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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Hospital Pharmacists’ Knowledge and Perceptions of Antibiotic Use and Resistance in Indonesia Febrianti, Yosi; Lubisa, Ratu Aini; Yulianto, Yulianto; Wulandari, Denia Yuni; Wahdini, Ade indah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.686

Abstract

Background: Inappropriate antibiotic use in Indonesia contributes significantly to increasing antibiotic resistance, which poses a serious threat to public health. Hospital pharmacists play a crucial role in antibiotic management, so their knowledge of antibiotic use and resistance is crucial to supporting infection control efforts and the rational use of antibiotics. Objectives: To assess the knowledge and perception of hospital pharmacists on antibiotic use and resistance. Material and Methods: The research design is cross-sectional and involves collecting data through a questionnaire. Data was then analyzed using the SPSS program's Chi-square test. Results: A total of 103 responses were received, 93 (90.3%) respondents had good knowledge and 83 (80.5%) had positive perceptions of antibiotic use and resistance. Conclusions: The study's results indicate that pharmacists' knowledge of antibiotic resistance does not correlate with their perception of this issue (p=0.416).
Karakteristik Pasien TB Resisten Obat di Kalimantan Selatan : Studi Ekologi terhadap Kesiapan Implementasi Regimen BPaL/M Sandi, Dita Ayulia Dwi; Nurrahma, Ika Maulida; Isnani , Nazhipah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.738

Abstract

This study aims to describe the prevalence and analyze risk factors associated with the incidence of Drug-Resistant Tuberculosis (DR-TB), as well as to analyze the readiness of the implementation of the BPaL/M regimen in South Kalimantan based on patient characteristics. This study used an observational-analytical approach with a cross-sectional design. Data were obtained from the South Kalimantan Provincial Tuberculosis Information System in 2022-2023. The study sample consisted of 151 patients with DR-TB. The chi-square test was used for statistical analysis. The incidence of DR-TB in South Kalimantan in 2023 was 0.95%, with the highest incidence coming from Banjarmasin City, namely 37.36%. Drug-resistant tuberculosis (DR-TB) in South Kalimantan was most common in the elderly (>45 years) (54.30%), men (62.91%), unemployed (56.29%), and non-pregnant (98.68%). Most drug-resistant TB patients were individuals who had undergone previous treatment (63.58%), did not have comorbid DM (75.50%) and were HIV negative (98.68%). A total of 76.16% received a short-term therapy regimen and 94.70% of RO-TB patients in 2022-2023 met the criteria for receiving BPaL/M regimen therapy. The conclusion of this study is that the factors that influence the incidence of RO-TB in South Kalimantan are occupation (p 0.016), history of previous TB treatment (p 0.000) and HIV status (p 0.000), the BPaL/M regimen with a shorter duration (6 months) can be implemented in RO-TB patients in South Kalimantan by continuously improving monitoring to achieve and reduce side effects of drug events.
Potensi Antiinflamasi Ekstrak dan Fraksi n-Heksana Daun Galam (Melaleuca cajuputi) Asal Kalimantan Selatan Sutomo, Sutomo; Arnida, Arnida; Amalina, Amalina; Fadlilaturrahmah, Fadlilaturrahmah; Fitriana, Mia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.754

Abstract

South Kalimantan has a unique topography that includes tidal areas and swamps, and peatlands. One of the natural resources that grows well in this area is the galam tree (Melaleuca cajuputi). Traditionally, this plant has been used to treat various inflammatory conditions, such as intestinal inflammation, sore throat, itchy skin, and rheumatism. M. cajuputi contains flavonoid compounds that are believed to have anti-inflammatory properties. This study aimed to determine the anti-inflammatory activity of ethanol extracts and n-hexane fractions of M. cajuputi leaves from South Kalimantan using a protein denaturation inhibition method with IC50 values as the parameter. Sodium diclofenac was used as the positive control in this study. The results of the anti-inflammatory activity test showed that the IC50 values for sodium diclofenac, ethanol extract, and n-hexane fraction of M. cajuputi leaves were 14.948; 51.577; and 61.700 ppm, respectively. Statistical analysis revealed a significant difference between the IC50 value of sodium diclofenac and those of the ethanol extract and n-hexane fraction. Based on the study conducted, it can be concluded that the ethanol extract and n-hexane fraction have anti-inflammatory activity, although their potency is lower than that of sodium diclofenac
Persepsi Preseptor Klinik Dan Komunitas Mengenai Peran Sebagai Pendidik Dalam Praktek Kerja Profesi Apoteker Lingga, Herningtyas Nautika; Intannia, Difa; Khumaira Sari, Anna; Normaidah, Normaidah; Ikhwan Rizki, Muhammad
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.755

Abstract

Preceptors are essential in guiding and being role models for students' knowledge, skills, and practices in implementing pharmacy internship program (PKPA) based on experiential learning. Guidance takes place in a clinical environment in a healthcare system that allows students to experience health services, interact with professional teams, and interact directly with the community. This study analyzes preceptors' perceptions regarding their role as educators in implementing PKPA. This study is a descriptive survey with a cross-sectional design using a questionnaire as an instrument. The study subjects were pharmacists who acted as preceptors in implementing PKPA with a purposive sampling technique. The data analysis used descriptive analysis. The results showed that of the 31 preceptors involved, the majority were female (74.19%), with an age range of 36-45 years (58.07%), and the place of practice was in a health center (58.07%). Preceptors' perceptions regarding the implementation of PKPA are generally positive. Aspects rated high with a score of more than 4 are the aspects of recognition/award, teamwork, communication, preparation, evaluation, appreciation, and the impact of student attendance. Meanwhile, the lowest ratings are in workload (3.75 ± 0.84) and facilities and infrastructure (3.86 ± 0.72). Preceptors provide positive perceptions about their role as educators in implementing the pharmacy internship program.
Karakteristik dan Uji Aktivitas Antiosidan Ekstrak Kolagen Sisik Ikan Gabus (Channa sp.) Su'aida, Nily; Ridha, ainur; Soemarie, Yulistia Budianti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.652

