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Sainstech Farma: Jurnal Ilmu Kefarmasian
Published by Institut Sains dan Teknologi Nasional
ISSN : 20867816     EISSN : 27761878     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal ini memuat artikel penelitian kefarmasian meliputi kimia farmasi, biologi farmasi, bahan alam farmasi, teknologi farmasi, farmasi komunitas dan klinis, serta bioteknologi farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Aktivitas Antifungi Ekstrak Daun Bisbul (Diospyros blancoi A. DC.) terhadap Trichophyton mentagrophytes dan Malassezia furfur Rachmatiah, Tiah; Octaviani, Resti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 15 No 2 (2022): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v15i2.1288

Abstract

Bisbul (Diospyros blancoi A. DC.) adalah tanaman yang sering digunakan sebagai obat tradisional. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antifungi ekstrak daun bisbul terhadap Trichophyton mentagrophytes dan Malassezia furfur. Ekstrak dibuat dengan cara maserasi bertingkat menggunakan diklorometana dan etanol 70%. Aktivitas antifungi dari ekstrak diklorometana dan ekstrak etanol 70 % diuji dengan metode difusi cakram dalam media Sabouraud Dextrose Agar (SDA) pada konsentrasi ekstrak 20%, 40% dan 60% dengan kontrol positif ketokonazol dan kontrol negatif DMSO 100%. Konsentrasi Hambat Minimun (KHM) ekstrak diklorometana dan ekstrak etanol 70% terhadap kedua fungi tersebut dilakukan dengan metode dilusi padat pada media SDA. Hasil penelitian menunjukkan bahwa ekstrak diklorometana daun bisbul memiliki aktivitas antifungi terhadap T. mentagrophytes pada konsentrasi 20%, 40% dan 60% memberikan Diameter Daya Hambat (DDH) berturut-turut 7,40 mm, 9,97mm, dan 12,37 mm, namun tidak memiliki aktivitas terhadap M. furfur. Aktivitas antifungi ekstrak etanol 70% terhadap T. mentagrophytes pada konsentrasi yang sama mempunyai DDH berturut-turut 19,67 mm, 21,76 mm dan 23,57 mm, sementara itu pada M. furfur memiliki DDH berturut-turut 10,60 mm, 11,22 mm, dan 11,69 mm. KHM ekstrak diklorometana ada pada konsentrasi 20% terhadap T. mentagrophytes sedangkan KHM ekstrak etanol 70% daun bisbul ada pada konsentrasi 10% terhadap T. mentagrophytes dan pada konsentrasi 20% terhadap M. furfur.
Aktivitas Antioksidan Krim Ekstrak Etil Asetat Kulit Buah Rambutan (Nephelium lappaceum, L.) Tipe Minyak dalam Air (M/A) Kusuma, Ika Maruya; Febriani, Amelia; Zahra, Nada
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 15 No 2 (2022): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v15i2.1304

Abstract

Kulit buah rambutan mengandung senyawa golongan flavonoid dan tanin yang menjadikan kulit buah rambutan dapat dimanfaaatkan sebagai antioksidan alami. Penelitian ini bertujuan untuk membuat krim ekstrak etil asetat kulit buah rambutan dengan tipe minyak dalam air (MA) dan krim diuji aktivitas antioksidannya dengan metode 1,1-diphenyl-2-picrylhydrazil (DPPH) untuk menentukan nilai IC50. Penelitian dilakukan dengan cara pembuatan ekstrak dari kulit buah rambutan secara maserasi dengan pelarut etial asetat. Krim dibuat dengan konsentrasi 2,5% ekstrak kulit buah rambutan, tipe M/A. Selanjutnya krim diuji aktivitas antioksidannya dengan metode DPPH menggunakan spektofotometer UV-Vis. Pengujian aktivitas antioksidan pada krim ekstrak etil asetat kulit buah rambutan 2,5% dilakukan pada konsentrasi sebesar 200, 100, 50 dan 25 ppm. Hasil penelitian menunjukkan krim ekstrak etil asetat kulit buah rambutan 2,5% secara organoleptik memiliki warna kuning kehijauan pekat, berbau kulit rambutan lemah, karakteristik mudah dicuci dengan air dan lebih kental. Krim ekstrak etil asetat kulit buah rambutan memiliki nilai pH ±6 dengan tipe krim minyak dalam air (MA). Hasil uji aktivitas antioksidan krim ekstrak etil asetat kulit buah rambutan memiliki nilai IC50 sebesar 126,43 ppm. Penelitian ini dapat disimpulkan bahwa ekstrak etil asetat kulit buah rambutan dapat diformulasikan menjadi krim antioksidan dengan tipe krim MA dengan kategori sedang.
Tyrosinase Enzyme Inhibition Activity Test by Ethanol Extract of Taro Leaf (Typhonium flagelliforme (Lodd.) Blume) In Vitro Sholikha, Munawarohthus; Wahyuningtyas, Wahyuningtyas; Puspitasari, Lia
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1451

