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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 116 Documents
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Physical Characteristics and Shelf Life Estimation Of Instant Powder Drink Made from The Combination Of Yellow Sweet Potatoes and Red Beans Chaidir Masyhuri Majiding; Muhammad Nuzul Azhim Ash Siddiq; Fahrul Rozi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38633

Abstract

Introdiction: In this modern era, people demand everything fast and practical. Likewise, in terms of food or beverage, people tend to prefer instant products. Instant products are food or beverage products that are easy to serve or consume in a relatively short time, such as instant powdered drinks. The physical characteristics of instant products can be interpreted as the essential properties of their ingredients in addition to chemical and biochemical properties. The physical characteristics are needed to develop instant products that are useful for producing quality food or beverage products. Aims: Instant powder drink product from the combination of yellow sweet potatoes and red beans need to be analyzed for their physical characteristics through yield, water absorption, solubility, viscosity, and shelf life. Result: The results of the analysis showed that the instant powder drink product combination of yellow sweet potato and red bean had a yield of 30.40%, a water absorption capacity of 4.98 ml, a solubility of 63.42%, and a viscosity of 14.80 cp. At the same time, the shelf life of this product is based on the assumption of average storage temperature in Indonesia (around 28ºC-38ºC), which is approximately 5 months of shelf life. Conclusion: Based on the results of the analysis, instant powder drink products have fairly good product stability and the product can be stored at room temperature or refrigerator
Xenograft Models for Preclinical Assessment of Anticancer Therapies: A Comprehensive Review Ebrahim sadaqa; Muhammad Ikhlas Arsul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38677

Abstract

Introduction: Xenograft models play a pivotal role in preclinical studies for assessing the efficacy of anticancer medications. In this comprehensive review, we present an overview of current advancements and future prospects in xenograft research, focusing on their significance in guiding drug development and clinical translation. Aim: Our aim is to conduct an in-depth review of xenograft models, their utility in evaluating anticancer drug effectiveness and ultimately improve patient outcomes. Methods We conducted an in-depth literature search using databases such as ScienceDirect, Google Scholar and PubMed with keywords including "xenograft model, cancer CDX PDX." We then reviewed and analyzed relevant studies that utilized xenograft models in order to highlight key findings and contributions made through such models. Results: Our analysis showcases the essential role of xenograft models in assessing the efficacy of anticancer drugs. We discuss the benefits and limitations of these models, emphasizing their importance in guiding drug development and clinical decision-making. Conclusion: Xenograft models remain invaluable tools in preclinical cancer research despite their inherent limitations, with researchers continually striving to refine and enhance these models to ensure their reliability in an ever-evolving field of cancer therapeutics. Utilizing xenograft models allows researchers to evaluate anticancer drug activity more accurately while striving for improved patient outcomes.
Formulation and Antibacterial Activity of Porang (Amorphophallus muelleri Blume) Extract Gel Against Propionibacterium acne Nurshalati Tahar; Dwi Wahyuni; Rabiatul Adawiyah; Khaerani; Munifah Wahyuddin
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38744

Abstract

Introduction: The increase in bacterial resistance to antibiotics provides an opportunity to obtain antibacterial compounds from natural ingredients. Porang is a plant belonging to the Araceae family that has potential against Propionibacterium acne. Aims: This study aims to determine the effectiveness of the preparation of porang tuber extract gel against Propionibacterium acne. Methods: The porang were extraction by maceration using ethanol. The extract porang were made gel with various concentration and evaluation their stability and antibacterial activity using disc diffusion method. Result: The hedonic test showed no significant differenece each of formula and stable during storage in two weeks. On the other hand, only formula F2 and F3 can inhibit of Propionibacterium acnee. Conclusion: The porang extract can made of gel and good stability. The formula F2 and F3 have antibacterial activity.
Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review Doloking, Haeria; Lallo, Subehan; Manggau, Marianti A; Rifai, Yusnita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.39968

