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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 195 Documents
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Formulasi Sediaan Shampoo Bar Ekstrak Daun Waru (Hibiscus tiliaceus L) dan Uji Aktivitas Antijamur terhadap Candida albicans Amanah, Nur; Retno Sari, Dwi; Muhammad fauzi, Fawwaz
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.740

Abstract

Sensitive, oily, or dandruff-prone scalp conditions can cause discomfort and negatively affect hair health. Candida albicans is an opportunistic fungus known to contribute to dandruff formation. Waru leaves (Hibiscus tiliaceus L.) contain various bioactive compounds, including saponins, flavonoids, polyphenols, and tannins, which are reported to have antifungal properties. This study aimed to analyze the active compounds of waru leaf extract, evaluate the physical stability of a shampoo bar formulation, and assess its antifungal activity against Candida albicans. This research employed an experimental design, with extraction carried out using maceration in 96% ethanol. The obtained extract was formulated into shampoo bars at concentrations of 3%, 6%, and 9%. The formulations were evaluated for organoleptic properties, pH, foam height, and foam stability. Antifungal activity was tested using the disc diffusion method against Candida albicans, with three replications. A commercial shampoo bar (“x”) was used as the positive control, while the base formulation without active ingredients served as the negative control. The results showed that all formulations met the physical evaluation criteria, except for pH values which exceeded the Indonesian National Standard (SNI). Antifungal testing revealed inhibition zones of 5.7 mm, 6.05 mm, and 6.85 mm for formulas I, II, and III, respectively, with the 9% formulation demonstrating the highest inhibitory activity against Candida albicans. In conclusion, waru leaf extract (Hibiscus tiliaceus L.) can be successfully formulated into a shampoo bar and exhibits antifungal activity against Candida albicans, with the 9% concentration showing the greatest effectiveness.
Identifikasi dan Analisis Galaktomanan dari Bungkil Sawit sebagai Bahan Baku Biomaterial dengan Metode FTIR dan NMR Yogananda, Amrina Amalia; Alfian, Muhammad; Faizah, Nurul; Cahyani , Anggun Cita; Yulianti, Selvia; Irawan , Hisba Cahyani; Saputro, Rafly Restu Dwi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.756

Abstract

Palm kernel meal contains polysaccharide compounds, including galactomannan, which is made up of galactose and mannose units. This study aims to extract and identify the structure of galactomannan from palm kernel meal using FTIR and NMR spectroscopy. Extraction was carried out using a hot water extraction method with a material-to-solvent ratio of 1:5 at 80°C for 60 minutes, followed by precipitation with 96% ethanol, subsequent freeze-drying, and followed by characterization through FTIR and NMR to confirm the presence of characteristic functional groups associated with galactomannan. The extraction yielded 0,77% then the FTIR spectrum revealed strong bands at 1065.67, 1032.65, and 1009.16 cm⁻¹, indicating the presence of C–O and C–O–C stretching related to glycosidic bonds—key features of the galactomannan polysaccharide structure. The 1H-NMR spectrum exhibited a distinct signal for the anomeric proton in the range of approximately 5.0–5.4 ppm, with the protons from the C2–C6 positions appearing between 3.2 and 4.1 ppm. Additionally, the 13C-NMR spectrum displayed a peak for the anomeric carbon around 102–105 ppm, along with other ring carbon peaks in the range of 60–85 ppm, which align with the structure of galactomannan. These findings confirm that palm kernel meal holds promise as a source of galactomannan for developing polysaccharide-based biomaterials
Analisis Efektivitas-Biaya Antihipertensi Amlodipin Dibandingkan Candesartan Pada Pasien Stroke Iskemik Rawat Jalan di Rumah Sakit Surakarta Lestari, Rizkia Putri; Andayani , Tri Murti; Rahmawati , Ismi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.768