Abstract

Hyperpigmentation is an event that occurs due to excessive production of skin pigment. Skin color is strongly influenced by the presence of melanin, where the presence of melanin is strongly influenced by the enzyme tyrosinase. Taro leaf (Typhonium flagelliforme (Lodd.) Blume) are one of the plants have flavonoid compounds used as antioxidants and tyrosinase inhibitors. The aim of this study was to test the ethanol extract of taro leaf as a tyrosinase inhibitor. Taro leaf in this study were obtained through an extraction process using 96% ethanol solvent by maceration method. The thick ethanol extract of taro leaf was tested for phytochemical screening, total flavonoid levels, and tyrosinase inhibition test. The method used for tyrosinase inhibition test was enzymatic method in vitro. The results of this study indicated that there was a total flavonoid compound content of 0.7378% (b/b) and the inhibitor activity can be seen from the IC50 value for the diphenolation reaction (L-DOPA substrate) which was 13.307 mg/mL. This value was greater when compared with 0.093 mg/mL of phenolic acid, so that the ethanol extract of taro leaf has the potential to inhibit tyrosinase activity.
Perbedaan Kualitas Hidup antara Terapi Hemodialisis dengan Terapi Continuous Ambulatory Peritoneal Dialysis (CAPD) pada Pasien Gagal Ginjal Kronik Musnelina, Lili; Kurniati, Ditha; Ferdinal, Del
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1452

Abstract

Chronic Kidney Disease (CKD) is a progressive and irreversible disorder of kidney function. CKD patients who enter the final stage must immediately get renal replacement therapy to maintain their life. The most widely used kidney replacement therapy hemodialysis (HD) and peritonial dialysis (CAPD). Therapies performed either HD or CAPD cause various side effects such as physical fatigue, impaired concentration, disruption of social life and risk of infection. Side effects affect the quality of life of CKD patients. The purpose of this study was to the determine the differences quality of life chronic kidney failure patients between HD and CAPD. This research was an analytic observational research using the SF- 36 questionnaire. The results have shown that the average value of quality of life was significally different, the average score in the CAPD therapy group was 71.06 ± 13.92 and the HD therapy group the average score was 48.08 ± 14.37. The study found a that the majority of the CAPD therapy group have a good quality of life than the HD therapy group.
Potensi Larvasida Ekstrak Daun Alpukat (Persea americana) terhadap Larva Nyamuk Aedes aegypti Wenas, Desy Muliana; Fajrin, Muhammad Nur; Subaryanti, Subaryanti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1480

