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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Uji Network Pharmacology Dan Docking Moleculer Senyawa Metabolit Sekunder Begonia willemii Endemik Sulawesi Tengah Terhadap Reseptor Kanker Serviks Jamal, Jamaluddin; Musnina , Wa Ode Sitti Musnina; Setiawan , Muh. Risky Setiawan; Rumi , Amelia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.645

Abstract

One of the most common types of cancer in Indonesia is cervical cancer. Cervical cancer is caused by infection with the Human Papilloma Virus (HPV) that grows in the cervix. Begonia willemii is a new plant in Central Sulawesi that is used as an anticancer. This study aims to determine the chemical compounds contained in the ethanol extract of Begonia willemii using LC-MS, and identify proteins that interact with the chemical compounds of Begonia willemii in the cervical cancer disease pathway, and determine the interaction between compounds contained in the ethanol extract of Begonia willemii with target proteins as cervical anticancer using the molecular docking method. This research method starts from sample preparation, then maceration extraction for three days using 96% ethanol solvent, the extract results are then analyzed using LC-MS, after which Network pharmacology is carried out to determine the target protein for cervical cancer and in molecular docking simulations with Autodock 4.2 software. The protein model was downloaded from the Protein Data Bank with the code 6GU2. The results of this study obtained a percentage yield of Begonia willemii extract of 10.52%, there was 1 compound component contained in the LC-MS results, namely 3-Chloro-4-methylaniline, and the results of Network pharmacology obtained CDK1 protein which has the highest degree value. Based on the results of molecular docking of the CDK1 protein (PDB ID: 6GU2), the affinity energy of the 3-Chloro-4-methylaniline compound was obtained at -5.4 kcal/mol and the affinity energy of Ribociclib (positive control) was -8.6 kcal/mol. The affinity energy of the natural ligand (Flavopiridol) was -9.9 kcal/mol. Based on these results, it is known that the 3-Chloro-4-methylaniline compound has an effectiveness that is not as strong as the natural ligands (Flavopiridol) and Ribociclib (positive control).
Pengaruh Penggunaan Alat Bantu Pillbox Terhadap Tingkat Kepatuhan Minum Obat Dan Keberhasilan Terapi Pada Pasien Hipertensi Dengan komplikasi Gagal Jantung di RSU Nirwana Banjarbaru Wati, Helmina; Restiana Rusida, Esty; Nurhaliza , Siti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.655

Abstract

Hypertension is recognised as a primary risk factor for the development of heart failure. Hypertension exerts an increased workload on the heart, thereby impeding its capacity to circulate blood throughout the body. The treatment of hypertension necessitates adherence to regular medication in order to regulate blood pressure and mitigate the risk of organ damage. The objective of this study is to ascertain the discrepancy in medication adherence levels subsequent to the provision of a pillbox device in comparison to patients who did not receive the pillbox device. Additionally, the study seeks to examine the correlation between adherence levels and blood pressure reduction. This study was a prospective pre-experimental study conducted from April to June 2022, involving 76 patients divided into two groups: the treatment group (given a pillbox) and the control group, each consisting of 38 patients. The analysis of the data was conducted utilising the SPSS software, employing the Mann-Whitney U test and the chi-square test. The findings demonstrated that 29 patients (76.31%) in the treatment group exhibited adherence to medication, in contrast to 10 patients (26.31%) in the control group. The mean blood pressure measurements in the treatment group before and after the intervention were 160/95 mmHg and 142/88 mmHg, respectively, compared to the control group, which had measurements of 151/86 mmHg and 144/79 mmHg before and after the intervention. Conclusion: A significant discrepancy in medication adherence was observed between patients who utilised the pillbox and those who did not (p-value = 0.000), and a substantial association was identified between medication adherence and blood pressure reduction following the administration of the pillbox (p-value = 0.001).
Aktivitas Antibakteri Sediaan Microneedle Acne Patch Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn) terhadap Staphylococcus epidermidis Fitriana, Mia; Sarwo, Laura; Wathan, Nashrul
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.658