Abstract

Hypertension is one of the risk factor for ischemic stroke. Amlodipin and Candesartan are hypertensive therapies in stroke patients. The use of antihypertensive drugs requires long-term treatment, so it is necessary to conduct a cost-effectiveness analysis to determine effective and efficient use of drugs. The purpose of this study is to find out the most cost-saving antihypertensive at Hospital Surakarta. The study was conducted retrospectively on outpatient ischemic stroke patients at the Surakarta Regional General Hospital for the periode 2023-2024. Sample number data used was 114 on ischemic stroke patients according to the inclusion criteria. Effectiveness is seen from the patient's blood pressure reaching the target and the cost is calculated from the provider's perspective, including direct medical costs. CEA is calculated based on the value of ACER and ICER. The results showed the effectiveness of Amlodipin 66,10% and Candesartan 54,55%. The average total cost of Amlodipin is Rp. 556,129 ± 208,187 and Rp. 620,436 ± 232,382 for Candesartan. The value of ACER for amlodipine was Rp. 8,413.44, while candesartan is Rp. 11,377.32. The calculation of the ICER value obtained a negative result Rp. 5,584. The results of the cost-effectiveness analysis showed that amlodipin is a cost-saving antihypertensive for outpatient ischemic stroke patients.
Formulasi Tablet Hisap Ekstrak Etanol Umbi Sarang Semut Asal Kalimantan Tengah Sartika, Fera; Handayanai , Rezqi; Rahmawati , Ade Catur
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.771

Abstract

Central Kalimantan is one of the provinces in Indonesia that annually experiences haze disasters caused by forest and land fires, leading to significant negative health impacts, such as the prevalence of Acute Respiratory Infections (ARI). One of the local community's efforts to manage ARI involves utilizing medicinal plants as traditional therapy, specifically the Sarang Semut tuber (Myrmecodia tuberosa Jack). According to previous studies, the ethanolic extract of Sarang Semut tuber contains secondary metabolites, including alkaloids, flavonoids, saponins, quinones, tannins, steroids, and triterpenoids. The objective of this research is to develop an innovative pharmaceutical formulation in the form of lozenges using the ethanolic extract of Sarang Semut tuber as the active ingredient. The lozenges were prepared using the wet granulation method, with a target tablet weight of 500 mg. The formulation varied the ratio of fillers, specifically mannitol-sucrose, across three formulas: F I (75:25), F II (50:50), dan F III (25:75). The tablets were evaluated through physical property tests, including organoleptic properties, weight and size uniformity, hardness, friability, and disintegration time. The results demonstrated that the ethanolic extract of Sarang Semut tuber can be successfully formulated into lozenges with physical characteristics that meet evaluation standards, particularly Formula III. The resulting lozenges exhibited an optimal disintegration time ( 6,33 ± 0,46 second), low friability (0,99 ±0,00%),), and high hardness (2,092 ±0,27 kg). These findings suggest that Sarang Semut tuber ethanolic extract holds significant potential for further development into standardized traditional medicine.
Kuesioner Pengetahuan, Sikap, Dan Perilaku Masyarakat Tentang Interaksi Obat Dan Makanan-Minuman: Studi Validitas Dan Reliabilitas Sari, Okta Muthia; Azizah, Putri Nur; Azizah, Marshanda Wan; Feteriyani, Rina; Rahmatillah, Mustafa
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.779

