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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 195 Documents
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Biomedicine Potential of Oil Palm (Elaeis guineensis) Leaves: In Vitro Evaluation of Antibacterial, Antibiofilm, and Antioxidant Activities Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Dwi Sandi, Dita Ayulia; Ridha, Muhammad Rasyid; Bachri, Moch. Saiful
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.794

Abstract

Oil palm (Elaeis guineensis) leaves possess diverse pharmacological properties with promising development potential, particularly as antibiofilm and antioxidant agents. This study aimed to evaluate the antibacterial, antibiofilm, and antioxidant activities of E. guineensis leaf extract. The leaves were macerated in acetone for five days. Antibacterial activity was determined using the disc diffusion method against four bacterial species: Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa. The extract exhibited moderate antibacterial activity, with the highest inhibition observed against P. acnes (6.79 mm at 25%). Antibiofilm activity was evaluated using a microdilution method, showing concentration-dependent inhibition, with the highest activity at 1% concentration, reaching 83.90% (mid-phase, S. aureus) and 71.28% (E. coli). Antioxidant activity was assessed using DPPH, FRAP, and ABTS assays, yielding IC50 values of 99.19 ppm, 119.12 ppm, and 123.37 ppm, respectively, indicating moderate antioxidant capacity (IC50 > 50-150 ppm). Overall, E. guineensis leaf extract demonstrates moderate antibacterial, antibiofilm, and antioxidant activities, suggesting its potential as a preliminary candidate for further pharmacological investigation.
Formulation And Physical Evaluation Of Effervescent Granules Containing 70% Ethanol Extract Of Butterfly Pea Flower (Clitoria Ternatea L.) Sulaiman , Muhammad; Abdurrahman, Abdurrahman; Afra, Fairuz Yaumi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.796

Abstract

Butterfly pea (Clitoria ternatea L.) is a plant commonly found in Indonesia, known to possess bioactive antioxidant properties with an Inhibitory Concentration (IC₅₀) value of 41.36 ppm. Based on this, the ethanol extract of butterfly pea flower has the potential to be formulated into effervescent granules using various concentrations of citric acid, tartaric acid, and sodium bicarbonate. This study aims to determine the effect of different concentrations of citric acid, tartaric acid, and sodium bicarbonate on the physical properties of the effervescent granules and to identify the optimal formula based on the evaluation results. The effervescent granules were formulated into four different formulas using the butterfly pea flower extract as the active ingredient and were evaluated through various physical tests. Based on organoleptic tests, all formulas exhibited a slightly sour taste, a greenish- brown color, and a distinctive butterfly pea aroma. The results of the physical evaluations showed that the compressibility index ranged from 9.41%-21.88%, flow time from 2.47-3.59 seconds, angle of repose from 29.78°-35.53°, dissolution time from 3.48-5.55 minutes, and pH values from 4.66-5.65. Based on these evaluations, it can be concluded that the variation in the concentrations of citric acid, tartaric acid, and sodium bicarbonate affects the physical characteristics of the granules. Among the tested formulas, Formula 2 demonstrated the most favorable and optimal physical characteristics compared to the others.
Interaksi Antara Ekstrak Clitoria ternatea L Dan Antibiotik Pada Aktivitas Antibakteri Terhadap Staphylococcus aureus Nabila Wanda, Yumna Hanum; Rahma Putri, Citra Destya; Risandiansyah, Rio
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.800

