cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Khurin In Wahyuni
Contact Email
lppm.stikesrsam@gmail.com
Phone
+628563002065
Journal Mail Official
jpham.stikesrsam@gmail.com
Editorial Address
Jl By Pass KM 33 Krian Sidoarjo
Location
Kab. sidoarjo,
Jawa timur
INDONESIA
Journal of Pharmaceutical Care Anwar Medika
Published by Sekolah Tinggi Ilmu Kesehatan Rumah Sakit Anwar Medika
ISSN : 26548364     EISSN : 26847361     DOI : 10.36932/jpcam
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Journal of Pharmaceutical care Anwar Medika (J-PhAM) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, detailed scopes of articles accepted for submission to J-PhAM are: 1. Pharmaceutics & Biopharmaceutics. 2. Pharmaceutical Chemistry. 3. Biological Pharmacy 4. Clinical Pharmacy 5. Community Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 60 Documents
 2   3   4   5   6 
Perbandingan Efektivitas Antipiretik dan Analgesik Dua Merek Dagang Parasetamol dan Produk Generik Terhadap Mencit (Mus Musculus) Jantan Cinthya Ratna Yuniar; Nasruhan Arifianto; Dian Nita Triana
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 4 No 2 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v4i2.67

Abstract

Antipyretics and analgesics are drugs that can suppress or reduce the increase in body temperature and suppress pain by inhibiting COX. In the market, branded products are often considered to have a higher quality than generic products, and patients are often found who are fanatical about one of these trademarks. Even though the products on the market have been tested for the quality of these products. Therefore, a study was conducted to compare the antipyretic and analgesic effectiveness of branded paracetamol at a higher price with branded paracetamol at a generic price (cheap) and generic paracetamol in mice induced by fever and induced pain. Experimental animals in this study used male mice (Mus musculus). The stages of antipyretic research are giving treatment to experimental animals before being treated, mice are measured rectal temperature (initial temperature), then injected with 5% peptone subcutaneously. One hour later the rectal temperature was measured again, after which the mice were treated with the test material and negative control. To test the effectiveness of analgesics, a chemical stimulation method was used which was carried out on male mice (mus musculus) given the pain-inducing compound acetic acid 0.6% (writhing test). The antipyretic test results obtained in the form of the percentage of the antipyretic power of branded paracetamol at an expensive price, branded paracetamol at a generic price (cheap) and paracetamol generic products at 0.86%, 1.07% and 0.41%, respectively, at the minute to minute observation. -60. The most effective antipyretic effect of paracetamol used to reduce the rectal temperature of febrile mice was brand B paracetamol and the lowest effectiveness was found in generic paracetamol. The analgesic effectiveness test in this study showed that there was a significant difference in analgesic effectiveness from each test group. The greatest analgesic effectiveness occurred in brand A paracetamol products with % pain inhibition in a total of 20 minutes by 47.37% and the smallest analgesic effectiveness occurred in generic paracetamol products with % pain inhibition in a total time of 20 minutes by 38.05%.
KANDUNGAN TOTAL FLAVONOID EKSTRAK AKAR MANGROVE DENGAN METODE SPEKTROFOTOMETRI UV-VIS Jannatus Mega Blezensky; Mahmiah Mahmiah; Giftania Wardani Sudjarwo
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 4 No 2 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v4i2.81

Abstract

Mangrove mempunyai jenis akar yang berbeda-beda, akar mangrove mengandung senyawa flavonoid yang mempunyai manfaat sebagai antioksidan yang signifikan, sehingga penting untuk diteliti. Flavonoid memiliki kemampuan sebagai antioksidan karena mampu mendonasikan atom H dari gugus hidroksi kepada senyawa radikal bebas. Tujuan dari penelitian ini adalah untuk mengetahui kandungan total flavonoid ekstrak akar mangrove dengan metode spektrofotometri UV-Vis. Metode dari penelitian ini adalah studi literatur, yaitu dengan mengumpulkan literatur dari jurnal/artikel ilmiah dan akan dibahas dalam bentuk ulasan. Pada penelitian studi literatur ini didapatkan hasil bahwa spesies yang sering digunakan dan diteliti yaitu Rhizophora mucronata. Metode ekstraksi yang banyak digunakan yaitu metode maserasi. Pelarut yang banyak digunakan serta sering menghasilkan kandungan total flavonoid ekstrak akar mangrove yang tertinggi yaitu pelarut metanol. Pada penelitian studi literatur kandungan total flavonoid ekstrak akar mangrove dengan metode spektrofotometri UV-Vis ini, hasil menunjukkan bahwa kandungan total flavonoid beragam dan bervariasi, yaitu mulai dari rentang sebesar 0.00778 ± 0.00007 (mg RE/g) hingga 792 ± 0.28 (mg QE/g).
KERASIONALAN PENGGUNAAN ANTIBIOTIK DI PUSKESMAS Adinugraha Amarullah; Farida Anwari; Aprilia Citra Dewi; Eka Yuni Danam Sari
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 4 No 2 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v4i2.133

