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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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ANALYSIS OF RET-HE IN CHRONIC KIDNEY DISEASE PATIENTS AT DR.WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR Febrina Rovani; Asvin Nurulita; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1481

Abstract

Anemia, the common feature of Chronic Kidney Disease (CKD), is a multifactorial process due to disordered erythropoiesis and iron homeostasis. Determining the cause of anemia is important for adequate management. A bone marrow biopsy using Prussian Blue as the gold standard for diagnosis is invasive and more complicated to perform. Reticulocytes-Hemoglobin (Ret-He) a new parameter that indicates the hemoglobin content in reticulocytes is faster, easier, and less expensive. This study aimed to analyze the Ret-He in determining the iron status in patients with CKD. A cross-sectional study was held in the Clinical Pathology Laboratory of Dr. Wahidin Sudirohusodo Hospital Makassar during April-August 2016. Forty-five (45) samples were tested for iron serum (Fe), Total Iron Binding Capacity (TIBC), and Complete Blood Count (CBC) ordered by the physician. Reticulocytes-Hemoglobin was tested using the whole blood. Subjects were around the age of 19-71 years, no significant difference was found between numbers of males and females (46.6% and 53.3%). Hemoglobin median was 8 (5.0-15) g/dL, Fe 50 (6-177) U/mL, TIBC 183 (73-379), Transferrin Saturation (Tsat) 25 (5-95)%. Spearman correlation test method showed significant correlations between Ret-He and iron serum r=0.533, p <0.001, Ret-He and TIBC r=0.321 p=0.031 Ret-He and transferrin saturation r=0.416 p=0.019. The Mann-Whitney method showed no significant difference of Ret-He in both groups (Tsat <20% and >20%). There were significant correlations between Ret-He and iron, Ret-He and TIBC, Ret-He and transferrin saturation. A further study using larger samples is suggested to consider factors affecting the result of Ret-He.
LEUKEMIA SEL BERAMBUT Reini Meilani Isbach; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1069

Abstract

Hairy cell leukaemia (HCL) is a neoplastic disorder of B lymphocytes originally described by Bouroncle et al. in 1958. HCL clinicalmanifestations varies, generally characterized by various degrees of splenomegaly, pancytopenia, or emphasis only on the two cell lines(bisitopenia), with the hairy cells in varying amounts in the peripheral blood smear and bone marrow. HCL is a very rare case, there areonly about 2% of all leukaemias more frequently in men than women (4:1) with the average age of disease onset between 50–55 years.The etiology of HCL is still not known. A case of HCL Leukaemia in a female patient, aged 55 years is reported which was a rare case.HCL diagnosis in this patient was based on the clinical manifestation (splenomegaly), and laboratory results (bisitopenia, neutropeniaand monositopenia) and about 80% hairy cells were found in peripheral blood smears. Definite diagnosis of HCL should be made by bonemarrow examination, immunophenotyping and cytogenesis.
KUNYIT PUTIH DAN BUAH MENGKUDU SEBAGAI HEPATOPROTEKTOR TERKAIT KARBON TETRAKLORIDA Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.389

Abstract

Herbal remedies are prescribed for the treatment of various liver diseases including for Hepatoprotector purpose. The present study was aimed to investigate and to know the hepatoprotective activity of Curcuma zedoaria extract combined with Morinda citrifolia extract against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP, and bilirubin. The results of serum analysis suggest that the use of Curcuma zedoaria extract combined with Morinda citrifolia extract exhibited significant protective effect related to the hepatic damage in CCl4 induced hepatotoxicity model and further evidence of its hepatoprotective activity
PENGUKURAN DAN APLIKASI KLINIK THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1032

Abstract

Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of ThrombinActivatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation andfibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activatedby thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review willdiscuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.
KESEPANCARAN (HOMOLOGI) LEGIONELLA PNEUMOPHILA JARINGAN DISTRIBUSI AIR DAN PNEUMONIA NOSOKOMIAL Noormartany .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1028

Abstract

L. pneumophila is one of the nosocomial pneumonia causes that contaminated hospital water distribution system. The aim of this study was to determine the homology between L. pneumophila 16S rRNA base sequence found in the water distribution systemand the sequence derived from the sputum of nosocomial pneumonia patients identified at RSHS Bandung as well as the homology of L. pneumophila 16S rRNA found in the same system network. The study also include the nosocomial pneumonia patients at RSHSBandung with L. pneumophila from GenBank. The research using descriptive bioinformatics BLAST method by comparative analyticapproach, which performed from April 2006 to February 2008. The material consists of 60 biofilm samples from water distributionsystem and pneumonia nosocomial patient’s sputum is positive L.pneumophila from water distribution system in her/his room. Inthe result was found: out of the 60 biofilm samples from the water distribution system, there are seven (7) L. pneumophila positivePCR and culture. During the 12 months of observation, there is only one (1) out of 31 pneumonia nosocomial patients with positively L. pneumophila PCR and culture. The conclusion so far can be mentioned that: The water distribution system in RSHS for patient roomsmay become the source for nosocomial pneumonia transmission of L. pneumophila and also was detected a new species of L. pneumophilathat is genetically different from that has been found in GenBank.
UJI CEPAT (RAPID TEST) ANTIBODI IgM TERHADAP Salmonella typhi DEMAM TIFOID Rini Riyant; Prihatini .; Siti Rochmatoen
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.935

