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INDONESIA
Jurnal Kefarmasian AKFARINDO
Published by Akademi Farmasi Indonesia Yogyakarta
ISSN : 25287257     EISSN : 25287265     DOI : -
Core Subject : Health, Science, Social,
Immunology & microbiology Medicine & Pharmacology Social Sciences
The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 195 Documents
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MOTIVASI DAN SIKAPAPOTEKER DALAM PENGENDALIAN PERSEDIAAN FARMASI DI APOTEK KOTA PALU Diana, Khusnul; Rinaldhi Tandah, Muhamad; Dibyo, Arya; Putri, Meliani
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.110

Abstract

Pharmaceutical supplies are the main commodity in the pharmaceutical sector in service facilities, one of which is a pharmacy. Controlling pharmaceutical supplies in pharmacies is one of the duties and responsibilities of a pharmacist managing a pharmacy (APA). The task can run well if the pharmacist has high motivation and a good attitude in controlling pharmaceutical inventory. This study aimed to measure the attitude and motivation of pharmacists in inventory control and how the influence of motivation on attitudes in managing pharmaceutical inventory in pharmacies. This type of research is a descriptive observational study with cross-sectional data collection. The sample used is pharmacist managing pharmacies (APA) in pharmacies in Palu City as many as 73 respondents. The attitude and motivation of pharmacists were measured using a questionnaire that had been tested for validity and reliability. The results of the respondent's data were analyzed descriptively and a simple linear regression test. The outcome on the measurement of pharmacist motivation was dominated by the moderate category, with as many as 51 respondents (69.86%). The results of measuring the attitude of pharmacists in controlling pharmaceutical inventory in pharmacies are dominated in the good category as many as 36 respondents (49.32%). With a simple regression test, the tcount value is 0.783 (< ttable = 1.66), which means that there is no significant effect between motivation on the attitude of the pharmacist. The linear regression equation is Y=39,527+0,151X, meaning that if the motivation value increases by 1, the attitude will increase by 0.151. It can be concluded that the attitude in controlling pharmaceutical inventory by pharmacists in pharmacies is not influenced by motivation.
SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA KALKON TERHADAP BAKTERI KONTAMINAN PRODUK DARAH GRAM NEGATIF DAN POSITIF Wiwit Sepvianti; Christiyani Kusumaningrum, Serafica Btari
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.112

Abstract

Background: The development of chalcone-based antibiotics has been widely carried out today, variations in the location and type of functional groups were carried out to find chalcone with the best bacterial inhibitory activity. However, the obstacle faced was that not all variations of chalcone showed good bacterial inhibitory activity. The trend of increasing or decreasing antibacterial activity due to variations in the location and type of substituent in chalcone is difficult to detect, because comparative data on the inhibitory activity of chalcone are not current or are no longer relevant to current conditions where the test bacteria have mutation as a form of adaptation or resistance to antibiotics. Objective: This research was conducted to provide current data on the antibacterial activity of chalcone against gram-positive and gram-negative bacteria. Methods: Chalcone was synthesized by Claisen-Schmidt condensation and activity test by diffusion method. Results: The yield of chalcone obtained in this study was 96.15%, with the percent purity based on the results of GC-MS was 100%. Inhibitory activity of chalcone on gram-negative bacteria Escherichia coli is in the strong category with an inhibitory value of 81.30% while Acinetobacter is weak with a percentage of 43.0%. In gram-positive bacteria Staphylococcus aureus the inhibitory ability is moderate with a percentage of 64.0%, while in Staphylococcus epidermidis and Bacillus sp the inhibitory activity is weak with a percentage of 35.5% and 43.0%, respectively. Conclusion: Chalcone have strong activity on Gram-negative bacteria and tend to be moderate on Gram-positive bacteria.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JARAK MERAH (Jatropha gossypiifolia) ASAL KABUPATEN BANTAENG Wahyuddin, Nurzadrina; Ismail, Ismail; Mashar, Harlyanti Muthma'innah; Dali
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.115

