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Medica Hospitalia
Published by RSUP Dr. Kariadi Semarang
ISSN : 23014369     EISSN : 26857898     DOI : https://doi.org/10.36408/mhjcm
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.
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Articles 584 Documents
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Korelasi Status Gizi dengan Phase Angle pada Pasien Gagal Ginjal Kronis yang Menjalani Hemodialisis Hartanto, Okky; Puruhita, Niken; Khairuddin, Khairuddin; Muis, Siti Fatimah; Christianto, Febe
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.795

Abstract

BACKGROUND: Nutritional problem are often experienced by patients with chronic kidney disease (CKD) undergoing regular hemodialysis. There are various tools that can be used to evaluate nutritional status, such as the 7-point Subjective Global Assessment (SGA), nevertheless, malnutrition in these patients is still underdiagnosed and resulting in worse clinical outcomes. Phase Angle (PhA) as measured by multi-frequency Bioelectrical Impedance Analysis (BIA) may detect nutritional problem in early stage in order to start nutrition therapy early. OBJECTIVE: To analyze correlation between nutritional status and PhA in CKD patients with regular hemodialysis. METHODS: The subject of this study were 39 CKD patients undergoing regular hemodialysis who met the inclusion and exclusion criteria. Nutritional status was evaluated by 7-point SGA, while PhA was measured by multi-frequency BIA. Correlation between variables analyzed by Spearman correlation test. RESULT: Positive correlation was observed between nutritional status and PhA (r = 0,64; p < 0,001). There was a negative correlation between PhA and number of comorbids (r = -0,381, p = 0,017). PhA was not correlated with sex and hemodialysis duration. CONCLUSION: There is positive correlation between nutritional status measured by 7-point SGA and PhA in CKD patients with regular hemodialysis.
DAYA ANTIBAKTERI EKSTRAK ETANOL KEMBANG SEPATU (Hibiscus rosa sinensis L.) SEBAGAI ALTERNATIF BAHAN MEDIKAMEN SALURAN AKAR TERHADAP Enterococcus faecalis Choirunnisa, Efika; Wibowo, Gustantyo Wahyu; Antari, Arlita Leniseptaria; Purnomo, Brigitta Natania Renata
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.809

Abstract

BACKGROUND: Enterococcus faecalis is the dominant bacteria found in root canals, especially in failure of root canal treatment. Therefore, antibacterial agents are required as a means to achieve complete disinfection of the root canal system. One of the natural ingredients that has been proven to have antibacterial properties is the ethanol extract of hibiscus (H. rosa sinensis L.), so it has the potential to be used as a root canal medicament to inhibit growth and eliminate E. faecalis bacteria.   OBJECTIVE: Testing the effectiveness of hibiscus (H. rosa sinensis L.) ethanol extract as a potential root canal medicament. METHOD: The study was conducted using a true experimental post-test only control group design in 6 treatment groups with various concentrations of hibiscus extract (100%, 50%, 25%, 12.5%, 6.25, and 3.125%) and a positive control group. (Brain Heart Infusion added E. faecalis) and negative (Brain Heart Infusion). The extract was then diluted to the concentration used and added with 1.5x108CFU/ml E. faecalis and then cultured using the spread method on NA media, incubated anaerobically at 37oC for 24 hours, then the colonies that grew were counted using a colony counter. RESULT: The results showed that 100% concentration had the highest ability to inhibit the growth of E. faecalis bacteria (92.7%) with an average number of colonies growing of 4.4 x 102 CFU/ml. The minimum inhibitory concentration (MIC) was shown at a concentration of 50%, with an inhibiting ability of 90.17% and the average number of colonies that grew was 5.9 x103 CFU/ml. Kruskal Wallis statistical test showed a significant difference in the number of colonies (p<0.05). CONCLUSION: Hibiscus extract with a concentration of 100% has the highest ability to inhibit the growth of E. faecalis bacteria and MIC is present at a concentration of 50%.
Nilai Rerata Volume Trombosit, Rasio Trombosit Limfosit, Rasio Rerata Volume Trombosit-Limfosit sebagai Prediktor Tingkat Keparahan Sindrom Koroner Kronik Wijaya, Friska; Limantoro, Charles; Fitria, Indah; Suharti, Catharina; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.813

