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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Antioxidant Activity and Body Scrub Formulation from Yellow Dragon Fruit Peel (Selenicereus megalanthus) Extract. Yoga Wardana, Fendi; Islamiyah, Tufa Nur; Arifin, Irnandhea Putri
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.542

Abstract

Antioxidant agents are substances that repress oxidation responses due to free radicals which can cause harm to unsaturated greasy acids in cell divider films, blood vessel cells and lipid tissue. Dragon fruit has been reported to have high antioxidant activity. The aim of the research was to determine the antioxidants in yellow dragon fruit peel (Selenicereus megalanthus) extract and formulate them as body scrub. Research design of laboratory experiments, the yellow dragon fruit peel was extracted by maceration using 96% ethanol. Antioxidant activity testing was carried out using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Preparation of the formula using extract concentration variations of 1% and 3%. The evaluation of body scrub preparation include homogeneity, organoleptic, pH and dispersive power. The yellow dragon fruit peel extract showed antioxidant activity with IC50 value of 2.7 ppm (strong antioxidant). The results of the evaluation of the two formulas did not provide a significant difference. Both body scrub preparations were homogeneous, organoleptic evaluation showed a yellowish-white color and does not become rancid, pH range of 7.7-7.8 and dispersive power range of 4.3-4.4 cm. The yellow dragon fruit peel extract has very strong antioxidant activity and can be formulated as a scrub product.
Aktivitas Antioksidan Sediaan Nutraceutical Tablet Hisap Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3 Dipahayu, Damaranie; Safira, Irma Adinda
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.543

Abstract

Purple sweet potato leaf extract Ipomoea batatas L variety Antin-3 (Antin-3 leaf extract) is a source of natural antioxidants because of its high flavonoid and polyphenol content. This study aims to determine the effect of variations in binding components on the antioxidant activity of nutraceutical preparations of EDA3 lozenges. The binding material used is PVP K-30 with concentrations of 5% and 10% (F1; F2), both samples will be seen for their antioxidant activity using the DPPH method. From the study result, the extract obtained an average IC50 value in F1 of 24.1ppm ± 0.8; F2 of 63.4ppm ± 2.0; pure vitamin C was 10.1 ppm± 0.1. In the Independent T-Test statistical test, sig 2-tailed (0.00) <0.05 was obtained, which means that there is an effect of the binder on antioxidant activity with sig 2-tailed (0.00) <0.05. Antin-3 leaf extract lozenges with 5% PVP K-30 have been shown to have three times greater antioxidant activity (DPPH method) compared to Antin-3 leaf extract lozenges with 10% PVP K-30.
Profil Senyawa Fitokimia Menggunakan Metode FTIR dan Pengujian Nilai SPF Secara In Vitro Formulasi Lotion O/W Ekstrak Etanol 96% Daun Binahong Hijau Nurluthfiana, Deby; Adiyas Putra, Teguh; Irawan, Ade
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.546

Abstract

The 96% ethanol extract of green binahong leaves contains flavonoid compounds with potential activity as a sunscreen. Flavonoid compounds have been identified via FTIR and show part of this functional group. in the form of aliphatic C-H, C=O, C=C, and C-O. This research aims to determine the stability of the physical and chemical quality of o/w type sunscreen lotion and its activity as a sunscreen in vitro using a UV-vis spectrophotometer. The extract is obtained using the ethanol maceration method and then formulated into lotion and o/w cream and tested for physical and chemical stability and tested for SPF in vitro with a spectrophotometer. The results of this research indicate that the o/w lotion formula is stable during the storage period of 6 cycles. The increase in the diameter value of spreadability and sticking time is influenced by storage factors, the longer the preparation is stored, the viscosity will decrease. Sunscreen activity calculated using the Mansur equation shows that the SPF value at 0.5%, 2.5% and 4.5% levels of green binahong leaf extract is 3.37; 8.25 ; 8.93. The sunscreen lotion preparation of 96% ethanol extract of green binahong leaves is stable during storage and has activity as a sunscreen.
Uji Aktivitas Antibakteri Ekstrak Etil Asetat Daun Tigaron (Crataeva nurvala Buch.Ham) Terhadap Bakteri Propionibacterium acnes Dengan Metode Difusi Sumuran Sari, Putri Kartika; Sari, Novita; Fitriyanti, Fitriyanti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.559

