteristics of previous thyroid disease history, regional metastases, and ultrasound examination results can influence the clinical examination between the two variants of PTC, namely classic PTC and PTCVF. Aim: Understanding the differences in the history of previous thyroid disease, metastases, and ultrasound examination abnormalities between Classical Papillary Carcinoma and Follicular variants at Dr. Kariadi Hospital, Semarang. Methods: A cross sectional study with consecutive sampling method in classic PTC and PTCVF patients in Dr. Kariadi Hospital, Semarang who was diagnosed in the period January to June 2019. In this study, the number of samples obtained was 18 medical records with classic PTC cases and 20 medical records with PTCVF cases. The dependent variables, namely history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities, all of which were on an ordinal scale, were analyzed using non-parametric chi-square test and Fisher's Exact test. Results: In the non-parametric chi-square test and Fisher's Exact test, the results were not significant (p = 0.474), regional metastases were not significant (p = 0.359), ultrasound size abnormalities were not significant (p = 0.323), and abnormalities. ultrasound nodal was not significant (p = 0.595). Conclusion: There was no statistically significant difference in the history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities between classic PTC and PTCVF patients at Dr. Kariadi Hospital, Semarang.

Neuroimaging Findings in Patients with Covid-19 in Indonesia Sadikin, Cindy; Meryana, Meryana; Besin, Valentinus; Saelan, Yanna
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Covid-19 caused by the SARS-CoV-2 virus has spread worldwide, including Indonesia. Neurological manifestations has also been reported in Covid-19 positive patients. Yet documentation of their neuroimaging findings are lacking, especially in Indonesia. Objective: To understand neuroimaging findings in Covid-19 positive patients Methods: An observational study from medical record of Covid-19 positive patients in our hospital who developed abnormal neurologic manifestations and were followed up by neuroimaging examination from May to August 2020. Covid-19 positive diagnosis was confirmed from nasopharyngeal swab using the Real Time Polymerase Chain Reaction (RT-PCR). Neurological examination was performed by a neurologist, who then referred patients for neuroimaging examination using CT or MRI. Radiological expertise was performed by a radiologist. Results: A total of 288 patients who are Covid-19 positive from nasopharyngeal RT-PCR swab admitted to our hospital from May to August 2020. Ten patients (3.5%) had abnormal neurologic manifestations and further neuroimaging examination follow up. Range of age 33-72 years old and slight male predominance (60%). Frequent clinical symptoms were decreased consciousness (40%), altered mental status (30%) and tremors (20%). Neuroimaging findings were large vessel occlusion (30%), vasculitis (20%), post hipoxic leucoencephalopathy (10%), basal ganglia encephalopathy (10%), non specific small vessel ischemia changes and negative findings (30%). Most patients were discharged with clinical improvement (60%), while 40% mortality rate were seen in patient with large vessel occlusion (30%) and vasculitis (10%). Conclusion: Neuroimaging findings in Covid-19 positive patients were large vessel occlusion (LVO), vasculitis, post hipoxic leucoencephalopathy and basal ganglia encephalopathy Keywords: Covid-19, neurological, manifestation, neuroimaging

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Aziz Alfarisy

Contact Email
medicahospitalia@rskariadi.co.id

Phone
-

Journal Mail Official
medicahospitalia@rskariadi.co.id

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Aziz Alfarisy

Contact Email medicahospitalia@rskariadi.co.id

Phone -

Journal Mail Official medicahospitalia@rskariadi.co.id

Editorial Address -

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Aziz Alfarisy

Contact Email
medicahospitalia@rskariadi.co.id

Phone
-

Journal Mail Official
medicahospitalia@rskariadi.co.id

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA