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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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EFISIENSI SISTEM PENYIMPANAN OBAT DI BEBERAPA PUSKESMAS DAERAH YOGYAKARTA Rosita, Melia Eka; Fajri, M. Alif; Nilansari, Anis Febri
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.521

Abstract

Medicine storage is an activity to ensure that the medicines received are placed in a place that is considered safe, which includes 3 elements, namely spatial planning and preparation of the medicine warehouse, safeguarding the quality of medicines, and recording medicine stock. Medication storage errors can cause drug shortages, losses due to lost or damaged and expired drugs, and also result in the potency of a drug decreasing which then results in it being ineffective if consumed by the patient. The aim of this research is to determine the suitability of drug storage and determine the efficiency of drug storage at the Sleman Health Center, Yogyakarta City and Bantul. This research is non-experimental research, with a descriptive qualitative research type and design. The results of research on drug storage in the three community health centers meet the standards in the "Very Good" category based on the Pharmaceutical Management Training Materials in Community Health Centers published by the Ministry of Health in 2010, as well as technical instructions for pharmaceutical service standards in Community Health Centers from the Ministry of Health in 2019. Results of drug storage efficiency Value The Turn Over Ratio (TOR) at the Sleman Community Health Center was 10.87 times, the Yogyakarta City Health Center 9.55 times and the Bantul Community Health Center 11.33 times. The percentage of expired and damaged medicines at the Sleman Community Health Center was 5.33%, Yogyakarta City Health Center 7.5% and Bantul Community Health Center 3.63%. The percentage of dead stock medicines at the Sleman Community Health Center is 9.38%, the Yogyakarta City Health Center is 10.12% and the Bantul Community Health Center is 1.35%.
PROFIL JUMLAH NEOVASKULARISASI LUKA MENCIT HIPERGLIKEMIK YANG DIBERIKAN GEL EKSTRAK BUAH OKRA (Abelmoschus esculentus L.) Chandra, Pra Panca Bayu; Lisnawati, Nia; Susanti, Yanthy
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.523

Abstract

This study aimed to examine the gel activity of okra fruit extract (Abelmoschus esculentus L.) in mice with hyperglycemic conditions based on histopathological indicator parameters, namely the amount of neovascularization. Mus musculus strain male mice were hyperglycemic with STZ at a dose of 0.06 mg/gBW. Mice were divided into 8 groups (n=6). Group 1 (Non-DM Control), Group 2 (DM Control), Groups 3 to 8 (Test). The dose of glibenclamide was 5 mg/KgBW, the dose of okra fruit extract was 400 mg/KgBW and the dose of CMC Na was 5 mL/KgBW. Therapy was given once a day (oral and topical) for 15 days of therapy which was seen on days 0, 5, 11 and 15. The results of the study showed an increase in the number of neovascularizations on the 15th day of therapy in the test group compared to the control group. Administration of a combination of topical okra fruit extract gel with okra fruit extract orally for 15 days of therapy was able to increase the amount of neovascularization compared to administration without the combination or only orally. Administration of a combination of topical gel and oral okra fruit extract accelerated the wound healing process in hyperglycemic mice compared to non-combination administration. Management of fasting blood glucose levels has an effect on the success of the diabetic wound healing process.  
FORMULASI SEDIAAN CREAM BLUSH ON MENGGUNAKAN EKSTRAK BUNGA MAWAR MERAH (Rosa damascena P.Mill) SEBAGAI PEWARNA ALAMI Tampubolon, Antetti
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.524

Abstract

Blush on is a form of cosmetic preparation, aiming to give color to the cheeks and dimensions to the face. The purpose of this study was to determine the possibility of red rose extract (Rosa damascena P. Mill.) to be formulated as a blush on cream preparation, and the effective concentration to fulfill physical tests and evaluations. This research is an experimental study. Data collection was carried out through the formulation of blush on cream with the addition of red rose flower extract in a concentration combination of 10%, 20% and 30%. Then organoleptic test, stability test, pH test, topical test, irritation test, and hedonic test were carried out. Through research it is known that the preparation of blush on cream from red rose flower extract: fulfills the physical evaluation test and stability test; while the hedonic test at concentrations of 0% and 10% were included in the preferred category, and preparations at concentrations of 20% and 30% were included in the very preferred category by the panelists. The conclusion of this study is that cream blush from red rose flower extract is able to produce preparations that meet physical tests and evaluations; and can be formulated as a natural dye in blush on cream preparations that produce pale pink, intense pink, and intense red colors. The higher the concentration of the extract, the darker the resulting color.
FORMULASI SEDIAAN DEODORAN SPRAY EKSTRAKDAUN MANGKOKAN (Polyscias scutellaria (Burm.f.) Fosberg) DAN UJI EFEKTIVITAS ANTIBAKTERI Staphylococcus epidermidis Huzaemah, Salma Haninah; Setiawan, Agus; Puspitasari, Ranny
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.525