Abstract

Background: In the last few decades there has been an increase in cases of chronic diseases and premature aging which are some of the key factors in influencing public health. This condition is caused by various causes, but the main factor is the number of free radicals that exceed the body's capacity to neutralize them. Antioxidants have an important role as health protective factors because they can neutralize and protect cells from the presence of free radicals. Red castor leaves have been reported to have good activity as an antioxidant. The chemical content of this plant is anthraquinone, flavonoid, saponin, tannin and terpenoid. Objective: This study aimed to evaluate the antioxidant activity of red jatropha leaf extract using the DPPH method. Methods Samples were extracted using 70% ethanol by maceration method. The antioxidant activity test was carried out using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) using a comparison of Vitamin C. Each test used a variation of the concentration of the solution. For red jatropha leaf extract using concentration variations of 20, 40, 60, 80 and 100 g/ml, while for vitamin C using concentration variations of 10, 15, 20, 25, and 30 g/ml. The absorbance of each test solution was measured using a spectrophotometer at a wavelength of 515 nm. The results are reported as IC50 values. Results: The results showed that the IC50 values ​​of red jatropha leaf extract and vitamin C were 47.81 and 14.99 g/ml, respectively. This value indicates that the Chinese jatropha leaf extract has a very strong antioxidant activity (IC50 <50 g/ml). Conclusion: Red jatropha leaf extract showed very strong antioxidant activity with an IC50 value of 47.81 g/ml so it has great potential as an antioxidant that can be used for the development of traditional medicinal raw materials.
HUBUNGAN ANTARA TINGKAT PENDIDIKAN TERHADAP PENGETAHUAN MASYARAKAT TENTANG HIPERTENSI DI POSBINDU DESA SRIGADING, SANDEN, BANTUL, YOGYAKARTA Fitria Dhirisma; Idhen Aura Moerdhanti
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.116

Abstract

The results of basic health research or Riskesdas in 2018, an increase in the prevalence of non-communicable diseases such as cancer, stroke, kidney disease, diabetes mellitus and hypertension, with the prevalence of hypertension in DIY 32.86%. Providing correct information is expected to be able to increase public knowledge about hypertension. One of the factors that can affect knowledge is a person's education level. The higher the level of education, the higher the knowledge. This study aims to determine the relationship between education level and public knowledge about hypertension in Posbindu, Srigading, Sanden, Bantul. This study used an observational method. Collecting data using a closed questionnaire which is given directly to the respondents. The data obtained were analyzed using the chi-square, with a 95% confidence level in the form of a table of the relationship between education level and public knowledge about hypertension with a sample size of 70 respondents. The results showed that there was no significant relationship between education level and public knowledge about hypertension with a significance value of 0.593. The majority of respondents have good knowledge of 82.9%, this is supported by an active environment in the implementation of Posbindu activities which are carried out regularly.
FORMULASI DAN EVALUASI GRANUL DISPERSI PADAT EKSTRAK KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DENGAN PERBANDINGAN KITOSAN:PVP K-30 1:2 Abdullah, Hannah Savitri; Imtihani, Hilya Nur
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.119

Abstract

Background: Mangrove crab shells (Scylla serrata) contain chitosan which functions as an anticholesterol. Chitosan is insoluble in water but soluble in acids such as acetic acid. In the process of increasing the solubility, a solid dispersion system is made. The solid dispersion is then formulated into granules. Objective: The purpose of this study was to determine the physical properties of the solid dispersion chitosan granules (FI) and the physical mixture granules (FII). Methods: The method used for the manufacture of solid dispersions is solvent evaporation using PVP K-30 (1:2) as a carrier. The solid dispersion will be made in the form of granules by wet granulation method which will then evaluate the quality of the granules. Results: From this study, the granule flow rate FI=12.89 g/second, and FII=24.58 g/second. The angle of repose of the granules FI=22,13o, and FII=9,46o. The compressibility and Hausner granule FI ratio were found to be 20% and 1.25; while FII obtained 9.90% and 1.11. The percentage of water content of FI granules is 6.38%, and FII is 2.04%. Conclusion: The formulation in this study was able to produce granules that met the requirements, and there was a significant difference between the physical properties of FI and FII granules.
PROFIL PENGGUNAAN OBAT ANALGETIK BERDASARKAN RESEP DOKTER DI APOTEK KIMIA FARMA TITIBUMI Diyah Dwi Lestari; Dwi Hastuti
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.120