Abstract

Penggunaan produk obat yang wajar termasuk ketika pasien menerima produk obat sesuai dengan indikasi penggunaan. Antibiotik merupakan salah satu obat yang harus diperhatikan dalam penggunaannya. Penggunaan antibiotik yang berlebihan dan tidak tepat dapat menyebabkan masalah kekebalan bakteri terhadap antibiotik. Tujuan dari penelitian ini adalah untuk mengetahui profil indikasi yang layak untuk penggunaan antibiotik oral di Puskesmas Driyorejo-Gresik dan Krian Sidoarjo. Metode penelitian adalah observasi deskriptif dengan pengumpulan data secara retrospektif. Data penggunaan antibiotik pada tahun 2018 dari bulan Januari sampai Desember 2018 menggunakan teknik simple random sampling. Data yang diperoleh dievaluasi dalam bentuk tabel dan grafik di Microsoft Office Excel. Hasil penelitian didapatkan data jenis antibiotika yang digunakan yaitu berjumlah 12 jenis antibiotika (amoxicillin, ciprofloxacin, cefadroxil, cefixime, clindamisin, metronidazol, eritromisin, thiamphenicol, chloramphenicol, azitromisin, doxyxiclin, cotrimoxsazol). Data kerasionalan indikasi penggunaan antibiotika oral didapatkan antibiotika rasional berjumlah 333 pasien (97%) dan antibiotika tidak rasional berjumlah 10 pasien (3%) pada penggunaan antibiotika cefadroxil untuk demam tifoid, antibiotika thiamphenicol, cefadroxil, amoxicillin untuk sakit kepala (cefalgia), antibiotika cefixime untuk nyeri otot (myalgia), dan antibiotika eritromisin untuk infeksi saluran kencing (gonore). Penelitian ini menyimpulkan bahwa penggunaan antibiotika rasional pada Puskesmas berjumlah 333 pasien (97%) dan antibiotika tidak rasional berjumlah 10 pasien (3%) penggunaan sesuai dengan terapi empiris.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAN MINYAK ATSIRI SIRIH HIJAU TERHADAP Methicillin Resistant Staphylococcus aureus Khoirun Nisyak; A'yunil Hisbiyah; Arinil Haqqo
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 1 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i1.82

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) adalah jenis bakteri Staphylococcus aureus yang mengalami resistensi terhadap antibiotik jenis metisilin dan turunannya. MRSA merupakan salah satu bakteri patogen yang menjadi penyebab terjadinya infeksi nosokomial di tempat pelayanan kesehatan. Daun sirih hijau (Piper betle Linn) merupakan salah satu tanaman obat yang telah lama digunakan oleh masyarakat Indonesia. Penelitian bertujuan untuk mengetahui potensi aktivitas antibakteri tanaman sirih hijau terhadap MRSA. Bahan uji yang digunakan dari dauns irih hijau meliputi ekstrak etanol dan minyak atsiri. Ekstrak etanol daun sirih hijau diperoleh dengan metode maserasi, sedangkan minyak atsiri daun sirih hijau diperoleh dengan metode distilasi uap. Kandungan senyawa kimia dalam ekstrak etanol daun sirih hijau diidentifikasi melalui skrining fitokimia. Identifikasi senyawa kimia dalam minyak atsiri sirih hijau dianalisa menggunakan Kromatografi Gas-Spektrometer Massa (KG-SM). Ekstrak etanol daun sirih mengandung senyawa flavonoid, tannin, polifenol, saponin, dan terpenoid. Minyak atsiri daun sirih hijau mengandung senyawa kavikol, beta-karyofilena, dan turunan senyawa sesquiterpene. Uji aktivitas antibakteri terhadap bakteri MRSA dilakukan dengan metode difusi Kirby Bauer. Berdasarkan hasil penelitian, minyak atsiri daun sirih lebih menghambat pertumbuhan MRSA dibandingkan dengan ekstrak etanol sirih hijau.
Tingkat Risiko Penyakit Kardiovaskular 10-tahun Menggunakan Systematic Coronary Risk Evaluation (SCORE) pada Kohort Pekerja di Perusahaan Jasa Transportasi Ellok Dian Novita; Yosi Irawati Wibowo; Sylvi Irawati
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 1 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i1.112

