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Hubungan Kadar Kreatinin Serum Dengan Kadar Mineral Pada Pasien Chronic Kidney Disease Kusuma, Diah Ayu; Samsuria, Indranila Kustarini
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Pendahuluan : Chronic Kidney Disease (CKD) merupakan gangguan fungsi ginjal yang irreversible, yaitu kemampuan tubuh gagal untuk mempertahankan metabolisme dan keseimbangan cairan dan elektrolit dan juga mineral. Sebagian besar proses metabolisme memerlukan dan dipengaruhi oleh elektrolit. Konsentrasi elektrolit mineral yang tidak normal dapat menyebabkan banyak gangguan . Saat fungsi ginjal semakin memburuk menjadi Stadium CKD 4 dan 5, ekskresinya cenderung berkurang dan tidak dapat dikompensasi. Tujuan penelitian ini adalah melihat pengaruh CKD pada mineral yaitu magnesium dan calcium. Metode : Penelitian ini adalah penelitian observasional retrospektif dengan pendekatan belah lintang (cross sectional) dengan melihat rekam medik pada senter tunggal di RSUP Dr. Kariadi Semarang selama periode 1 Januari 2017 – 31 Desember 2018 untuk kemudian dilihat hubungan pengaruh kadar kreatinin serum dengan magnesium dan calcium pada pasien CKD dengan terapi hemodialisis. Hasil dan pembahasan: Terdapat hubungan signifikan positif lemah antara kreatinin serum dengan magnesium (p=0,032, r= 0,327). Tidak terdapat hubungan antara kreatinin serum dengan kadar kalsium. Simpulan : Dari hasil penelitian dapat disimpulkan bahwa secara statistik terdapat hubungan yang bermakna antara kadar kreatinin serum dengan magnesium pada pasien Chronic Kidney Disease (CKD) dengan terapi hemodialisis. Kata Kunci Kreatinin, mineral, magnesium Chronic Kidney Disease, hemodialisis. ABSTRACT Introduction: Chronic Kidney Disease (CKD) is an irreversible kidney function disorder, which is the body's ability to fail to maintain metabolism and balance fluid and electrolytes and minerals. Most metabolic processes require and are influenced by electrolytes. Abnormal mineral electrolyte concentrations can cause many disturbances. When kidney function getting worse to stages CKD 4 and 5, the excretion tends to decrease and cannot be compensated. The purpose of this study is to look at the effect of CKD on minerals namely magnesium and calcium. Method: This study was a retrospective observational study with a cross sectional approach by looking at medical records at RSUP Dr. Kariadi Semarang during the period of 1 January 2017 - 31 December 2018 to see the correlation of influence of serum creatinine levels with magnesium and calcium in CKD patients with hemodialysis therapy. Results and discussion: There was a significantly weak positive correlation between serum creatinine and magnesium (p = 0.032, r = 0.327). There is no correlation between serum creatinine and calcium levels. Conclusion: The results of the study it can be concluded that there is a statistically significant correlation between serum creatinine levels with magnesium in Chronic Kidney Disease (CKD) patients with hemodialysis therapy. Keywords Creatinine, minerals, magnesium Chronic Kidney Disease, hemodialysis.

