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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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VALIDATION OF HIV VIRAL LOAD Bioneer AccuPower® HIV-1 Quantitative RT-PCR Kit Compare to Roche-Cobas®4800 System HIV-1 Maskito, Veronika Juanita; Kosasih, Agus Susanto; Sugiarto, Christine
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2418

Abstract

The Bioneer AccuPower®HIV-1 Quantitative renewed the LoD from 38 IU/mL to 33 IU/mL. Performance evaluation of the kit has not been carried out in Indonesia since the alteration, as it is expected that the new kit will have improved sensitivity. This study is a cross-sectional evaluation of the correlation, sensitivity, and specificity of the Bioneer-AccuPower HIV Quantitative RT-PCR Kit compared to the Roche-Cobas 4800 System HIV-1. We obtained venous EDTA plasma from 211 HIV patients tested in the Clinical Pathology Laboratory of Dharmais Hospital, Indonesia. Subject werw  71 high-viral-load samples (>1000 copies/mL), 60 low-viral-load samples (<1000 copies/mL), and 80 undetectable-viral-load samples (<14.2 copies/mL/<24.42 IU/mL). Exclusion criteria were samples under the limit of quantification of each instrument (Roche-Cobas®4800 20 copies/mL (34.4 IU/mL); Bioneer-AccuPower 69.4 copies/mL (49.97 IU/mL)). Ethical Declaration released by Dharmais Hospital Ethical Committee No.DP.04.03/11.7/0872024. The categorical contingency correlation in determining whether the HIV viral load sample was high, low, or undetectable was 0.863. The sensitivity, specificity, and accuracy of the Bioneer-AccuPower HIV Quantitative RT-PCR Kit, compared to the Roche Cobas 4800 System HIV-1, in quantifying HIV viral load were 99.15%, 96.25%, and 98.10%, respectively. Regarding the limit of quantification of each instrument, the Bioneer-AccuPower HIV Quantitative RT-PCR Kit performed well in determining HIV RNA viral loads, making it suitable for HIV screening. It exhibits a strong correlation compared to the Roche Cobas® 4800 System HIV-1. However, it required a larger study that did not limit the sample according to the limit of quantification of both instruments and sequenced the discrepancy samples.
Agreement between SARS-CoV-2 Antibody Test Results Using FIA and ECLIA Methods in Post-COVID-19 Infection and Sinovac Vaccination Hubertus, Johanis; Sidharta, Brigitte Rina Aninda; Kurniati, Amiroh
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2419

Abstract

Coronavirus Disease 2019 (COVID-19) is a pandemic that needs to be urgently addressed through the formation of antibodies, such as vaccination.  Automated SARS-CoV-2 antibody tests in hospitals are limited due to maintenance issues and high costs.  This study aimed to determine the agreement of SARS-CoV-2 antibody test results using the FIA and ECLIA methods in post-COVID-19 infection and Sinovac vaccination. An observational analytical study with a cross-sectional approach was conducted at Dr.  Moewardi Hospital from September to November 2022. The FIA method (FRENDTM NanoEntek) and ECLIA method (Cobas e411) were employed, revealing significant differences and strong correlations in both the COVID-19 infection group (r=0.9999, p<0.0001) and the Sinovac vaccination group (r=0.997, p<0.0001).  The Passing and Bablok test showed systematic, proportional, and random differences in both the COVID-19 infection group (95% CI = -65.60 to -41.97; 95% CI = 3.42 to 3.70; 95% CI = -4.76 to 4.76) and the Sinovac vaccination group (95% CI = -21.71 to -8.69; 95% CI = 2.23 to 2.96;  95% CI = -12.37 to 12.37). In conclusion, there is no method of agreement between the results of SARS-CoV-2 antibody testing using the FIA and ECLIA methods in both post-COVID-19 infection and post-Sinovac vaccination groups
Association of Asprosin Levels in Metabolic Syndrome Jayanti, Evy Tri; maria diah, pramudianti; Kunti Dewi Saraswati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2422

Abstract

Metabolic syndrome (MS) is a condition characterized by disruptions in the body's metabolism. The risk factors for MS are impacted by age, gender, body mass index (BMI), and low-density lipoprotein (LDL) to high-density lipoprotein (HDL) cholesterol ratio. Asprosin is a hormone protein secreted by white adipose tissue that stimulates oxidative stress and proinflammation, affecting changes in body metabolism that trigger the development of MS. To assess the relationship between serum asprosin levels, age, gender, BMI, and LDL/HDL cholesterol ratio on the incidence of MS where asprosin can be used as a single marker for predicting MS. An observational study with a cross-sectional approach was conducted at Dr. Moewardi General Hospital (RSDM) in Surakarta from November to December 2023, involving 85 consecutively sampled subjects. The population was selected based on inclusion criteria. Asprosin examination was performed using the Rayto RT 2100 instrument with the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis involved the use of the Kolmogorov-Smirnov test, followed by bivariate and multivariate analysis. There was a significant difference (p <0.001) between the MS and non-MS groups in terms of age, LDL/HDL cholesterol ratio, and asprosin variable. The mean serum asprosin level in the MS group was 25.81 (3.11-122.02) ng/mL. The cutoff value of asprosin was found to be >11.35 with a sensitivity of 83.3% and specificity of 79.1%. There was an association between serum asprosin levels, age, and LDL/HDL cholesterol ratio with the occurrence of MS. Further research is needed with a prospective cohort study design before and after the onset of MS.
Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Analysis of Insulin Resistance (HOMA-IR) with Urinary Albumin-Creatinine Ratio (uACR) in Non-Diabetic (DM) Subjects Wali Syafaat, Andi; Nurahmi; Kurniawan, Liong Boy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2434

