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Sainstech Farma: Jurnal Ilmu Kefarmasian
Published by Institut Sains dan Teknologi Nasional
ISSN : 20867816     EISSN : 27761878     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal ini memuat artikel penelitian kefarmasian meliputi kimia farmasi, biologi farmasi, bahan alam farmasi, teknologi farmasi, farmasi komunitas dan klinis, serta bioteknologi farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Sintesis Analog Kurkumin (2E,6E)-2-(4-Hidroksi-3-Metoksi-5-((Pirolidin)metil)benziliden) -6-(4-Metoksibenziliden)Sikloheksan-1-on Rahmawati, Nur; Fitriana, Adita Silvia; Sholikha, Munawarohthus
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1578

Abstract

Curcumin is a potential compound to be developed. However, the clinical use of these compounds is limited due to their low stability and bioavailability. Therefore, to increase the pharmacological activity of curcumin, it is necessary to modify the chemical structure of curcumin. Curcumin analog compound (2E,6E)-2-(4-hydroxy-3-methoxy-5-((pyrrolidine)methyl)benzylidene)-6-(4-methoxybenzyliden)cyclohexane-1-on can be synthesized in 3 steps. Phase I, the reaction between p-methoxybenzaldehyde and cyclohexanone took place aldol condensation reaction with NaOH catalyst. Phase II, the Clasein-Schmidt reaction between compound 1 (the result of the synthesis of stage I) and vanillin involved dilute HCl as the catalyst. Phase III, reacting the results of the synthesis of phase II with Mannich pyrrolidine base by adapting the method used by Geschickter and Maeadow. Compound 3 as a result of purification was observed using Thin Layer Chromatography using Ethyl Acetate:Methanol (1:1) as an eluent to obtain Rf 0.46 and a melting range of 130-131 oC. The yield obtained was 51.52% with the characteristics of a reddish brown powder. This compound needs further identification using the Mass Spectrum and NMR.
Penilaian Tingkat Kecemasan Pasien Program Rujuk Balik di Fasilitas Kesehatan Tingkat Pertama Kota Malang Permata, Agung; Fitri, Aldesra; Abdullah, Muhammad Rizal; Salmasfattah, Novyananda
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1591

Abstract

Referral Program Services (PRB) are health services provided to patients in health facilities based on referrals from specialist doctors or sub-specialists who treat these patients. This study aims to look at the characteristics and assess the level of anxiety of the Referral Patient Program at the First Level Health Facility in Malang City. Anxiety level assessment used the Generalized anxiety disorder-7 (GAD-7) questionnaire. This type of research is analytic observational with cross sectional design. The sampling technique was carried out using the convenience sample method. The sample of this study were Patients of the Referral Program (PRB) at First Level Health Facilities in Malang City, to be precise in the outpatient unit during May 2023 who met the inclusive and exclusion criteria. The data collected was analyzed descriptively according to the number of categories for each variable and determined the level of anxiety using the GAD-7 questionnaire to obtain an overview of the data in the form of frequency and proportion (%). The results of the study showed that there were 37 (37%) males and 63 (63%) females, the highest age was >60, namely 36 patients (36%), the highest diagnosis of hypertension was 58 patients (58%), last education the highest was at the senior high school level, namely 42 patients (42%), in the employment status of the highest DRR patients, namely not working, 51 patients (51%), in marital status, 100 patients were married (100%), and the highest monthly income was <Rp. 2,500,000 ie 66 patients (66%). The anxiety level of PRB patients at FKTP Malang City obtained the highest level of anxiety at the mild anxiety level (48%) and the lowest at the severe anxiety level (2%).
Aktifitas Antifungi Ekstrak Daun Sembung Rambat (Mikania micrantha Kunth.) Asal Cileungsi, Bogor terhadap Trichophyton mentagrophytes Hamida, Fathin; Agustin, Anglia Ananda; Djuhariyah, Yayah Siti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1603

Abstract

American rope leaves (Mikania micrantha Kunth.) contains secondary metabolites such as flavonoids, tannins, saponins and steroids. This study aimed to observe antifungal activity of ethanol extract 96% of american rope leaves were 200 mg/mL, 400 mg/mL, and 600 mg/mL concentration against Trichophyton mentagrophytes by disc diffusion method on Sabouraud Dextrose Agar (SDA) medium. Ketoconazole were positive control. The results showed that the 96% ethanol extract of american rope leaves had antifungal activity against Trichophyton mentagrophytes. The minimum inhibitory concentration of 96% ethanol extract of american rope leaves against Trichophyton mentagrophytes at 100 mg/mL.
Etnobotani Tanaman Obat Sebagai Imunomodulator di Desa Adi Luhur Kecamatan Panca Jaya Provinsi Lampung Setyaningsih, Erwi Putri; Febriyanti, Risma
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1606