Pengaruh Terapi Spiritual Emotional Freedom Technique (SEFT) Terhadap Penurunan Tingkat Depresi Pada Pasien Kanker Serviks Wijayati, Sugih; Fitriyanti, Suci Abrelia; Arwani, Arwani
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang: Reaksi psikologis yang dapat muncul setelah pasien didiagnosis kanker serviks pada umumnya merasa shock mental, takut, tidak bisa menerima kenyataan, sampai pada keadaan depresi. Depresi berdampak pada gangguan mood yang dikarakteristikkan dengan kesedihan yang intens, berlangsung dalam waktu lama, dan mengganggu kehidupan normal.Kondisi ini terjadi pada pasien kanker servix .Salah satu terapi komplementer yang dapat digunakan untuk menurunkan tingkat depresi pada pasien kanker servix yaitu terapi Spiritual Emotional Freedom Technique (SEFT).Salah satu dampak depresi yang akan muncul adalah lemahnya kondisi fisik yang akan menghambat proses pengobatan dan mendukung sel kanker servix semakin berkembang. Tujuan: untuk mengetahui pengaruh terapi SEFT terhadap tingkat depresi pada pasien kanker serviks di RSUD Dr. Moewardi Surakarta. Metode: Jenis penelitian ini adalah penelitian pra – eksperimental dengan desain penelitian pre and post-test without control group. Sampel dalam penelitian ini sebanyak 33 responden dengan teknik consecutive sampling. Uji analisis data dengan uji Wilcoxon – test. Hasil: Hasil penelitian menunjukkan penurunan skor depresi dari 28 (depresi sedang) menjadi 20 (depresi klinis) setelah dilakukan SEFT dan perubahan skor depresi secara statistik bermakna (p = 0,000). Kesimpulan: ada penurunan terapi SEFT terhadap tingkat depresi pada pasien kanker serviks. Kata kunci : depresi , SEFT, kanker serviks. Abstract Background : Psychological reactions commonly occur among cervical cancer patients are mental alteration, fear, denial and depression. Depression is a mood disorder characterized by prolonged sorrow, which can disrupt normal life. The SEFT therapy is an effective complementary therapy to reduce depression level. Aims: This study aims to examine the effect of SEFT therapy on depression among cervical cancer patients at Dr. Moewardi Surakarta General Hospital. Methods: A pre - experimental study using pre and post-test without control group design was applied to 33 respondents recruited by consecutive sampling method. The data were analyzed using the Wilcoxon test. Result: The depression score was decreased from 28 (moderate depression) to 20 (clinical depression) after intervention, which is statistically significant (p= 0.000). Conclusion : It is concluded that there is positive effect of SEFT therapy on depression level among cervical cancer patients. Keyword : depression, SEFT. Cervical Cancer.

Gambaran audiogram pada anak dengan penyakit ginjal kronis yang menjalani hemodialisis Muyassaroh, Muyassaroh; Muryawan, Heru; Cahyani, Nastiti Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang: Penyakit ginjal kronis (PGK) adalah kerusakan ginjal atau penurunan laju filtrasi glomerulus (GFR) kurang dari 60 mL / min / 1,73 m2 paling sedikit 3 bulan. Pasien PGK memiliki resiko kejadian kurang pendengaran yang tinggi. Tujuan: Mengetahui gambaran audiogram anak dengan PGK yang menjalani hemodialisis. Metode : Diskriptif retrospektif 7 kasus PGK ada anak yang menjalani hemodialisis di RSUP Dr.Kariadi Semarang Juli 2017. Hasil : didapatkan 5 kasus(71,4%) kurang pendengaran sensorineural, 1 kasus (14,3%) kurang pendengaran campuran (MHL) dan 1 kasus (14,3%) normal. Derajat kurang pendengaran bervariasi dari derajat ringan sampai sangat berat. Kesimpulan: Kurang pendengaran sensorineural sebagian besar terjadi pada anak dengan PGK yang menjalani hemodialisis. Kata kunci : Audiogram, SNHL, PGK Background: Chronic kidney disease (CKD) is kidney damage or a decrease in glomerular filtration rate (GFR) of less than 60 mL / min / 1.73 m2 for at least 3 months. Patients with CKD have a high risk of hearing loss. Objective: The aim of illustrate the audiogram on children with chronic kidney disease undergoing hemodialysis. Methode : Descriptif retrospective to seven cases of children with chronic kidney disease who undergoing hemodialysis in Karyadi hospital juli 2017. Result : Five cases (71,4%) with sensorineural hearing loss. One case(14,3%) showed severe mix hearing loss, one cases(14,3%) with normal audiogram. The degree of hearing loss from mild to profound Conclusion: Sensorineural hearing loss may occur in the majority of children with CKD on hemodialysis Keywords : Audiogram, SNHL, PGK