Abstract

Salah satu strategi awal pencegahan dan pengendalian penyakit tidak menular, termasuk penyakit kardiovaskular, adalah dengan melakukan penilaian tingkat risiko penyakit kardiovaskular pada level individu maupun populasi. Systematic Coronary Risk Evaluation (SCORE) merupakan salah satu metode yang digunakan untuk menilai tingkat risiko penyakit kardiovaskular 10-tahun. Tingkat risiko penyakit kardiovaskular 10-tahun pada populasi pekerja dapat berbeda daripada risiko pada populasi umum. Penelitian mengenai prevalensi tingkat risiko penyakit kardiovaskular 10-tahun pada populasi pekerja di Indonesia masih sangat terbatas. Penelitian ini bertujuan untuk memetakan prevalensi tingkat risiko penyakit kardiovaskular 10-tahun pada populasi pekerja dewasa dari suatu perusahaan jasa transportasi (industry kerah biru), disebut dengan PT “X”, di Jawa Timur. Desain penelitian adalah cross-sectional. Sumber data yang digunakan adalah database hasil pemeriksaan kesehatan PT “X” pada tahun 2021. Data dianalisis secara deskriptif. Tingkat risiko penyakit kardiovaskular 10-tahun dinilai menggunakan SCORE. Sebanyak 2.423 orang dari 2.451 pekerja memenuhi kriteria inklusi. Prevalensi tingkat risiko penyakit kardiovaskular 10-tahun adalah sebagai berikut: tingkat risiko menengah 70,00%, rendah 23,65%, tinggi 5,98%, dan sangat tinggi 0,37%. Meskipun prevalensi tingkat risiko penyakit kardiovaskular 10-tahun sangat tinggi-tinggi pada populasi pekerja di PT “X” lebih rendah dibandingkan dengan penelitian terdahulu, relative besarnya prevalensi faktor risiko kardiovaskular yang penting seperti merokok dan obesitas pada populasi pekerja tetap perlu dikendalikan untuk pencegahan primer dan pencegahan kejadian kardiovaskular dini.
EDUKASI DALAM PERUBAHAN PENGETAHUAN, PERILAKU, DAN KADAR GULA DARAH PUASA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 Khurin In Wahyuni; Siti Mutmainah; Ofraliya Renna Eka Sugiyanto; Yakobus Ofaristo Pakae; Bella Fevi Aristia; Dewi Rahmawati
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 1 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i1.143

