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Medica Hospitalia
Published by RSUP Dr. Kariadi Semarang
ISSN : 23014369     EISSN : 26857898     DOI : https://doi.org/10.36408/mhjcm
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.
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Articles 584 Documents
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The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus: The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus Cahyono, Chemy Wiryawan; Mughni, Abdul; Susilaningsih, Neni; Nugrahadi, Dimas Erlangga; Mahendra, Vito
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.764

Abstract

INTRODUCTION: WHO predicts an increase in the number of people with diabetes in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. Another marker for measuring insulin resistance is the homeostasis model assessment-insulin resistance (HOMA-IR). Bariatric surgery is the most effective therapy for patients both in terms of weight loss and improvement in obesity-related diseases such as Type-2 Diabetes Mellitus (DM). OBJECTIVE: This study aims to prove the improvement of HOMA Beta values and Diameter of the islets of Langerhans in type 2 diabetes mellitus rats that underwent Sleeve Gastrectomy and Pancreatic Omentoplasty. METHODS: This study is an experimental post-test control group design study with 18 male Sprague-Dawley rats. Samples are divided into 1 control group and 2 treatment groups (Sleeve gastrectomy and Omentoplasty). Rats’ pancreas and glucose level were measured by using HOMA IR method and Hematoxylin eosin-paraffin block method. Data of islets Langerhans were measured using ANOVA, while HOMA Beta values were measured by Mann Whitney and Kruskall Wallis test. RESULTS: HOMA Beta values in treatment Group P1 (Sleeve gastrectomy) and Group P2 (Sleeve gastrectomy + omentoplasty) are statistically different compared to control group. Islets cells of Langerhans diameter in treatment groups 1 and 2 was not statistically different compared to control group. HOMA Beta Value and Langerhans diameter was correlated moderately. CONCLUSION: Sleeve Gastrectomy and Pancreatic Omentoplasty in type 2 diabetes mellitus rats improved the HOMA Beta values and the diameter of the islets of Langerhans. KEYWORDS: Sleeve Gastrectomy; Omentoplasty; Diabetes mellitus; HOMA Beta; Langerhan's Islet
Cut-Off Kadar Insulin Like Growth Factor-1, Leptin dan Adiponektin Darah Tali Pusat Pada Bayi Berat Lahir Rendah: Cut-Off Levels of Insulin Like Growth Factor-1, Leptin and Adiponectin Umbilical Cord Blood In Low Birth Weight Babies Mexitalia, Maria; Perdani, Putri; Saputra, Epriyan; Irawan Saputra, Gatot
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.765

Abstract

LATAR BELAKANG : Insulin-like  Growth Factor-I (IGF-I) berperan dalam pertumbuhan janin terutama pada usia kehamilan lanjut. Adiponektin dan leptin berhubungan dengan depot adipose dalam modulasi metabolisme dan homeostasis energi. Ketiga hormon tersebut memiliki peran penting pada pertumbuhan janin. TUJUAN : Untuk mengetahui nilai cut off kadar IGF-1, leptin dan adiponektin pada bayi berat lahir rendah  (BBLR) sesuai masa kehamilan dan kecil masa kehamilan. METODE : Observasional analitik dengan desain belah lintang, dilaksanakan pada bulan November 2018 - Januari 2019. Subjek adalah  bayi baru lahir, kehamilan  tunggal dengan berat lahir >1000 gram dan <2500 gram, serta usia ibu saat hamil <40 tahun Sampel darah tali pusat diambil setelah bayi lahir, sebelum plasenta dilahirkan. Pemeriksaan IGF-1, leptin dan adiponektin menggunakan teknik immunoassay kuantitatif dengan metode ELISA. Data hasil penelitian merupakan data numerik, dilakukan uji ROC dan uji diagnosis untuk mendapatkan nilai cut-off. HASIL :  Selama periode penelitian, terdapat 46 subyek yang terdiri atas 11 bayi kecil masa kehamilan dan 35 bayi sesuai masa kehamilan. Jenis kelamin laki-laki sebanyak 24 bayi (52,2%) dan perempuan 22 bayi (47,8%). Sebanyak 41,3% bayi lahir dari ibu dengan preeklampsia. Didapatkan nilai cut-off IGF-1 adalah 51,12 ng/ml, nilai cut-off untuk leptin adalah 3,3 ng/ml, dan nilai cut-off adiponectin 19,60 ng/ml. KESIMPULAN : Terdapat perbedaan kadar IGF-1, leptin dan adiponektin darah tali pusat BBLR sesuai masa kehamilan dengan BBLR kecil masa kehamilan dengan nilai cut-off masing-masing. KATA KUNCI    : Bayi berat lahir rendah, darah tali pusat, cut-off, IGF-1, leptin, adiponektin
Pengaruh Pemberian Fenitoin Oral dan Vitamin C Oral terhadap Jumlah Kolagen dan Diameter pada Fistula Enterokutan Tikus Wistar: Effect Phenytoin and Vitamin C Therapy to Collagen Deposition and Diameter of Enterocutaneous Fistula in Wistar Rat Pambudi Utomo, Gede; Riwanto, Ignatius; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.766