Tablet Hisap Dan Relaksasi Nafas Dalam Untuk Mengurangi Nyeri Tenggorok Pada Pasien Post Operasi Dengan General Anesthesia (GA) Susianto, Arip; Pratiwi, Hikmi Muharromah; Simamora, Evi Komala
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang: Standar prosedur penanganan pada pasien paska bedah di RSUP Dr Kariadi belum cukup efektif untuk mengurangi nyeri tenggorok paska operasi dengan pamasangan endotrakeal tube pada General Anesthesia (GA). Penggunaan tablet hisap terbukti mampu menurunkan nyeri tenggorok, akan tetapi bukti penelitian masih terbatas. Penelitian ini untuk menguji keefektivitasan pemberian tablet hisap dan relaksasi napas dalam untuk mengurangi derajat nyeri tenggorok paska operasi. Metode: Penelitian dilakukan dengan desain quasi experimental pre-posttest pada 11 Juli – 30 Oktober 2019. Subyek penelitian berjumlah 60 pasien paska operasi dengan general anesthesia yang dikelompokan menjadi 30 kelompok intervensi dan 30 kelompok kontrol. Nyeri tenggorok paska operasi diukur dengan menggunakan Visual Analogue Scale (VAS) pada 6 jam paska operasi dan dievaluasi tiap 12 jam selama 48 jam. Hasil: Perbedaan rerata skor VAS antara kelompok kontrol dan kelompok intervensi secara signifikan terjadi pada penilaian nyeri 36 jam paska operasi (t = -3,70, p = 0,002) dan 48 jam paska operasi ( t = -4,28, p = 0,000). Skor VAS pada kelompok intervensi lebih rendah secara signifikan dibandingan dengan skor VAS pada kelompok kontrol. Simpulan: Pemberian tablet hisap dan relaksasi napas dalam secara signifikan menurunkan tingkat nyeri tenggorak paska operasi. Pemberian tablet hisap dapat dijadikan sebagai intervensi alternatif untuk penangangan pasien dengan komplikasi nyeri tenggorok paska operasi. Key words: Nyeri tenggorok, Endotracheal Tube, Tablet hisap, Relaksasi napas dalam, Visual Analogue Scale (VAS) Background: The standard procedures of post operative patients at RSUP Dr Kariadi Semarang was ineffective to reduce post operative sore throat with Endotracheal Tube insertion in General Anesthesia. Lozenges was proven may reduce sore throat while the evidences were still limited. Methods: The research design was quasi experimental pre-post test on 11 july - 30 october 2019. The study subjects were 60 post operative patients with General Anesthesia grouped into 30 intervention grups and 30 control groups. Post operative sore throat was measured using Visual Analogue Scale (VAS) at 6 hours after surgery then evaluated every 12 hours for 48 hours. Results: Mean difference VAS score between intervention group and control group significantly in the assessment of pain 36 hours (t = -3,70, p = 0,002) and 48 hours ( t = -4,28, p = 0,000) post operatively. VAS score in intervention group was significantly lower than VAS score in control group. Conclusion: Lozenges and deep breath relaxation reduce significantly post operative sore throat. Lozenges could be used as an alternative intervention to treat patients with post operative sore throat. Keywords: Sore Throat, Endotracheal Tube, Lozenges, Deep Breath Relaxation, Visual Analogue Scale.