Abstract

Typhoid fever is caused by Salmonella typhi. The definitive diagnosis can be made by isolation of Salmonella typhi from blood, bone marrow or other body fluids. To support the clinical diagnosis of typhoid fever in Indonesia, where most hospitals and health centres haveno facilities for cultures, a rapid test for the detection of lipopolysaccharides (LPS) Salmonella typhi-specific IgM antibodies was evaluatedon serum samples from patients with typhoid fever. This study is proposed to know the rapid test diagnostic value for the detection oflipopolysaccharides (LPS) Salmonella typhi-specific IgM antibodies. A cross sectional, observational analytical study on 27 typhoidfever and 25 dengue hemorrhagic fever patients of the Dr. Soetomo Hospital, Dr. M Soewandhi General Hospital and Gotong-RoyongClinic has been conducted from January – May 2007. The diagnosis of typhoid fever patients was based on positive gall culture whilethe diagnosis of dengue hemorrhagic fever was based on negative gall culture, positive serology examination for dengue hemorrhagicfever and a recovery from dengue hemorrhagic fever with standard treatment. The sera from patients were examined using a rapid testfor the detection of lipopolysacharides (LPS) Salmonella typhi specific IgM antibodies from Amgenix Onsight of the first blood samples(collected on admission to the hospital) the rapid test for IgM antibodies showed the following: sensitivity 70.4%, specificity 80.0%,positive predictive value 79.2%, negative predictive value 71.4%, diagnostic efficiency 75% respectively. Of the second blood samples(collected 2–3 weeks during the illness) therapid test for IgM antibodies showed the following: sensitivity 88.9%, positive predictive value 82.8%, negative predictive value 87.0%, and diagnostic efficiency 84.6% respectively. The rapid test for IgM antibodies has a high diagnostic value for typhoid fever. The assay uses stabilized components which can be stored at room temperature; the test does notrequire special equipment and may be used in health centres that have no facilities for culture.
ANALISIS CD4 PADA PENATALAKSANAAN PASIEN KOINFEKSI HIV-TB Nursin Abd. Kadir; Nurhayana Sennang; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.991

Abstract

The Human Immunodeficiency Virus (HIV) epidemic has increased the burden of tuberculosis (TB) among young adults, especially in populations where the prevalence of TB infection is high like Indonesia. TB is the most common opportunistic infection on HIV patients(50%) in developing countries. CD4 also known as T helper lymphocytes are coordinators of body`s immune response, and it has beendeclining in HIV infection and be worsened by TB infection. CD4 count are standard laboratory marker of disease progression to followupandprognosisantiretroviraltherapyinHIVinfection.AimstoseethevalueofCD4countofHIV-TBco-infectedpatientsbeforeandafterantituberculosistogetherwithantiretroviraltherapy.AlongitudinalstudywasconductedbycollectingsecondarydatafromthemedicalrecordandtheresultsofClinicalPathologyLaboratoryofHIV-TBco-infectedpatientsatWahidinSudirohusodoHospitalperiodJuly2007–August2008.DatawereanalyzedbyWilcoxonSignedRankTestandMannWhitneyTestwitha=0.05.Totalsamples(n)were20patients(14patientswithcontinoustherapyand6uncontinoustherapy).WefounddifferentmeansbetweenCD4countbeforeandafterTherapy.CD4countbeforetherapywas71.15±81.04andaftertherapywas114.95±109.71(p=0.089)withWilcoxonSignedRankTest.Theanalyzedwerecontinuedbydividedsamplesincontinousgroupcomparedwithuncontinousgrouptherapy.TheresultshowedtheCD4alterationincontinousgroupwas853.8%anduncontinousgroupwas-56.6%wherep=0.000(MannWhitneytest).CD4counthasincreasedsignificantlyinHIV-TBco-infectedpatients8.5foldfromCD4baselinewithcontinoustherapyandtheuncontinous one has decreased 0.5 fold from CD4 baseline.
KORELASI ANTARA PERIKSAAN DARAH SAMAR TINJA MENGGUNAKAN ANTI-HEMOGLOBIN MANUSIA DAN PENGAMATAN MIKROSKOPIS Liana Liana; Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.897

