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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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POLA MIKROORGANISME PADA LIANG VAGINA WANITA HAMIL DI RSU DR. SOETOMO SURABAYA Sianny Herawati; M.Y. Probohoesodo; Prihatini .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.846

Abstract

In pregnant women especially in the third trimester, it is seldom that attention is paid to microorganism in the vagina. Many studies have reported about microorganism in the vagina which possibly can infect the foetus. This is due to the migration of bacterial colonization in the vagina to the foetus during labour, causing infection or sepsis in the foetus after delivery. To study the microorganism pattern in the vagina of pregnant women, pathogenic as well as normal flora of the vagina. If the microorganism is known, prevention or treatment before and after delivery can be applied. Population was recruited from pregnant women in the third trimester who visited The Maternity Outpatient Clinic, Dr. Soetomo Hospital from September until October 2005. Specimens from ostium of the cervix and posterior fornix of the vagina were collected in Amies media and examined in the Department of Clinical Pathology, Airlangga University/ Dr. Soetomo Hospital to detect any bacteria, fungi and parasites using direct method and culture. The microorganism pattern from 30 pregnant women consisted of non-haemolytic Streptococcus 25%, Escherichia coli 25%, Lactobacillus 35%, Staphylococcus aureus 10%, and Staphylococcus coagulase negative 5%. The result of fungi examination showed 14 (47%) samples with negative result and 16 (53%) samples with positive result (Candida sp). The pattern of microorganism was dominated by Lactobacillus and Candida sp but no parasites in the vagina were found.
NILAI DIAGNOSTIK IgA ANTIVCA ANTIBODI EPSTEIN-BARR DI KARSINOMA NASOFARING Betty Agustina Tambunan; Aryati Aryati; Windu Nafika
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1101

Abstract

Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult, so most patients arrived already in an advanced stage. The biopsyas the gold standard for the diagnosis of NPC at an early stage also have limitations. Epstein-Barr virus as the cause of NPC is pavingthe way for early diagnosis was through serological method. The purpose of this study is to know the diagnostic value of IgA antiviralcapsid antigen (VCA) Epstein-Barr antibody for NPC by analyzing it. The samples were NPC patients and others whome have head-neckmalignancies arrived in the Oncology Outpatient Clinic, Dr. Soetomo Hospital. Their sera were examined for IgA antiVCA Epstein-Barrantibody using ELISA method and then analyzed for its diagnostic value using the 2x2 table with a 95% confidence interval. IgA antiVCAcutoff was determined by ROC. The results show that the diagnostic value of IgA antiVCA Epstein-Barr antibody have the sensitivityand specificity around 93.3% and 93.8%, respectively. Positive predict value was 96.6%% and the negative one was 88.2%, while thediagnostic efficiency was 93.5%. The positive likelihood ratio was 14.9 times and the negative was only 0.07. The cut off value of IgAantiVCA according ROC was 13.45 U/mL with AUC 97.9%. Based on this study, can be concluded that IgA antiVCA Epstein-Barr antibodyshowed an excellent validity in supporting the diagnosis of NPC. However, the researchers needed further research to know the obtainableearly stage of NPC.
ANALISIS BEBAN KERJA DI INSTALASI LABORATORIUM Amiroh Kurniati; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.445

Abstract

Human resources (HR) planning is associated with an institution’s strategic plan, so the study of the required number of support personnel is in line with the direction of business development planning of the Laboratory Installation Unit. WISN (work load indicator staff need) method is a calculation based on the analysis of health manpower needs of the workload (work load analysis) and is considered as the most accurate method to calculate labour requirements in short-term. Based on the results of the analysis of manpower needs at the Laboratory Installation of Lung Health of the Community Hall Surakarta, it is known that there is still a lack of a number of five (5) persons of the health laboratory staff. The persons still lacking consist of: one (1) laboratory person related to clinical pathology laboratory, one (1) laboratory person for smear microscopy laboratory, and still three (3) microbiology laboratory persons. These persons are needed to be able to carry out the activities for a good laboratory service, and quality which is in accordance with the related applicable standards.
THE ASSOCIATION BETWEEN ASYMPTOMATIC BACTERIURIA AND GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS Reni Marlina; Ricke Loesnihari; Santi Syafril
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1334