Abstract

Diabetes Mellitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin, atau keduanya. DM tipe 2 merupakan golongan diabetes dengan prevalensi tertinggi. Salah satu upaya untuk penanganan dan pencegahan timbulnya peningkatan DM tipe 2 adalah dengan edukasi menggunakan media booklet. Edukasi adalah kegiatan penyampaian pesan kesehatan kepada kelompok atau individu dengan tujuan agar dapat memperoleh pengetahuan dan perubahan perilaku yang lebih baik. Penelitian ini menggunakan rancangan One Group Pretest Posttest Design. Penelitian ini bertujuan untuk mengetahui pengetahuan, perubahan perilaku dan perbedaan kadar gula darah puasa sebelum dan sesudah pemberian edukasi dengan media booklet terhadap pasien DM tipe 2 di Rumah Sakit Anwar Medika. Penelitian ini dilakukan dari bulan Februari-Mei 2020 dengan sampel 56 pasien. Pengukuran pengetahuan menggunakan kuesioner ADL Knowledge, perubahan perilaku menggunakan kuesioner DSMQ sedangkan kadar gula darah puasa dengan alat tes gula darah puasa. Hasil analisis kuantitatif dilakukan dengan menggunakan uji Wilcoxon Signed Rank Test menunjukkan bahwa terdapat perbedaan yang signifikan antara pengetahuan, perubahan perilaku serta kadar gula darah puasa sebelum dan sesudah pemberian edukasi dengan nilai p value < 0,05 (p = 0,000; α = 0,05). Sedangkan hasil uji Spearman’Rank’s diperoleh nilai koefisien korelasi sebesar 0,882 dengan nilai p= 0,000. Hal ini menunjukan hubungan antara variabel pengetahuan dan perilaku cukup kuat, sehingga menunjukkan H0 ditolak dan H1 diterima maka ada hubungan antara pengetahuan dengan perilaku pada pasien DM tipe 2 di Rumah Sakit Anwar Medika.
Analysis of Health Promotion Strategies on Knowledge and Attitude of Healthy Lifestyle for Academics and Staff in STIKES ARRAHMA Mandiri Indonesia Abd Syakur; Katmini Katmini; Ratna Wardani
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 1 (2022): Journal of Pharmaceutical Care Anwar Medika
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i1.146

Abstract

The goal of encouraging Clean and Healthy Living Behaviour (PHBS which stands for Perilaku Hidup Bersih & Sehat) in the workplace is to provide employees the tools they need to adopt healthier lifestyles on the job and to encourage them to take an active role in fostering a positive work environment. This research set out to compare the effectiveness of two health promotion approaches (the one-way method and the two-way method) in improving STIKES Arrahma Mandiri Indonesia's faculty members and staff with, and commitment to, implementing PHBS. Preliminary experimental studies of this sort employ a post-test-pre-test design with a single experimental group. Men and women of varying educational and economic backgrounds made up the 70-participant sample used in this study. (p <0.05) Knowledge and attitudes were found to increase significantly with education (p=0.000) and income (p=0.001), but not with age (p=0.324); there was a significant difference (p 0.05) between the control group and the intervention group in both the one-way and two-way methods; the increase in knowledge in the One-Way Method intervention group was 49.75% while in the Two-Way Method intervention group, it was 51.04%; and there was a significant difference (p <0.05). We might generalize from this research that STIKES Arrahma Mandiri Indonesia faculty and staff members’ knowledge and attitudes concerning PHBS are influenced by both individual characteristics and variations in health promotion tactics
Studi In silico : Toksisitas Senyawa Potensial Sebagai Antikanker Turunan N-((4-Fluorofenil) Karbamatiol) Benzamida Anindi Lupita Nasyanka; Diah Ratnasari; Jannatun Na&#039;imah; Siti Nur Asiyah
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 2 (2023): Journal of Pharmaceutical Care Anwar Medika (J-PhAM)
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i2.144

Abstract

The potential derivative compound N-((4- Fluorophenyl ) Carbamatiol ) Benzamide a has been predicted to have good activity at the sirtuin-1 receptor which plays a role in triggering cancer on the p53 protein . Toxicity plays a very important role in the safety of the drugs used in the development of new drugs. Therefore, this study aims to determine the toxicity prediction of NBFFT derivatives as anticancer drug candidates. The method used is quantitative descriptive analysis based on the results of in silico toxicity predictions using the Read Across method through the ProTox web server system. on NBFFT derivatives in the ChemBL database with comparators of tenovin and hydroxyurea. The results showed that the derivative compound N-((4 -Fluorophenyl ) carbamatiol ) Benzamide a as an anticancer candidate, it is included in category V (possibly dangerous if consumed) which corresponds to tenovin as a comparison. In addition, predictions of hepatotoxic events were found in these derivative compounds through the MMP stress response pathway, p53, and the nuclear cell nucleus receptor (AhR) type signaling pathway.
Safety and Efficacy of Bedaquiline-Pretomanid-Linezolid (BPaL) in Patients with Drug-Resistant Tuberculosis: (Review from Clinical Evidence) Oki Nugraha Putra; Ana Khusnul Faizah; Nani Khusnul Wijayanti DN
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 2 (2023): Journal of Pharmaceutical Care Anwar Medika (J-PhAM)
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i2.150

