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Acta Chimica Asiana
Published by Universitas Mataram
ISSN : 2550049x     EISSN : 25500503     DOI : -
Core Subject : Science,
Chemistry
Acta Chimica Asiana (online ISSN 2550-0503, print ISSN 2550-049x) is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles in all areas of Chemistry and Chemical Engineering. Significant finding that is insufficient to be presented as comprehensive paper but needs to reach the reader immediately may also be submitted as a short communication. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal published by the Indonesian Chemical Society, Chapter Nusa Tenggara and the University of Mataram. All papers published free of charge. Upon request, language assistance may also be provided to ensure valuable works in chemistry meet their readers. Acta Chimica Asiana is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including applied chemistry, and chemical engineering. Subject areas include (but are by no means limited to): 1. Analytical chemistry, including new techniques and instrumentation 2. Biochemistry and medicinal chemistry 3. Inorganic chemistry, including main group, transition metal, and f-block compounds, as well as coordination, organometallic, and solid state chemistry 4. Materials chemistry of hard and soft matter, from the nanoscale upwards 5. Nuclear chemistry and radioactivity 6. Organic chemistry, including synthesis, characterization, and properties of organic compounds, as well as study of organic reactions and their mechanisms 7. Physical chemistry and chemical physics 8. Sustainable, green, and environmental chemistry 9. Theoretical and computational chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 116 Documents
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Network pharmacology and molecular docking simulation uncovered the potential of hexacyclinic acid as anti-osteoarthritis by regulating IL-17 signaling pathway Setiawansyah, Arif
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.238

Abstract

Hexacyclinic acid has shown promising pharmacological activities, yet its molecular mechanisms and therapeutic potential remain largely unexplored. This study aimed to identify potential disease targets and elucidate the mechanism of action of hexacyclinic acid using an integrated computational approach. We employed network pharmacology analysis to predict potential targets and pathways of hexacyclinic acid using SuperPred and Swiss Target server, followed by protein-protein interaction network construction via STRING database. Pathway enrichment analysis was performed using ShyniGO and DAVID databases. Molecular docking studies were conducted using AutoDock Vina to evaluate binding affinities between hexacyclinic acid and identified target proteins. Binding poses and interactions were visualized using Biovia Discovery Studio Visualizer. Disease prediction analysis identified osteoarthritis as the most promising target, with the IL-17 signaling pathway emerging as the most significant KEGG pathway. TNF-α and IL-1β were identified as key molecular targets within this pathway. Molecular docking simulations corroborated these findings, revealing favorable binding energies between hexacyclinic acid and TNF-α (-8.62 kcal/mol) and IL-1β (-8.76 kcal/mol). These results suggest that hexacyclinic acid may exert its anti-osteoarthritis effects by modulating the IL-17 signaling pathway, particularly through interactions with TNF-α and IL-1β. The strong binding affinities observed indicate a potentially high efficacy of hexacyclinic acid in targeting these inflammatory mediators. These results have significant clinical implications, potentially leading to the development of new therapeutic strategies for osteoarthritis management with reduced side effects compared to current treatments. Future research should focus on experimental validation through in vitro and in vivo models to confirm these computational predictions and establish hexacyclinic acid as a viable candidate for clinical development
Hydrothermal synthesis of crystalline Aluminium(III)-Tartrate: effect of tartrate type and molar ratio Prananto, Yuniar Ponco; Purwonugroho, Danar; Dzakwan, M. Naufal Tsaqif; Setianingsih, Tutik; Syarifah, Nidatul
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.244

Abstract

Aluminium(III)-tartrate (Al-T) complex is a compound that commonly used as mordent in textile dyeing. This complex is soluble in hot water; thus, information on the isolation of crystallised Al-T is limited. Isolation of crystallised Al-T is needed to gain a high purity complex for further application in the textile industry. This study aims to synthesize and isolate crystalline complex of Al-T. Hydrothermal method was used to obtain the targeted complex. Effects of tartrate precursor and Al(III):tartrate mol ratio in the synthesis of Al-T complex were also investigated. The synthesis was done at 150 °C for 24 hours in several Al(III):tartrate mol ratios (1:2, 2:1, and 2:3) using two different tartrate precursors, namely L-tartaric acid and KNa-tartrate. The synthesized complexes were identified by infrared spectroscopy and powder-XRD analyses, and then further characterised by UV Vis - DRS, DTA-TGA, and SEM. Experimental data shows that the mol ratio affects the precipitation of the Al-T complex, in which a white crystalline solid was only precipitated out from the 2:1 reaction by both tartrate precursors. Different tartrate precursors used in the synthesis may alter the crystallization and result in an Al-T complex with slightly different thermal decomposition profile, UV-Vis DRS spectra profile, and different yield due to the different nature of the tartrate precursor. This finding is expected to support the possibility of Al-T mass production as mordent in textile dyeing
Biomass waste as a photoprotective agent in the formulation of sunscreen preparation Vioniken, Elzandra Imola; Ratnasari, Devi
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.246