Abstract

Antibiotic combination is a strategy to enhance antibacterial effectiveness by acting on different cellular targets. The utilization of natural ingredients as adjuvants also has the potential to improve antimicrobial responses. Butterfly pea (Clitoria ternatea L.) is known to contain antibacterial compounds that can potentiate antibiotic activity. Research regarding the interaction of Clitoria ternatea extracts with antibiotics against Staphylococcus aureus remains limited; therefore, this study aims to evaluate the interaction patterns of these combinations. Clitoria ternatea L. simplicia was macerated using three solvents: ethanol, ethyl acetate, and n-hexane. Antibacterial testing was conducted based on the Zone of Inhibition (ZOI) using the Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method, which is suitable as an initial screening method for antimicrobial interactions. Extracts were tested at a concentration of 50% (500,000 ppm), with the inoculum standardized to 0.5 McFarland, and each treatment was replicated 3×2 times. Data were analyzed using One-way ANOVA or non-parametric tests (Kruskal-Wallis) depending on the data distribution, followed by appropriate post hoc tests (Tukey, Games-Howell, or Mann-Whitney). The significance level was set at p < 0,05, and the type of interaction was determined based on AZDAST interpretation criteria (synergistic, additive, antagonistic, or not distinguishable). The results showed that the combination of ethanol extract and amoxicillin produced an additive effect (55.06 ± 1.68 mm), The combination of ethyl acetate extract with amoxicillin (52.38 ± 2.60 mm). n-hexane extract with amoxicillin (52.60 ± 3.99 mm), and all extract combinations with tetracycline (37.76-42.70 mm) yielded results that were not distinguishable compared to either single antibiotics or their double doses. It can be concluded that the combination of ethanol and ethyl acetate extracts with amoxicillin can enhance antibacterial activity compared to single treatments by providing an additive effect. Meanwhile, the combinations of ethanol and ethyl acetate extracts with tetracycline, as well as the combinations of n-hexane extract with both amoxicillin and tetracycline, showed no significant difference (not distinguishable).
Aktivitas Antibakteri dan Formulasi Gel Topikal Ekstrak Akar Zingiber cassumunar Roxb. Terhadap Propionibacterium acnes Nurhasanah, Hana; Lestaria, Tresna; Rahmiyani, Ira; Virgianti, Dewi Peti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.805

Abstract

Acne is a common inflammatory skin disorder affecting both adolescents and adults, primarily caused by the colonization of Propionibacterium acnes, which induces skin inflammation. The development of natural-based anti-acne agents may offer a safer alternative to synthetic drugs. Zingiber cassumunar Roxb. (bangle rhizome) contains flavonoids, terpenoids, saponins, and essential oils known for their strong antibacterial properties. Aim: this study aimed to evaluate the antibacterial activity of Z. cassumunar rhizome extracts against P. acnes and to formulate a topical anti-acne gel. Method: extraction was conducted using successive maceration with n-hexane, ethyl acetate, and 70% ethanol. Antibacterial activity was determined by the disk diffusion method, and gels containing n-hexane extract at concentrations of 5%, 10%, and 15% were evaluated for their physical quality. Results: the n-hexane extract exhibited the highest antibacterial activity, producing an inhibition zone of 7.56 ± 0.11 mm. The 15% extract gel (F3) showed the strongest antibacterial effect (9.26 ± 0.08 mm) and met all physical quality requirements. Conclusion: these findings indicate that the n-hexane extract gel of Z. cassumunar rhizome possesses promising potential as a natural topical formulation for treating acne caused by P. acnes.
Hubungan Behavior Change Technique (BCT) Dengan Kepatuhan Minum Obat Pada Pasien Hipertensi Di Klinik Jelita Banjarmasin Wahyunita, Sari; Kurniawan , Guntur; Sari , Tri Yusna; Rosyad, Muhammad Ihsan
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.815

Abstract

Hypertension is a chronic disease with a high prevalence and requires long-term medication adherence to maintain controlled blood pressure. However, patient adherence levels remain low. Behavior Change Technique (BCT) is used as a behavioral change approach to improve medication adherence. This study aims to determine the level of medication adherence among hypertensive patients, the implementation of BCT, and the relationship between BCT and medication adherence at Jelita Clinic Banjarmasin. The design cross sectional, with a sample of 33 uncontrolled hypertensive patients. The research instruments included the MMAS-8 questionnaire to assess adherence and the Taxonomy v1 questionnaire for BCT intervention. Data were analyzed using the korelasi test. The results in the m adherence improved to 67% in the moderate category and 33% in the low category. In addition, hypertension classification showed improvement after the intervention. The korelasi test obtained a value of r = 0.485 with p = 0.004, indicating a significant and moderately strong relationship between BCT and medication adherence. It can be concluded that the Behavior Change Technique (BCT) is effective in improving patients' adherence to antihypertensive medication and contributes to better blood pressure control.

Page 20 of 20 | Total Record : 195

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