Abstract

Background: One of the health problems that is often faced is pain in the limbs. Pain can be overcome by using analgesic drugs. The use of analgesic drugs at Kimia Farma Titibumi Pharmacy is classified as fast moving, this is due to the location of the pharmacy which is close to clinics and practicing doctors. Almost all doctors around the pharmacy prescribe analgesic drugs. Objective: The purpose of this study was to determine the profile of the use of analgesic drugs with a doctor's prescription at Kimia Farma Titibumi Pharmacy for the period January - May 2020. Methods: The method in this research is descriptive observational research. Collecting data in the form of prescriptions containing analgesic drugs at Kimia Farma Titibumi Pharmacy for the period January - May 2020. The data were analyzed descriptively. The data results were presented in tabular form about the profile of analgesic drug use based on doctor's prescriptions at the Titibumi Kimia Farma pharmacy. Results: The results and conclusions of this study are the use of analgesic therapy the most is single therapy, namely metamizole with 35 prescriptions (21.21%), while for combination therapy, paracetamol + tramadol with 18 prescriptions (10,91%). The highest class of drugs is the non-opioid group with 122 prescriptions (73.94%). Conclusion: Of the 165 existing prescriptions, 163 prescriptions (98.79%) had the appropriate dosage, and there were 2 prescriptions (1.21%) that did not match the dosage.
PERAN miRNA-21 PENEKAN GEN PTEN PENSIYALAN PI3K/AKT PADA KANKER KOLOREKTAL Ismail, Ismail; Pulio, Arisanti; Bura, Elvin; Selfiana; Mutmainnah, Nur
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.121

Abstract

Colorectal cancer is one of the leading causes of death in the world caused by various factors such as genetic mutations, epigenetics, dysregulation of communication signaling pathways and gut microbiota. In the presence of genetic, epigenetic mutations, there is a loss of expression and function of PTEN (Phosphatase and TENsin homologues) resulting in continued activation of the PI3K/Akt intracellular signaling cascade involved in colorectal carcinogenesis. The solution to this problem is to use miRNA-21. which plays an important role by suppressing the biological marker PTEN gene that is useful for diagnosis and treatment in colorectal cancer. The aim of this study was to determine the specifi c binding of miRNA-21 with the PTEN gene that plays a role in colorectal cancer based on the AGhybrid and Logistic Probability values. Complete sequences of PTEN genes were obtained from FASTA NCBI and CDS data were obtained from Refseq. Prediction of the binding of mature miRNA-21 with the PTEN gene was carried out using the StarMir Sfold 2.2 website. The predicted results of miRNA-21 binding with 1 target obtained 296 binding models. Specific binding was seen from AGhybrid -23.600 and logistic probability 0.818, there was a binding between PTEN gene binding and miR-21-5p at seedless CDS position 3627-3653 as evidenced by the lowest AGhybrid value of all bindings that occurred.
HUBUNGAN MEDICATION RELATED BURDEN DENGAN KEPATUHAN TERAPI PADA PASIEN STROKE DI RUMAH SAKIT PKU MUHAMMADIYAH GAMPING PERIODE OKTOBER – NOVEMBER 2021 Hanita Christiandari; Supadmi, Woro; Sudibyo, Joko
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.122