Abstract

BACKGROUND: The increase in platelet aggregation and inflammation play an essential role in atherosclerosis. Furthermore, the level of activity depends on their size, with larger platelets facilitating the thrombosis process. Severe Coronary Artery Disease (CAD) is associated with low lymphocyte count. It is also linked with Mean platelet volume [MPV], Platelet Lymphocyte Ratio [PLR], and Mean Platelet Volume to Lymphocyte Ratio [MPVLR]. OBJECTIVE:  This study aims to investigate MPV, PLR, and MPVLR as predictors of the severity of Coronary Artery Lesion in Chronic Coronary Syndrome (CCS) using the Gensini score. METHOD: This is a cross sectional study conducted in Dr. Kariadi General Hospital, involving a total sample of 68 respondents. Furthermore, CCS were evaluated before conducting coronary angiography. The study comprises of two group of patients divided according to their Gensini scores, namely mild and severe, for ≤ 20 and > 20, respectively. MPV, PLR, and MPVLR were then compared between the two groups. RESULT: At a cut-off level of 3.4, MPVLR predicted the coronary artery severity with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value of 80%, 50%, 82%, and 47% (area under the curve [AUC] 0.67; 95% confidence interval [CI], 0.52-0.82; p 0.029). Meanwhile, its value ≥3.4 has OR 1.55; 95% CI, 0.99-2.43; p 0.034. CONCLUSION: This study conclude that MPVLR ≥3.4 can be used as a predictor of Coronary Artery Lesion Severity based on the Gensini score in CCS cases.
Perbandingan Kombinasi Senam Kaki dengan Hidroterapi dan Tanpa Hidroterapi Terhadap Range Of Motion Aktif Ekstremitas Bawah pada Lansia Fahrezi, Andhwika Afif; Supatmo, Yuswo; Marijo, Marijo; Adji, Raden Mas Soerjo
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.814

Abstract

Background: Aging results in a decrease in various body functions, one of them is in the aspect of mobility. Increasing age can reduce the range of motion of the joints. One of the easy physical activities for the elderly is foot exercise and hydrotherapy (warm water soaks) in order to minimize the decrease in ROM. Aim : To compare the combination of foot exercises with hydrotherapy and without hydrotherapy on active ROM of the lower extremities in the elderly. Methods : This research is an experimental study with parallel 3 groups pre and post-test design. The research subjects were 21 elderly people in RW 04 Karang Wetan, West Ungaran, Semarang Regency. Active ROM of the lower extremity was measured before and after intervention using a goniometer. analyzing the data of this study using the Paired T test and One Way ANOVA method. Results: There was no significant increase in the active ROM of the lower extremities in the control group, p=0.114 (p>0.05). The range of active motion of the lower extremities (pre test to post test) in the combination treatment group of foot exercise and hydrotherapy p < 0.001 (p < 0.05) and the treatment group of foot exercise p = 0.001 (p < 0.05) experienced a significant increase . However, there was no significant difference in the increase in active ROM of the lower extremities in the combination treatment group with foot exercises and hydrotherapy, p=1.00 (p<0.05) and the foot exercise treatment group. Conclusion:Physical activity in the form of a combination of foot exercises with hydrotherapy and without hydrotherapy performed 3 times a week for 5 weeks has been shown to increase the active ROM of the lower extremities in the elderly. However, there was no significant difference between the two which was more effective in increasing the active ROM of the lower extremities in the elderly.
Platelet-Rich Plasma (PRP) As A New Approach And Promising Therapy In Patients With Alopecia Areata Ametati, Holy; Kadarhadi, Elva; Gunawan, Imelda; Malik, Diah Adriani; Rahayu, Muji
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.818

Abstract

Background: Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory condition that causes well-defined areas of hair loss on the scalp and/or body. A new biotechnology called platelet-rich plasma (PRP) was developed as a result of increased interest in tissue engineering and cell-based therapies. This therapy is defined as an autologous, non-allergic preparation of platelets in concentrated plasma. Study aimed to evaluate the effect of PRP treatment in alopecia areata. Case: This study included 3 patients complaining of multiple patchy alopecia areata. They were treated with combination of PRP therapy, topical fluocinolone acetonide 0.025% cream, minoxidil 2 and 5%, and ketoconazole 2% scalp solution. One patient was also treated with intralesional triamcinolone acetonide injections. PRP was injected intradermally every 4 weeks and final monitoring was conducted after 4-6 sessions. Evaluation and follow up results were determined using photographic monitoring as well as patient’s satisfaction. Results: Administration of autologous PRP had significance hair regrowth in all three patients in this study. PRP treatment sessions varied from 3 to 6 sessions. However, significance outcomes in these patients were established after 3 sessions of PRP treatment, while the best results were obtained after 4-6 sessions of PRP treatment. No major side effects was reported. Conclusion: PRP is effective in promoting hair growth. PRP treatment for alopecia areata is safe, easy to perform, and can achieve patient’s satisfaction, without any major adverse effects. However, further research on standardized protocol of PRP methods are needed.
Pengaruh Penambahan Kinesiotaping pada Rehabilitasi Pasca Stroke Fase Kronis yang Mendapatkan Weight Shifting Training terhadap Kecepatan Berjalan Zakaria, Nieke; Handoyo, Rudy; Setiawati, Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.821

