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Nursalam Hamzah
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universitas Islam Negeri Alauddin Makassar, Indonesia
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 115 Documents
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Effect of Aerobic Fermentation on Total Phenolic, Flavonoid, and Antioxidant Activity of Leucaena leucocephala (Lam.) de Wit Dewantara, Jeisen Pajar; Marpaung, Mauritz Pandapotan; Khairunnisa; Hidayati, Nurul; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57063

Abstract

Introduction: Leucaena leucocephala (Lam.) de Wit., commonly known as the petai cina plant, contains significant concentrations of bioactive compounds, particularly flavonoids and phenolic compounds, and demonstrates substantial antioxidant properties. These beneficial compounds, however, can be significantly influenced by various processing methods, with fermentation during simplicia preparation being a notable factor. Aims: This research investigated the impact of fermentation on three key characteristics of petai cina leaf extract: total flavonoid content, total phenolic content, and antioxidant activity. Methods: The study utilized experimental methodology, incorporating both qualitative and quantitative analyses to evaluate these properties. The results revealed that five days fermentation demonstrated the highest value of TFC, TPC, and antioxidant activity. Result: The extract yielded a TFC of 279.08 mg QE/g, while TPC measured 282.34 mg GAE/g. The antioxidant activity demonstrated notable potency, with an IC50 and AAI values of 69.66 µg/mL and 0.574. Conclusion: These findings conclusively demonstrate that the fermentation process significantly influences the concentration of flavonoids and phenolic compounds, yet unsignificant impact antioxidant activity in the extract. This enhanced understanding of fermentation's effects on bioactive compounds in L. leucocephala provides valuable insights for optimizing processing methods to maximize the plant's therapeutic potential.
Prediction Activity Pharmacology and Molecular Docking of Secondary Metabolite Compounds of Tamarind Leaves (Tamarindus indica) as Anticancer Muslikh, Faisal Akhmal; Riwanti, Pramudita; Alrayan, Reza
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57090

Abstract

Introduction: Cancer remains one of the leading causes of morbidity and mortality worldwide, with incidence and death rates increasing annually. One of the most effective therapeutic targets for cancer is the Epidermal Growth Factor Receptor (EGFR). However, the use of synthetic EGFR inhibitors is often associated with significant side effects.  Aims: This study aims to evaluate the potential of compounds derived from Tamarindus indica (tamarind) leaves as anticancer agents through an in silico approach, including pharmacological activity prediction (PASS) and molecular docking against the EGFR receptor.  Methods: Pharmacological activities were predicted using the Way2Drug webtool, while molecular docking analysis was performed using Molegro Virtual Docker (MVD).  Result: The PASS prediction results indicated that the compounds in Tamarindus indica leaves possess a broad spectrum of anticancer activities. Docking analysis revealed that isovitexin exhibited the lowest rerank score among the test compounds and controls (erlotinib and the native ligand), indicating stronger binding affinity to EGFR. Conclusion: These findings support the potential of tamarind leaves, particularly isovitexin, as a promising computationally-predicted anticancer therapeutic candidate.
Anti-inflammatory Potential of Tithonia diversifolia Leaves in Carrageenan-Induced Edema Model in Mice (Mus Musculus) Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Aksa, Rahmat; Amriani, Amriani; Rahimah, Sitti; Rahayu, Riska
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57119

Abstract

Introduction: Edema is a common sign of inflammation characterized by increased tissue volume. Tithonia diversifolia leaves have traditionally been used as anti-inflammatory agents because they contain active compounds such as flavonoids, alkaloids, steroids, terpenoids, tannins, sesquiterpenoids, phenolic acids, and saponins. Aims: Determine the anti-inflammatory effects of ethanol extract of Tithonia diversifolia leaves on rats (Mus musculus) induced by carrageenan. Method: Extraction was carried out using maceration. The experimental design was pre- and post-test with five groups: healthy controls, positive controls (sodium diclofenac), and three treatment groups receiving 12.5 mg/30 gBW, 25 mg/30 gBW, and 37.5 mg/30 gBW of Tithonia diversifolia leaf extract. Edema was induced with carrageenan and measured using a plethysmometer at certain intervals. Result: The results showed that a dose of 37.5 mg/30 gBW significantly decreased edema volume, comparable to the diclofenac group (p>0.05). Conclusion: The ethanol extract of paitan leaves at this dose can function as an effective anti-inflammatory agent.
Beyond The Skin Barrier: How Transfersomes and Transethosomes are Revolutionizing Topical Therapies Widayanti Supraba; Husni, Patihul; Chaerunisaa, Anis Yohana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57146

Abstract

Introduction: The fundamental challenge of effective skin permeation has long limited the therapeutic potential of topical drug delivery systems. Conventional formulations frequently fail to achieve adequate penetration through the skin barrier, necessitating innovative approaches to enhance drug bioavailability while maintaining targeted delivery to specific skin layers.  Aims: This review evaluates the transformative impact of transfersomes and transethosomes as advanced nanovesicular systems designed to overcome traditional limitations in topical drug delivery. Methods: The review examines ultra-deformable nanovesicle technologies through comprehensive analysis of their operational mechanisms, including osmotic gradient exploitation in transfersomes and ethanol-facilitated lipid fluidization in transethosomes. Performance comparisons with conventional formulations across various therapeutic applications were conducted to assess clinical efficacy and delivery capabilities. Result: These nanovesicular systems demonstrate superior performance in delivering diverse therapeutic agents to targeted skin layers while effectively minimizing systemic absorption. The analysis reveals significant advantages over traditional formulations, with enhanced penetration capabilities that extend to macromolecular therapeutics and biologics when integrated with complementary technologies such as microneedle arrays and iontophoresis. Current research developments focus on addressing existing limitations through lyophilization techniques, hybrid polymer systems, and advanced manufacturing processes. Conclusion: Transfersomes and transethosomes represent a significant advancement in topical drug delivery technology, offering promising solutions to longstanding permeation challenges. The future trajectory toward personalized formulations and sustainable production methods using plant-derived components indicates their potential to fundamentally redefine treatment approaches in dermatology, oncology, and pain management, establishing minimally invasive yet highly effective therapeutic options as the standard in patient care.
Toxicity and Alpha Glucosidase Inhibitory Activity of Roasted Kedawung Seed (Parkia timoriana) Supandi, Supandi; Hadi, Ismanurrahman; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57945

Abstract

Introduction: Kedawung (P. timoriana) seeds are empirically utilised as a traditional medicine; it also contains various phytochemical compounds, antioxidant activities as well as other beneficial pharmacological effects. In some regions in Indonesia, the utilisation of kedawung seeds is usually done by involving the roasting process. Aims: This study aims to investigate the effect of roasting on phytochemical compounds, toxicity and alpha glucosidase inhibitory effects. Method: Kedawung seeds were roasted at 150 ºC (15 minutes); then separated from the skin, powdered and macerated in ethanol. Result: The extract was phytochemically screened with the results obtained showing positive for saponins, flavonoids, alkaloids, and terpenoids. The following test is toxicity test using BSLT (Brine Shrimp Lethality Test) method as well as inhibitory activity on alpha glucosidase enzyme. The test results showed that kedawung extract had an LC50 of 78.18 ppm in the BSLT test, as well as inhibition of alpha glucosidase enzyme at 265.24 ppm. Conclusion: The results obtained show that the ethanol extract of roasted kedawung seeds still has phytochemical metabolite compounds, but is moderately toxic and has weak inhibition on alpha glucosidase

Page 12 of 12 | Total Record : 115

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