Abstract

The mangkokan plant (Polyscias scutellaria (Burm.f.) Fosberg) has properties as a diuretic, anti-inflammatory, breast inflammation, swelling and promotes milk production. Mangkokan leaves have antibacterial activity against bacteria that cause body odor. The purpose of this study was to determine the formulation and effectiveness of the antibacterial deodorant spray of mangkokan leaf extract (Polyscias scutellaria (Burm.f.) Fosberg) against Staphylococcus epidermidis bacteria ATCC 12228. The type of research used is in-vitro experimental. Mangkokan leaf extract is formulated in the form of a deodorant spray with a concentration of 10%, 15% and 20%. Preparation evaluation includes organoleptic, pH and viscosity tests. Antibacterial activity testing was carried out in-vitro using the disc diffusion method against S. epidermidis bacteria ATCC 12228. The results showed that the secondary metabolites contained in mangkokan leaves (Polyscias scutellaria (Burm.f.) Fosberg) were alkaloids, flavonoids, saponins, tannins and terpenoids. Mangkokan leaf extract spray deodorant preparation (Polyscias scutellaria (Burm.f.) Fosberg) can inhibit the growth of Staphylococcus epidermidis bacteria ATCC 12228 shown at a concentration of 20% with an average inhibition zone of 7.06 mm in the medium category. Preparation of deodorant spray for mangkokan leaf extract (Polyscias scutellaria (Burm.f.) Fosberg) with a concentration of 10%, 15% and 20% according to the requirements of SNI 16-4951-1998 namely organoleptic test, pH test, spray pattern, but does not meet the homogeneity requirements because there are extract granules. The results of data analysis using Kruskal Wallis obtained Asymp.Sig 0.015 (Sig. <0.05) which means that they reject H0 and accept H1. There was also a significant difference between F1 and the positive control.  
HUBUNGAN PENGETAHUAN TERHADAP PERSEPSI PEMBERIAN TERAPI PENCEGAHAN TUBERKULOSIS (TPT) PETUGAS PENGELOLA PROGRAM TB PUSKESMAS DI KABUPATEN SUMENEP Trisno, Zetiawan; Hidayat, Adi Noval
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.526

Abstract

            Tuberculosis is a deadly infectious disease that ranks Indonesia second in the world. Providing Tuberculosis Preventive Therapy (TPT) is one of the strategies in TB control efforts. Knowledge of TPT by Puskesmas TB program officers plays an important role in encouraging the perception and behavior of TPT provision. TPT achievement in Sumenep District is still low (28%) in 2022. This study aims to determine how the relationship between knowledge and perceptions of TPT permissions of puskesmas program officers in Sumenep District. The research method used was analytical quantitative research with a cross sectional design. The population in this study were 30 TB program officers and the sample selection technique used total sampling. The results showed that most of the puskesmas TB program manager had good knowledge (63.33%) and the perception of providing TPT was positive (70%). The results of the statistical analysis test using chi-square showed p value (0.001) <0.05, OR = 23.8, then knowledge has a significant relationship on perceptions of TPT provision on puskesmas TB program manager in Sumenep district. Knowledge about TPT is positively related to perceptions on the dimensions of perceived susceptibility, perceived severity, health motivation and cues to action. The Sumenep district health office is expected to support the supervision of the implementation of the TPT administration program and provide training or refreshers to the Head of Puskesmas, doctors, Puskesmas TB program manager
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI BUAH NYIRIH (Xylocarpus granatum) DENGAN METODE DPPH SECARA SPEKTROFOTOMETRI UV-VIS Achmad Kadri Ansyori; Mutmainna Tamrin; Hayatus Sa'adah
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.527

Abstract

   The nyirih plant (Xylocarpus granatum) is a type of mangrove that has been used for generations by coastal communities as traditional medicine. The flavonoid compounds contained in the nyirih plant are a group of polyphenols which have potential as antioxidants that can reduce free radicals. The aim of this research was to determine the antioxidant activity of ethanol extract of nyirih fruit seeds. The research carried out was non-experimental research, the stages of this research started from plant determination and sample collection, making simplicia, making extracts using the maceration method with 70% ethanol, phytochemical screening, and antioxidant activity testing using the DPPH method as free radicals which were measured using a spectrophotometer. UV-Vis. The research results obtained showed that the ethanol extract of nyirih fruit seeds positively contained secondary metabolites in the form of alkaloids, flavonoids, tannins and saponins. The results of the antioxidant activity test of the ethanol extract of nyirih fruit seeds obtained an IC50 value of 8.2729 ppm in the very strong antioxidant category.
EKSPLORASI KEARIFAN LOKAL KHAS BORNEO: BIOSINTESIS NANOPARTIKEL PERAK EKSTRAK  ETANOL DAUN KOKANG (Lepishanthes amoena (Hass) Leenh) Aminah; Rahman, Nurul Aulia; Amalia, Sindi; Hardiani, Lia; Khairunnisa, Annida; Jubaidah, Siti; Puspita, Alfiana Dwi
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.528