Abstract

Avocado (Persea americana Mill.) leaves contain saponins, tannins, flavonoids and alkaloids that have potential as larvicides. The purpose of this study was to determine the larvicidal activity of ethanol extract of avocado (Persea americana) leaves against Aedes aegypti larvae. The test was carried out on 210 larvae which were divided intro 7 groups, namely group I, II, III, IV, V which were ethanol extract of avocado leaves with concentration of 0,1%; 0,5%; 1%; 1,5%; and 2%. Positive control (group VI) was given Temephos 0,01% solution and group VII as negative control was only given Aquadest. Each treatment groups were observed for larvae death and counted every hour for 24 hours. LC50 and LT50 values were calculated using probit analysis. The results showed that ethanol extract of avocado leaf had larvicidal activity against Aedes aegypti larvae with LC50 = 0,03% at 3 hours and LT50 = at 1 hour 42 minutes. The ethanol extract of avocado leaf had a potential as larvicidal against Aedes aegypti larvae.
Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Sectio Caesarea di RSUD Budhi Asih Periode Juni-Desember 2020 Pratiwi, Ritha Widya; Simanjuntak, Yenny Yosalina; Veriyanti, Putu Rika
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1493

Abstract

Sectio Caesarea (SC) surgical patients are given prophylactic antibiotics to prevent surgical wound infections (SWIs). This study aimed to determine the pattern of use of prophylactic antibiotics in SC surgical patients at Budhi Asih Hospital. This research used a descriptive research type with a cross sectional approach. Number of samples 201 medical records with retrospective data collection. The patient inclusion criteria used were patients delivered by Sectio Caesarea and the patients who had a complete medical record. The results showed that the characteristics of Sectio Caesarea surgical patients at were based on age ≤ 20 years were 14 people (7%), were based on age of 21–34 years there were 133 people (66.2%), and were based on age ≥ 35 years old as much as 54 peoples (26.9%). Based on parity 1-2 people as 114 peoples (56.7%) and parity ≥ 3 people as 87 peoples (43.3%). Based on the history of SC 1-2 times as many as 193 people (96%) and ≥ 3 times as many as 8 people (4%). Based on the prescription pattern using ceftriaxone as many as 200 people (99.5%) and those using amoxicilin as many as 1 person (0.5%). Based on the route of prophylactic antibiotics intravenously, it was 200 people (99.5%) and orally 1 person (0.5%). Based on the time and frequency of prophylactic antibiotics, 201 people (100%) were given. Based on the duration of antibiotics, 201 people (100%) were not added prophylactic antibiotics. Based on the duration of surgery ≤ 60 minutes is 201 people (100%). Based on the Surgical Site Infection(SSI), those who experienced the SSI were 2 people (1%) and those who did not experience the SSI were 199 people (99%). The prophylactic antibiotics used were ceftriaxone with a dose of 1-2 grams/day, the time for drug administration was appropriate 30-60 minutes before surgery, appropriate antibiotics were given intravenously.
Analisis Rhodamin B pada Lip Tint Menggunakan Metode Kromatografi Cair Kinerja Tinggi (KCKT) Puspitasari, Lia; Azizah, Kholipia; Thalib, Amlius
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1495

Abstract

Rhodamine B is a dangerous colorant and is prohibited for use in various cosmetic products. The aim of this study was to analyze Rhodamine B in lip tint cosmetics, using the High Performance Liquid Chromatography (HPLC) system. Quantitative determination of Rhodamine B was carried out on 8 samples consisting of 4 BPOM registered samples and 4 non BPOM registered samples. The samples were taken at the Cakung traditional market with a randomized sampling method. The quantitative analysis of Rhodamine B by HPLC was carried out with a C18 stationary phase and a mobile phase of a mixture of acetonitrile and diammonium hydrogen phosphate (80:20); the sample injection volume was 20 µl and the eluent flow rate was 0.71 mL/minute. The results showed that Rhodamine B was not detected in the 8 lip tint samples tested.
Antioxidant Cream Formulation Type W/O Ethyl Acetate Extract of Rambutan Fruit Peel (Nephelium lappaceum L .) Waste with the DPPH Method Febriani, Amelia; Kusuma, Ika Maruya; Zahra, Nada
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1496