Prediction Score of Antegrade Chronic Total Occlusion Percutaneous Coronary Intervention Success in Dr. Kariadi Central General Hospital Semarang Pudjiastuti, Anggit; Rifqi, Sodiqur; Sofia, Sefri Noventi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Lesion characteristics of chronic total occlusion (CTO) are predictors of percutaneous coronary intervention (PCI) success. A prediction score consist of these predictors can help CTO-PCI operators. Various prediction score had been established but none had been established in Indonesian population. Methods: This observational cohort study was performed in patients underwent native vessel CTO-PCI in Dr.Kariadi Hospital during 2018. Target vessels, ostial lesion, blunt stump, calcification, long lesion, bending, side branch, bridging collateral, and retrograde collateral were angiographic variables proposed to be predictors of CTO-PCI success. All of the variables were quantitatively assessed by two observers. Bivariate and multivariate analysis used to identify independent predictors of CTO-PCI success and to establish a scoring model. Results: A total 200 patients underwent CTO-PCI procedures were included to this study. All of the procedures used antegrade approach. The prediction score established as follows: bending (1 point), calcification (2 point), blunt stump (3 point), long lesion (1 point), and poor retrograde collateral filling (2 point). Total score ranged from 0 to 9 with decreased probability of success from 92.3% to 0.5%. Score value ? 3 categorized as difficult lesion with higher risk to failure compared to score value <3 (OR 15.4; p<0.001). The score model had good calibration and discrimination in predict CTO-PCI success (AUC 0.88; p<0.001). Conclusion: Bending, calcification, blunt stump, long lesion, and poor retrograde collateral were predictors of CTO-PCI success. The score consist of these variables could predict antegrade CTO-PCI success. Keywords: chronic total occlusion; percutaneous coronary intervention; success; prediction score.

Antioxidant and Anti-inflammatory effect of Graptophyllum pictum (L.) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids Azhar, Abu; Riwanto, Ignatius; Nugroho, Eriawan Agung; Susilaningsih, Neni; Prajoko, Yan Wisnu; Budiono, Parish; Prasetyo, Sigit Adi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory and plebotonic medicines, high fiber diet and changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory and plebotonic medicine) since its anti-inflammatory effect may be related to antioxidant property. ObjectiveTo elaborate the anti-inflammatory and anti-oxidant effect of GP on experimental hemorrhoid in male Wistar rats. MethodsA Randomized Controlled Trial Post-test only design in hemorrhoid-like rats using croton oil induced into the anus for 30 seconds each day for 3 consecutive days. 14 Wistar rats were randomly allocated into 2 groups. Group 1 got normal saline solution, while group 2 treated with GPE 100mg/Kg bw for 5 consecutive days. On the 9th experimental day, the blood was drawn for Elisa examination of COX-2 and SOD levels. As COX-2 and SOD normally distributed, pool t-test and product moment correlation was used for statistical analysis. Results All of Wistar rats were still alive. COX-2 levels (ng/ml) in the GPE group was 266.28±158.47, was significantly lower compared to control (595.21±68.92) (p=0.000). Serum SOD levels (ng/ml) in the GPE was 77.00±11.0, and was significantly higher than the control 28.00±4.00 (p=0.02). Correlation between COX-2 and SOD serum level was significantly strong negative correlation (p=0,000 and r=-0.842) Conclusions GPE at a dose of 100 mg/kg bw has antioxidant and anti-inflammatory effects on artificial hemorrhoids through decreased COX-2 levels, and elevated SOD levels. There is a strong negative correlation between SOD and COX-2 serum level. KeywordsGraptophyllum pictum, hemorrhoids, Croton oil, COX-2, SOD.

