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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 18 Documents
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Search results for , issue "Vol. 9 No. 1 (2025)" : 18 Documents clear
Differences In Serum IL-6 Levels Between First-Trimester Normal Pregnancy and Spontaneous Abortion Vella Amalia; Utama, Bobby Indra; Dessy Arisanty; Nelmi Silvia
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.115-123.2025

Abstract

Objectives: In spontaneous abortion cases without previously known predisposing factors, an increase proinflammatory cytokines, especially interleukin 6 (IL-6), found in local and systemic specimens compared to normal 1st -trimester pregnancies. Therefore, IL-6 is thought to have a role in implantation failure in early pregnancy resulting in spontaneous abortion. However, research on serum IL-6 levels in spontaneous abortion patients is still limited in Indonesia. This study aims to determine the difference in serum IL-6 levels in normal pregnancy 1 st - trimester and spontaneous abortion in hospitals in Padang City; Method: This study is an analytical study with a cross-sectional design using secondary data of 21 blood serum samples from each research group at the Biomedical Laboratory of FK Unand. Samples were collected using a consecutive sampling technique. A serum examination was performed with the ELISA technique. Bivariate data analysis using Mann-Whitney statistical test based on data type and distribution; Result: The results showed that the mean value of serum IL-6 levels was 280,56 ng/L in the normal pregnancy group in the 1st -trimester and the median value of the spontaneous abortion group was 279,78 ng/L. There was no significant difference in serum IL-6 levels in normal pregnancy in the 1st -trimester and spontaneous abortion (p = 0,980); Conclusion: This study concluded that there was no difference in serum IL-6 levels between patients with normal pregnancy in the 1st -trimester and spontaneous abortion in hospitals in Padang City. Keywords: Spontaneous abortion, first trimester, serum interleukin 6, cytokines, ELISA
Relationship of Determinant Factors to Severity Level of Caesarean Section Based on the INA-CBGs System at Dr. M. Djamil Padang Fauzi Ahmad Hasibuan; Aladin, Aladin; Yetti, Husna
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.23-29.2025

Abstract

Abstract Introduction: Cesarean deliveries are increasing worldwide and now account for one fifth (21%) of all deliveries. This has exceeded the standard for caesarean section operations by WHO by around 5-15%. In Indonesia cesarean delivery rate was 17.6% percent with the highest proportion in DKI Jakarta (31.1%), the lowest in Papua (3.3%). West Sumatra is ranked second highest with a caesarean section rate of 23.8%. Objective: To determine the relationship between age, education, employment, nutritional status, number of ANCs, underlying diseases, and the severity of caesarean section. Method: This research is an observational analytical design with a croseksio area approach. It aims to relate the relationship between age, education, employment, nutritional status, number of ANCs, and underlying diseases, and the severity of caesarean section. Results: This study had 400 research subjects who underwent caesarean section operations, with 16 research subjects experiencing caesarean sections with severe severity, 276 research subjects experiencing moderate severity, and 108 research subjects experiencing mild severity. Using the Chi-Square correlation test, there was significant relationship between a history of ANC and the history of underlying disease on the severity of caesarean section. There was no significant relationship between age, education, employment, or nutritional status on the severity of caesarean section. Conclusion: There was significant relationship between history of ANC and history of underlying disease on the severity of caesarean section. Keywords: Determinant Factors, Cesarean section, Level severity, INA-CBGs  
Gut Microbiota Profile in Endometriosis Patients at Dr. M. Djamil Padang, West Sumatra, Indonesia Haviz Yuad; Utama, Bobby Indra; Lipoeto, Nur Indrawaty; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.134-145.2025