Abstract

UVA and UVB radiation from sunlight may lead to erythema and skin cancer. Those risks can be reduced by using photoprotective agents. Sunscreen is a photoprotective agent that successfully protects the skin from ultraviolet radiation. However, the active ingredients containing synthetic chemicals can hurt the skin. This review provides knowledge regarding using lignin compounds obtained from biomass waste as photoprotective agents that have been investigated for performance. The method of study applied is a literature review of original research conducted within the last ten years. Data were searched using the keywords biomass waste, photoprotective, and sunscreen on the Pubmed and Google Scholar websites. The results showed that lignin can be found in varying levels of biomass waste, such as banana stems, coconut shells, corn stalks, rice straws, and others. Delignification of lignin from biomass can be accomplished using basic solvents, acidic solvents, organosolvents, and Deep Eutectic Solvents (DES). The delignification procedure using DES is considered more environmentally friendly and less toxic. The higher the lignin concentration in the cream, the greater the SPF value. This is because lignin contains phenolic, ketone, and other chromophore functional groups capable of absorbing UV radiation. Furthermore, converting lignin molecules into nanoparticles and modifying their chemical structure may enhance the SPF value of lignin-containing creams. The addition of phenolic hydroxyl auxochrome groups and catechol units to the lignin molecule was found to increase the SPF value of lignin. It may be concluded that lignin can be utilized as a photoprotective agent, and biomass waste can be transformed into high-value cosmetic products.
Degrading colour with magnets: degradation of methylene blue MnOx-Fe3O4 using the photo-fenton method Ramadhanti, Aulia Rizki; Awaluddin, Amir; Nurhayati, Nurhayati; Siregar , Sri Hilma
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.236

Abstract

One practical approach to reducing methylene blue (MB) levels is through the Advanced Oxidation Processes (AOPs) method, which utilizes hydroxyl radicals (•OH) to degrade the colored compounds. AOPs have proven to be a highly efficient technology in treating coloured wastewater, with the ability to produce strong oxidants that break down molecules that are difficult to decompose naturally. One of the widely used AOP technologies is the Fenton heterogeneous catalyst, which is known for its affordable price, ease of reuse, and the fact that it does not produce solid sludge. In this study, MnOx-Fe3O4 composites were synthesized using the hydrothermal method with variations in the addition of Fe3O4 in ratios of 1:5 and 1:10. Several variables tested in the MB degradation process included the volume of H₂O₂ used (5, 10, and 15 mL), composite contact time, and the effect of pH on degradation efficiency. The results showed that the addition of 5 mL of H₂O₂ to the MnOx-Fe3O4 composite significantly increased the degradation efficiency of methylene blue up to 92.54% within 120 minutes, with an optimal pH of 9. The addition of H₂O₂ was shown to accelerate the degradation process, which shows great potential in wastewater treatment applications. In addition, the magnetic properties of the MnOx-Fe3O4 composite allow easy separation of the catalyst after the treatment process, thus accelerating and facilitating the recovery and reuse of the catalyst. This degradation process involves the formation of hydroxyl radicals (•OH), which are highly reactive and can efficiently break down MB molecules. Thus, this study demonstrates that the MnOx-Fe3O4 composite has the potential to be a highly efficient and environmentally friendly catalyst for treating coloured wastewater. This catalyst is also expected to be reusable in several cycles, making it a sustainable and effective choice in industrial wastewater treatment.
Gravity column chromatography of n-hexane fraction of Rhizophora mucronata leaves from West Nusa Tenggara and their antioxidant activity Permatasari, Lina; Muliasari, Handa; Hafizah, Qori'atul; Rizka Nirmala, Annisa; Ilmi, Hilkatul
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.243