Abstract

The incidence of infection often occurs in patients with Diabetes Mellitus (DM) due to hyperglycemia that causes dysfunction of chemotaxis, phagocytic activity, malfunction of neutrophils and glycosuria. It is followed by other complications that lead to the malfunction of the bladder. Highly urinary glucose level is an exellent medium for pathogenic microorganisms growth. Asymptomatic Bacteriuria (ASB) is a risk factor for symptomatic urinary tract infection spontaneously or due to urinary catheters. This study aimed to analyze the association between the incidence of ASB of type 2 DM and glycemic control. The study was conducted during June-August 2016 with a cross-sectional method. Subjects were type 2 DM patients with age ≤60 years, who were treated in the Endocrinology Out-Patient Clinic of the Adam Malik Hospital. HbA1c was measured by Indiko automatic analyzer. Its association with urine culture results was analyzed. A total of 50 samples were enrolled, consisting of 25 females, and 25 males, with 19 having an exellent glycemic control (HbA1c <7%) and 31 with poor glycemic control (HbA1c ≥7%). Thirteen positive ASB were found, 5 with good glycemic control and 8 with poor glycemic control. Statistical analysis revealed a nonsignificant association between glycemic control and culture results (p = 1.000). Somers’d did not show a significant association between glycemic control and the incidence of ASB (p=0.968, d=-0.005). However, significant differences in culture results between gender, in which the ASB were found in samples of four females and two males (p=0.004). Somers’d revealed a significant association between culture results and gender (p=0.001; d=-0.360). Most of the bacteria found were Gram-negative. There was no significant association between glycemic control with an incidence of ASB. However, gender had significant differences in the incidence of ASB, which occurred more frequently in DM females than males. Urinalysis should be performed in patients with type 2 DM with ASB. However, further study was needed to analyze the relationship between glycemic control with the incidence of ASB and other factors that might affect the incidence of ASB.
PROKALSITONIN SEBAGAI PENANDA PEMBEDA INFEKSI BAKTERI DAN NON BAKTERI Bastiana Bastiana; Aryati Aryati; Dominicus Husada; M.Y. Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1019

Abstract

Early diagnosis of an infection and prompt administration of an antibiotic can dramatically reduce morbidity and mortality.Procalcitonin (PCT), a precursor of calcitonin, has been proposed as a marker of bacterial infection. The aim of this study is to assess theefficiency of procalcitonin in children for the diagnosis of bacterial vs. non bacterial infection. This was a prospective, cross-sectional study.The subjects were enrolled consecutively, consisting of feverish children (temperature ³38.5° C) admitted to the Pediatric EmergencyDepartment with ages up to 12 years old. The subjects were divided into two groups according to their final diagnosis, bacterial and nonbacterial infection. Serum PCT concentration was measured by enzyme linked fluorescent assay (ELFA) method. Sensitivity, specificity,positive predictive and negative predictive values, and receiver operating curve (ROC) of PCT were calculated. Out of 54 patients,24 (44.4%) had a final diagnosis of bacterial infection. PCT showed a wide concentration range in the bacterial infection group (median:1.09 ng/mL, lower (L)=0.05 ng/mL, upper (U)=128.7 ng/mL) compared with non bacterial infection group (0.21 ng/mL; L=0.05ng/mL; U=12.15 ng/mL). There was a significant difference in PCT between the 2 groups (p=0.020). ROC analysis demonstrated anarea under curve (AUC) of 0.686 (95% CI, 0.534 to 0.838). Using a cut-off point of 0.5 ng/mL, the sensitivity, and specificity, positivepredictive and negative predictive values of PCT were 66.7%, 76.7%, 69.6%, 74.2%, respectively. In this study, PCT may be useful fordifferentiation of bacterial vs. non bacterial infection in children.
PENGARUH RESTRIKSI KALORI TERHADAP KADAR HIDROGEN PEROKSIDA DAN KADAR GLUKOSA DARAH PADA TIKUS TUA E. Harianja; Anik Widijanti; Putu Moda Arsana; K. Handono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.921