Abstract

Test for occult blood in faeces is an important part of the early detection of colorectal cancer, gastrointestinal bleeding, and anaemia.Colorectal cancer is the second leading cause of cancer deaths in the United States. Immunochemistry method for detection of humanhaemoglobin in faeces has been developed. The advantages of this method are improving analytical sensitivity and specificity, alsoavoiding the dietary restrictions requirement, compared with benzidine test, and guaiacum test. A study was performed to correlate theresult of fecal occult blood by immunochemistry method using anti-human haemoglobin and microscopic examination of red blood cellsin faeces of outpatients in the Clinical Pathology Laboratory, Dr. Soetomo Hospital, Surabaya. Faeces of fifty one patients tested for fecaloccult blood were examined by immunochemistry method compared with microscopic examination of red blood cells. Comparison ofthe two methods was done by statistical analysis, Mc Nemar test. The correlation was measured using ROC curve. The results showed acorrelation between immunochemistry method and microscopic examination with average red blood cells (RBC) ≤ 2/hpf, p = 0.008; RBC≥ 3/hpf, p = 0.289. ROC curve showed r = 0.941. In conclusion, a significant correlation between positive results of immunochemistrymethod and microscopic examination with average red blood cells ≥ 3/hpf. Further research using larger and more representativesamples should be carried out.
DIFFERENCES OF PLASMA INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-α LEVELS IN HEALTHY PEOPLE, RIFAMPICIN RESISTANT AND SENSITIVE PULMONARY TUBERCULOSIS PATIENTS Wahyu Setiani Wibowo; Jusak Nugraha; Soedarsono Soedarsono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1452

Abstract

Increased tuberculosis in the world is caused by increased HIV-infected and antituberculous drugs (rifampicin) resistant individuals. IL-6 and TNF-α play an essential role in explaining the different degrees of inflammation in Rifampicin Resistant (RR) and Rifampicin Sensitive (RS) pulmonary tuberculosis patients, and healthy people. The research aimed to analyze the differences in plasma IL-6 and TNF-α levels in healthy people, Rifampicin Resistant (RR), and Rifampicin Sensitive (RS) pulmonary tuberculosis patients. A cross-sectional study was conducted from July-September 2017. Thirty-nine subjects were classified into RR pulmonary tuberculosis (n=15), RS pulmonary tuberculosis (n=12) based on GeneXpert examination and treated by antituberculous drugs ≤ 1 month, and healthy people (n=12) based on AFB results, Thorax X-ray, and tuberculin tests. IL-6 and TNF-α were done in all subjects using ELISA U-CyTech®(Biosciences, Inc.). Anova analyzed differences of IL-6 and TNF-α levels between groups. The mean IL-6 levels (pg/mL) in RR and RS pulmonary tuberculosis patients, and healthy people were 54.56±59.13, 27.05±37.04, 4.42±2.83, respectively. The mean TNF-α levels (pg/mL) in RR and RS pulmonary tuberculosis patients, and healthy people were 263.54±327.58, 250.25±314.20, 9.04±5.89, respectively. The mean differences between  IL-6 and TNF-α levels (pg/mL) between RR pulmonary tuberculosis patients and healthy people were 50.14±15.29 (p<0.05) and 254.59±8460 (p<0.05). Significant differences of mean IL-6 and TNF-α levels were found between RR pulmonary tuberculosis patients and healthy people.
MUTANT HBV INFECTION ON aa143 (T143S) Maimun Z Arthamin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 2 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i2.949

Abstract

Lebih dari satu dasawarsa lalu, segi penting mutan virus hepatitis B (HBV) telah teralihkan dari sejumlah kenyataan teoriyang tidak diketahui menjadi faktor untuk dipertimbangkan saat mendiagnosis penyakit. Laporan mutan virus hepatitis B (HBsAg)dalam petentu “suatu” telah diperkenalkan. Mutan diisolasi dari penderita seorang laki-laki tanpa gejala berumur 25 tahun, yangditemukan positif HBsAg tetap, positif untuk antibodi permukaan anti-hepatitis B(anti-HBs) dan negatif untuk kedua penutuplengkap virus hepatitis B antigen (HbeAg) serta penutup lengkap anti-hepatitis B antibodi (anti-HBe). Reaksi rantai polimerase danurutannya dilakukan serta memperlihatkan genotipe C jenis turunan (subtype) adrq+. Hasil urutan DNA di kawasan “suatu” petentumemperlihatkan adanya mutasi di aa143 (T143S). Yang disajikan ini adalah kasus HBsAg mutan di aa143 (T143S). Sebab “suatu”petentu menunjukkan kawasan imunodominan HBsAg, perubahan sisa dalam “suatu” petentu menjadikan daya antigen merangsangpembentukan zat anti.

Page 40 of 133 | Total Record : 1328

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