Abstract

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Burns Wound-Healing Activity in Male White Rats of Matoa Stem Bark (Pometia pinnata) Ethanolic Extract Lilianturi, Fresi; Fajriyah, Shofiatul Fajriyah; Shoviantari, Fenita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42469

Abstract

Introduction: Burns are a global public health problem. The activity of herbal products in stimulating burn wound healing is supported by many animal studies and few clinical trials. The people of Papua New Guinea use the chewed bark of the matoa tree to heal burns. Matoa's stem bark contains flavonoids, terpenoids and tannins that promote wound healing. These compounds have antimicrobial, antioxidant and wound healing properties. They increase blood clotting, fight infection and accelerate wound healing. Aims: The aim of this research was to determine whether ethanol extract of Matoa stem bark has anti-burn activity against male white rats of the Sprague Dawley strain. Method: In this study, a method was used to measure the area of burn wound in 5 treatment groups for 14 days. Group I were treated with the MEBO ointment (the positive control group); Group II with vaseline flavum (the negative control); Group III was given Matoa bark extract ointment at a concentration of 10%; group IV at a concentration of 20%, while group V at a concentration of 30%. Result: Qualitative analysis of chemical compounds shows that the ethanolic extract of Matoa stem bark contains flavonoids, triterpenoid tannins, and saponins. Ethanol extract of matoa bark 20% and 30% had burn wound healing activity in male Sprague-Dawley white rats. Activity was significantly different from negative control and not significantly different from positive control. Conclusion: A 20% and 30% ethanolic extract of the stem bark Matoa is considered a topical agent for use in treating burns wound.
Mechanism of Apoptosis Induction in Oral Cancer Cells by Uncaria-derived Flavonoids Ridho, Fiki Muhammad; Iqbal, Mohammad; Agustina, Arista Widya; Syachputra, Andika Julyanto
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42944

Abstract

Introduction: Oral cancer is cancer that occurs in the oral cavity and oropharynx, ranking 16th as the most common cancer found with a number of new cases of 377,713 and a number of deaths of 177,757 cases in 2020. Several types of flavonoids contained in the genus Uncaria were found to have anticancer bioactivity, one of which is inducing apoptosis in oral cancer cells. Aim: This study aims to review the potential and mechanisms involved of flavonoids in inducing apoptosis in oral cancer cells. The literature review method was used in this study by conducting a systematic literature search on PubMed, ScienceDirect, and Google Scholar until October 2023. Results: A total of 13 studies were included in this study and our findings conclude that flavonoids, especially quercetin, kaempferol, rutin, umbelliferon, and epigallocatechin gallate (EGCG), have the potential to be used as anticancer agents, one of which has the ability to induce apoptosis, both through extrinsic and intrinsic pathway, in several oral cancer cell lines, including SCC-4, SCC-9, SCC-25, SAS, KB/VCR, Tca-8113, YD10B, YD38, MC-3, KB, and HSC-3, through the mechanism of inhibiting anti-apoptotic expression, activating pro-apoptotic protein expression, generating ROS, and regulating PI3K/AKT, MAPK, and JAK/STAT signaling pathways. Conclusion: We conclude that Uncaria-derived flavonoids hav the potential to induce apoptosis, both extrinsic and intrinsic, in oral cancer cells.
Formulation and Characterization of Edible Film with Concentration Various of Sodium Carboxymethyl Cellulose from Kepok Banana (Musa paradisiaca L.) Bark and Plasticizer Ningsi, Surya; Abbas, Nurfahima; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.45330