Hubungan Gambaran Histopatologi Dan Derajat Konka Hipertrofi Dengan Sumbatan Hidung Pada Rinosinustis Kronik Kusuma Dewi, Anna Mailasari; Aditomo, Rano; Hariyati, Riece; Kusuma Astuti, Meira Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang : Hidung tersumbat dapat disebabkan karena kelainan struktur hidung seperti deviasi septum, atresia koana, konka hipertrofi, celah palatum, hipertrofi adenoid, dan neoplasma. Dua puluh persen populasi dengan hidung tersumbat disebabkan konka hipertrofi. Konka hipertrofi merupakan pembesaran konka akibat bertambahnya ukuran sel konka, yang disebabkan hiperplasia dan hipertrofi lapisan mukosa dan tulang konka. Gambaran hipertrofi dan hiperplasi dapat dilihat melalui pemeriksaan histopatologi. Tujuan penelitian ini untuk mengetahui hubungan gambaran histopatologi dan derajat konka hipertrofi dengan sumbatan hidung pada pasien rinosinusitis kronik (RSK). Metode : Desain penelitian korelasi dengan metode belah lintang pada pasien RSK dengan konka hipertrofi yang menjalani operasi Bedah Sinus Endoskopik Fungsional (BSEF) dan konkotomi. Derajat konka hipertrofi dinilai berdasarkan nasoendoskopi, sedangkan sumbatan hidung menggunakan kuesioner Nasal Obstruction Symptom Evaluation (NOSE). Uji hipotesis yang digunakan adalah uji korelasi Spearman. Hasil : Karakteristik subyek penelitian sebanyak 33 orang, perempuan 60% lebih banyak daripada laki-laki 40%. Derajat sumbatan hidung ringan (30%), sedang (27%), berat (30%) dan sangat berat (13%). Konka hipertrofi terbanyak yaitu derajat 3 (54,5%). Hasil analisis dengan uji korelasi Spearman menunjukkan terdapat korelasi positif dengan nilai korelasi sedang antara derajat konka hipertrofi dengan derajat sumbatan hidung (p=0.02 dan rho = 0.404. Tidak terdapat hubungan yang bermakna antara derajat sumbatan hidung dengan gambaran histopatologi konka inferior (hiperplasia sel goblet, pembentukan kelenjar submukosa, eosinofil, limfosit, neutrofil). Simpulan : Derajat konka hipertrofi berpengaruh terhadap sumbatan hidung. Gambaran histopatologi konka hipertrofi tidak berpengaruh terhadap derajat sumbatan hidung pada pasien RSK. Kata kunci : Rinosinusitis kronik, sumbatan hidung, konka hipertrofi Background: Nasal congestion can be caused by abnormalities of nasal structures such as deviation of the septum, choanal atresia, turbinate hypertrophy, cleft palate, adenoid hypertrophy, and neoplasms. Twenty percent of the population with nasal congestion is due to turbinate hypertrophy. Turbinate hypertrophy is an enlargement of turbinate due to an increase in the size of turbinate cells, which is caused by hyperplasia and hypertrophy of the mucosal layers and turbinate bones. Description of hypertrophy and hyperplasia can be seen through histopathological examination. The purpose of this study was to determine the relationship between histopathological features and the degree of turbinate hypertrophy with nasal obstruction in patients with chronic rhinosinusitis (CRS). Methode: The correlative study design with a cross-sectional method in CSR patients with turbinate hypertrophy who underwent Functional Endoscopic Sinus Surgery (FESS) and turbinectomy. The degree of turbinate hypertrophy was assessed based on nasoendoscopy, whereas nasal obstruction used the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire. The hypothesis test used is the Spearman correlation test. Result: The characteristics of the study subjects were 33 people, more women (60%) than men (40%). The degree of nasal obstruction is mild (30%), moderate (27%), severe (30%) and very severe (13%). Turbinate hypertrophy grade 3 was the most (54,5%). The analyzed using Spearman correlative test showed a positive correlation with a moderate correlation between the degree of turbinate hypertrophy with the degree of nasal obstruction (p=0.02 dan rho = 0.404). There was no significant relationship between the degree of nasal obstruction with histopathological features of the inferior turbinate (goblet cell hyperplasia, the formation of submucosal glands, eosinophils, lymphocytes, and neutrophils). Conclusion: The degree of turbinate hypertrophy affects nasal obstruction. Histopathological features of turbinate hypertrophy do not affect the degree of nasal obstruction in CSR patients. Keyword: Chronic rhinosinusitis, nasal obstruction, turbinate hypertrophy