Abstract

An ethnobotanical study was conducted to see the interaction of local people with their environment and to study the relationship between humans and their surrounding plants. The people in Adi Luhur Village have used traditional medicinal plants for a long time as evidenced by the existence of a women's farmer group in Adi Luhur Village. Each house has a family of medicinal plants to meet the needs of herbal medicines that can be used to prevent or treat disease. This study aims to determine the types of immunomodulatory plants used by the people in Adi Luhur Village, Panca Jaya District, Lampung Province. The type of research was observational using descriptive qualitative research methods. Sampling was carried out in the community of Adi Luhur Village, Panca Jaya District, Lampung Province by purposive sampling. The sample was determined based on the similarity between characteristics and inclusion criteria including the people of Adi Luhur Village who are willing to be respondents and fill out a questionnaire, people who have consumed herbal medicine in the last one month, and people in the age range of 20-75 years. Filling out the questionnaire involved a respondent of 110 people. Determination of the number of samples based on Lameshow calculations of the total population of 1.989 people. Based on the results of the study, information was obtained that in Adi Luhur Village 5 plants were cultivated and could be used as immunomodulators, namely sambiloto, turmeric, ginger, lempuyang, and finger root which are consumed by boiling and then drinking. The part of the plant that was taken for the leaves is sambiloto, while the parts for the rhizome were ginger, turmeric, lempuyang, and finger root.
Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Rawat Jalan di Rumah Sakit Setia Mitra Jakarta Wulandari, Ainun; Arum, Fitria Diah; Febriani, Amelia
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1629

Abstract

The high number of people with high mobility raises the possibility of increased risk factors for hypertension. Hypertension ranks eighth out of the top ten diseases based on the highest number of patients in 2022 at Setia Mitra Hospital. Management of hypertension can be done using drugs. Drug use needs to be evaluated by assessing the rationality of drug use. Rational use of drugs is expected to increase the effectiveness of therapy, so that therapeutic goals are achieved and prevent disease complications. The aim of the study was to evaluate the use of antihypertensive drugs based on age, sex, blood pressure, drug combinations used, and rationality of drug use. The research was a descriptive study with retrospective data collection. The sampling technique was purposive sampling. The results of the research on outpatient hypertension characteristics at Setia Mitra Hospital were highest based on age, namely 56-65 years by 34% and gender, namely female patients by 70%. Blood pressure for the initial treatment was stage 2 hypertension at 62%, while the blood pressure for the final treatment was prehypertension by 54%. The distribution of the most prescribed drugs was single therapy at 40.1%. The rationality of using antihypertensive drugs based on the right patient was 94%, the right indication was 100%, the right drug was 90%, and the right dose was 96%. 90% of the use of antihypertensive drugs in outpatients at Setia Mitra Jakarta Hospital ffulfilsrationality based on the right patient, indication, drug, and dose.
Uji Aktivitas Antioksidan Infusa Daun Strawberry (Fragaria x annanasa) Dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrilhidrazil) Kusuma, Ika Maruya; Djuhariah, Yayah Siti; Desi, Ika Pusma
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1630

Abstract

Antioxidant activity in strawberry leaves comes from flavonoid compounds. This study aims to determine the antioxidant activity of strawberry leaf infusion which was tested using the DPPH method. The leaves were dried, powdered, made infusion with water solvent, then tested for phytochemical screening. Then testing the antioxidant activity with the DPPH method to get the IC50 value. The results showed that strawberry leaf infusion had strong antioxidant activity with an IC50 value of 69.455 ppm and contained secondary metabolites of alkaloids, saponins, flavonoids, tannins, steroids/triterpenoids.
Cemaran Coliform Limbah Cair Tempe dan Air Minum Isi Ulang di Daerah Parung, Jawa Barat Marliyah, Tiah; Syafriana, Vilya
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1663

Abstract

Tempeh is a food source of vegetable protein that is produced from the fermentation process. The manufacturing process of tempeh will produce solid waste and liquid waste. The solid waste from tempeh is usually used for animal feed, while the liquid waste flows into the river. Sub Parung district has some food industries, one of which is the tempeh industry and a refill drinking water depot near the tempeh factories. This study aims to determine whether the liquid waste from tempeh and the refill drinking water in the region was contaminated by Coliform bacteria. The samples used in this study were tempeh liquid waste from the tempeh X factory and drinking water from the refill drinking water depot. This qualitative descriptive study used the Most Probable Number (MPN) method. The results showed that the sample of refill drinking water did not contaminated with bacteria, but the tempeh liquid waste sample contained E. coli and Coliform bacteria with a total Coliform of about 6.2/100 mL. These findings indicate that the DAMIU found near the tempeh factories is safe to consume.
Review: Pemanfaatan Nanosains dan Nanoteknologi untuk Meningkatkan Efektivitas Obat Indrawati, Teti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1682