Abstract

Introduction: Bark of kepok banana (Musa paradisiaca L.) contains high cellulose that can be synthesized into sodium carboxymethyl cellulose (Na-CMC). Na-CMC can be used as a raw material for the preparation of edible film. Aims: The purpose of this study was to determine the concentration of sodium carboxymethyl cellulose from kepok banana bark combine with plasticizer to produce edible films with good characteristics and quality. Methodology: Edible films were made with varying concentrations of 6%, 10%, and 14% Na-CMC; 4% glycerol and 9% sorbitol as plasticizer. Edible films were made using casting method and characterized including organoleptic test, thickness, pH, water absorption, elongation, and tensile strength. Result: Edible film made is in the form of thin layer, transparent white in color, and odorless; thickness 0,10±0,01-0,38±0,01 mm; pH 7,1±0,08-7,7±0,04; moisture content 35,47-91,97%; elongation 16,33±3,66-53,29±6,13%; and tensile strength 0,0528±0,00-3,9871±0,04 MPa.. Conclusion: Different concentrations of Na-CMC and plasticizer affect the characteristics produced. The best result based on Japanese Industrial Standard (JIS) is formula F5 with 10% Na-CMC concentration and 9% sorbitol as plasticizer
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Aaptamine Enhanced Doxorubicin Activity on B-Cell Lymphoma 2 (Bcl-2): A Multi-Structural Molecular Docking Study Setiawansyah, Arif; Susanti, Gita; Alrayan, Reza; Hadi, Ismanurrahman; Ikhlas Arsul, Muhammad; Luthfiana, Dewi; Wismayani, Leni; Hidayati, Nurul
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.46796

Abstract

Doxorubicin, a widely used chemotherapeutic agent, targets Bcl-2, but its efficacy can be limited by drug resistance. Its combination with natural derived compound can be a therapeutic approach to overcome this problem. This study aimed to investigate the molecular interactions and binding affinities of aaptamine and doxorubicin with Bcl-2 using molecular docking simulations, and to evaluate the potential synergistic effects of their combination. Molecular docking studies were performed to predict the binding modes and affinities of aaptamine and doxorubicin along with their combination to Bcl-2. Molecular docking simulation results showed that aaptamine binds to the BH3 binding groove of Bcl-2, forming key interactions with residues like Asp70, Tyr67, Phe112 and Glu111. Aaptamine stabilized the binding of doxorubicin to Bcl-2 through hydrophobic bonding and van der Waals interactions, resulting in enhanced binding affinity. The combination of aaptamine and doxorubicin exhibits synergistic anticancer effects by enhancing the binding affinity of doxorubicin to Bcl-2. Molecular docking simulations provided insights into the stabilizing interactions between aaptamine, doxorubicin, and Bcl-2, suggesting a potential strategy for overcoming Bcl-2-mediated drug resistance in cancer. However, further in vitro investigation is needed to be implemented.
Breaking Boundaries: A Comparative Analysis of Weak vs. Strong Bases in Eugenol Isolation from Syzygium aromaticum (L.) Merr. & LM Perry Handayani, Dwi; Sitindaon, Rina SE; Hidayati, Nurul; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.47483

Abstract

Eugenol, a phenolic compound classified within the phenylpropanoid group, stands out as a key constituent of clove oil, boasting a myriad of biological activities. Its isolation typically involves the utilization of an alkaline solution, yet the choice of alkaline agent significantly impacts the yield of eugenol. This study delves into the impact of various alkaline solutions on the isolated eugenol content from Syzygium aromaticum essential oil, leveraging its acidic properties to form a soluble eugenol salt in an aqueous medium. Employing alkaline solutions with a concentration of 1 N, including both strong bases (such as KOH, NaOH, and Ba(OH)₂) and weak bases (like Ni(OH)₂, Al(OH)₃, and Zn(OH)₂), we scrutinized the diverse outcomes on eugenol content. Results revealed that KOH yielded the highest eugenol content at 96.91%, while Zn(OH)₂ displayed the lowest at 20.99%. Nevertheless, the potential of weak alkaline solutions in the eugenol isolation process from Syzygium aromaticum essential oil remains noteworthy. Future endeavors should focus on optimizing the ideal concentration of weak alkaline solutions for this purpose.

Page 9 of 12 | Total Record : 116

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