Abstract

Rambutan fruit peel contains phenolic chemical compound including geraniin and corilagin, which is a class of flavonoids, also elagic acid from tannin, which act as antioxidants and free radical scavengers. This study aimed to formulate a type water-in-oil (W/O) cream containing an ethyl acetate extract of rambutan peel and tested its antioxidant activity. The extraction of rambutan peel was carried out by maceration with an ethyl acetate solvent. The cream was made with a concentration of 5% rambutan peel extract, type W/O, and then its antioxidant activity was tested by the DPPH method using a UV-Vis spectrophotometer. Test for antioxidant activity in 5% cream of ethyl acetate extract of rambutan fruit peel was carried out at concentrations of 200, 100, 50, 25, and 12.5 ppm. The results showed that the organoleptic cream of ethyl acetate extract of rambutan fruit peel at 5% has a yellow-brown color, has a weak smell of rambutan peel, has characteristics that were not easily washed off with water, thick, and has a pH value of 5 (meets pH criteria) with water-in-oil cream type (W/O). The results of the antioxidant activity test of the ethyl acetate extract cream of rambutan peels had an IC50 value of 124.92 g/mL (moderate antioxidant category).
The Effect of Fever Medicine Advertising on Television onPurchase Decisions Fever Medicine in RW 01 Cipedak Jagakarsa South of Jakarta Wulandari, Ainun; Fiandani, Afifah
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1497

Abstract

Advertising is a form of non-personal communication activity delivered through the media by paying for the space it uses to convey messages that are persuasive, reminding, and offering a product to consumers by companies, non- commercial institutions, and interested individuals. Advertising can affect the feelings of someone who sees it, so that it can influence purchasing decisions. The purpose of this study was to determine the effect of fever medicine advertisements on television on purchasing decisions for fever medicine in the community of RW 01 Cipedak, Jagakarsa, South of Jakarta. This research was an observational study with a quantitative descriptive cross sectional method. The number of respondents obtained was 120 people. The sampling technique in this study used cluster random sampling. Data obtained through questionnaire. The research results obtained that the advertising variable has a positive effect on people's attitudes with sig. 0.000 (p value <0.05), the public attitudes variabel has a positive affect on purchasing decisions with sig. 0.000 (p value <0.05). The results showed that advertisements for fever medicine on television indirectly influenced the purchasing decisions of fever medicine for the people of RW 01 Cipedak Village, Jagakarsa Distrik, South Jakarta.
Analisis Kadar Pemanis Buatan pada Suplemen Anak dengan Metode Kromatografi Cair Kinerja Tinggi (KCKT) dan Spektrofotometri UV-Vis Puspitasari, Lia; Thalib, Amlius; Finanti, Hanif Mifta
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1569

Abstract

Sweeteners are food additives in the form of natural sweeteners and artificial sweeteners that give a sweet taste to food products. The use of sweeteners that are not in accordance with the limits set can have a negative impact on health. This study aims to determine whether the levels of artificial sweeteners in the form of saccharin and cyclamate in children's supplements have met the requirements set by BPOM according to the Decree of the Head of BPOM No. 12 of 2014 and Circular Letter No. HK.04.01.42.421.12.17.1666 of 2017 concerning Limits. Maximum Permitted Use of Artificial Sweeteners in Traditional Medicinal Products and Food Supplements. Three samples of children's supplements were taken randomly at several drug stores. The research method used for the determination of saccharin levels using HPLC and the determination of cyclamate levels using UV-VIS spectrophotometer The results of the analysis of saccharin levels are; sample (1084) = 463.02 mg/kg, sample (1085) = 363.01 mg/kg, and sample (1114) = 652.61 mg/kg. As for the levels of cyclamate obtained, sample content (1084) = 763.34 mg/kg, sample (1085) = 1279.87 mg/kg, and sample (1114) = 436.07 mg/kg. In conclusion, all samples tested for saccharin levels met the requirements for the maximum limit of 1000 mg/kg set by BPOM. Meanwhile, the sample (1085) tested for cyclamate did not meet the requirements for the maximum limit of 1250 mg/kg set by BPOM.

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