Abstract

In the last few decades, many diseases have been caused by Radical Oxidative Stress (ROS) or free radicals. Compounds that act as natural antioxidants have been widely developed to counteract these free radicals. Rhizpora mucronata was a mangrove species reported to possess strong antioxidant activity. However, the research is limited to extracts; fractions with more specific compound components have not been explored. The n-hexane fraction of R. mucronata leaves was reported to have high total flavonoid content (TFC). The TFC has a positive correlation with antioxidant activity. Therefore, this study aimed to simplify the compound components in the n-hexane fraction of R. mucronata leaves using gravity column chromatography (GCG) and determine their antioxidant activity. The n-hexane fraction was fractionated using GCG with increasing solvent polarity (n-hexane, chloroform, ethyl acetate, and methanol). The fractions were tested for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The fractionation using GCG resulted in 80 fractions. These fractions were grouped based on their thin-layer chromatography (TLC) profiles, resulting in 12 groups of fractions (A-L). Fractions D, F, G, H, J, K, and L, the fractions with enough yield, determined their antioxidant activity using the DPPH and ABTS methods. Fractions D and J tested by the DPPH method had IC50 values of 28.68 ± 1.58 ppm and 9.59 ± 0.39 ppm, respectively. Meanwhile, fractions D and J tested by the ABTS method had IC50 values of 15.10 ± 1.00 ppm and 3.16 ± 0.55 ppm, respectively. Meanwhile, fractions F, G, H, K, and L exhibit antioxidant activity with IC50 values greater than 100 ppm. Fractions D and J have potent antioxidant activity, and both were tested using DPPH and ABTS methods. Therefore, fractions D and J can be further developed as natural antioxidants.
Tailoring AlGaN nanoalloys with transition metal dopants for enhanced energy storage: A DFT Study Mollaamin, Fatemeh
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.245

Abstract

The notable fragile signal intensity close to the parallel edge of the nanocluster sample might be owing to silicon or germanium binding induced non-spherical distribution of AlGaSiN or AlGaGeN heteroclusters. However, a considerable deviation exists from doping atoms of palladium or platinum as electron acceptors on the surface of AlGaPdN or AlGaPtN heteroclusters. Then, magnetic parameters exhibited the same tendency of shielding for palladium or platinum; however, a considerable deviation exists from doping atoms of palladium or platinum as electron acceptors on the surface of Pd–AlGaN or Pt–AlGaN hetero-clusters. Therefore, it can be considered that palladium or platinum atoms in the functionalized AlGaPdN or AlGaPtN might have more impressive sensitivity for accepting the electrons in the process of hydrogen adsorption. The advantages of platinum or palladium over aluminum gallium nitride include its higher electron and hole mobility, allowing platinum or palladium doping devices to operate at higher frequencies than silicon or germanium doping devices. As a matter of fact, it can be observed that doped heteroclusters of AlGaPdN or AlGaPtN might ameliorate the capability of AlGaN for energy storage.
Coconut shell charcoal briquettes production using banana corm adhesive Pratika, Remi Ayu; Armadany, Fery Indradewi; Fahyuddin
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.249

Abstract

The production of biomass-based briquettes from coconut shell charcoal and banana corm adhesive has been successfully carried out. This research aims to determine whether the banana corm may serve as an adhesive for briquette production from coconut shell charcoal. The concentration of banana corm utilized as adhesive is 10, 20, 30, 40, and 50%. For comparison analysis, this study also employed tapioca flour adhesive with the same concentration. The briquettes adhere to the SNI 01-6235-2000 standard for briquettes. The quality of briquettes is determined based on fixed carbon content and calorific value. The minimum standard calorific value and fixed carbon content are 5000 cal/g and 65%, respectively. Briquettes with a 90:10 ratio (coconut shell charcoal to banana corm adhesive ratio) had the highest calorific value of 7250 cal/g and fixed carbon content of 80.04%. In comparison, the tapioca flour adhesive provides a calorific value and fixed carbon content of 6995 cal/g and 81.09%, respectively. Furthermore, another indicator that determines briquette quality is the content of moisture, ash, and volatile matter. Briquettes with a 90:10 ratio possessed low moisture content (3.55%), ash content (6.45%), volatile matter content (9.96%), and burning rate (0.020 g/sec). This result indicates that the briquettes with a 90:10 ratio exhibit the greatest quality. Briquettes with banana corms adhesive have similar characteristics to tapioca flour, especially in terms of calorific value. As a result, the highlight of this research lies in offering banana corm, which has scientific contribution and future potential as an alternative adhesive in the briquetting process
Bioactive peptides from traditional homemade fermented foods as an alternative for treatment Suraya, Nabella; Tjandrawati Nugroho, Titania; Ismawati, Ismawati; Saryono, Saryono
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.252