Abstract

Objective: Endometriosis (EMS) is a chronic gynecological condition affecting up to 10% of women worldwide. The pathogenesis associated with hormonal imbalance, immune dysregulation, and changes in the gut microbiota. Gut microbiota dysbiosis may drive chronic inflammation that contributes to the progression of EMS. This study hypothesizes that certain gut microbiota profiles are associated with these factors in EMS patients, potentially developing non-invasive diagnostics and more targeted therapies. Methods: This is an observational analytical study with a case-control design conducted at Dr. M. Djamil Padang General Hospital in May 2024 with a sample size of 44 people. Case samples were women aged 18–40 years who were diagnosed with endometriosis based on the inclusion criteria, while the control group were women of reproductive age without a diagnosis of endometriosis. Data testing used the Next Generation Sequencing method, microbiome analysis test, and SPSS test. Results: The majority of EMS patients were aged 30-37 years, married, and had Nullipara obstetric status. In addition, the gut microbiota was dominated by the phyla Bacteroidetes and Firmicutes. Conclusion: There is a relationship between gut microbiota dysbiosis and the incidence of endometriosis, namely an increase in Bacteroidetes and a decrease in Firmicutes Keywords: endometriosis, dysbiosis, bacteroides, firmicutes, gut microbiota
Relationship Between Placenta Accreta Index Score and Management in Placenta Accreta Patients in RSUP Dr. M. Djamil Padang Azhari, Nabilah; Defrin, Defrin; Nurhayati, Nurhayati
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.124-133.2025

Abstract

Introduction : Placenta acreta index is a scoring system using ultrasound parameters used to diagnose placenta accreta. Parameters included are the number of previous caesarean section, location of the placenta, grading of lacunae, presence of bridging blood vessels, thickness of the myometrium. The management of placenta accreta is conservative and definitive management, where the definitive management performed is hysterectomy. The purpose of this study was to determine the relationship between PAI score and placenta accreta management in patients with placenta accreta at Dr. M. Djamil Hospital Padang. Method : This type of research was observational analytic with cross sectional research design. This study was conducted in the medical record section uses a total sampling technique of 184 patients. Data analysis used univariate analysis, bivariate with Chi square test. Result : The results of this study showed that 67.9% of patients with PAI≥4 scores, 56.5% of patients who underwent hysterectomy, and after the statistical test obtained a p value <0.001, then H0 was rejected, meaning that there was a relationship between placenta accreta index scores and placenta accreta management. Conclusion : It is conclude from the results of this study there is a significant relationship between PAI score and placenta accreta management (P<0.05) in placenta accreta patients. Keywords: Hysterectomy, placenta accreta, PAI score
Gambaran Kadar Hemoglobin pada Remaja Putri; Studi Kasus di SMP Negeri 27 Padang Burhan, Ida Rahmah; Firdawati, Firdawati; Asy Syukri, Muhammad Hasbi; Fauziah Nur; Fikri Rahman; Putri, Rizqy Nurfathonah; Asyifa Delfilaura; Rahadi, Didan Ariadapa; Dharma, Fitri Yeni
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.105-114.2025

Abstract

Introduction: The prevalence of anemia in adolescent girls worldwide is reported to be around 40-88%. Adolescent girls with anemia can affect work productivity or academic ability at school due to a lack of enthusiasm for learning and focus. Anemia in adolescent girls can continue throughout their lives and put them at risk of becoming anemic pregnant women who can give birth to premature babies and leading to stunting. This study aims to determine the description of hemoglobin levels in female adolescents at SMP Negeri 27 Padang. Method: The research was descriptive, using a sample of 116 adolescent girls selected by proportionate stratified random sampling. Hemoglobin levels were examined using the Point of Care Testing (POCT) method using capillary blood. Results: The results show that most hemoglobin levels are normal, namely 60 respondents (51,7%), low hemoglobin levels are 55 respondents (47,4%), and high hemoglobin levels are 1 respondents (0,9%). Conclusion: It can be concluded that hemoglobin levels among adolescent girls at SMP Negeri 27 Padang generally have normal hemoglobin levels. Keywords: Adolescent girls, anemia, hemoglobin
Uterine Corpus Endometrial Carcinoma in Young Women Caesar Muhammad Wijaya; Antonius, Puja Agung; Syamel Muhammad; Anugrah, Mutia Paramadita
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.161-166.2025