Abstract

Insulin resistance (IR) is a conduit ion characterized by reduced sensitivity of peripheral tissues to the effects of insulin, resulting in a decrease in insulin's ability to stimulate glucose utilization in the body. This condition is not only found in obese subjects with diabetes mellitus (DM) but also in non-DM obese subjects. Kidney damage causes albuminuria, measured by calculating the albumin-to-creatinine ratio (uACR). IR is considered a strong predictor for determining the risk of albuminuria. The relationship between IR and uACR in non-DM adults has not been further studied. This study aims to analyze the relationship between HOMA-IR and uACR in non DM adults. This is a cross-sectional study using a sample of 90 non-DM adult subjects aged 20-40 years. Insulin levels in the blood and uACR were measured using the ECLIA method. Data were analyzed using SPSS version 25.No association was found between HOMA-IR and uACR in non-DM adult subjects (r = -0.55, p = 0.608). Furthermore, HOMA-IR had no relationship with uACR when classified by gender, age, or obesity status in non-DM adult subjects. There was no association between HOMA-IR and uACR in non-DM adult subjects.
Clinicopathological Profile of Cervical Tuberculous Lymphadenitis: Experience from Universitas Airlangga Hospital Ari Wanda, Dewi Sartika; rahaju, anny setijo; Sita Sari, Aditya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2436

Abstract

Tuberculous lymphadenitis is the most common form of extrapulmonary TB, and the most common location is in the neck. It is quite challenging to diagnose lymph TB. Clinical presentation, along with multiple modalities is usually used to diagnose it. This retrospective observational descriptive study collected data from medical recordsof Universitas Airlangga hospital of 147 patients suffering from tuberculous lymphadenitis during the period of 2022-2023. All patients in this study presented with lumps in the neck area (painless nodules [n = 90, 61.22%] and unilateral nodules [n = 133, 90.48%]), while other symptoms such as fever, cough, and weight loss were less common. FNAB revealed 60 patients (40.8%) confirmed with tuberculous lymphadenitis primary tuberculous lymphadenitis (n = 48, 32.6%) and tuberculous lymphadenitis with secondary infections (n = 12, 8.2%). The histopathological review mostly revealed tuberculous lymphadenitis (88%). Only 10 patients (34.48%) with tuberculous lymphadenitis were found from neck ultrasound examination. Eighty-five patients performed GeneXpert MTB/RIF assay and showed positive results in most cases (n = 43, 50.59%). Negative acid-fast bacilli (AFB) results in granulomatous lesions, do not exclude the possibility of tuberculosis. The combination of pathology examination, GeneXpert MTB/RIF assay, and neck ultrasonography makes the diagnosis of cervical tuberculous lymphadenitis accurate.
The Concordance of Platelet Counts on Hematology Analyzer with Thrombocytopenia Sample with Platelet Clump Prabawa, I Putu Yuda; Lestari, Anak Agung Wiradewi; Wande, I Nyoman; Mahartini, Ni Nyoman; Herawati, Sianny; Cong, Tzeto Han
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2437

Abstract

Pseudo-thrombocytopenia is a pre-analytical issue commonly observed in clinical laboratory settings due to platelet aggregation or clumps. In cases of thrombocytopenia, it is essential to conduct a platelet count via Peripheral Blood Smear (PBS) to identify clumping and subsequently re-evaluate the platelet count. The examination of platelets can now be carried out through different methodologies offered by Hematology Analyzers, such as PLT-I, PLT-O, and PLT-F. The primary objective of this research was to evaluate the correlation and agreement of platelet count findings (PLT-I, PLT-O, and PLT-F) in samples displaying flagged platelet clumps between a Hematology Analyzer and PBS at Prof. dr. I.G.N.G. Ngoerah General Hospital, Bali. An analytical cross-sectional observational study was conducted on 71 samples of thrombocytopenia with platelet clump flagging on the Sysmex® XN-1000 Series Hematology Analyzer at Prof. dr. I. G. N. G. Ngoerah Hospital. SPSS version 26.0 and MedCalc were used to conduct statistical analysis. There was a significant difference in the PLT clump Fluorescence index (p = 0.001) between the sample groups with and without the clump, and there was a strong positive correlation of the PLT count results between the Hematology Analyzer (p <0.001) and PBS in the sample groups with and without the clump. The Bland-Altman mean bias was lowest in the sample group without clumps against PLT-I (0.39x103/ml; 95% LOA: -57.05-57.83) and highest in the sample group with a clump to PLT-F (105.38x103/ml; 95% LOA: -14.7-225.46). There is a strong positive correlation and concordance of platelet count results between the Hematology Analyzer and PBS. However, there is no concordance between the platelet count results from the Hematology Analyzer and PBS in the clump group.
Lipoprotein(a) and ApoB100 Levels as Markers for Diabetic Retinopathy Nawar Mazin Jawad; Mahmood, Halla; Aber Abdul Amir Mohamad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2438