Abstract

Science and nanotechnology in the pharmaceutical field, among others, are used to increase drug effectiveness and optimal safety. The research was conducted using the review method with the aim of this study to obtain information about the utilization of nanoscience and nanotechnology which can be used as reference material for development in the pharmaceutical field. Nano-drug delivery system technology is carried out by developing materials used both from natural origin, synthetic, and semi-synthetic as well as developing drug delivery systems. Nano-drug delivery system technology or known as smart drugs promises a very bright future through various modifications of drug dosage forms developed from conventional dosage forms to dosage forms with drug delivery systems with controlled drug release. Nano-drugs with nano-delivery systems can be made using carriers in the form of natural polymers, or synthetic ones that can be biodegradable or non-biodegradable. Efficient therapy using nanotechnology is carried out in order to increase the safety level of the drug, as well as the ability of the drug to reach its target with minimal side effects. There are three ways to do this: increasing the solubility and bioavailability of drugs, creating new dosage forms, and using better routes of administration. Nanotechnology has great potential in contributing to the national economy and the nation's competitiveness, although much needs to be done to transform scientific and technological excellence into the economic field.
Studi Literatur Aktivitas Antibakteri Ekstrak Daun, Kulit Buah, Biji Kopi Arabika (Coffea arabica) dan Robusta (Coffea canephora) Terhadap Berbagai Bakteri Febriani, Amelia; Koriah, Siti; Syafriana, Vilya
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1683

Abstract

Coffee is a plant containing secondary metabolite compounds with potent antibacterial activity in its leaves, seeds, and even fruit peel. This study aims to analyze the antibacterial activity of extracts from arabica (Coffea arabica) and robusta (Coffea canephora) coffee leaves, fruit peel, and seeds against various bacterial strains. The research was conducted using a literature review method, employing databases such as Pubmed, Google Scholar, and Science Direct, and utilizing a combination of different keywords such as antibacterial, arabica coffee leaves, robusta coffee leaves, arabica coffee fruit peel, robusta coffee fruit peel, arabica coffee seeds, robusta coffee seeds, diffusion, and dilution. According to the findings of various studies, the coffee plant contains alkaloids, flavonoids, tannins, steroids, saponins, phenols, caffeine, and chlorogenic acid. Extracts of leaves, fruit peels, arabica coffee beans, and robusta coffee beans were obtained using maceration and heating extraction procedures such as soxhletation and steeping. These extracts were found to be effective at inhibiting the growth of Staphylococcus aureus, Escherichia coli, Edwardsiella tarda, and Streptococcus agalactiae. Robusta coffee leaf extract has the ability to suppress the growth of microorganisms such as Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Klebsiella pneumoniae. Arabica and robusta coffee fruit peel extracts have been shown to suppress the growth of bacteria such as Staphylococcus aureus, Vibrio cholerae, and Escherichia coli. Arabica coffee bean extract has been shown to prevent the growth of Lactobacillus acidophilus and Enterococcus faecalis, whilst robusta coffee bean extract has been shown to inhibit the growth of Staphylococcus epidermidis, Staphylococcus aureus, and Escherichia coli.
Uji Efektivitas Antiinflamasi Ekstrak Daun Jamblang (Syzygium cumini L.) terhadap Mencit (Mus musculus L.) yang diinduksi Karagenan Zunnita, Oktaviana; Moerfiah, Moerfiah; Auliya, Risa
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 17 No 1 (2024): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v17i1.1574

Abstract

Inflammation is a protective process against tissue injury caused by infection, trauma, or chemicals. The mechanism of inflammation starts from a stimulus that will cause cell damage, these cells will release several phospholipids, one of which is arachidonic acid. Free arachidonic acid will be activated by cyclooxygenase and lipoxygenase enzymes. This enzyme converts arachidonic acid into an unstable form which is further metabolized to leukotrienes, prostaglandins, prostacyclin, and thromboxane. One of the natural medicines used as an inflammatory treatment is jamblang leaf, because there are flavonoids that can inhibit cyclooxygenase and lipoxygenase enzymes. This study aims to determine the anti-inflammatory effect and the best dose of jamblang leaf extract. The method used was 1% carrageenan induction and a digital plethysmometer to measure the volume of inflammation on the soles of the test animals' feet. The test animals used were 25 mice divided into 5 treatment groups, each group consisting of 5 mice. The treatment group consisted of: negative control of 1% Na-CMC, positive control of Diclofenac Sodium 0.182 mg/20 g BW, dose 1 of jamblang leaf extract 10 mg/20 g BW, dose 2: 15 mg/20 g BW and dose 3: 20 mg/kg 20 g BB. The results showed that all doses of jamblang leaf extract had an anti-inflammatory effect and dose 3 was the best dose that reduced the volume of inflammation.

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