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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 117 Documents
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The Evaluation of Loose Powder Formulation of Manihot Starch and Maydis Starch with Natural Orange Sweet Potato Monika, Kris MonikaYanti; Dewi, Putu Indra Cyntia; Pasha, Ni Luh Sanjiwani Putri
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.47656

Abstract

Introduction: Starch is an inert additive and can be mixed with almost all drugs without causing a reaction. The use of natural dyes has a better level of safety compared to synthetic dyes. Objective: Comparing the physical evaluation of loose powder preparations made from maydis starch with manihot starch and the use of a natural dyes in the form of orange sweet potato. Method: Making orange sweet potato tuber extract using meseration and the solvent ethanol (95%): acetone (98%) (5:5). Then the powder preparation is made and a physical evaluation is carried out in the form of organoleptics, particle size distribution, homogeneity, humidity and flow rate. Results: The results show that the organoleptic test for each formula is good, the distribution of F2 particles is the best, the homogeneity test for each formula is good, the humidity test is that F1 is higher than F2 by 1.05 ± 0.01%, the flow speed test for F2 is better than F1 namely 23.53 ± 0.35 g/sec. Conclusion: Powder preparations made from Manihot starch are better than powder preparations made from Maydis starch.
Analisis Perbandingan Metode Autodock 4.2 dan Autodock Vina dalam Memprediksi Interaksi Thiazolidinedione dengan Reseptor PPARG Reynaldi, Muhammad Andre; Faradilla, Aulia; Sari, Rafika; Riza, Hafrizal; Najini, Robby
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.47852

Abstract

Introduction: Molecular docking simulation is an in silico method that plays a role in drug discovery and analyzing drug interactions with receptors. The method using Autodock 4.2 and Autodock Vina is widely used in molecular docking simulations, especially for analyzing interactions that occur between ligands and receptors. Aims: This study was aims to compare the Autodock 4.2 and Autodock Vina methods in simulating the docking of thiazolidinedione against PPARG in terms of bond energy and type of interaction parameters. Methods: The method used in this research was molecular docking simulation using Autodock 4.2 and Autodock Vina. The two methods compared the interaction results and binding affinity scores in the thiazolidinedione group against PPARG. Result: The results of this study show that the interactions using the Autodock 4.2 and Autodock Vina methods have similar amino acids that are bound and the same active site. The binding affinity score also shows that the best are troglitazone, pioglitazone, native ligand and rosiglitazone. Conclusion: Based on the results of this study, it shows that molecular docking simulations using the Autodock 4.2 and Autodock Vina methods thiazolidinedione with PPARG have similar docking score patterns and almost the same types of interactions.
Formulasi Sediaan Emulsi Kombinasi Mikroalga Chlorella sp. dengan Minyak Ikan Gurami (Osphronemus gouramy L.) Utari, Widi Gustita; Alfayzah, Faradillah; Junaida, Alfini; Maharani, Della Shinta; Pratama, Muhammad Imran Ade; Pratiwi, Eskarani Tri
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.49670

Abstract

Introduction:. Chlorella sp. is a type of microalgae that has high nutritional value and is often cultivated for various purposes such as medicines or supplements. One of the efforts that can be made to optimize the benefits of Chlorella sp. microalgae with a combination of gourami fish oil formulated in an emulsion reparation. Aims: determine the best formula and physical stability of Chlorella sp. microalgae emulsion with gourami fish oil. Method: making emulsion with varying concentrations of Chlorella sp. microalgae with gourami fish oil (F1= 1:1, F2= 2:1, and F3=3:1). The physical preparation stability test will be carried out such as organoleptic test, homogeneity, pH, viscosity, emulsion type and stability. Results: all three formulas met the requirements for physical evaluation of emulsion preparations, only in the stability test there was separation at F3 (3:1). The type of emulsion produced is oil in water (O/W). Conclusion: the best formula according to the test results is F1 & F2.
Integrating The Network Pharmacology and Molecular Docking to Uncover The Potential Mechanism Of Rutin In Fighting Diabetes Mellitus Putri, Stella Anatasya Putri; Maharani, Andi Rani Gustia; Luthfiana, Dewi; Nweze, Leonard Chinecherem; Setiawansyah, Arif; Susanti, Gita; Doloking, Haeria
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.49701