Kombinasi Suplementasi Omega 3 Dengan Restriksi Kalori Terhadap Penyembuhan Luka Bakar Tikus Sprague Dawley Kajian Pada VEGF dan Re-Epitelisasi bayu ardha, doglas rama; Dharmana, Edi; Prabowo, Erik
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Cedera sel yang luas pada luka bakar melepaskan banyak mediator inflamasi. Respon tubuh yang berlebihan pada keadaan tersebut akan memperberat kerusakan sel yang sudah terjadi. Nurtrisi (lemak) yang cukup seperti omega 3 dapat membantu proses penyembuhan luka serta mencegah infeksi pada luka supaya tidak menjadi luka kronis. Maka dari itu peneliti memilih judul penelitian tentang efektifitas kombinasi suplementasi omega 3 dengan restriksi kalori terhadap penyembuhan luka bakar pada tikus Sprague Dawley, ditinjau dari VEGF dan Re-epitelisasi. Untuk mengetahui tingkat efektifitas suplementasi Omega 3 dan retriksi kalori pada penyembuhan luka bakar. Peneliti dalam melakukan penelitian menggunakan metode penelitian eksperimental dengan menggunakan 1 kelas kontrol dan 3 kelas perlakuan tikus Sprague Dawley, yang diinduksi luka bakar kemudian diberi perlakuan, dan diamati secara berkala. Hasil penelitian didapatkan perbedaan yang signifikan antara kelompok kontrol dan kelompok perlakuan yang di uji dengan one way ANOVA mempunyai nilai p = 0,000 (p < 0,05), dan uji Mann-Whitney didapatkan perbedaan yang signifikan antara kelompok perlakuan 1, 2, 3, dan kelompok kontrol p = 0,025; 0,004; 0,004; 0,004; 0,004, nilai p < 0,05. Dan uji Games-Howell ditunjukkan pada kolom rerata ± SD jika memuat huruf yang berbeda berarti ada perbedaan yang bermakna (p-value <0.05) K1 = 23,3587a ± 0,57556; P1 = 17,1015b ± 2,60108; P2 = 124,1503c ± 15,30168; P3 = 237,5053d ± 0,78263. Kesimpulan yang peneliti dapat bahwa kombinasi suplementasi omega 3 dengan retriksi kalori berpengaruh signifikan terhadap penyembuhan luka bakar pada tikus Sprague Dawley. Kata kunci : Penyembuhan Luka bakar, Sprague Dawley, Omega 3, Retriksi Kalori Extensive cell injury to burns releases inflammatory mediators. It’s led to excessive body response and cause aggravate cell damage that has already occurred. Adequate nutrients (fat) like omega 3 can help the healing process and prevent infection in wounds to become chronic. Therefore the researchers chose the title of the study of the effectiveness combination omega-3 supplementation with calorie restriction for burns in Sprague Dawley rats, in terms of VEGF and Re-epithelialization. To determine the effectiveness of Omega 3 supplementation and calorie restriction when healing burns. The researchers using experimental research methods with 1 control and 3 training classes of Sprague Dawley mice, which were induced by burns were then observed periodically. The results showed a significant difference between the control group and the treatment group tested by one way ANOVA having a value of p = 0,000 (p <0.05), and the Mann-Whitney test found a significant difference between the treatment groups 1, 2, 3, and the control group p = 0.025; 0.004; 0.004; 0.004; 0.004, p value <0.05. And the Games-Howell test is shown in the mean column ± SD if it contains different letters it means there is a significant difference (p-value <0.05) K1 = 23.3587a ± 0.57556; P1 = 17.1015b ± 2.60108; P2 = 124,1503c ± 15.30168; P3 = 237.5053 d ± 0.78263. The researchers concluded that the combination of omega-3 supplementation with calorie retention had a significant effect on burn healing in Sprague Dawley rats. Keywords: Burn Healing, Sprague Dawley, Omega 3, Calorie Restriction

