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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 116 Documents
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English English Fitril Imani; Yusnita Rifai; Herlina Rante; Ansari Masri; Andri Anugrah Pratama; Musabbiha
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37548

Abstract

This study aims to predict the compounds from Ocimum basillicum that have potential as glioma inhibitors by inhibiting the enzyme isocitrate dehydrogenase (IDH). Forty-two compounds from Ocimum basillicum were carried out by molecular docking to the IDH receptor using the AutodockTools 1.5.7 program and continued prediction of pharmacokinetic profile and toxicity using ADMETab 2.0 and Toxtree. The validation of the molecular docking method showed an RMSD value of 1.8509 A. As a result of the research, we discovered several compounds had the best interactions in our investigation. Those compounds were Apigenin, Catechin, Chloronergic Acid, Ellagic Acid, Quercetin, Rutin, Eriodictyol, and Chicoric Acid, with binding affinity values of -7.1, -6.7, -7.1, -7.1, -7.1, -8.5, -7.2, and -6.5, respectively. Several compounds are predicted to have the potential to be developed as glioma inhibitors. Furthermore, the ADMET's predictions show that these potential compounds still require improvement in pharmacokinetics and toxicity. However, further laboratory investigations like in vitro and in vivo assays need to be conducted.
Profiling Secondary Metabolite of Fresh and Fermented Marigold Flowers and Butterfly Pea Flowers Ni Luh Putu Kris Monika Yanti; Sukrasno; Defri Rizaldy; Arif Al Iman
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37714

Abstract

Communities in Bali use "Usada" as an essential plant for traditional medicine. Utilization of a plant as herbal medicine is based on the metabolites contained therein, such as in the marigold flower (Tagetes erecta L.) and butterfly pea flower (Clitoria ternatea L.). Identification of secondary metabolite profiles was carried out by aerobic fermentation. This study aims to identify the secondary metabolite profiles of untreated extracts compared to fermented extracts. Aerobic fermentation is carried out by stacking fresh samples. Extraction by percolation using n-hexane for marigold flowers and methanol for butterfly pea flowers. The extract profile was analyzed by densitometric thin-layer chromatography (TLC). Separation pattern, retention time, and m/z fragmentation with LC-MS/MS. Determined antioxidant activity using the DPPH method, calculating the levels of total phenol (TPC), total flavonoids (TFC), and total carotenoids in each sample. The TLC profiles of control extracts and marigold flower fermentation were similar, However, in the fermented pea flower extract, the intensity of the spots was thicker, and a new compound was formed from the TLC pattern. The TPC of the control and fermented extracts ranged from 0,816 - 1,154 g GAE/100 g extract, the TFC ranged from 0,067 - 0,610 g QE/100 g extract, and the highest total carotenoid was in the fermented marigold flower extract with levels of 215 mg/g simplicia. All control and fermented extracts had antioxidant activity ranging from 46,71 ppm-75,30 ppm. LC-MS/MS analysis showed five compounds from the fermented butterfly pea flower extract, while the control only identified one compound. The fermentation process for each extract experienced changes in the profile of secondary metabolites, starting from UV absorption, spot intensity, compound levels, types of compounds contained, and their antioxidant activity.
Antibacterial Activity Test of Roll on Deodorant Extract Ethanol Tamarind Seed Coat Rahim, Abdul Rahim; Salmiah; Ihsan, Ersi Arviana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37568

Abstract

Introduction: Armpit odor is one of the problems caused by bacteria, one of which is Staphylococcus aureus. The rind of the tamarind seed contains tannins and flavonoids that function as antibacterial. Aims: The purpose of this study was to formulate the ethanolic extract of tamarind seed coat into roll-on deodorant preparations and to determine the zone of inhibition from variations in the concentration of the extract. Methods: The method used is the well diffusion method and the data obtained are then analyzed using Statistical Product and Service solution (SPSS). The level of confidence used is 95% to see the significance of each evaluation of the preparation. Result: The results showed that the roll on deodorant preparation of ethanol extract of tamarind seed coat did not meet the requirements for good dispersibility, adhesion and viscosity for topical preparations in general and emulsion preparations. The pH of the preparation met the axillary skin pH he standard for topical preparations. The roll-on deodorant preparation of ethanol extract of tamarind seed cultivars was effective in inhibiting the growth of Staphylococcus aureus bacteria. Conclusion: The results of inhibition zone 3 formulations containing extracts were in the strong category and the value increased with increasing concentration of tamarind seed coat extract in the deodorant preparation.
Antibacterial Activity of Jackfruit Leaf (Artocarpus Heterophyllus LMK.) Ethanol Extract Gel on Propionibacterium acnes Fitrya Fitrya; Elsa Fitria Apriani; Adik Ahmadi; Dina Permata Wijaya; Khazanah Nurain
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37608