Abstract

Latar Belakang : Enterocutaneous fistula (ECF) adalah salah satu tantangan bagi banyak ahli bedah di dunia. Meskipun terdapat perkembangan dalam perawatan medis dan tekhnik operasi, namun morbiditas dan mortalitas terkait ECF masih tinggi. Keberhasilan dalam tatalaksana ECF memerlukan perawatan yang komprehensif dan sumber daya yang mahal, dimana tidak terjangkau oleh sebagian masyarakat Indonesia. Fenitoin dan Vitamin C adalah obat yang murah dan telah menunjukan manfaat baik dalam penyembuhan luka. Tujuan : Penelitian ini bertujuan untuk mengetahui apakah pemberian fenitoin dan vitamin C akan meningkatkan kolagenisasi dan menurunkan diameter ECF pada tikus wistar. Kemudian untuk mengevaluasi apakah pemberian kombinasi fenitoin dan vitamin C memberikan hasil yang lebih baik dibandingkan pemberian tunggal fenitoin atau fitamin C Metode : Peneliti membuat caecostoma sebagai model ECF pada 24 ekor tikus. Tikus kemudian dibagi menjadi empat kelompok perlakuan dengan : perawatan NaCl,  Kombinasi fenitoin-vitamin C, Fenitoin saja dan Vitamin C saja. Pengamatan hasil dilakukan pada hari ke-7 dengan mengamati deposisi kolagen dan mengukur diameter ECF. Hasil : Penelitian ini menunjukan perbedaan kolagenisasi dan penurunan diameter ECF bermakna secara statistik (p<0.05) pada tiap kelompok perlakuan jika dibandingkan kelompok kontrol (5,521 + 2,552 %; 9,395 ± 0,582 mm). Penelitian ini juga mengungkapkan bahwa pemberian kombinasi fenitoin dengan vitamin C (28,110 ± 6,535 %; 5,742 ± 0,394 mm) memberikan hasil yang lebih baik (p<0.05) dibanding pemberian tunggal fenitoin (15,448 ± 5,184 %; 8,101 ± 0,822 mm) atau vitamin C (19,118 ± 4,190 %; 6,883 ± 0,744 mm). Kesimpulan : Kami menyimpulkan baik fenitoin maupun vitamin C memiliki efek baik dalam penyembuhan ECF. Pemberian kombinasi Fenitoin dan vitamin C terbukti lebih bermanfaat dibandingkan pemberian tunggal. Kata Kunci :  Enterocutaneous fistula, Fenitoin, Vitamin C, kolagen, Diameter fistula
Correlation Between Body Mass Index, Gender, and Age With Cholelithiasis : Correlation Between Body Mass Index, Gender, and Age With Cholelithiasis Al Atsariyah, Fatimah; Parish Budiono, Bernardus; Mahati, Endang; Lestari Partiningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.771

Abstract

BACKGROUND : Gallstones are formed due to deposit or hypersaturation of one or more of the bile components, namely cholesterol, bilirubin, bile salts, calcium, protein, fatty acids, and phospholipids. BMI, gender, and age are the factors that can trigger the formation of gallstones. In Indonesia, cholelithiasis cases have received less attention because they are often asymptomatic, making it difficult to detect and often misdiagnosed, resulting in a lack of official publication about the incidence of gallstones in Indonesia. AIM : To determine the correlation between BMI, Gender, and Age with cholelitiasis in Dr. Kariadi Hospital. METHOD : This was an observational study using cross-sectional design. Data were taken from medical records of patients in Digestive Surgery Department Dr. Kariadi Hospital from January 2018 until March 2020. A total of 100 patients were selected as subjects (50 patients with cholethiasis and 50 patienst without cholelithiasis). Pearson Chi-Square correlation was used for statistical analysis. RESULTS : Pearson Chi-Square test of BMI (p = 0.001) and Age (p = 0.041) was statistically significant for cholelithiasis risk (p < 0.05). While Gender (p = 0.224) was not statistically significant for cholelithiasis risk. CONCLUSION : There wa a significant correlation between BMI and Age with Cholelithiasis and there was no significant correlation between Gender with Cholelithiasis. KEYWORDS : Body Mass Index (BMI), Gender, Age, Cholelithiasis.
Analisis Faktor Predisposisi Coated Tongue Di Rumah Sakit Nasional Diponegoro: An Analysis of Predisposition Factors of Coated Tongue in Diponegoro National Rachmawati, Dini; Santoso, Oedijani; Triwahyu Hutami, Hesti
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.773