Ekspresi Reseptor Estrogen, Reseptor Progesteron Dan Digit Ratio Pada Pasien Meningioma Prakoso, Teguh Iman; Arifin, Mohammad Thohar; Sadhana, Udadi; Puspasari, Dik; Kusuma Astuti, Meira Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan ER didapatkan masing–masing nilai p = 0,4 (r = 0,2), p = 0,5 ( r = -0,1), dan p = 0,9 (r = 0,1). Secara statistik terdapat hubungan yang sangat lemah antara Digit Ratio kanan, Digit Ratio kiri, selisih Digit Ratio kanan kiri dengan ER dan PR pada pasien meningioma Simpulan Terdapat hubungan yang sangat lemah antara reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio pada pasien meningioma. Kata kunci : Reseptor Estrogen, Reseptor Progesteron, Digit Ratio, Meningioma. Background Meningiomas are primary intracranial benign tumors that are affected by the balance of estrogen and progesterone. Digit Ratio (2D: 4D) is strongly influenced by exposure to prenatal androgen hormones especially estrogen and testosterone. Objective To determine the relationship between estrogen receptor (ER) and progesterone receptor (PR) with Digit Ratio (2D: 4D) in meningioma patients. Method Analytical observational research with cross-sectional study design. The total sample of 25 meningioma patients who underwent ER and PR examinations. Digit Ratio measurements were performed at the clinic and neurosurgical ward of RSUP Dr. Kariadi Semarang. The Spearman test was used for the statistical test. Results Right, left and right-left difference digit ratio with mean value of 1.0046; 1,0021 and 0,0492. After Spearman test, the relationship between right Digit Ratio, left Digit Ratio and Difference between right and left Digit Ratio with PR was p = 0.5 (r = 0.1), p = 0.8 (r = 0.1), and p = 0.3 (r = 0.2). Correlation between right Digit Ratio, left Digit Ratio and Difference between left and right Digit Ratio with ER was p = 0.4 (r = 0.2), p = 0.5 (r = -0.1), and p = 0.9 (r = 0.1). Statistically there is a very weak relationship between right Digit Ratio, left Digit Ratio, difference between right and left Digit Ratio with ER and PR in patients with meningiomas. Conclusions There is a very weak relationship between estrogen receptors (ER) and progesterone receptors (PR) and Digit Ratio in meningioma patient. Keywords: Estrogen Receptor, Progesterone Receptor, Digit Ratio, Meningioma.