Abstract

Background: Stroke is the leading cause of disability including decreased walking speed. It is estimated that 73% of stroke sufferers have a lack of motor control and result in limited mobilization. Kinesiotaping(KT) is a method that can be added to other forms of exercise including weight shifting training. With the addition of kinesiotaping is expected to occur improvements in muscle performance and balance so that the speed of walking increases. Objective: To prove the effect of the addition of KT on chronic stroke rehabilitation that gets weight shifting training on walking speed. Methods: This study is a randomized controlled trial pre-test and post test control group design. There were 18 subjects of chronic stroke rehabilitation patients divided into 2 groups, namely the control group that got weight shifting training (9 people) and the treatment group that got the addition of kinesiotaping to weight shifting training (9 people). The walking speed assessment was measured before and after 4 weeks of treatment. Results: There was a significant difference in the mean walking speed before and after treatment in each group (p<0.001). In the treatment group 0.60 ± 0.08 and 0.68 ± 0.07 at the end. In the control group 0.62 ± 0.05 at the beginning and 0.64 ± 0.05 at the end. There was a sigificant difference in the mean walking speed increase in both groups (p<0.001). Conclusion: The mean increased walking speed was higher in the group that got the addition of KT in chronic phase stroke rehabilitation who received weight shifting training.
PERBANDINGAN ANTARA POLA KUMAN TRAKEA DAN STOMA DENGAN ANGKA KEJADIAN INFEKSI STOMA TRAKEA DI RSMH PALEMBANG Kusmawijaya, Vitta; Yanti, Lisa Apri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.825

Abstract

BACKGROUND: Tracheostomy is a procedure to incise or make a hole in the trachea. The use of tracheal cannula leads to direct exposure of pathogens to the respiratory tract. It is necessary to identify bacterial pattern in an attempt to overcome tracheal stoma infections in order to prevent further complications. OBJECTIVE : This study is to compare bacterial pattern in trachea and tracheal stoma on the incidence of tracheal stoma infection. METHODS: Observational research with a cross-sectional design. Medical record data on 60 subjects who underwent tracheal and tracheal stoma swabs and culture examination from November 2020 to October 2021 were collected. Bivariate analysis using Fischer exact test and Chi-square categorical comparative test. RESULTS: Sixty subjects obtained 13 species of bacteria, all identified as gram-negative bacteria. Most of the bacterial sequences and analysis of bacterial pattern were Pseudomonas aeruginosa(p>0.05), Klebsiela pneumonia(p>0.05), Escherichia coli (p>0.05) and Serratia marcescen(p>0.05) on the incidence of tracheal stoma infection. CONCLUSION: There is no difference in the bacterial pattern of the trachea and tracheal stoma on the incidence of tracheal stoma infection.
Analisis Variasi Genetik Gen Angiotensinogen M235T pada Penderita Stroke Iskemik di Rumah Sakit Umum Pusat Dr. Kariadi, Semarang secara Polymerase Chain Reaction Restriction Fragment Length Polimorfism (PCR- RFLP) Tugasworo, Dodik; Retnaningsih, Retnaningsih; Kurnianto, Aditya; Suryadi, Suryadi; Rahmawati, Dani; Rahmayanti, Rahmayanti; Budiman, Jethro
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.833