Abstract

Acne is often accompanied by inflammation and triggers antibacterial activity such as S. Epidermidis. A. Bilimbi folium are known to inhibit the growth of S. Epidermidis. Microneedle (MN) is a preparation with small needles measuring 50-900 μm that can be applied to deliver active ingredients for acne treatment. The effect of concentration of A. Bilimbi MN acne patch leaf extract can cause changes in antibacterial activity. The purpose of this study was to determine the effect of the concentration of ethanol extract of A. Bilimbi folium on MN acne patch preparation on the inhibition of S. Epidermidis. The research was conducted by making 5 MN formulas with different extract concentrations and then testing the antibacterial activity with agar diffusion method. The negative control used was the formula without extracts while the positive control used chloramphenicol and acne patch preparation on the market. The results showed the clear zone of F1 (1%), F2 (5%), F3 (10%), F4 (15%), F5 (20%) of 1.86±0.485 mm; 3.15±0.556 mm; 5±0.526 mm; 8.25±0.687 mm; 9.43±0.809 mm, respectively. The conclusion of this study is that there was an effect of the concentration of ethanol extract of A. Bilimbi folium in the preparation of microneedle acne patches on the antibacterial activity of S. Epidermidis.
Pengujian Antibakteri Ekstrak Etanol Daun Bunga Lilin (Pachystachys Lutea L.) Terhadap Bakteri Staphylococcus Aureus Atcc 1055 Dan Escherichia Coli Atcc 25922 Kartikawati, Endah; Slamet , Tuty; Pulungan, Habiba Fikri Farika; Yuni , Mutiara Khairati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.551

Abstract

Staphylococcus aureus and Escherichia coli are two pathogenic bacteria that often cause infections in humans. In efforts to combat various infections caused by pathogenic bacteria, the use of medicinal plants as alternative treatments is gaining increasing attention. One such plant is the Candle Flower (Pachystachys lutea L). This study was conducted to identify the antibacterial activity of Candle Flower leaf extract (Pachystachys lutea L) against Staphylococcus aureus and Escherichia coli using the disk diffusion method. The results showed antibacterial activity against Staphylococcus aureus, forming clear zones at concentrations of 6.25%, 12.5%, 25%, and 50%, measuring 6.00, 6.93, 8.06, and 10.81 mm, respectively. Meanwhile, the antibacterial activity against Escherichia coli formed clear zones at concentrations of 6.25%, 12.5%, 25%, and 50%, measuring 8.10, 8.52, 9.72, and 12.35 mm, respectively. The ethanol extract of Candle Flower leaves (Pachystachys lutea L.) can inhibit the growth of Staphylococcus aureus ATCC 1055, with the best concentration being 50%, forming a clear zone diameter of 10.56 mm, and against Escherichia coli, with the best concentration being 50%, forming a clear zone diameter of 12.35 mm. The clear zones formed fall into the criteria of strong inhibition zones.
Formulasi dan Uji In Vivo Krim Luka Bakar dari Ekstrak Daun Alpukat (Persea americana Mill.) pada Mencit (Mus musculus) Usman, Yusnita; Muin, Rahmatullah; Muthmainna B
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.600

