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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 115 Documents
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In Vitro Drug Release Evaluations of Piroxicam Self-Nanoemulsifying Drug Delivery System (SNEDDS) Nugroho, Septiawan Adi; Alrayan , Reza; Prasongko, Erfan Tri; Hutami, Shabrina Nindya
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52795

Abstract

Introdiction: Piroxicam is Non-Steroidal Anti-Inflammatory Drug that belongs to the BCS Class 2, characterized by low solubility. The SNEDDS (Self-Nanoemulsifying Drug Delivery System) approach for piroxicam is believed to enhance its solubility and accelerate drug release. Aims: This study aims to demonstrate that SNEDDS piroxicam has a faster drug release rate compared to piroxicam powder and commercially available piroxicam capsules. Methods: SNEDDS formulation equivalent to 20 mg of piroxicam, containing a combination of oleic acid, Kolliphor EL, and Transcutol in a ratio of 2:7:4, was tested for drug release using a dissolution method in simulated gastric fluid without enzymes at pH 1.2. The concentration of dissolved drug was measured using a validated spectrophotometric method. Result: At the 45th minute, the dissolution rate of piroxicam SNEDDS reached 101.525%, significantly higher than 47.550% achieved by piroxicam powder and 87,081 % commercially piroxicam capsules at the same time. Additionally, the dissolution efficiency of piroxicam SNEDDS is superior, with a rate of 85.539%, compared to 34.510% for piroxicam powder and 66.17% for commercially available piroxicam capsules. Conclusion: The development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) for piroxicam has shown promising potential to improve solubility and drug release, as demonstrated by superior in-vitro release rates compared to piroxicam powder and commercial piroxicam capsules
Organic Nanoparticle Genotoxicity: Current Understanding and Future Testing Needs Sadaqa, Ebrahim; Setiawansyah, Arif; Nugroho, Bambang Hernawan; Hidayati, Nurul; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52943

Abstract

Organic nanoparticles derived from biocompatible materials like chitosan, alginate, and lipids have garnered immense interest for drug delivery, bioimaging, and other biomedical applications. However, as their use rapidly expands, a comprehensive evaluation of their potential genotoxicity is crucial to ensure safe implementation. This review provides an in-depth analysis of the genotoxic risks associated with these organic nanoparticles. The review elucidates how the unique physicochemical properties of organic nanoparticles can induce genetic damage through mechanisms such as direct DNA binding, oxidative stress, inflammation, and impairment of DNA repair pathways. Importantly, this genotoxicity can occur even in the absence of overt cytotoxicity, leading to heritable mutations and long-term adverse effects like cancer and reproductive abnormalities. A critical assessment of established and emerging genotoxicity testing methods, including their strengths, limitations, and opportunities for standardization, is presented. The review synthesizes findings from existing in vitro and in vivo studies, revealing the contrasting genotoxic profiles of different organic nanoparticle formulations and exposure scenarios. Furthermore, the review provides insights into the multifaceted factors influencing nanoparticle genotoxicity, guiding the strategic engineering of safer designs. This comprehensive analysis underscores the pivotal importance of rigorous genotoxicity screening in the responsible development of organic nanomaterials. By harmonizing their innovative capabilities with a commitment to genetic integrity, this review paves the way for realizing the vast potential of organic nanoparticles while safeguarding human and environmental health.
uni efektivitas hypnotif sedative dari ekstrak Buah tabu air (legendária sideraria) terhadap menti Jantan Putih galar swiss webster Niza, Hairun; Putri, Nadilah; Marpaung, Mauritz Pandopo; Afriliza, Dini; Wilsya, Mayaranti
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.53228