Abstract

This study aims to isolate collagen from the scales of snakehead fish (Channa sp.) and evaluate the antioxidant activity of the extracted collagen. Collagen was isolated using a 0.5 M acetic acid method, involving dissolution and purification procedures. The collagen extract was characterized using FTIR analysis to detect functional groups and phytochemical tests to identify active compounds. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method to measure free radical scavenging potential. The results indicated that the collagen extract from snakehead fish scales contains bioactive compounds with significant antioxidant activity. The IC₅₀ values demonstrated a strong ability to neutralize free radicals, showing higher potency than the control. FTIR analysis detected hydroxyl (3330.21 cm⁻¹), methyl (2111.83 cm⁻¹), and carbonyl (1635.85 cm⁻¹) groups as characteristic phytochemical components of Channa sp. collagen extract. The IC₅₀ values at different concentrations were classified as very strong at low concentrations (25%), strong at moderate concentrations (50%), and moderate at higher concentrations (75%). The antioxidant activity of snakehead fish scale extract was very strong at lower concentrations but decreased as the concentration increased
Preclinical Study of n-Hexane Extract of Kapul Fruit (Baccaurea macrocarpa) as an Anti-Inflammatory Rizki, Muhammad Ikhwan; Rahmatullah, Satrio Wibowo; Izma, Hayatun; Isnani, Nazhipah; Ramadhani , Syahrizal
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.769

Abstract

Plants of the genus Baccaurea have long been traditionally used in folk medicine. Previous studies reported that the n-hexane extract of kapul fruit (Baccaurea macrocarpa) exhibited extreme antioxidant activity with an IC₅₀ value of 33.11 ppm. However, its potential anti-inflammatory activity has not been extensively investigated. The results demonstrated that all three doses of the n-hexane extract exhibited anti-inflammatory activity, as indicated by a reduction in edema volume. Among the tested doses, 600 mg/kg BW was the most effective ini decreasing edema volume. Statistical analysis using one-way ANOVA showed a significance value of 0.000, confirming a significant difference among the five treatment groups. Furthermore, post hoc analysis indicated that dose III did not differ significantly from the positive control but showed a significant difference compared to the negative control. Conversely, doses I and II exhibited significant differences when compared to both the positive and negative controls. These findings suggest that the n-hexane extract of B. macrocarpa fruit possesses anti-inflammatory activity, with the 600 mg/kg BW dose demonstrating the most potent effect, comparable to that of diclofenac sodium
COST UTILITY ANALYSIS PENGOBATAN HEMODIALISIS PASIEN GAGAL GINJAL KRONIK DI RUMAH SAKIT PEMERINTAH DAN SWASTA DI KALIMANTAN SELATAN Maulidie Alfiannor Saputera, Mochammad; Ismail, Hasan; Rio Pambudi, Didik; Rahmadina, Aprillia; Muslim, Muhamad
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.629

Abstract

Health care costs have continued to increase over time in patient treatment. Cost-utility analysis, a branch of pharmacoeconomic evaluation, assesses patient utility in relation to incurred costs. Chronic kidney disease (CKD) is among the most prevalent diseases in South Kalimantan; therefore, this study aimed to analyze the cost-utility of CKD patients undergoing hemodialysis. This research employed a cross-sectional design conducted in two hospitals as comparison sites, with a total of 43 participants (16 from a private hospital and 27 from a public hospital). Data were collected prospectively using the validated and reliable EQ-5D-5L questionnaire and Visual Analog Scale (VAS) to assess patient health status, along with observation sheets for cost data. The results showed that the Cost Utility Ratio (CUR) in the private hospital was Rp 78,928.88, while in the public hospital it was Rp 159,868.76, yielding an Incremental Cost Utility Ratio (ICUR) of Rp 8,626.80 per QALY. In conclusion, the private hospital demonstrated better cost-utility compared to the public hospital in providing hemodialysis treatment for CKD patients, as indicated by the ICUR value.
Efektivitas Enkapsulasi Nano Kitosan Serai Dapur dalam Meningkatkan Depolarisasi Mitokondria pada Sel Kanker HSC-3 Komariah, Komariah; Moksidy, Jenyfer Ignatia; Nugroho, Didi; Ranggaini, Dewi; Anggraeni , Rezky; Halim , Johni
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.602

Abstract

Oral cancer ranks 12th among the most common types of cancer worldwide, with a prevalence of approximately 25%-40% occurring on the lateral borders and the underside of the tongue. Conventional therapies often cause side effects that damage normal cells, prompting the use of safer natural alternatives, such as Cymbopogon citratus (lemongrass). The active compounds in lemongrass leaves can enhance the production of reactive oxygen species (ROS), which trigger apoptosis through the depolarization of mitochondrial membrane potential (MMP). To improve the stability of these active compounds, they are encapsulated with chitosan, which is modified into nanoparticles to enhance diffusion through cell membranes, thereby increasing their effectiveness as anticancer agents. This study involved nine groups, including a negative control, a positive control (doxorubicin), nano chitosan, lemongrass extract, and five treatment groups with various encapsulation concentrations (100%, 75%, 50%, 25%, and 12.5%). The results showed that nano chitosan encapsulation of lemongrass extract significantly increased MMP depolarization compared to the control. The depolarization effect increased with higher encapsulation concentrations, with the lowest red fluorescence intensity observed at the 100% concentration, indicating the highest level of depolarization in HSC-3 cells.

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