Abstract

Tigaron (C. nurvala buch.Ham.) is a plant can be found in India, Africa, Australia, Japan, Myanmar, Sri Lanka, Malaysia, India and China. Traditionally, the bark, leaves, flowers and root are used in traditional medicine to cure various disease conditions. The leaves of this plant used to treat abscesses, wounds and skin diseases. This study aims to determine of secondary metabolite and antibacterial activity test from ethyl acetate extract of tigaron leaves (C. nurvala buch.Ham.) in inhibiting growth of Propionibacterium acnes with varying concentration which are 0.31 mg/ml, 1.55 mg/ml, 7.75 mg/ml, 38.75 mg/ml, 193.75 mg/ml, negative control Na-CMC 0, 5% and positive control antibiotic clindamycin. Tigaron leaves were extracted using the maceration method using ethyl acetate solvent, secondary metabolite compounds detected using phytochemical screening method and antibacterial activity test using the well diffusion method. The final yield of ethyl acetate extract of tigaron leaves (C. nurvala buch. Ham.) was obtained at 1%. The secondary metabolite contained are alkaloids, flavonoids and steroids. The results showed that concentration of 0.31 mg/mL was included in the weak category inhibition zone (4.97 mm), 1.55 mg/mL (5.97 mm), 7.75 mg/mL (7.08 mm), 38.75 mg/mL (10.02 mm) which was included in the medium category inhibition zone and concentration of 193.75 mg/mL which is included in the strong category inhibition zone, clindamycin antibiotic as a positive control showed a strong zone of inhibition (16.5 mm). Ethyl acetate extract of tigaron leaves (C. nurvala buch.Ham.) can inhibit the growth of Propionibacterium acnes.
Sensitivity of Bacteria causing Hospital-Acquired Pneumonia (HAP) in the Intensive Care Unit (ICU) to Empiric Antibiotics APRILIANY, FITRI; Umboro, Recta Olivia; Ersalena, Vera Fitriya; Setiawan, Deni; Cholisah, Elis
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.565

Abstract

The main therapy for the treatment of pneumonia is antibiotics. The use of antibiotics requires special attention to prevent antibiotic resistance. Therefore, it is important to know the pathogenic microorganisms that cause hospital-acquired pneumonia (HAP) infections. This study aimed to describe the sensitivity of negative-positive bacteria to empiric antibiotics in HAP patients. The study method was an analytical descriptive observational study with a cross-sectional design. Data were collected from patient medical records for the period January 2019 – December 2020. Inclusion criteria were ICU patients diagnosed with HAP, aged 15 years, with complete medical records (age, sputum culture, leukocytes, chest x-ray results), treatment history and outcome parameters (vital signs). Exclusion criteria were pregnant patients, involuntary discharge, and ICU stay of less than 48 hours. The data in this study were analyzed descriptively and Likelihood Ratio. The results of the description showed that the empiric antibiotics with sensitivity more than 70% against gram-positive bacteria causing HAP were rifampin (78%), TMP-sulfamethoxazole (78%), vancomycin (100%), and linezolid (100%) while the empiric antibiotics with sensitivity more than 70% against gram-negative bacteria was cefoperazone-sulbactam (≥75%), followed amikacin and imipenem (≥55%). Meanwhile, the empiric antibiotics had a very low sensitivity (≤ 50%) against ESLB-producing bacteria and MRSA. There is a significant relationship between age and educational level factors and bacterial growth in sputum cultures (p<0.05). Conclusion: Vancomycin and linezolid are sensitive to gram-positive bacteria, cefoperazone-sulbactam is sensitive to gram-negative bacteria and resistance to ESLB-producing bacteria and MRSA has occurred.
Karakterisasi Fitokimia dan Uji Daya Hambat Senyawa Daun Kelakai (stenochlaena palustris) Khas Kalimatan Terhadap Bakteri Propionibacterium acnes Secara In Vitro Apriliyana, Nafisah Sofia; Su'aida, Nily; Fadillah, Aris; Abdi, Muhammad; Azkya, Nurizka; Nadiati, Nadiati; Halimah, Siti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.576