Abstract

Introduction: Rutin is a flavonol glycoside that is known to have blood sugar reducing activity. However, its molecular mechanism in reducing blood sugar level remains unclear. This study was employed to elucidate the pharmacological mechanism of rutin as antidiabetic agent. Methods: Potential target of rutin was screened in relevant databases to construct a compound-target network. Network pharmacology was utilized to identify targets associated with disease, gene ontology and KEGG pathways and confirmed its potential binding affinity using Autodock 4.2 assisted by ADT interface. Result: The result highlighted mTor, PIK3R1, and NFKB1R as a potential target of Rutin through network pharmacology. This target involved in the insulin signaling pathways, insulin resistance, type 2 diabetes mellitus, B receptor signaling pathways, AGE-RAGE signaling pathway in diabetic complications and pancreatic cancer. All docking protocols were valid with RMSD value for TNF-a, NF-KB, PI3K were 0.72 Å, 0.67 Å, ​​and 0.54 Å, respectively. The molecular docking has confirmed the potential mechanism of rutin as antidiabetic agent by stably bound with these proteins with estimated free binding energy values of -8.54 kcal/mol (NF-KB), -8.01 kcal/mol (PI3K), and -6.22 kcal/mol (TNF-a). Conclusion: The study has given insight into the molecular mechanism of rutin in the management of DM by stably bound with NF-KB, TNF-a, and PI3K. However, further laboratory experimental research is needed, particularly in vitro and in vivo assay
Comparison of L-Ascorbic Acid Content of Red Dragon Fruit (Hylocereus lemairei (Hook.) Britton & Rose) Based on the Level Maturity Fitria, Faizatul; Arifah, Farida Noor; Arni, Gerhana Dyeah Gusti; Bashori, Rizka Islamia
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.49909

Abstract

Introdiction: Red dragon fruit (Hylocereus lemairei (Hook.) Britton & Rose) It has abundant antioxidant content that is able to suppress oxidative stress from free radicals. One of them is vitamin C (L-ascorbic acid is an important molecule in plants and animals that functions as a cofactor of various enzymes. This compound is most abundant in fruits, but the level is affected by the level of ripeness of the fruit. Aims: This study also aims to determine the difference in vitamin C levels of red dragon fruit at different levels of ripeness, namely raw, half-ripe, and ripe.. Result: The analysis used includes qualitative and quantitative using UV-Vis spectrophotometer. The qualitative analysis used three tests, treatment I used FeSO4 5% and NaOH 10%, treatment II with iodine 10%, treatment III used KMnO4 as an oxidizer. All qualitative tests on red dragon fruit from all maturity levels showed positive results with vitamin C content. while quantitative analysis of vitamin C levels showed different levels ranging from raw, half-ripe, and ripe with each value of 0.7112 mg/5g; 0.5380 mg/5g; and 0.3410 mg/5g. Conclusion: These results showed that there was a decrease in vitamin C levels with the increasing level of fruit ripeness
Comparison of Tannin Levels in Brewed and Boiled Green Tea (Camellia Sinensis (L.) Kuntze) by UV-Vis Spectrophotometric Method Styawan, Anita Agustina; Atun Yuliana
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.42618

Abstract

Introduction: Green tea (Camellia sinensis (L.) Kuntze) has antibacterial and antioxidant properties that are effective in preventing and treating diseases. Green tea contains tannin compounds with antidiarrheal properties, stops bleeding and prevents inflammation of the oral mucosa. To get its properties, the way tea is processed affects the tannin content in tea. Aims: To determine the tannin content in brewed and boiled green tea using UV-Vis Spectrophotometric method. Method: The research method used was experimental research. The sample used was green tea taken from the cultivation site "Mbok Karti" Kemuning, Ngargoyoso, Karanganyar. Extracted using the reflux method. Determination of levels analyzed by UV-Vis Spectrophotometry method. Qualitative test results using FeCl3 1% that brewed and boiled green tea contains tannins by showing a change in color to blackish green. Result: The results of quantitative tests using UV-Vis Spectrophotometry obtained a comparison of tannin levels in brewed green tea of 0.05163% w/b and boiled ones of 0.04988% w/b. Where in every 200 grams of brewed green tea samples there are 103.26 mg of tannins for boiled green tea samples there are 99.67 mg of tannins. Tannin levels in brewed green tea are greater than those boiled because tannins are damaged at temperatures above 80°C. While when boiling uses temperatures above 80°C. Whereas when boiling uses temperatures above 80°C. Conclusion: So it is concluded that brewed green tea has higher tannin levels than boiled green tea.
Identification of Pathogenic Bacteria in Liquid Waste from "X" Hospital in Kediri City Tri Ana Mulyati; Binti Mu’arofah; Fery Eko Pujiono; Reza Alrayan
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.50196