Abstract

Aging is a syndrome of progressive, universal and irreversible alterations. Endocrinology alterations in aging consist of insulin resistance, hyperinsulinemia, increase of hydrogen peroxide and glucose blood level. At the beginning of aging process the Pancreaticcellsproducemoreinsulininorderiskeepbloodglucosewithinnormallevel.Butthepersistentofhyperglycemiaconditioncausedthepancreatic-cellsunabletoproduceadequateinsulinduetointernalfactorsorexternalfactors.Asthisconditionprogress,wouldbedisturbedfastingandpost-prandialbloodglucose(hyperglicemia).Besidesinsulinresistance,freeradicalsalsoincreasedasaconsequenceoffailurecompensationofcellsinthebody.TheaimofthisstudyistodeterminethatintermittentanddailycalorierestrictioninoldmaleWistarratscanreduceserumhydrogenperoxide,andbloodglucoselevel.Themethodofthisstudywasanexperimentalstudywithpost-testcontrolgroupdesign.TwentyfourmaleWistarratsabout12monthsold,weredividedintofourequalgroupsandeachgroupcontainsixrats:(i)adlibitumfed(control),(ii)2-1intermittentwith2daysfedand1dayfast,(iii)1-1intermittentwith1dayfedand1dayfast,and(iv)40%continuouscalorierestrictioneveryday.Independentvariableinthisstudywascalorieintakeandbodyweight.Dependentvariableswerehydrogenperoxideleveland.Bloodglucoselevel.Thedifferenceofeachgroupwasanalyzedwithone way ANOVA and the least significant difference was analyzed by the use post hoc tests, using p < 0.05. The result of this study for hydrogen peroxide and blood glucose level in control group with experimental groups were p 0.000 and p 0.001. There was positivecorrelation between hydrogen peroxide level and blood glucose level r 0.791. We conclude that calorie restriction decrease hydrogenperoxide level and as well as regulating of blood glucose level. The best one of this method is 40% calorie restriction.
DIAGNOSIS MOLEKUL DAN APLIKASI DALAM PENGOBATAN HEPATITIS B & C Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.974

Abstract

In the whole world, up to now hepatitis B and C virus are still the main causes of chronic hepatitis, cirrhosis until hepatocellularcarcinoma. Most diagnosis is based on a serological examination such as the determination of antigen and antibody, for exampleHbsAg, HbeAg and anti HCV. Recently, for hepatitis C examination, HCV core antigen is used for the detection of HCV infection duringthe window period, chronic C hepatitis and for treatment monitoring. At present, serological assays are not sufficient to confirm thediagnosis of hepatitis B and C due to mutations of false negative HbsAg or HbeAg results. Occult hepatitis B can occur with a negativeresult of HbsAg, which cause difficulties in confirming the diagnosis and treatment as well. The success of treatment can be influencedof both hepatitis B and hepatitis C that have genotypes. By using molecular examination, such as determination of HBV-DNA and HCVRNA,it is expected that the problem of serological determination can be overcome. Molecular examination is not only useful for just thediagnosis confirmation, such as for active phase and replicative determination. This sequence is also very useful as a data base prior tothe treatment of hepatitis B and hepatitis C as well as for their following success result.
LEUKEMIA LIMFOBLASTIK AKUT PADA DEWASA DENGAN FENOTIP BILINEAGE (LIMFOID-B DAN T) Maimun Z A; Budiman Budiman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 2 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i2.886