Abstract

The flavonoid content of avocado leaves (Persea americana Mill.) supports its activity in healing burns. This research aims to make a cream formula from avocado leaf extract (Persea americana Mill.) and test the activity of this preparation in vivo using mice with 1x1 cm2 burn wounds. The cream formula is made with 4 different extract concentrations, namely F0 (cream base), F1 (1%), F2 (5%), and F3 (10%). Then, the physical characteristics of the preparation are evaluated, namely organoleptic, pH, homogeneity, spreadability, adhesive power and emulsion type. Next, an activity test was carried out using 12 mice which were divided into 4 groups treated according to the cream formula that had been made with observation for 14 days. The physical characteristics test results were analyzed based on the physical condition of the cream preparation according to the test category, while the activity test results were analyzed based on the percentage of wound healing area. The results showed that the formulation was an O/W type, semi-solid, with a greenish color, consistent with the extract concentration, and all physical parameters met the requirements. Activity testing demonstrated the highest burn wound healing percentage at F4, at 76%. Therefore, it was concluded that avocado leaf extract can be formulated into a cream with good in vivo activity for healing burns in mice.
Pengetahuan, Sikap Dan Perilaku Mahasiswa Terhadap Efek Penyembuhan Luka Dari Bubuk Kopi (Coffea sp.) Desty, Rani Tiara; Waris , Muhammad Anugerah Alam; Putri , Rolita Ramadani
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.632

Abstract

Coffee grounds (Coffea sp.) is a traditional medicine that can be used to heal wounds. This coffee powder contains alkoloids, flavonoids, tannins, steroids, saponins, phenols, caffeine and chlorogenic acid. Based on preliminary studies, there are still many students who do not know the benefits of coffee for healing wounds. The aim of this research is to determine the knowledge, attitudes and behavior of students regarding the wound healing effects of coffee grounds (Coffea sp.). The type of research used is quantitative descriptive with a cross-sectional approach. The sampling method in this research uses probability sampling with disproportionate stratified random sampling technique as the sample determination technique. The subjects of this research were 147 midwifery students from the Surakarta Ministry of Health Polytechnic. The results of the research showed that students in the Diploma III Midwifery Study Program, Poltekkes Kemenkes Surakarta, had a level of insufficient knowledge, namely 60.5%, sufficient attitude, namely 72.1%, and inadequate behavior, namely 81.6% regarding the effect of coffee on wound healing. It is hoped that there will be further research related to providing counseling on coffee for wound healing to midwifery students.
Hubungan Faktor Sosiodemografi terhadap Kepuasan Pengguna Aplikasi CERDIK (Cerdas Swamedikasi) di Martapura Kalimantan Selatan Astuti, Karunita; Ramadhani, Syahrizal; Arrahimi, Ahmad Rusadi; Wati, Helmina; Haiqal, Ade
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.641

Abstract

Self-medication is a condition where patients buy drugs without doctor's prescription for common complaints such as fever, pain, dizziness, cough, influenza, ulcers, diarrhea and several skin diseases. Advances in digital technology have influenced various aspects of life including medical services, one of which is the CERDIK application. This study aims to determine respondent satisfaction in using the application and relationship with sociodemographics of the respondents. The method used is non-experimental descriptive on questionnaire in 84 respondents. The results show a very high level of satisfaction with this application. The respondents showed 83 sample (99%) felt very satisfied and only one sample felt quite satisfied with the CERDIK application. The average value of respondent satisfaction overall reached 95%. Furthermore, there is a relationship between sociodemographics including gender, ages, educations and professions with satisfaction using the CERDIK. This shows the application is very helpful for patients in obtaining information about self-medication drugs
Pengaruh Pemberian Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Terhadap Penurunan Tekanan Sistolik Diastolik Pada Tikus Putih (Rattus norvegicus) Model Hipertensi Putra, Bayu; Azizah, Rizqi Nur; Kosman, Rachmat; Iskandar , A. Nasyrah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.642