Abstract

Bioactive peptides in fermented foods are attracting scientific interest due to their prospective applications as nutraceutical and functional foods. Conventional fermented foods are naturally processed at home through the action of lactic acid bacteria (LAB). These bacteria break down food components and generate lactic acid, various organic acids, hydrogen peroxide, carbon dioxide, and short-chain peptides, which offer numerous health benefits. The bioactive peptides formed during fermentation exhibit diverse biological functions influenced by their structural compositions. Following enzymatic hydrolysis, peptides initially inactive within the native protein matrix are released and exhibit biological activity. This review aims to comprehensively examine the functional properties of bioactive peptides derived from the fermentation of traditional foods, with a particular emphasis on their therapeutic potential, including antidiabetic, antihypertensive, and anticarcinogenic activities. This review examines the health benefits of various bioactive peptides produced by lactic acid bacteria during the fermentation of traditional foods. Microbial bioactivity during the fermentation process can produce hydrolytic enzymes that break down macromolecules in food into smaller compounds, such as bioactive peptides. A wide range of peptides have been identified as improving insulin uptake, decreasing blood glucose concentrations, and inhibiting key enzymes involved in the pathogenesis of diabetes. Specific peptides exert antihypertensive effects by acting as angiotensin-converting enzyme (ACE) inhibitors, thereby preventing the transformation of angiotensin I into angiotensin II. Moreover, some bioactive peptides demonstrate immunomodulatory properties by enhancing immune responses and inducing apoptosis in cancer cells. This article provides a comprehensive overview of the therapeutic and health-promoting potentials of bioactive peptides derived from fermented foods.
SINTESIS DAN KARAKTERISASI KOMPOSIT Fe3O4-ARANG AKTIF KULIT BUAH IHAU (Dimocarpus Longan var. malesianus Leenh.) SEBAGAI ADSORBEN METHYLENE BLUE Ananda, Azizah Fithri; Wirawan, Teguh; Widodo, Nanang Tri
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.253

Abstract

Research has been conducted on the synthesis and characterization of Fe3O4-active charcoal composite of ihau fruit peel (MAACI) as a methylene blue dye adsorbent. This research aimed to produce activated charcoal from ihau fruit peel (AACI) composited with magnetite (Fe3O4). AACI was prepared by carbonating Ihau fruit peel in a furnace at 425C for 1 hour and chemically activated by immersion in an HCl solution for 24 hours. The synthesis of MAACI was carried out using the coprecipitation method with FeCl3 • 6H2O and FeSO4 • 7H2O in a 3:2 ratio, followed by compounding with AACI. The MAACI was characterized by Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD). The characterization results showed that the FTIR spectrum exhibits an absorption peak at a wavenumber of 586.36 cm-1, indicating the presence of the Fe-O group. SEM analysis revealed that the MMACI has denser pores and a coarser texture compared to activated charcoal. Meanwhile, XRD results showed a diffraction pattern that matches the characterization of magnetite (Fe3O4). The adsorption of methylene blue by MAACI yielded optimum results at a pH of 9 with a contact time of 45 minutes. The maximum adsorption capacity obtained was 8.7014 mg/g, and the adsorption process followed the Langmuir isotherm model. This adsorption takes place spontaneously, is endothermic and occurs physically.
Effect of different solvents on antioxidant activity of Euphorbia hirta L. extract Suarjana, Nyoman; Nyandra, Made; Astuti, Ni Putu Widya; Kurniati, Ni Made; Sumadewi, Ni Luh Utari; Putra, I Made Wisnu Adhi; Andrianto, Nurrahman
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.256

Abstract

Euphorbia hirta L. is a species of plant renowned for its antioxidant properties. However, the optimal solvent for extracting these bioactive compounds to maximize antioxidant activity had not been systematically identified and compared. Previous knowledge suggested that solvent choice affects yield and efficacy; however, there was a lack of conclusive, comparative data specifically for E. hirta extracts using different solvents. The focus of this work was to investigate how different solvents affected the content of phenolics and flavonoids, as well as the antioxidant effect of E. hirta extract. The aerial part of E. hirta powder was extracted with ethanol, ethyl acetate, and n-hexane to obtain the crude extracts. Folin-Ciocalteu reagent and AlCl3 solution were used to assess the total phenolic and flavonoid contents, respectively. The ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) techniques were used to assess antioxidant activity. The total content of phenolics and flavonoids of E. hirta ethanol extract (127.827 ± 2.609 mg GAE/g extract and 28.507 ± 0.464 mg QE/g extract, respectively) was substantially higher than that of the other extracts (p<0.0001). The findings of the FRAP test exhibited that the E. hirta ethanol extract (48.009 ± 1.873 mg AAE/g extract) had a substantially greater reducing power value (p<0.0001) in comparison to other extracts. The ethanol extract of E. hirta had a considerably lower IC50 value (6.154 ± 0.063 ppm and 9.429 ± 0.183 ppm for DPPH and ABTS assays, respectively, with p<0.0001) than the other extracts. This study found that solvent polarity had a substantial influence on the antioxidant activity of E. hirta extracts, with ethanol being an optimal solvent for the extraction procedure.

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