Abstract

Introdiction: Hospitals can not only be a place for people to seek treatment, but they can also get diseases, especially infectious diseases. One source of the spread of infectious diseases comes from hospital waste, so proper waste processing is needed. Hospital wastewater contains many pathogenic bacteria such as Enterobacter cloacae, Bacillus sp., Kluyvera sp., Enterobacter sakazaki, Klebsiella oxytoca and E.coli. This makes it necessary to manage hospital wastewater to prevent the spread of disease, especially by pathogenic bacteria. On the other hand, research is still needed on the specific types of bacteria found in wastewater, including hospitals in Kediri City. Aims: to determine the types of pathogenic bacteria at the "X" hospital in Kediri City. Result: the density of bacteria in the bottom waste was greater than in the top and middle parts, with an average of 1,830 bacteria/100 ml. The results of the identification test showed that pathogenic bacteria contained in the waste from hospital "X" in Kediri City included Klebsiella (25%), E.coli (50%) and Pseudomonas (25%). Conclusion: The waste from "X" Hospital Kediri City contains three types of pathogenic bacteria: Klebsiella, E. coli, and Pseudomonas.
Fermentation Influences the Total Flavonoid Content and Antioxidant Activity of Syzygium polyanthum Saputri, Aurya; Christian, Yulius Evan; Hidayati, Nurul; Indah, Indah; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.51645

Abstract

Introduction: Syzygium polyanthum are widely recognized for their rich phytochemical profile, including flavonoids and phenolics. However, the bioavailability of these compounds can be limited, prompting exploration of methods to enhance their accessibility and potency. Aims: This study investigates the effects of fermentation on the bioactive compounds and antioxidant properties of Syzygium polyanthum. Methods: Three sample groups were examined: fresh leaves, leaves fermented for 3 days, and leaves fermented for 5 days. Qualitative and quantitative analyses were conducted to assess flavonoid content, phenolic compounds, and antioxidant activity in each sample. Result: The results demonstrated that fermentation significantly impacted these properties, with the 5-day fermented sample exhibiting the highest values: total flavonoid content of 279.850 mg QE/g, total phenol content of 135 mg GAE/g, and antioxidant activity with an IC50 of 51.89 ppm. Conclusion: These findings suggest that fermentation can be an effective method to enhance the nutritional and medicinal properties of Syzygium polyanthum leaves. This research provides valuable insights into the potential applications of fermented Syzygium polyanthum in the food and pharmaceutical industries, paving the way for further exploration of its health-promoting properties.
Recent Updates on the Potential of Medicinal Plants from Indonesia as Anti-Atherosclerotic Agents Prasesti, Gayuk Kalih; Narsa, Angga Cipta; Rijai, Akhmad Jaizzur; Lestari, Kharina Septi; Zulkaida, Zulkaida
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52261

Abstract

Atherosclerosis is one of the causes of problems in the cardiovascular system. This condition can be prevented by using natural products, one of which is medicinal plants. This review collects data on medicinal plants that are easily found in Indonesia that can reduce or improve atherosclerosis conditions. There are 10 plants reviewed that have a high level of safety and potential to be developed as medicine. The plant parts used are fruit and leaves. Some are commonly used as cooking spices such as turmeric and garlic which are found to be useful for improving atherosclerosis conditions. In the context of modern drug development, Indonesia holds significant potential for exploring these plants as sources of active compounds for pharmaceutical applications. Scientific studies of these natural materials are crucial for identifying bioactive components and understanding their mechanisms of action. With the right approach, Indonesia's natural resources could form the basis for developing new, safer, and more effective drugs. Additionally, Indonesia has a considerable opportunity in the global market for natural health products, including nutraceuticals and dietary supplements, as global interest in natural health solutions continues to grow.
Aktivitas Antibakteri Bakteri Asam Laktat yang diisolasi dari Makanan Tradisional Dangke, Kabupaten Enrekang, Sulawesi Selatan Tanjung, Asbar; Tanfil, Ardi; Nur, Jumriah
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52549

Abstract

Introduction: Lactic acid bacteria (LAB) produce lactic acid as the end product of carbohydrate metabolism. LAB is known to have benefits, including balancing the microflora in the gut, is bacteriostatic, and is also reported to be able to stimulate the immune system. LAB can be isolated and characterized from various food products spread throughout Indonesia. Dangke is a food product in the form of processed cow's milk which is traditionally produced by the people of Enrekang Regency, South Sulawesi. Aims: To isolate and explore the characteristics of LAB both phenotype and genotype isolated from dangke as well as in vitro studies on the potential and mechanisms of their inhibition of the growth of pathogenic bacteria. Method: Research started with the process of collecting samples of dangke in Enrekang Regency, isolation and identification of indigenous LAB in dangke samples, characterization and continued with in vitro studies on the potential of LAB from dangke to inhibit bacterial growth. Results: LAB isolated from dangke macroscopic characteristics in the form of round colonies, mucoid texture, entire edge, elevation convex and translucent with a size of 2.2 mm. Microscopic characteristics in the form of rod-shaped gram-positive bacteria. Isolated LAB has the ability to grow in extreme conditions approaching intestinal conditions, namely growing in an environment with an acidic pH range of 3-5 and tolerant to bile salts. Secondary metabolites produced can inhibit the growth of S. aureus bacteria in vitro. Conclusion: LAB isolated from dangke have demonstrated significant potential for probiotic and antibacterial applications.

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