Abstract

Introduction: The rising prevalence of sleep disorders and concerns about conventional sedative medications' side effects has created an urgent need for safer therapeutic alternatives. Aims: This study investigated the sedative-hypnotic properties of Lagenaria siceraria fruit ethanol extract in a controlled laboratory setting using Swiss Webster male mice. Methods: The research employed a randomized design with 28 male mice (2-3 months old, 20-30 grams) divided into seven groups. Two control groups received either 0.5% NaCMC (negative control) or 0.013 mg/kgBW Diazepam (positive control). The remaining five experimental groups were administered L. siceraria extract at doses ranging from 21 to 49 mg/kgBW. All treatments were administered orally under controlled conditions. Statistical analysis using two-way ANOVA revealed significant differences between treatment groups (p<0.005). Result: Subsequent Duncan's test analysis demonstrated that the highest dose of L. siceraria extract (49 mg/kgBW) produced sedative-hypnotic effects comparable to the standard Diazepam treatment. This finding suggests that L. siceraria extract could potentially serve as a natural alternative to conventional sedative medications. Conclusion: The results of this study provide compelling evidence for the sedative-hypnotic properties of L. siceraria extract, warranting further investigation into its mechanism of action and potential therapeutic applications. Future research should focus on establishing optimal dosing regimens and evaluating long-term safety profiles before clinical implementation can be considered.
Potential of Thibbun Nabawi Habbatusauda (Nigella sativa); Review of the Active Pharmacological Timoquinone Mardan, Mardan; Ismail, Isriany; Rauf, Afrisusnawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 4 No 2 (2021)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Habbatusauda or Black Seed or Black Cumin (Nigella sativa) has been widely mentioned in various Islamic studies, including its potential as a "cure for all diseases except death. The hadith can be interpreted as improving immunity and enhancing memory (physical and cognitive aspects). Scientifically, the high content of thymoquinone and DHA in Black Seed plays a major role as an immunomodulator and brain nutrition. Black Seed contains both hydrophilic and lipophilic compounds. Amino acids, proteins, carbohydrates, essential oils, fixed oils, sterols, alkaloids, saponins and crude fiber, and minerals, thymoquinone, p-cymene, longifoline thujene, carvacrol, cubebene, pinene, limonene, pinene, sabinene are the ingredients. Timoquinone is present at a concentration of 3.5-8.7 mg/g in oil. Black Seed Oil is also high in DHA (3%). The content of the active compound Timoquinone is most responsible for its wide range of effects.
Toxicity and Antioxidant Activity of Teabags of Mangrove Lenggadai (Bruguiera parviflora) and Stevia (Stevia rbaudiana Bertoni) Leaves Andjelie, Tiara; Lubis, Minda Sari; Nasution, Haris Munandar; Rani, Zulmai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52548

Abstract

Introduction: Mangrove plants are known to have a lot of potential as medicine. One of the most commonly found mangroves is the lenggadai mangrove (Bruguiera parviflora).  Utilization of herbal drinks is made to prevent the onset of various diseases. The mixed teabag of mangrove lenggadai leaves and stevia leaves (Stevia rbaudiana bertoni) is named Mangrove Lenggadai Stevia (MLS) teabag. Aims: the purpose of this study is to see which MLS teabag formulation has good antioxidant activity and toxicity activity. Methods: The research conducted was experimental in nature. The data collected are quantitative and qualitative data which are taken from the results of sample collection, physical characteristics of MLS teabag quality, phytochemical screening of simplisia, antioxidant activity test using DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, toxicity test using Brine Shrimp Lethality Test (BSLT) method on Artemia salina Leach shrimp larvae, stability and hedonic level Result: MLS teabags have characteristics according to the quality requirements of SNI 4324:2014. The results of determining the antioxidant activity of MLS teabags obtained an IC50 value of 13.38 µg/mL. The results of the toxicity test of MLS teabags obtained an LC50 value of 8.74 µg/mL. Conclusion: MLS tea bags have physical quality characteristics that meet the requirements of SNI 4324: 2014 and have the potential as antioxidants and toxicity activity against Artemia salina Leach.
Acute Antinflammatory Effect of Marsdenia tinctoria Leaf Water Extract in Carragenan-induced Rats Supito, Sarasvati Sekar Ayu; Sutjiatmo, Afifah Bambang; Kusumawardhana, Gelar Taufiq; Vikasari, Suci Nar
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52967

Abstract

Introduction: Tarum areuy (Marsdenia tinctoria) is a plant whose efficacy has not been widely explored. Traditionally used for infections and inflammation related disease.. Aims: To determine the anti-inflammatory effect of M. tinctoria leaf water extract on animals induced by carrageenan.Methods: Extract preparation by boiling in water. Animals were divided into groups, namely control, comparison (diclofenac sodium 4.5 mg/kgBW) and M. tinctoria leaf water extract (20, 40, 80 mg/kgBW). Induction of 0.1 mL of 1% carrageenan was given as much as intraplantar and the test preparation was given orally. Inflammatory and inflammatory inhibition percentages were measured every 30 minutes for 240 minutes. The t-test was utilized in data analysis.  Result: All test doses of M. tinctoria leaf water extract was effective to reduce inflammation in comparison to the control (p<0.05). A dose of 20 mg/kgBW was the optimal anti-inflammatory.. Conclusion: M. tinctoria leaf water extract has the potential as an anti-inflammatory.
Development of Captopril Analysis Method in Traditional Antihypertensive Medicine by Densitometry Risthanti, Reine; Sumartha, I Gede Ari; Alkindi, Fawandi Fuad; Budiono, Ryanto; Ananda, Rizka Widya
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.53926