Abstract

Biosynthesis of silver nanoparticles (AgNP) is a process of changing Ag+ ions to Ag0. The biosynthesis method in this research is green synthesis using natural ingredients to reduce silver, this synthesis is safer, environmentally friendly and economical. Based on this, this research aims to determine the optimal reaction conditions in the biosynthesis process using ethanol extract from cock leaves. The research method carried out pH optimization with variations of 8, 9, and 10 and then obtained the best pH, where the pH optimization will later be used in the AgNO3 optimization process with variations of 1mM, 2mM, and 4mM. After obtaining the best Ag optimization, the next stage was extract optimization using variations of 0.5%, 1% and 2%, the results of which will be seen based on the SPR peak of 400-500 nm which indicates the formation of AgNPs. The results of the research showed that AgNPs from cockang leaf ethanol extract were able to reduce at pH 8, AgNO3 2mM and 4mM, as well as 0.5% extract, and the contact time reaction showed a good formula for AgNP 1, AgNP2, AgNP3 which was indicated by the absorbance intensity at long waves that form AgNPs at the SPR peak of 400-500. Based on the results of SEM characterization, the morphology at a concentration of 2 mM has a surface that is not very smooth and the size is not very uniform, but at a concentration of 4 mM the surface is smooth and the particles are not uniform. With particle sizes in the range of 50-80 nm.
GAMBARAN TINGKAT PENGETAHUAN MASYARAKAT TENTANG DAGUSIBU OBAT DI KAMPUNG MARGOYUDAN KOTA SURAKARTA Mursiany, Anita; Avrila, Nesya; Umboro, Recta Olivia
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.530

Abstract

One of the most pressing needs of the community is medicine. People can buy medicines without a doctor's prescription or get them with a doctor's prescription. Until now, many people have purchased medicines independently without first consulting a medical professional. Due to ignorance and lack of information, this can result in cases of irrational drug use. Get, Use, Store, and Dispose (DAGUSIBU) medicine is a program designed to help families be aware of medicine. The purpose of this study is to determine how much knowledge the community in Margoyudan Village, Surakarta City, has about DAGUSIBU medicine. Purposive sampling was used in this study to select participants in a descriptive quantitative research design using questionnaires distributed to residents of Margoyudan Village. The percentage of correct answers was then analyzed and used to calculate the level of knowledge. Based on the results of the study, the general public's understanding of DAGUSIBU medicine in Margoyudan Village fell into three categories: good (68%), fair (23.9%), and poor (7.9%).
IDENTIFIKASI BAHAN KIMIA OBAT SIBUTRAMIN HCl PADA JAMU PELANGSING YANG BEREDAR DI KOTA BATAM MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Mayefis, Delladari; Marliza, Hesti; Fadhil, Muhammad
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.531

Abstract

Traditional medicine is a mixture of natural ingredients in the form of simplicia, animals, minerals, sarian or galenic. One form of traditional medicine is slimming herbal medicine. In slimming herbal medicine, medicinal chemicals are prohibited from being added to traditional medicine preparations because they harm health if used continuously. One of the medicinal chemicals that is often misused is sibutramine HCl. The aim of this research is to identify the chemical drug sibutramine HCl in slimming herbal medicine circulating in Batam City. The method used is a qualitative method using thin layer chromatography and a quantitative method using UV-Vis spectrophotometry. The ferrous phases used are ethyl acetate : n-Hexane (7:3), acetone : chloroform (7:3), acetone : chloroform : n-hexane (5:3:2) and the stationary phase used is GF254 silica gel plate . The results of qualitative identification of slimming herbal medicine circulating in Batam City showed that there was no chemical drug sibutramine HCl in each sample. Quantitative testing was not carried out because there were no samples that were positive for containing the chemical drug sibutramine HCl
PENETAPAN KADAR FENOL TOTAL EKSTRAK ETANOL RIMPANG TEMU PUTIH (Curcuma zedoaria (Christm.) Roscoe) DENGAN PERBEDAAN KONSENTRASI PELARUT Maulida, Mielsya; Nurhasnawati, Henny; Sundu, Reksi
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.543

Abstract

White Temu (Curcuma zedoaria (Berg.) Roscoe) has an actoxidant activity because it contains phenolic compounds. Phenolic compounds are aromatic compounds with a structure derived from benzene so that they have aromatic rings and the presence of one or more hydroxyl (OH) groups. This study aims to determine the total phenol content of white rhizome ethanol extract with the difference in solvent concentration using UV-Vis spectrophotometry. The research conducted is an experimental research. The results showed that the rhizome of white temu contained secondary metabolite compounds in the form of phenolics, alkaloids, flavonoids, saponins, and terpenoids. Based on the results of determining the total phenol content of white temu extract with a difference in ethanol solvent concentrations of 30%, 50%, and 70%, the levels were 23.4477±0.9827 mg GAE/g, 32.2464±1.3022 mg GAE/g, and 51.6880±0.4948 mg GAE/g. The results of statistical analysis obtained normal and homogeneous data so that a one-way anova test with p value results was used(0.00) < (0.05) so it can be concluded that there is a significant difference in the total phenol levels of the three samples.

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