Abstract

Introduction : Endometrial carcinoma is a malignant epithelial tumor that forms in the uterus's inner lining, or endometrium. The average age at diagnosis is 61 years, with cases diagnosed after 50 years more than 90%. Endometrial carcinoma is rare in young women, usually defined as occurring under age 50 or menopause, with rare cases occurring under age 40. Case Report : A 35-year-old woman nulliparous complaints of abdominal pain since 3 months ago and complained of weight loss. Based on the anamnesis, the patient is not married. On physical examination, revealed an area of firmness in the suprapubic region associated with pain on palpation. On ultrasound examination, the uterus was found to be anteflexed, with an inhomogeneous appearance, and a solid cystic mass along the uterus. Adnexa measuring 10.02 x 10.20 x 12.02 cm, vascular scale 4, not clearly defined. The patient was diagnosed with suspected uterine corpus carcinoma. Result : In this patient, a total hysterectomy and bilateral salpingo-oophorectomy were performed because the patient did not want fertility. Conclussion : In young women who want to preserve fertility, conservative management is often implemented. But, when fertility-sparing treatment is not considered, the rate of recurrence and progression is considerably low in this case. Ultimately, although fertility-sparing treatments are an attractive alternative to surgery resulting in permanent loss of fertility, unfortunately, they can only be applied in a subset of cases. The standard surgical procedure recommended is a total extra-fascial hysterectomy with bilateral salpingo-oophorectomy. Keywords: Uterine Corpus Endometrial Carcinoma, Young Women
Anal Incontinence in Chronic Total Perineal Rupture : A Case Report Roby Putrama; Sari, Yulia Margaretta; Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.145-152.2025

Abstract

Objective: Obstetric anal sphincter injury is a complication of vaginal delivery that, if inadequately managed, can lead to total perineal rupture and fecal incontinence, significantly impacting a patient's quality of life. This case report aims to describe the management of long-standing total perineal rupture in a patient with fecal incontinence. Method: A 37-year-old woman with a 1-year history of fecal incontinence and 15-year history of uncontrolled flatus following an unattended perineal tear during her first delivery was referred for evaluation. Physical examination and transperineal ultrasound revealed a perineal defect involving the external and internal anal sphincter. The patient was managed with sphincteroplasty and perineorrhaphy. Postoperative care included cleansing, catheterization, and medications, along with dietary modifications. Result: The patient’s Wexner score of 14 indicated moderate to severe fecal incontinence. After surgical management, the patient experienced improved control over bowel movements and enhanced quality of life. Conclusion: Vaginal lacerations can cause severe injuries to the perineal body and anal sphincters. Early identification and appropriate surgical intervention, such as sphincteroplasty and perineorrhaphy, are essential in improving outcomes and restoring quality of life in patients with obstetric anal sphincter injuries. Keywords: Obstetric anal sphincter injury, fecal incontinence, sphincteroplasty, perineorrhaphy, perineal rupture
The Role of Endothelial Nitrit Oxide in Preeclampsia Onset Ramya Sausan; Yusrawati, Yusrawati; Karmia, Hudila Rifa
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.41-48.2025

Abstract

Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with significant maternal and fetal morbidity and mortality. Endothelial dysfunction plays a critical role in the pathogenesis of preeclampsia, with nitric oxide (NO) being a key regulator of vascular tone and endothelial function. This study aims to investigate the relationship between endothelial nitric oxide (eNOS) levels and the onset of preeclampsia. Methods: A cross-sectional study was conducted on pregnant women diagnosed with severe preeclampsia and receive treatment at Dr. M. Djamil Hospital, Padang. After met the inclusion criteria and do not have exclusion criteria, demographic and clinical data was taken. Maternal plasma concentrations of eNOS were determined by ELISA. Non-parametric statistics were used for analysis. Results: The study evaluated the levels of endothelial nitric oxide synthase (eNOS) in two groups of preeclampsia patients: those with Early Onset Preeclampsia (EOP) and Late Onset Preeclampsia (LOPE). The median eNOS levels were 50.43 pg/ml for the EOP group (range: 28.72 - 232.78 pg/ml) and 54.76 pg/ml for the LOPE group (range: 15.39 - 235.70 pg/ml). A Mann-Whitney U test revealed a p-value of 0.303, indicating no statistically significant difference in eNOS levels between the two groups. This suggests that the timing of preeclampsia onset does not significantly influence eNOS levels, providing insights into the disease's mechanisms. Conclusion: eNOS levels in the early preeclampsia (EOP) group were found to be lower compared to the late preeclampsia (LOPE) group. Although there was a difference in eNOS levels between the two groups, the difference was not statistically significant. Keywords: Preeclampsia, endothelial dysfunction, nitric oxide; pregnancy, hypertensive disorders
The Efficacy of Dequalinium Chloride Against Vulvovaginitis in Pregnancy Mila Permata Sari; Djanas, Dovy; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.49-62.2025