Abstract

Introduction: The utilisation of traditional medicine to address health concerns is on the rise. One such traditional medicine product is antihypertensive herbal medicine. The Indonesian Food and Drug Authority (BPOM) has identified the presence of medicinal chemicals in traditional medicinal products, which has the potential to pose a significant risk to consumers. Captopril is one of the antihypertensive drugs that may be added as BKO in herbal medicine. Aims: The objective of this study was to develop a method for the analysis of the chemical content of captopril in antihypertensive herbs sold online under the following brands: A, B, C, and D. Method: The analytical method used was TLC-densitometry, utilising a mobile phase of chloroform: methanol (7:3). Result: The results show that the method used has fulfilled the requisite validation criteria for linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, and precision parameters. The results of the analysis demonstrated that the sample did not contain any detectable quantities of captopril. Conclusion: The developed method has been proven to be effective for the analysis of captopril in antihypertensive herbal products and it can be confirmed that there is no presence of captopril medicinal chemicals in samples from brands A, B, C, and D
Comparison of Caffeine Compound Levels in Brewed and Boiled Oolong Tea Leaves (Camellia sinensis (L.) Kuntze) Based on Different Processing Methods Styawan, Anita Agustina; Aristhasari Putri; Ocha Ardela Fitria Kresnaya
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.54457

Abstract

Introduction: Tea contains many compounds that are beneficial for the body, namely caffeine. The process of brewing tea with a time and temperature that is not optimal can affect the caffeine content in it. And the brewing process by heating can widen the distance between the molecules in the tea. The higher the temperature and the longer the brewing time, the higher the caffeine content.. Aims: This study aims to analyze the caffeine content of brewed and boiled oolong tea, then compare the caffeine content of oolong tea with brewing (without heating) and boiled (with heating) processes. Methods: The research method used is experimental. This study used dried samples of oolong tea leaves (Camellia sinensis (L.) Kuntze). Quantitative analysis using UV-Vis Spectrophotometry. Result: Quantitatively, the caffeine content in brewed oolong tea was 3.522% w/w and the caffeine content in boiled oolong tea was 4.001% w/w. The conclusion of this study is that there is no significant difference in caffeine levels in brewed and boiled oolong tea with a significant value of P> 0.05.
Antihyperuricemia Effectiveness of Ethanol Extract Combination of Bitter Melon (Momordica charantia) and Moringa (Moringa oleifera L.) in Caffeine-Induced Rats (Rattus norvegicus) Mahmudah, Rifa'atul; Yusuf , Muhammad Ilyas; Risnawati, Risnawati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.55482

Abstract

Introduction: Hyperuricemia is a condition characterized by elevated blood uric acid levels exceeding normal limits. Herbal medicines, such as bitter melon (Momordica charantia) and moringa (Moringa oleifera), have potential efficacy in reducing uric acid levels. This study aims to evaluate the effectiveness of a combination of BME (Bitter Melon Extract) and MLE (Moringa Leaf Extract) as an anti-hyperuricemia treatment. Aims: This experimental study assesses the quality standardization of the extracts, including specific and non-specific parameters. The effectiveness of the combined extracts was tested on caffeine-induced hyperuricemic rats, which were divided into six groups: negative control (Na.CMC 0.5%), positive control (Allopurinol), and four treatment groups receiving different doses of BME and MLE (D1, D2, D3, D4).  Result: The results showed that the combination of BME and MLE met the quality standard parameters. All four dosage variations demonstrated a reduction in uric acid levels. Among them, D3 (1.8 mg/kg BW of BME and 600 mg/kg BW of MLE) was the most effective, with a 41.3% reduction in uric acid levels. Statistical analysis using the Least Significant Difference (LSD) method indicated a significant difference between the negative control group and the treatment groups on the 7th day. Conclusion: The combination of BME and MLE has proven to be effective as an anti-hyperuricemia agent. Further research is needed to explore the potential of herbal medicines as alternative treatments for hyperuricemia.
Antiobesity Effect of NADES (Natural Deep Eutectic Solvent) Extract of Purslane Herb (Portulaca oleracea L.) on Male Rats (Rattus norvegicus) Azizah, Rizqi Nur; Santi, Irma; Awali, Muhammad Noer; Putra, Bayu; , Faradiba
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.56230

Abstract

Introduction: Obesity is a metabolic disorder characterized by excessive fat accumulation, leading to various health complications. One potential approach to managing obesity is through natural products, such as medicinal plants. Aims: This study evaluates the anti-obesity activity of purslane (Portulaca oleracea L.) extract obtained using the green extraction method in male rats (Rattus norvegicus). Method: A total of 18 male rats were divided into six groups: normal control, negative control (Na-CMC + NADES), positive control (orlistat), and three treatment groups receiving NADES Purslane Herb Extract (NPHE) at doses of 50, 100, and 200 mg/kg BW. The treatment groups were induced with a high-fat diet for 30 days, followed by 14 days of therapy. Result: Statistical analysis using One-Way ANOVA and Bonferroni post-hoc test showed that NADES purslane herb extract exhibited significant anti-obesity effects, with the most effective dose being 200 mg/kg BW, which reduced body weight by 13.004% and BMI by 17.935% in male rats. Conclusion: These findings suggest that purslane extract has potential as a natural anti-obesity agent. Further research is needed to explore its bioactive compounds and mechanisms of action, supporting its potential development in pharmaceutical and nutraceutical applications.

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