Abstract

Introduction: Artocarpus heterophyllus LMK. leaves contain flavonoids, tannins, and saponins, which have the potential to be antibacterial. Aims: This study aims to test the antibacterial activity of A. heterophyllus leaves ethanol extract, which is formulated in a gel preparation. Methods: Antibacterial testing was done on the acne-causing bacteria Propionibacterium acnes. The gel formula is designed with an extract concentration of 5, 10, or 15% with Carbopol 940 and HPMC as the bases. The antibacterial activity test was carried out using the well diffusion method. Result: The results of the study showed that the concentration of the extract affected pH, adhesive power, removability, and viscosity. Antibacterial activity tests showed that the gel of A. heterophyllus extract could inhibit Propionibacterium acnes bacteria. The higher the concentration of the extract, the greater the antibacterial activity. Conclusion: It can be concluded that the gel with an extract concentration of 15% gave the strongest antibacterial activity with an inhibition zone of 10.9 ± 1.18 mm.
: bahasa indonesia Oktariani Pramiastuti okta; Ratna Tika Nikhmatul Laili
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37703

Abstract

Introduction: Temu blenyeh (Curcuma purpurascens Blume) is a species of Curcuma belonging to the Zingiberaceae family. This plant contains secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols, which function as antimicrobials. Aims: The aims of this study was to determine the antimicrobial activity of the ethanol extract of intersection blenyeh against Streptococcus mutans and Candida albicans. Methods: The extraction process was carried out by maceration, and the antimicrobial activity test was carried out using paper disc diffusion. The negative control used in this study was 5% DMSO, while the positive control was 0.2% Chlorhexidine. Result: The results of phytochemical screening using the TLC method showed that the ethanol extract of intersection blenyeh contained flavonoids, alkaloids, terpenoids, saponins, tannins, and polyphenols. The results of the antimicrobial activity test of the ethanol extract of the temu blenyeh at concentrations of 30; 40; 50; 60; and 70% against Streptococcus mutans produced an inhibition zone belonging to the medium category with an average inhibition zone value of 6.75; 7.00; 7.08; 7.16; and 8.26 mm, while Candida albicans produced an inhibition zone that belonged to the very weak category with an average inhibition zone value of 2.75; 3.16; 3.33; 3.60; and 3.67 mm. Conclusion: The conclusion of this research is that the ethanol extract of intersection blenyeh has antimicrobial activity against Streptococcus mutans and Candida albicans.
Analysis of Body Weight Profile and Toxic Symptoms of White Rats on Giving Ethanol Fraction of Rambutan Peels (Nephelium lappaceum L) Anisa Pebiansyah; Lilis Tuslinah; Ade Yeni Aprilia
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.37708

Abstract

Introdiction: Rambutan peel (Nephelium lappaceum L) contains antioxidant compounds like flavonoids such as anthocyanins. The high antioxidant activity causes the high utilization of rambutan peel for treatment, but its side effects on the body are unknown. Aims: This study aimed to analyze the effect of giving rambutan rind ethanol fraction on body weight and toxic symptoms in white rats. Methods: The test was carried out using the OECD 425 method in which there were three treatment groups, each consisting of 5 test animals that were given the preparation orally. Treatment 1 was only given 1% CMC Na for 14 days; treatment 2 was given the ethanol fraction of rambutan peel 400 mg/200 g BW which was observed every 30 minutes for 4 hours, then up to 48 hours, then every day for up to 14 days. If there is none, it is continued with treatment 3, which is given the ethanol fraction of rambutan peel 1000 mg/200 g BW for 14 days. Symptoms of acute animal toxicity were observed for 14 days in that treatment. Result: The results showed that the ethanol fraction of rambutan peel doses of 400 mg/200 g BW and 1000 mg/200 g BW had a significant effect (p=0.017) in increasing the body weight profile of white rats, and there were no signs of acute toxicity in each treatment group. Conclusion: The dose of the ethanol fraction of rambutan peel 400 mg/200 g BW is the best, with an increased body weight of 25.17%.
The Potential of α- glucosidase Inhibition from Endophytic Fungi Associated in Portulaca oleracea L Siska; Asriani Suhaenah; Saripa Indira Syahraini Latuconsina
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38049