Abstract

Several acne therapy modalities have been widely used to eradicate Propionibacterium acnes, the causative pathogen of acne. However, it cannot treat acne optimally and has adverse effects. Kelakai (Stenochlaena palustris) possesses antibacterial activity. Based on the antibacterial activity of S. palustris, its leaf can be utilized as an alternative acne therapeutic substance. Therefore, this study investigated the effects of the ethanol extract of S. palustris leaf on P. acnes. The extraction of S. palustris was performed using maceration with 96% ethanol. The antibiotic activity test was divided into five groups: a positive control group (Clindamycin), a negative control group (Propionibacterium acnesATCC®6919), and three test groups with concentration gradients. Phytochemical analysis was positive for the identification of saponins, tannins, alkaloids, steroids and flavonoids. The inhibitory diameter of P. acnes at 75% extraction concentration was closest to that of the positive control group and has inhibition zone of diameter 13,99 + 0,77 (strong inhibition) indicating its effectiveness in inhibiting the growth of P. acnes. Based on the antibacterial activity of the ethanol extract of S. palustris leaf, the leaf extract has the potential to be used as a medicinal substance in acne therapy.
Efek Iradiasi Gamma Terhadap Aktivitas Inhibisi Xantin Oksidase Secara In Vitro pada Sediaan Jamu Anthiperurisemia Daun Sendok, Seledri dan Cabe (SESEJA) Nuraini, Nuraini; Fahrezi, Fahrul Arya; Arini, Arini Aprilliani
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.579

Abstract

Plants such as broadleaf plantain, celery, and java long peppers are known to lower uric acid levels, inhibit xanthine oxidase, and have analgesic effects. The process of food irradiation is used to preserve and improve food safety. This study aimed to determine the inhibition activity of xanthine oxidase before and after 10 kGy gamma irradiation in herbal medicine, by testing category I ionizing irradiation (Gamma Chamber & Gamma Cell) at a dose of 10 kGy and Elabscience® Xanthine Oxidase (XOD) Activity Assay Kit, in various concentrations (4 μg/mL; 8 μg/mL; 16 μg/mL; 31 μg/mL; 63μg/mL) with allopurinol as a comparator. The results showed that allopurinol had a very strong inhibitory activity against the enzyme xanthine oxidase, with an IC50 value of (1,445 μg/mL). Antihyperuricemia herbs before and after gamma irradiation of 10 kGy have the potential to be xanthine oxidase inhibitors at concentrations (4 μg/mL; 8 μg/mL; 16 μg/mL; 31 μg/mL; 63 μg/mL). Irradiation of 0 kGy showed weaker inhibitory activity compared to allopurinol, but was still very strong with an IC50 value of (24.548 μg/mL). Meanwhile, 10 kGy irradiation has stronger inhibitory activity than 0 kGy irradiation samples, with an IC50 value of (15.295 μg/mL). This suggests that a dose of 10 kGy has a higher potential in inhibiting the activity of the enzyme xanthine oxidase compared to a dose of 0 kGy.
FORMULASI SEDIAAN GUMMY CANDIES INFUSA BUAH KARAMUNTING (Rhodomyrtus tomentosa (AITON) HASSK.) Rakhmatullah, Aditya Noviadi; Chandra, M. Andi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.615

Abstract

Karamunting plant (R. tomentosa) (Aiton) Hassk.) is a plant that can be used as a source of natural antioxidants. Karamunting contains active compounds of natural antioxidants such as flavonoids. The purpose of this study was to find out the best formula based on the physical characteristics of the karamunting fruit infusion gummy candies preparation with different gelatin content and to determine the level of respondent's preference for the karamunting fruit infusion gummy candies preparation. The gummy candies formulation was made with variations in gelatin concentration of 7%, 9%, 10%, and 11%. The physical evaluations carried out included organoleptic tests, pH tests, water content tests, weight uniformity tests, elasticity tests, and hedonic tests. The organoleptic results showed that F1 and F2 were green in color, tasted not sweet, had a melon aroma, were semi-solid, and had a texture that was easily crushed or not chewy. F3 and F4 are green in color, taste less sweet and sweet, melon aroma, semi-solid, chewy texture, evaluation of gummy candies preparations shows pH 5.01-6.38, but the water content exceeds the requirements, namely 92.59% -58.11%. Based on the results of the study, it was concluded that based on the physical characteristics of the gummy candies infusion preparation of karamunting fruit, formula III met the requirements based on the results of the physical test of the preparation and became the most preferred formula based on the hedonic test
EVALUASI PENGGUNAAN OBAT DIABETES MELITUS PADA PASIEN PSIKIATRI DI RUMAH SAKIT JIWA SAMBANG LIHUM PERIODE 2022-2023 Saputri, Rina; Maulani, Eka Febrianti; Hidayah, Nur; Aryzki , Saftia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.634