Abstract

Regimens containing bedaquiline were administered for up to 11 months and 24 months in shorter and longer regimen to treat patients with drug-resistant tuberculosis (DR-TB), respectively. Pre XDR and XDR-TB are highly DR-TB with a lower success treatment than MDR-TB. Therapy for highly DR-TB with fewer drugs and shorter treatment is required to increase success treatment. Bedaquiline-pretomanid-linezolid (BPaL) is considered to be used for highly DR-TB. This was a narrative review summarize the efficacy and safety of the BPaL regimen to manage patients with highly DR-TB. The 26-week of BPaL regimen was reported to provide favorable outcomes in two previous trials, Nix and Zenix TB. BPaL offers treatment success, especially in highly drug-resistant tuberculosis compared to standard regimens containing bedaquiline. Nonetheless, adverse effects, such as hematologic toxicity or myelosuppression, peripheral neuropathy, and optic neuritis were more common in BPaL regimens than in standard regimens. The incidence QT prolongation was lower with BPaL regimens compared with standard regimens. Adding pretomanid to the bedaquiline-linezolid regimen prevents TB bacteria that are resistant to bedaquiline. It is necessary to periodically monitor adverse effects associated with linezolid in BPaL regimen and how to manage them accordingly. This review concludes that the BPaL regimen provides favorable outcomes, reduces pill burdens, and shortenes treatment. Health facilities should prepare for the implementation of BPaL to manage DR-TB patients. Keywords: Drug-resistant TB, BPaL, Efficacy, Safety
Comparison of the Use of Bisoprolol and Metoprolol in Heart Failure Patients Systematic Review Study Maysitha, Belvada Kania
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 2 (2023): Journal of Pharmaceutical Care Anwar Medika (J-PhAM)
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36932/jpcam.v5i2.147

Abstract

Heart failure is a leading cause of death worldwide, with increasing prevalence due to factors such as population ageing and lifestyle changes. Beta blockers have been the mainstay of chronic heart failure therapy for more than two decades, and studies have shown that they improve survival and reduce hospitalisation for heart failure events. However, there is debate about which beta blockers are more effective in treating heart failure, and prospective information on the relative effectiveness of beta blockers is limited. In this study, we conducted a systematic literature review to compare achievement, mortality, and arrhythmia rates between the use of bisoprolol and metoprolol in acute heart failure patients by extracting data from n=8 selected literatures according to the study inclusion criteria. Our findings suggest that both bisoprolol and metoprolol improve achievement rates and reduce mortality in heart failure patients, but there is little evidence to support the superiority of one beta blocker over the other. Conclusion krom this research are bisoprolol is more effective than metoprolol in reducing the achievement rate and mortality status in heart failure patients. In addition, bisoprolol is more effective for patients with ventricular tachycardia-type arrhythmias, while metoprolol is more effective for patients with atrial fibrillationtype arrhythmias. The findings of this study have important clinical implications for the treatment of heart failure patients and suggest that the choice of beta blocker be made based on the patient's clinical presentation and individualised needs.

Page 6 of 6 | Total Record : 60

 2   3   4   5   6 

Filter by Year

2018 2023


Reset
Filter By Issues
All Issue Vol 5 No 2 (2023): Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 5 No 1 (2022): Journal of Pharmaceutical Care Anwar Medika Vol 4 No 2 (2022): Journal of Pharmaceutical Care Anwar Medika Vol 4 No 1 (2021): Journal of Pharmaceutical Care Anwar Medika Vol 3 No 2 (2021): Journal of Pharmaceutical Care Anwar Medika Vol 3 No 1 (2020): Volume 3, Nomor 1, Desember 2020 Vol 2 No 2 (2020): Volume 2, Nomor 2, Juni 2020 Vol 2 No 1 (2019): Volume 2, Nomor 1, Desember 2019 Vol 1 No 2 (2019): Volume 1, Nomor 2, Juni 2019 Vol 1 No 1 (2018): Volume 1, Nomor 1, Desember 2018