Abstract

LATAR BELAKANG : Keluhan pada rongga mulut yang sering dialami oleh kelompok usia di atas 45 tahun berupa kerusakan gigi, kehilangan gigi, dan kelainan jaringan lunak. Beberapa hasil penelitian menunjukkan bahwa kelompok usia di atas 45 tahun memiliki keluhan coated tongue dengan persentase lesi tertinggi pada rongga mulut. Hal ini terjadi karena perubahan kondisi seperti perubahan konsumsi makanan, penurunan laju saliva, efek samping obat antihipertensi, merokok, dan perilaku menggosok lidah. TUJUAN : Penelitian ini bertujuan untuk mengetahui hubungan faktor predisposisi dengan terjadinya coated tongue, dan mengetahui faktor yang paling berperan terhadap coated tongue pada kelompok usia di atas 45 tahun di Rumah Sakit Nasional Diponegoro (RSND) di Kota Semarang. METODE : Penelitian ini menggunakan desain studi cross sectional, dengan 84 responden berusia >45 tahun di poli penyakit dalam. Penelitian ini dilakukan dengan wawancara faktor predisposisi dan Tongue Coating Index (TCI) Shimizu untuk penilaian coated tongue. Uji statistik menggunakan uji chi-square, uji regresi logistik. HASIL : Responden yang memiliki nilai TCI >50% sebanyak 82 responden, dan nilai ≤50% sebanyak 2 responden. Uji chi-square menunjukkan adanya hubungan antara coated tongue dengan xerostomia (P<0,05), menyikat lidah (P<0,05), namun tidak ada hubungan dengan merokok (P>0,05), mengonsumsi antihipertensi (P>0,05), dan mengonsumsi makanan lunak (P>0,05). Hasil uji regresi logistik menunjukkan secara parsial xerostomia dan menyikat lidah tidak memengaruhi kejadian coated tongue (P>0,05). KESIMPULAN : Terdapat hubungan antara xerostomia dan menyikat lidah dengan coated tongue. Tidak ada pengaruh secara parsial antara xerostomia dan menyikat lidah terhadap coated tongue. KATA KUNCI : Coated tongue; Faktor predisposisi; Kelompok usia diatas 45 tahun.
Pemberian Krim Ekstrak Moringa oleifera L. pada Tikus dengan Luka Insisi: Studi terhadap Kadar IL-1, IL-10 dan rasio IL-1:IL-10: The Application of Moringa oleifera L. Cream on Rats with Incision Wound: Study on the IL-1 Level, IL-10 Level and IL-1:IL-10 ratio Surya Utoyo, Frederick; Bahrudin, Udin; Prajoko, Yan Wisnu; Mahati, Endang; Maharani, Nani
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.778