Abstract

Introduction: The discovery of endophytic microbes, which are microorganisms that reside within plant tissues and can produce bioactive compounds with similar properties to their host plants, is one possible solution to this issue. Endophytic fungi are capable of manufacturing antibacterial, antifungal, antiviral, anticancer, antimalarial, and antidiabetic agents. Portulaca oleracea L. is a weed that has spread globally. Portulaca oleracea L.has been utilized as a nutritious and medicinal plant for countless centuries. Aims: This study seeks to assess the antidiabetic potential of the endophytic fungi Portulaca oleracea L. Methods: In this study, isolation, macroscopic testing, fermentation, and antidiabetic activity testing were conducted using the alpha-glucosidase method. Twelve isolates with macroscopically distinct characteristics were obtained from of isolating the endophytic fungi. The procedure then advances to the fermentation and ethyl acetate extraction phases. Result: The results showed that there was inhibition of the α-glucosidase enzyme in hydrolyzing substrates into glucose by secondary metabolite extracts of fungi associated with the plant Portulaca oleracea L. with the highest percentage inhibition on the lab scale in the 12th isolate (83.92%). Conclusion: This measurement gives good results as an α-glucosidase inhibitor, so its potential as a source of antidiabetic drug substances is very high.
Effectiveness Of Cassia alata L Leaf Extract Decrease Blood Glucose Level On Streptozotocin-Induced Male White Rats Niluh Puspita Dewi; Febry Grasela Aula; Indah Kurnia Utami; Ayu Wulandari; Rezky Yanuarty; Wayan Wirawan
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38400

Abstract

Introduction: Diabetes mellitus (DM) is a condition in which the body either fails to produce enough insulin at the right time or fails to use it properly. Aims: The goal of this study is to show how Cassia alata L. leaf extract affects blood glucose levels in streptozotocin-induced diabetic rats. Methods: Cassia alata L. leaves therapy is an alternative treatment for DM. In this investigation, laboratory techniques were employed. Streptozotocin was administered intraperitoneally to mice at a dose of 40 mg/kg body weight initially. Except that they produce normal controls. Six groups of 30 rats each received treatment with Cassia alata L. leaf extract at doses of 500 mg/kg body weight, 600 mg/kg body weight, and 700 mg/kg body weight in addition to the usual control group. Trial outcome data were first examined using one-way ANOVA to confirm differences between treatments and then put through the DUNCAN trial. Result: As a result, it was discovered that secondary metabolites of alkaloids, flavonoids, saponins, and tannins were present in the ethanol extract of Cassia alata L. leaves. A dose of 700 mg/kg body weight is an effective blood sugar-lowering dose, with an average reduction of 121 mg/dl. Conclusion: Ethanol extract from Cassia alata L. leaves has this effect.
The Use of an Ambroxol Solution to Assess Acute Dermal Irritation on Rabbit Skin Munifah Wahyuddin; Mukhriani; Vera Olfiana; Ika Puspita Sari; Rizka Humardewayanti Asdie; Titik Nuryastuti
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38401

Abstract

Ambroxol can overcome infections due to the presence of biofilms in the body by interfering with the formation of sticky biofilms and reducing biofilm production, so it has the potential to be used in topical preparations for the treatment of infections. This study aimed to measure the irritating effect on the skin of rabbits resulting from the ambroxol solution to assess the safety of the ambroxol solution. The methods refers to BPOM 2020, namely by dabbing 0.5 ml of ambroxol solution on the back skin of rabbits, then covering it with gauze and non-irritant plasters, after 4 hours of cleaning of residues is then observed at 1 , 24, 48 and 72 hours to see whether or not there was an effect of erythema and edema arising from the influence of the experiment, and at the end of the investigation, a histopathological test was carried out. The results of the research are Macroscopically the ambroxol solution did not show any erythema and edema, so the primary irritation index score was obtained for all test solutions with a score of 0. In contrast, in the microscopic irritation test, the score for erythema was 4 and for edema was 3. . From this research, it can be concluded that the ambroxol solution non-irritating to the skin. KEYWORDS: Biofilm, ambroxol solutions, acute irritation test.
Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves Magfirah Magfirah; Indah Kurnia Utami; I Dewa Ayu Nurllya K.D; Niluh Puspita Dewi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38469

Abstract

Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmittance, drug loading, emulsification time, particle size, index polydispersity, zeta potential, dissolution test, Scanning electron microscopy (SEM ) and validation of the analysis method including linearity, precision, accuracy, LOD, and LOQ. Result: The results showed the ratio of surfactant, co-surfactant, and olive oil which produced the optimum formula for SNEDDS, namely 26 ml; 17.5 ml; and 6.5 ml,% transmittance 85.90, drug loading 45.36, emulsification time for AGF, AIF, and aqua dest was 15-16 seconds, particle size 404.1 nm, index polydispersity 0.840, zeta potential -31.4 mV, dissolution test 92.13%, SEM in the form of spherical chunks, and the result of the validation test of the analytical method with a linearity of r = 0.9902, precision 0.436%, accuracy 103.738%, LOD 1.87 µ / ml and LOQ 5.57 µ / ml. SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant provide optimal nanoemulsion characteristics and validation of the analytical method meets the requirements. Conclusion: Formula 1 SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant is an optimal formula that provides good nanoemulsion characteristics and validation of analytical methods meets the requirements

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