Abstract

Introduction: Vulvovaginitis affects pregnancy outcomes and managing it involves the use of metronidazole or nystatin, which can cause local or systemic side effects. Dequalinium chloride (DQC) is suggested as a new treatment option for vulvovaginitis during pregnancy with minimal side effects. Objective: To compare the effectiveness of dequalinium chloride (DQC) versus metronidazole + nystatin (MN) in treating vulvovaginitis in pregnant women during their second and third trimesters. Method: A single-blind randomized controlled trial was conducted at the Andalas Public Health Center, Padang, from January to May 2024. Pregnant women in their second and third trimesters, meeting the inclusion and exclusion criteria, were enrolled. The participants were randomly assigned to either the DQC or MN group. Vaginal swabs were taken before and after a 6-day treatment, and PCR analysis was performed. Results: Eighteen patients were treated with DQC and MN. Most participants had bacterial vaginosis (DQC 78%, MN 83%), with half having candidiasis (DQC and MN 50%) and fewer cases of trichomoniasis (28% in both groups). Significant improvements were seen in the DQC group for symptoms (p=0.000), Gardnerella vaginalis (p=0.035), and Candida albicans (p=0.021). In the MN group, significant improvements were noted for symptoms (p=0.000) and Gardnerella vaginalis (p=0.002). No significant differences were observed between the groups for symptom resolution or microbial reduction. Conclusion: DQC is as effective as metronidazole + nystatin in treating bacterial vaginosis and candidiasis in pregnancy. Keywords: Vulvovaginitis, pregnancy, dequalinium chloride, metronidazole, nystatin
Lactobacillus species and Clamydia trachomatis characterisation in premature rupture of membranes and normal pregnancy Prima Indra; Roza Sri Yanti; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.95-104.2025

Abstract

The cause of premature rupture of membranes (PROM) remains uncertain. The vaginal microbiota might possess a significant influence on the vaginal environment and can impact the overall health of the female reproductive system. Objective: This study aims to determine the difference in the concentration of lactobacillus crispatus, lactobacillus vaginalis, and chlamydia trachomatis between patients with premature rupture of membranes and normal pregnancies; Methods: This study is an analytic study with a case-control design that was conducted at Dr. M. Djamil Hospital Padang during the period January 2024 to June 2024. This study performed DNA isolation using conventional PCR; Results: Lactobacillus crispatus, Lactobacillus vaginalis, and Chlamydia trachomatis reached 42,124,873.86/mL, 179.41/mL, and 287,062.30/mL, respectively in preterm rupture of membranes patients. In normal pregnancy, Lactobacillus crispatus, Lactobacillus vaginalis, and Chlamydia trachomatis reached 75,717,348.80/mL, 704,147.66/mL, and 0/mL, respectively. A significant difference in Lactobacillus vaginalis concentrations was found between the case and control groups, with the control group having a greater average concentration (28.88) compared to the case group (36.13), with a p-value <0.018. The case group had a significantly greater concentration of Chlamydia trachomatis (37.50) compared to the control group (27.50), with a p-value <0.001. The case and control groups had significantly different lactobacillus crispatus concentrations. The case group had 24.88 times less lactobacillus crispatus than the control group, which had 40.13 times more, with p-value <0.001; Conclusion:  In pregnant women, an increase in Chlamydia trachomatis and a reduction in Lactobacillus crispatus and Lactobacillus vaginalis can be an indicator of probable PROM. Keywords:  Lactobacillus vaginalis, chlamydia trachomatis, Lactobacillus crispatus, PROM, normal pregnancy.

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