Abstract

Stroke menduduki urutan ketiga terbesar penyebab kematian setelah penyakit jantung dan kanker, dengan laju mortalitas 18 % sampai 37 % untuk stroke pertama dan 62 % untuk stroke berulang. Stroke membutuhkan perawatan pengobatan jangka panjang, yang dapat menimbulkan beban pengobatan pada pasien. Beban pengobatan dalam jangka panjang tersebut dapat mengurangi kepatuhan terapi. Penelitian bertujuan mengetahui beban pengobatan, tingkat kepatuhan pasien, dan hubungan antara beban pengobatan dengan tingkat kepatuhan pasien Stroke di RS PKU Muhammadiyah Gamping. Penelitian ini merupakan penelitian observasional dengan pendekatan deskriptif potong lintang (cross-sectional). Adapun pengambilan data dilakukan secara prospektif berdasarkan wawancara langsung terhadap pasien meliputi beban pengobatan dengan kuesioner Living With Medicine Questionaire (LMQ) dan kepatuhan terapi dengan kuesioner Medication Adherence Rating Scale (MARS). Data dianalisis dengan uji Spearman Rho untuk menentukan hubungan antara medication related burden dengan kepatuhan pasien. Berdasarkan kuisioner LMQ sebanyak 8 pasien (16,32%) mengalami beban rendah dan 41 pasien (83,67%) mengalami beban sedang. Tingkat kepatuhan pada pasien stroke di RS PKU Muhammadiyah Gamping diketahui bahwa sebanyak 29 pasien (59,18%) memiliki tingkat kepatuhan sedang dan sebanyak 20 pasien (40,81%) memiliki tingkat kepatuhan tinggi. Berdasarkan nilai koefisien korelasi VAS dengan MARS menunjukkan korelasi negatif (CP = -0,186 dan P=0,201), hal ini berarti bahwa semakin tinggi beban pengobatan maka pasien akan semakin tidak patuh dan tidak ada hubungan yang signifikan antara beban pengobatan dengan kepatuhan pasien. Berdasarkan nilai koefisien korelasi VAS dengan MARS menunjukkan korelasi negatif (CP = -0,186 dan P=0,201), hal ini berarti bahwa semakin tinggi beban pengobatan maka pasien akan semakin tidak patuh dan tidak ada hubungan yang signifikan antara beban pengobatan dengan kepatuhan pasien. Kata Kunci : Stroke, Medication Related Burden, Kepatuhan Terapi
POTENSI PENGGUNAAN OBAT TIDAK TEPAT PADA PASIEN RAWAT JALAN GERIATRI BERDASARKAN KRITERIA BEERS 2019 Rahmawati, Reza; Harianti Putri, Yona; Handayani, Dian; Pertiwi, Reza; Putri Nurlita, Septia; Kamilla Putri, Dwi; Alawiya Simanullang, Khairatul
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.125

Abstract

Geriatric population continues to increased globally. In Indonesia, estimation of geriatric population is 7% and will be increase over years. One of geriatric medication problem is potentially inappropriate medication (PIM). Beers criteria 2019 is one of a tool to evaluate potentially inappropriate medication in geriatric. Therefore, this study aims to indentify the prevalence of potentially inappropriate medication incidence in geriatric outpatient at Pharmacy X in Bengkulu and risk factors associated with PIM. This research was done in cross sectional and prospective study. Data collection was done in 2 months from August-October 2021. The incidence of potentially inappropriate medication was analyzed using descriptive analysis according to Beers Criteria 2019 and risk factors were analyzed using logistic regression. This research reported that from 115 geriatric patients above ≥ 65 years old, out of 56 patients (48,70%) found with at least 1 potentially inappropriate medication (PIM). There were 101 PIM with average of PIM 1,8 PIM/patient. Drug should be avoid in almost geriatrics were 34,65%, drug used with caution in geriatrics were 54,46%, and drug interaction should be avoid in geriatric were 10,89%. Diuretic agents like furosemide and spironolactone were frequently used in geriatric patients but potentially inappropriate. Logistic regression showed that the number of drugs used is associated with the incidence of PIM in geriatric outpatient.
POTENSI ANTIBAKTERI EKSTRAK DAUN KOPASANDA (Chromolaena odorata L) TERHADAP Pseudomonas aeruginosa DAN Staphylococcus aureus Nurhanifah; St. Ratnah; Rante Pakadang, Sesilia
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.132

Abstract

Infectious disease is a human health problem that will develop from time to time. Skin infections can be caused by bacteria. Kopasanda Leaf Extract contains secondary metabolite compounds that act as antibacterial agents. The purpose of this study was to determine the class of chemical compounds and the antibacterial activity of Kopasanda leaf extract (Chromolaena odorata L) against Pseudomonas aeruginosa and Staphylococcus aureus based on the diameter of the inhibition zone. The working method used is the manufacture of simplicia, extraction, phytochemical screening, antibacterial activity testing with the disc diffusion method. Based on the results of the study, the average inhibition zone on Pseudomonas aeruginosa 2% was 11.3 mm, 4% concentration was 13.3 mm, 8% concentration was 19.3 mm and the positive control was 16.6 mm and the negative control was obtained. 0 mm. While the results of the measurement of the diameter of the inhibition zone on Staphylococcus aureus with a concentration of 2% of 12.6 mm, 4% concentration of 15.6 mm, 8% concentration of 18.6 mm, and 16.3 mm in positive control and 0 mm in negative control. which means it has no inhibition zone. The conclusion of this study was that all concentrations of kopasanda leaf extract used had antibacterial potential against Pseudomonas aeruginosa and Staphylococcus aureus.

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