Abstract

Background: Stroke is the leading cause of death and disability in the world. The incidence of ischemic stroke is influenced by genetic factors, environmental factors and their interactions. Genetic variation of the Angiotensinogen (AGT) M235T gene is associated with hypertension and diabetes mellitus, which are risk factors for stroke. Objective: To examine the genetic variation of the Angiotensinogen M235T gene in patients with Ischemic Stroke treated at Dr. Kariadi General hospital, Semarang. Method: The subjects of the study were 72 ischemic stroke patients who were treated at the outpatient clinic of the Neurology Department Dr. Kariadi Semarang in January - December 2013. DNA extraction of research subjects was performed at the CEBIOR laboratory, Diponegoro National Hospital from January to March 2020. Amplification was performed with Polymerase Chain Reaction (PCR). Digestion of PCR products was using Restriction Fragment Length Polymorphism (RFLP) method. Results: Out of 72 samples, the AGT M235T CT were found in 37 samples (51.4%), the AGT M235T TT gene was found in 35 samples (48.6%) and no samples showed the AGT M235T CC. Conclusion: There are 3 types of genetic variants of the AGT M235T gene, including the AGT M235T CT, the AGT M235T TT and the AGT M235T CC. Among the three types of variants, the variant of the AGT M235T CT gene is the most common variant found in ischemic stroke patients treated at the Dr. Kariadi General Hospital Semarang.
Risk Factors for Mortality Among Confirmed Covid-19 Patients At RSUP Dr.Kariadi Junaedi, Husain; Pramudo, Setyo Gundi; Bhima, Sigid Kirana Lintang; Dhanardono, Tuntas
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.834

Abstract

BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a communicable disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). On March 11, 2020 the World Health Organization (WHO) declared COVID-19 as pandemic causing mortality in more than 150 countries. China reports the most case is among people aged 30 – 79 years old and male, meanwhile in Italia the most case is among patients with cardiovascular disease, diabetes, chronic diseases, hypertension, and cancer. This encourages researcher to examine risk factors causing mortality among patients with confirmed COVID-19. METHOD: This is an observational study with multivariate analytical test. The samples involved medical records of died patients with confirmed COVID-19 at RSUP Dr.Kariadi. Risk factors being studied involved age, gender and comorbidities such as hypertension, diabetes, pneumonia, chronic obstructive pulmonary disease (COPD), heart disease, kidney disease, and cancer. Data were analyzed using multiple logistic regression with univariate, bivariate, multivariate, confounding and interaction tests. RESULT: An increased risk for mortality was found among confirmed COVID-19 patients aged over 60 years (3.25 times), suffered from hypertension (2.09 times), pneumonia (4.77 times), cancer (11.89 times), heart disease (3.55 times), and kidney disease (5.23 times). CONCLUSION: Risk factors involving age, hypertension, pneumonia, cancer, heart disease, and kidney disease increase risk for mortality among patients with confirmed COVID-19. The risk is heightened as patients aged older than 60 years old suffering from pneumonia and cancer simultaneously.
The Relationship Between Pre-Operative Clinical Characteristics With Changes In Post-Operative Memory Scores On Temporal Lobe Epilepsy Patient Bintoro, Aris Catur; Arifin, Muhammad Thohar; Harsono, Harsono; Muttaqin, Zainal; Hadisaputro, Soeharyo; Husni, Amin; Bakhtiar, Yuriz; Karlowe, Vega; Pratomo, Joko
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.844

Abstract

Background: Most temporal lobe epilepsy (TLE) will become seizure-free after anterior temporal lobectomy (ATL) surgery but often result in cognitive decline, specifically in verbal or visual memory. Objective: This study examined the relationship between several demographic characteristics and pre-operative clinical conditions with changes in pre-post surgical memory of TLE patients. Methods: This study used a retrospective cohort in which the subjects were TLE patients who had undergone ATL surgery at Kariadi Hospital or Telogorejo Hospital, Semarang. Demographic variables include the age of onset, duration of illness, level of education, and clinical variables include seizure frequency, EEG waveform, number of AED, lesion site, and IQ score. Results: Memory re-examination was conducted on TLE patients who had undergone surgery between 2018 and 2021, with 55 subjects who fulfilled the criteria. Characteristics of the subjects were male 31(56%) males, 38% Senior High School education, the mean age of onset was 13,87±6,899, age at surgery was 27,67±9,802, 21 (39%) normal pres-surgical EEG waveform, 31 (56%) lesion on the left and the most frequent seizures occurred in 36 subjects (65%). Statistical test results showed a significant relationship between age of onset and changes in verbal memory recognition scores (p 0.044), lesion side with changes in verbal memory task scores (p 0.018), recall (p 0.005), recognition (0.008), and IQ scores with changes in visual memory construction recall (p 0.041) Conclusion: Age of onset, lesion side, and IQ score characteristics were related to the changes in memory scores between pre- and post-operative anterior temporal lobectomy in TLE patients.

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