Abstract

LATAR BELAKANG : Saat ini, berbagai tanaman asli Indonesia dikembangkan sebagai bahan perawatan luka untuk hasil penyembuhan yang lebih baik. Salah satunya, yaitu Moringa oleifera L., yang  merupakan tanaman asli Indonesia serta berpotensi dapat membantu penyembuhan luka  melalui regulasi jalur sitokin inflamasi, interleukin (IL)-1 dan IL-10. TUJUAN : Untuk mengetahui pengaruh pemberian ekstrak Moringa oleifera L. terhadap IL-1, IL-10, dan rasio IL-1: IL-10 di jaringan kulit, pada tikus dengan luka insisi. METODE : Penelitian ini menggunakan desain post test only controlled group dengan sampel berupa 15 tikus Wistar yang dilakukan luka insisi. Sampel dibagi menjadi 3 kelompok perlakuan: perawatan luka dengan framycetin sulphate (KP), krim ekstrak Moringa oleifera L. 15% (M), dan krim plasebo (KN). Pengukuran kadar IL-1, IL-10, dan rasio IL-1:  IL-10 dilakukan pada hari ke-10 perlakuan melalui pengambilan jaringan. HASIL :  Kadar IL-1 pada kelompok perlakuan (M) tidak berbeda bermakna dibanding KN dan KP (33,56±4,68 vs 40,92±27,32 vs 30,23±3,92 pg/mL, p=0,543). Kelompok KP memiliki IL-10 lebih tinggi dibandingkan kelompok M dan KN (113,95±9,38; 91,75±5,65 dan 94,93±2,39 pg/mL, p<0,001), dan tidak didapatkan perbedaan antara kelompok M dan KN (p=0,296). Rasio IL-1: IL-10 kelompok KP, M, dan KN tidak menunjukan perbedaan bermakna (0,27±0,05, 0,37±0,06 dan 0,44±0,30, p=0,249). KESIMPULAN: Pemberian ekstrak Moringa oleifera L. secara topikal tidak mempengaruhi kadar IL-1 dan rasio IL-1 : IL-10 di jaringan kulit tikus dengan luka insisi. Kadar IL-10 di jaringan kulit tidak berbeda dibanding kelompok kontrol negatif, serta lebih rendah dibanding kelompok framycetin sulphate. KATA KUNCI           : Luka insisi, Moringa oleifera L., perawatan luka
Relationship Between Cognitive Dysfunction (MoCA-INA Score) with Disease Activity, Erythrocyte Sedimentation Rate, and C-Reactive Protein in Systemic Lupus Erythematosus Patients : Relationship Between Cognitive Dysfunction (MoCA-INA Score) with Disease Activity, Erythrocyte Sedimentation Rate, and C-Reactive Protein in Systemic Lupus Erythematosus Patients Bantar Sutoko; Suyanto Hadi; Elfian Rachmawati; Suharyo Hadisaputro; Handono Kalim
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.799

Abstract

BACKGROUND: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is one of the clinical manifestations affecting the brain in SLE, which the most frequent condition was cognitive dysfunction (CD). CD has a negative impact on the quality of life of SLE patients and causes impaired social function and reduced work productivity. Previous studies regarding correlation between cognitive dysfunction with disease activity, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) showed various results. AIM: The purpose of this study was to assess the correlation of CD using MoCA- INA score with disease activity (SLEDAI-2K score), ESR and CRP in SLE patients. METHODS: A cross-sectional study design was applied in this research. The subjects of this research were SLE patients measured by MoCA-INA score, SLEDAI-2K score, ESR, and CRP. Spearman rank correlation test was applied in this study to assess the relationship of the variables. RESULT: The study subjects consisted of 53 women diagnosed with SLE with an average age of 34 years old. 49.1 % of the subjects had high school education background. There was a moderate significant correlation between MoCA-INA score and ESR (r= -0.408, p=0.002) and also to CRP (r= -0.314 p=0.022). There was no significant correlation of disease activity and MoCA-INA score (r = -0.086 p = 0.539). CONCLUSION: The low levels of ESR and CRP were associated with CD in SLE patients. KEYWORDS: cognitive dysfunction, c-reactive protein, disease activity, erythrocyte sedimentation rate, systemic lupus erythematosus.
The Correlation Between Bullous Concha Volume and Type of Nasal Septal Deviation with Lund-Mackay CT Score in Chronic Rhinosinusitis: The Correlation Between Bullous Concha Volume and Type of Nasal Septal Deviation with Lund-Mackay CT Score in Chronic Rhinosinusitis Monica Cherlady Anastasia; Anna Mailasari Kusuma Dewi; Farah Hendara Ningrum
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.800

Abstract

BACKGROUND: Chronic rhinosinusitis is inflammation of the mucoperiosteum lining of the nose and paranasal sinuses for more than 12 weeks. Computed Tomography (CT scan) of the paranasal sinuses is the gold standard for diagnosing chronic rhinosinusitis. Nasal septal deviation and bullous concha are anatomical variation that often found in CT scan of chronic rhinosinusitis patients. The severity of chronic rhinosinusitis can be evaluated with Lund Mackay CT score. AIM: To analyse the correlation between bullous concha volume and type of nasal septum deviation with Lund-Mackay CT Score in chronic rhinosinusitis METHOD: This was an observational study with a cross sectional design. This study was conducted from March-May 2019. Subjects were CRS patients whom underwent paranasal sinuses CT scan in Dr. Kariadi Hospital Semarang whom met the criteria. The inclusion criteria were chronic rhinosinusitis patients more than 17 years old with deviated nasal septum and conchae bullosa. RESULT:  There were 50 CRS patients, the age average is 18 – 67 years. The mean volume of the bullous concha was  0.534 cm3. The highest deviation of the nasal septum is to the right (53.2%) and the highest total Lund-Mackay CT Score was 4 (56%). The correlation between septal type and bullous concha volume with Lund-Mackay CT Score CONCLUSION: Lund Mackay CT score didn't correlate with  septal type and bullous concha volume. KEYWORDS: Bullous Concha, Chronic Rhinosinusitis, Lund Mackay CT score, Nasal Septum Deviation
Potential Of Kenikir (Cosmos Caudatus Kunth) Leaves Essential Oil Against Candida Albicans Atcc 10231 In Vitro: Potential Of Kenikir (Cosmos Caudatus Kunth) Leaves Essential Oil Against Candida Albicans Atcc 10231 In Vitro Siti Zainatun Wasilah; Ratih Hardisari; Budi Martono; Wahyu Adi Pratama
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.803