Abstract

Hypertension is a major risk factor for cardiovascular diseases and can lead to serious complications if not managed optimally. This study aims to evaluate the effects and optimal dose of ethanol extract of purslane herb (Portulaca oleracea L.) in reducing systolic and diastolic blood pressure in hypertensive male rats. The rats were divided into several groups: a negative control, a positive control (captopril), and three treatment groups receiving ethanol extract of purslane at doses of 100, 200, and 300 mg/kg body weight. Systolic and diastolic blood pressure were measured throughout the study to assess the antihypertensive activity of the extract. The results showed that purslane extract at doses of 100, 200, and 300 mg/kg body weight significantly lowered blood pressure, likely due to bioactive compounds such as flavonoids, saponins, and phenols. These compounds exhibit vasodilatory activity, ACE enzyme inhibition, and diuretic effects that contribute to blood pressure reduction in the hypertensive rat model. Ethanol extract of purslane herb (Portulaca oleracea L.) was found to have a significant effect in reducing systolic and diastolic blood pressure in hypertensive rats, with the optimal dose for significant blood pressure reduction being 300 mg/kg body weight
Potensi Tanaman Endemik Sulawesi Tengah Etlingera Tjiasmantoi Sebagai Kandidat Obat Antituberkulosis Baru: Studi In Silico Dan In Vitro Azzahra, Zahwa; Amalia , Nurul Izza; Nursagita, Zhafirah Tri; Febriyadi, Febriyadi; Wardhani, Shara; Ihwan, Ihwan; Jamaluddin, Jamaluddin
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.646

Abstract

Plants of the Zingiberaceae family have a lot of potential as medicinal raw materials, especially the Etlingera genus which has antimicrobial activity. It is suspected that secondary metabolite compounds in the Etlingera genus play an important role in antimicrobial activity by activating STAT that affects the production of cytokines and chemokines that are important in fighting Mycobacterium tuberculosis bacteria, as is the case with the newly discovered Etlingera tjiasmantoi species as an endemic plant that is empirically used as an anticancer. This research was conducted to determine the potential of ethanol extract of Etlingera tjiasmantoi leaves as an antituberculosis in silico and in vitro. The research method went through two stages, namely in silico with the stages of network pharmacology test, molecular docking, and prediction of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) of compounds and in vitro to validate the results of in silico testing using the Resazurin Microtiter Assay (REMA) method. The results of in silico analysis showed that the Etlingera tjiasmantoi plant has a 2-Methyldecalin compound with a binding energy of -6.2 which is smaller than the isoniazid control ligand so that it has a strong bond with the JAK2 target protein and a good ADMET profile orally, in vitro tests showed that concentrations of 500 ppm and 750 ppm were able to fight Mycobacterium tuberculosis bacteria so that the ethanol extract of Etlingera tjiasmantoi leaves has the potential as a new antituberculosis drug candidate.
Uji Aktivitas Adaptogenik Ekstrak Etanol Buah Jambu Biji (Psidium guajava L.) pada Mencit Menggunakan Metode Swimming Endurance Test Pramiastuti , Oktariani; Muzaeni , Doni Wahyu; Istriningsih , Endang
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.662

Abstract

Adaptogenic activity is related to antioxidant activity that can neutralize the adverse effects of stress by reducing the formation of reactive oxygen species (ROS) in the early phase. Psidium guajava has been known to have antioxidant activity, one of which is the highest Vitamin C content in guava fruit among other fruits, strengthening the suspicion that this fruit has adaptogenic activity. This study was conducted with the aim of testing the adaptogenic activity produced from guava fruit using the swimming endurance test (SET) method. Guava fruit extract was produced from the maceration process using 96% ethanol solvent. The SET test was conducted to determine the immobile time in 5 groups of mice that were given orally for 7 consecutive days. CMC-Na 0.5% as a negative control was given to group I, amitriptyline 25 mg/Kg BW as a positive control was given to group II, and extracts with doses of 50, 150 and 250 mg/Kg BW were given to groups III, IV and V, respectively. The results showed adaptogenic activity if the immobilization time of the group given guava fruit ethanol extract was lower than the negative control group. At doses of 50, 150, and 250 mg/Kg BW, the test findings demonstrated that guava fruit ethanol extract was able to shorten the period that mice were immobilized in comparison to the negative control group, indicating that guava fruit ethanol extract has adaptogenic activity. This activity cannot be separated from the role of several groups of compounds, and a few of them are regarded as alkaloids, flavonoids, tannins, saponins, and vitamin C.

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