Abstract

Globally, in individuals of working age, diabetic retinopathy is the leading cause of visual loss. Prior observational research offered contradictory proof for the link between lipoprotein(a) and apoB100 with diabetic retinopathy. The objective of this study was to assess the relationship between lipoprotein(a) and apoB100 with diabetic retinopathy. This study involves 160 patients divided into four groups: non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), controlled type II diabetic patients without retinopathy (NODR), and healthy control persons) in Baghdad-Iraq. An enzyme-linked immunosorbent assay (ELISA) was used to measure lipoprotein(a) and apoB100. Lipoprotein(a) average levels were 30.80±12.28 µg/mL in healthy control patients, 50.92±21.64 µg/mL (p value <0.001, AUC = 0.765, sensitivity = 65, specificity = 90) in NPDR, 56.05±40.89 µg/mL (p value <0.001, AUC = 0.778, sensitivity = 85, specificity = 72.5) in PDR and 29.67±18.57 µg/mL (p value = 0.75, AUC = 0.549, sensitivity = 42.5, specificity = 82.5) in NODR. ApoB100 average levels were 69.28±24.01 ng/ml in healthy control patients, 80.99±20.22 ng/ml (p value = 0.02, AUC = 0.687, sensitivity = 77.5, specificity = 60) in NPDR, 86.44±16.97 ng/mL (p value <0.001, AUC = 0.762, sensitivity = 77.5, specificity = 70) in PDR and 65.89±12.64 ng/mL in NODR (p value = 0.43, AUC = 0.514, sensitivity = 75, and specificity = 70). The study demonstrated that Lipoprotein(a) is the best predictor for proliferative diabetic retinopathy and non-proliferative diabetic retinopathy.
Evaluation of the Antibacterial Capacity of a New Strain of Enterococcus faecium from the Honey Bee Gut al-shimmary, sana; Al-Thwani, Amina N.
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2444

Abstract

The recent development of antibiotic-resistant microorganisms has been a consequence of antibiotic overuse. Today, an increasing number of antibiotic-resistant microorganisms are a threat to public health. Bacteriocin is an antimicrobial peptide with potential as an alternative to antibiotics. Recent research has shown that bacteriocins effectively inhibit the growth of bacteria that have developed resistance. Enterococcus faecium (E. faecium) is among the producers of these compounds. The study aimed to isolate and investigate  E. faecium found in the gut of honey bees and demonstrate its bacteriocin-like inhibitor substances as an inhibitory agent against multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth.E. faecium was confirmed by sequencing the 16S rRNA gene. The screening involved assessing the impact of cell-free supernatant (CFS) obtained from E. faecium on the growth of MDR S. aureus and P. aeruginosa. The results reported a significant inhibition zone of 30 mm for S. aureus and 33 mm for P. aeruginosa. The optimum conditions for CFS production were as follows: the most suitable nitrogen and carbon sources were yeast extract and glucose, respectively. The optimal pH was 6, and the incubation period was 48 hours.
Cortisol as Biomarker for Stress, Depression, And Physical Activity Among Medical Student: A Systematic Review Pratama, Yanasta Yudo; Rismayanthi, Cerika; Rahayu, Atikah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2609

Abstract

Cortisol is one of the most commonly used stress biomarkers. Stress and depression are increasing in young people, especially among college students, especially medical students. Physical activity has been recommended for stress and depression relief, but its effect on cortisol has not been confirmed. This study aims to analyze cortisol measurements for stress, depression, their physical activity among medical student. This literature search utilized PubMed and Google Scholar, combining the keywords "cortisol", "stress", “depression”, “physical activity”, and "medical student" in publications from 2010 to 2025. Ten (10) studies that met our criteria. Most studies use saliva cortisol measurement to assess stress conditions. Our findings suggest cortisol as a measure of stress in medical students, but its contribution to the development of stress and depression remains unclear. There is no correlation between physical activity and cortisol in stress condition. Cortisol measurements can provide an objective test and reflect stress in medical students, but they do not adequately assess acute and stress-related cortisol release. Further studies are needed to assess the effectiveness of cortisol measurements.

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