Abstract

BACKGROUND : Kenikir is a medicinal plant whose leaves are often consumed as vegetables. Kenikir leaves contain active compounds such as flavonoids, polyphenols, saponins, tannins, alkaloids and essential oils. These compounds are thought to be able to inhibit the growth of Mycobacterium tuberculosa and Candida albicans ATCC 10231 strains OBJECTIVE : The purpose of this study was to describe the effect of kenikir leaf essential oil on the growth of the Candida albicans ATCC 10231 strains. with 4 concentrations and 6 repetitions in Candida albicans and the concentration of kenikir leaf essential oil concentration of 0.5%, 1%, 1.5%, 2%, METHOD : This type of research is a pure experimental research by providing treatment in the form of giving essential oil of kenikir leaves with various concentrations on the growth of the Candida albicans ATCC 10231 strains. The inhibition test of kenikir leaf essential oil on the growth of the  Candida albicans ATCC 10231 strains was carried out using the Kirby Bauer disk diffusion method. The research design used is Post Test Only with Control Group Design.Data obtained in the form of inhibition zone diameter, were analyzed using Variant Analysis (Anova), P£ 0,05 and continued with Post Hoc test. RESULT : The results showed that 0.5% essential oil concentration had a inhibition zone of 9.67 mm (moderate criteria); essential oil concentration of 1% with a inhibition zone of 9.72 mm with criteria moderate and 1.5% concentration with inhibition zone 11.86% with strong criteria and concentration 2% with inhibition zone 12.67 mm with strong criteria all concentrations affect the growth of Candida albicans  with the most optimal concentration of 2% for the Candida albicans ATCC 10231 strains. CONCLUSION : The higher the concentration of kenikir leaf extract, the inhibitory effect on the growth of Candida albicans ATCC 10231 strains was also higher. KEYWORDS : Cosmos caudatus Kunth, Candida albicans ATCC 10231 strains, diameter of the inhibition zone
Hubungan Antara Platelet-To-Lymphocyte Ratio dan Kadar Troponin I Pada Pasien Infark Miokard Akut Elevasi Segmen ST: Correlation Of Platelet-To-Lymphocyte Ratio And Troponin I Levels In Patients With St-Elevation Myocardial Infarction Tamariska Evelyn; Pipin Ardhianto; Dwi Retnoningrum; Mochamad Ali Sobirin
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.804

Abstract

INTRODUCTION:  Platelet and lymphocyte are significant in acute myocardial infarction (AMI) pathogenesis. Platelet-lymphocyte ratio (PLR) is a systemic biomarker which indicates thrombosis and inflammation. The diagnosis of AMI can be made by detecting elevated blood troponin I levels. The correlation between PLR and troponin I levels in ST-segment elevation myocardial infarction (STEMI) patients has not been widely known. AIM                : The objective of this study is to determine the correlation between PLR and troponin I levels in STEMI patients. METHODS    : This study was a cross-sectional study which data were obtained from the medical records of patients with STEMI admitted to Dr. Kariadi General Hospital Semarang from 2019 to 2020. Serum Troponin I levels were measured with Enzyme-Linked Fluorescent Assay (ELFA) method in less than 24 hours from symptoms onset. Complete blood counts were performed immediately on hospital admission. Correlations between variables were obtained using Spearman's test. RESULTS      : A total of 28 STEMI patients were included, 82.1% were male, mean age was 55.81 ± 2.13 years old. Mean symptoms onset was 7.52 ± 0.81 hours prior to admission. Mean PLR and troponin I levels were 233.32 ± 25.54 and 14.44 ± 3.16 μg/l, respectively. A moderately significant correlation was detected between troponin I levels and PLR in STEMI patients (r=0.333; p=0.042). Symptoms onset in STEMI patients had significant correlation to troponin I levels (r=0.596; p=0.001). CONCLUSION : A moderate positive correlation between PLR and troponin I levels is observed within 24 hours from symptoms onset in STEMI patients. KEYWORDS: Platelet-to-lymphocyte ratio; ST-segment elevation myocardial infarction; troponin I

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