Abstract

In this report we describe a patient with adult acute lymphoblastic leukemia with bilineage phenotypic. He was found to have massive right pleural effusion with mediastinal shift to the contra lateral side. There was also a smaller left pleural effusion. He had multiple bilateral cervical lymphadenopathy, tense ascites and bilateral pedal oedema up to the shins. He was otherwise clinically stable.His full blood count on admission showed Hb of 11.4 g/dl, platelets of 59 X 109/L and WBC of 12.99 × 109/L with blasts of 26%. His renal function was normal with a creatinine of 107 micromoles/L. Bone marrow trephine biopsy showed features consistent with acute lymphoblast leukemia-L1. Flow cytrometry of his blood was suggestive of bilineage phenotypic acute lymphoblast leukaemia. It showeda single population of blasts (about 31%) which expressed cCD3+, CD4-, CD7+, CD5-, CD19+, CD34+, TdT+, cytoplasm IgM, CD79a+ and 30% are CD10+, and there was aberrant CD33+ expression with no evidence of MPO or CD117 expression. Cytogenesis of the bone marrow trephine biopsy showed numerical and structural abnormalities in nine out of the seventeen cells analysed. These abnormalitiesare 43~47,XY, add (1)(p34.2), add(2)(p13), i(17)(q10), +21[cp9].
USING SIX SIGMA TO EVALUATE ANALYTICAL PERFORMANCE OF HEMATOLOGY ANALYZER Robiul Fuadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1375

Abstract

Background: Many medical decisions  in hospital are based on hematology examination results. We must be aware about their method performance. Sigma-metric is an excellent way to evaluate analytical performance quality. We will display the performance of our laboratory hematology analyzer, Cell Dyne Ruby, by sigma-metric analysis.Method: sigma analysis was calculated by a formula, sigma = (TEa – CV)/ Bias. Total Error Allowable  (TEa) was specified by the CLIA proficiency testing criteria. The coefficien of variant (CV) and bias data  were supplied from analyzer running three levels of control low (L), normal (N), and high (H) include following analytes: hemoglobin (Hb), Red Blood Cell count (RBC), Hematocrit (HCT), White Blood Cell count (WBC), and Platelet count (PLT).Results : Sigma value as follows Hb(L:4,33 N:6,68 H:2,62), RBC(L:3,43 N:3,84 H:3,46), HCT(L:2,52 N:1,73 H:2,27), WBC (L:7,14 N:8,44 H:6,38),and PLT (L:2,46 N:8,75 H:7,84). Average sigma value for all parameters were 4,75. Minimum sigma value for any business or manufacturing process was 3. More than 6 sigma value was world class performance.Conclusion: Hematology Analyzer Cell Dyne Ruby provides “Good” performance by sigma-metric.
UKURAN KALSIUM ION DALAM SERUM TOTAL KALSIUM (CALSIUM TOTAL) MENGGUNAKAN BERBAGAI ALAT SWA-ANALISIS (AUTO ANALYSER) J. Nugraha; Carolina M Viany S; Soehartini B. S.
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 2 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i2.940

Abstract

Calcium measurements in the emergency laboratory use several instruments. Nova pHox Plus (group A) measures ionized calciumwhereas Beckman Synchron CX5 (group B) and Cobas Integra (group C) measures total calcium. Comparison of the results from the threeauto analysers has never been performed. To compare calcium results using three auto analyzers are Nova pHox Plus, Beckman SynchronCX5, and Cobas Integra. Samples consisting of whole blood were examined by Nova pHox Plus auto analyser and serum samples wereexamined using Beckman Synchron CX5 and Cobas Integra auto analyser. This study has been carried out on 21 individuals. Statisticalanalysis was performed using T-test and Pearson correlation coefficient. The level of significance was determined as 0.05. Results of thethree auto analysers did not show significant correlation (P > 0.05). There were not significant correlation between Nova pHox Plusand Beckman CX5, Cobas Integra.

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