Abstract

Mental disorders are severe mental health problems that cause cognitive, affective and social functioning impairments. Diabetes mellitus is a disease with hyperglycemia. The use of diabetes mellitus drugs in psychiatric patients can pose a risk of potential interactions between drugs that will result in the possibility of irrational drug use. The purpose of this study was to evaluate the use of diabetes mellitus drugs in psychiatric patients at Sambang Lihum Mental Hospital. The method used is descriptive observational method with survey design and sampling technique, namely total sampling and retrospective data collection with appropriate assessment indicators are the 14 appropriate criteria from the Ministry of Health, so that the results obtained are the majority of gender is male as many as 15 people (55.56%) and the majority of age is 45-59 years as many as 16 people (59.26%). Evaluation of the use of single diabetes mellitus drugs as many as 9 people (33.33%) and a combination of 18 people (66.67%). Evaluation of the use of diabetes mellitus drugs was obtained by 26 rational people (96.30%) and 1 irrational person (3.70%) and all the use of diabetes mellitus drugs was in accordance with the hospital formulary and treatment guidelines. The conclusion of this study is that there is still irrational use of drugs in the criteria of patient adherence to treatment so that it has the potential to cause harm to the patient.
Evaluation of Antibiotic Use with ATC/DDD and DU90% Methods in Obstetrics and Gynecology Surgery Patients at a Hospital in Bandung Gazali, Munawir; Dewi Alfian, Sofa; Melyani Puspitasari, Irma; Satriasih, Tulus Satriasih
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.640

Abstract

Latar Belakang: Penggunaan antibiotik yang tidak rasional meningkatkan risiko resistensi, yang menyebabkan lamanya rawat inap (LOS) di rumah sakit dan biaya perawatan yang lebih tinggi. Infeksi nosokomial umum terjadi pada operasi obstetri dan ginekologi karena prosedur invasif. Prevalensi infeksi tempat operasi adalah 10–20% pada operasi caesar di negara-negara berpenghasilan rendah dan menengah, dan 1,7% pada histerektomi di negara-negara berpenghasilan tinggi seperti AS. Kami percaya prevalensinya tinggi di Indonesia. Oleh karena itu, penelitian ini mengevaluasi pola penggunaan antibiotik pada pasien bedah obstetri dan ginekologi menggunakan metode ATC/DDD dan DU90% dan menganalisis perbedaan LOS berdasarkan jenis dan kombinasi antibiotik di sebuah rumah sakit di Bandung, Indonesia. Metode: Data pasien dikumpulkan secara retrospektif dari Juni 2022 hingga Mei 2023. Metode ATC/DDD, standar internasional WHO, digunakan untuk mengukur penggunaan obat dan mengidentifikasi penggunaan antibiotik yang tidak tepat. Metode DU90% menyoroti antibiotik yang paling sering digunakan untuk fokus pada obat-obatan yang memerlukan pemantauan. Analisis Kruskal-Wallis dan Mann-Whitney diterapkan untuk analisis statistik. Hasil: Di antara 1.486 pasien, Ceftriaxone adalah antibiotik yang paling banyak digunakan (19,42 DDD/100 hari pasien), diikuti oleh Metronidazole dan Cefazolin. Ketiga antibiotik tersebut berada dalam segmen DU90%. Kombinasi antibiotik yang lebih kompleks dikaitkan dengan lama rawat inap (LOS) yang lebih panjang. LOS rata-rata terpendek adalah 3 hari dengan kombinasi Cephalosporin + Tetracycline, sedangkan yang terpanjang adalah 35 hari dengan kombinasi Cephalosporin + Nitroimidazole + Glikopeptida + Aminoglycoside. Kesimpulan: Penggunaan antibiotik yang rasional harus ditingkatkan, terutama menghindari kombinasi kompleks yang tidak perlu, untuk mengurangi resistensi, memperpendek LOS, dan menurunkan biaya.

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