Pengaruh Senam Sehat Anak Indonesia terhadap FEV1 (Forced Expired Volume in one second) dan FVC (Forced Vital Capacity) pada Anak Underweight Setiawati, Erna; Kesoema, Tanti Ajoe; Asmara Putri, Rahmi Isma; Julianti, Hari Peni
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Pendahuluan: Indonesia masih mengalami masalah gizi yaitu masih terdapatnya status gizi kurang bahkan gizi buruk. Nutrisi yang rendah atau buruk dapat mengurangi massa otot skeletal dan pernapasan, yang menyebabkan penurunan FVC dan FEV. FVC dan FEV merupakan parameter dari fungsi paru. Penelitian terdahulu menyebutkan bahwa olahraga dapat meningkatkan fungsi dari sistim pernapasan. Senam Sehat Anak Indonesia (SSAI) merupakan salah satu pilihan olahraga pada anak. Penelitian ini bertujuan menganalisis pengaruh SSAI terhadap FEV1 dan FVC pada anak underweight. Metoda: Penelitian ini menggunakan one group pre and posttest design. Populasi target adalah 24 anak underweight berusia 9-12 tahun di SDN Tembalang. Dilakukan pemeriksaan FEV1 dan FVC sebelum dan setelah pasien melakukan SSAI. Perbedaan sebelum dan sesudah perlakuan menggunakan uji t-berpasangan. Nilai p dianggap bermakna apabila nilai p<0,05. Hasil: Peningkatan FEV1 (0,66±0,25) liter, FVC (0,22±0,28) liter setelah SSAI berturut-turut p=0,23 dan p=0,71. Diskusi: Pada SSAI dilakukan gerakan-gerakan senam yang dapat meningkatkan elastisitas paru serta memperkuat otot-otot pernapasan sehingga meningkatkan volume udara yang dapat diambil saat bernapas. Peningkatan nilai FVC dapat disebabkan oleh peningkatan volume dan elastisitas paru-paru. FEV1, FEV bervariasi dan tergantung dari otot pernapasan. Pada penelitian ini walaupun tidak bermakna secara statistik namun dalam rerata nilai FEV1 dan FVC terdapat peningkatan setelah SSAI. Hal ini mungkin dikarenakan frekuensi senam yang digunakan adalah frekuensi yang paling minimal yaitu 2 kali per minggu. Simpulan: SSAI 2 kali per minggu selama 6 minggu sebagai salah satu pilihan olahraga pada anak underweight usia 9-12 tahun namun dalam penelitian ini tidak didapatkan peningkatan bermakna pada FEV1 dan FVC. Diperlukan penelitian lebih lanjut menggunakan frekuensi latihan yang lebih banyak dan durasi yang lebih panjang serta menggunakan kelompok kontrol. Kata kunci: Anak underweight; Forced Expired Volume in one second (FEV1); Forced Vital Capacity (FVC); Senam Sehat Anak Indonesia (SSAI) Introduction: Indonesia is still facing nutritional problems, the presence of low nutritional status and even poor nutrition. Low or poor nutrition can reduce skeletal and respiratory muscle mass, which causes a decrease in FVC and FEV. FVC and FEV are parameters of lung function. Previous research suggests that exercise can improve the function of the respiratory system. Senam Sehat Anak Indonesia (SSAI) is one of the sports for children. This study aims to analyze the effect of SSAI on FEV1 and FVC in underweight children. Method: The design of this study was one group pre and post test design. The target population was underweight children at Tembalang Elementary School. FEV1 and FVC were examined before and after the patient underwent SSAI. Difference before and after treatment using paired t-test. The p value is considered significant if the p value <0.05. Results: There was no significant increase of FEV1 (0.66 ± 0.25) liters, FVC (0.22 ± 0.28) liters after SSAI with p= 0.23 and p = 0.71, respectively. Discussion: At SSAI, gymnastic movements are performed that can increase lung elasticity and strengthen breathing muscles, thereby increasing the volume of air that can be taken while breathing. Increased FVC is caused by an increase in lung volume and elasticity. FEV1, FEV varies and depends on the respiratory muscles. In weak expiratory muscles, a person's ability to expiration rapidly decrease and also the FEV1.FVC index. The mean of FEV1 and FVC values ??after SSAI increased but were not significant. In this study, although not statistically significant, the mean values ??of FEV1 and FVC were increased after SSAI. This may be due to the frequency of gymnastics used is the most minimal frequency of 2 times per week. Conclusion: SSAI twice per week for 6 weeks as one of the exercise choices in underweight children aged 9-12 years but in this study no significant increase in FEV1 and FVC was found. Further research is needed using more exercise frequency and longer duration and using a control group.Keywords: Underweight children; Forced Expired Volume in one second (FEV1); Forced Vital Capacity (FVC); Senam Sehat Anak Indonesia (SSAI)

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Maya Nuriya Widyasari

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medica.hospitalia@yahoo.com

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Journal Mail Official
medica.hospitalia@yahoo.com

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Location
Kota semarang,

Jawa tengah

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Maya Nuriya Widyasari

Contact Email medica.hospitalia@yahoo.com

Phone -

Journal Mail Official medica.hospitalia@yahoo.com

Editorial Address -

Location Kota semarang, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Maya Nuriya Widyasari

Contact Email
medica.hospitalia@yahoo.com

Phone
-

Journal Mail Official
medica.hospitalia@yahoo.com

Editorial Address
-

Location
Kota semarang,

Jawa tengah

INDONESIA