Abstract

Drug–food interactions may lead to significant health problems, such as increased drug toxicity or reduced therapeutic effectiveness. However, a validated questionnaire in the Indonesian language that comprehensively measures public knowledge, attitudes, and practices regarding drug–food interactions is still lacking. This study aimed to evaluate the validity and reliability of a questionnaire assessing public knowledge, attitudes, and practices related to drug–food interactions. A cross-sectional study was conducted in Banjarmasin, South Kalimantan. Inclusion criteria included patients aged ≥18 years with a history of medication use in the past three months. The questionnaire was adapted and modified from previous studies. The research instrument consisted of a questionnaire covering the domains of knowledge, attitude and behaviour, using a dichotomous scale (Yes/No and Agree/Disagree). Each correct answer was scored as 1 and each incorrect answer as 0. The total score for each domain was calculated and categorised as high or low based on the median value. Validity testing was performed on 52 respondents using Pearson’s correlation coefficient, while reliability testing was assessed using Cronbach’s alpha with SPSS software. Results: The final questionnaire consisted of 5 items in the knowledge domain, 6 items in the attitude domain, and 7 items in the practice domain. All items were found valid (r > 0.273). Cronbach’s alpha values for knowledge, attitude, and practice were 0.682, 0.743, and 0.635, respectively, indicating acceptable reliability. Conclusion: This questionnaire demonstrates good validity and reliability, making it suitable for assessing the public’s knowledge, attitudes and behaviour regarding drug-food and drug-beverage interactions.
Cost Analysis Pasien Chronic Kidney Diseases di Instalasi Rawat Inap RS Soerojo Magelang Hapsari, Widarika Santi; Kartikawati, Nurfina Dian; Sabaan, Wahid
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.780

Abstract

Chronic Kidney Disease (CKD) is a global health problem with rapidly increasing prevalence and high treatment costs. In developing countries, CKD management is more complex due to the influence of socioeconomic factors and underlying comorbidities. This study aims to obtain an overview of treatment costs and analyze the influence of patient characteristics, comorbidities, and length of stay on direct medical costs for CKD patients at Soerojo Hospital. This study was retrospective using data from CKD patients undergoing inpatient hemodialysis in 2024. Data collected included patient characteristics and direct medical costs. Data analysis was performed descriptively and inferentially using normality tests followed by non-parametric tests (Kruskal-Wallis and Mann-Whitney) to examine cost differences between groups. A total of 87 patients participated in this study. The majority of patients were male (57.74%) and aged ≥60 years (42.53%). Patients with stage 5 CKD dominated (87.36%), most of whom had 1–3 comorbidities (56.32%) with a length of stay ≤5 days (60.92%). The highest direct medical costs were found in patients with stage 5 CKD, especially in the cost of procedures (Rp13,422,222 ± 11,203,121). In general, the cost of procedures was the largest expenditure component. Based on statistical analysis, the variables of the number of comorbidities and length of hospitalization showed a significant relationship (p<.05) with the total cost of care for CKD patients. This study concluded that high clinical complexity due to comorbidities and long LOS were the main predictors of increased direct medical costs.
Pengaruh Aplikasi Program Pill Time terhadap Tingkat Kepatuhan Pasien Hipertensi di Kelurahan Loktabat Selatan Banjarbaru Rusida, Esty Restiana; Akbar, Depy Oktapian; Saputra, Mochammad Maulidie Alfianoor; Wati, Helmina; Yanie, A.
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.784

Abstract

One of the diseases experienced by people throughout the region is hypertension. The increase in cases of hypertension is one of the causes of premature death worldwide. Patient compliance in consuming medication can affect the success of hypertension therapy, so appropriate intervention is needed as a recommendation for further therapy to control blood pressure and prevent complications by using appropriate media, easy to use and can be accessed anytime and anywhere using the Pill Time Program Application technology. The of this study was to determine the effect of the Pill Time program application on increasing medication adherence in hypertension patients in South Loktabat Village. This study used a pre-experimental method with a one-group pre-test and post-test design. 99 respondents were selected using simple random sampling. The research data were then analyzed using the Wilcoxon test. The results of the analysis show that the Pill Time program application has an influence on medication adherence in hypertension patients with a Sig. (2-tailed) value of 0.000 < 0.05.
Analisis Senyawa Minyak Atsiri Pada Daun Segar Dan Layu Tanaman Binjai (Mangifera Caesia) Secara Hs-Gc-Ms Susiani, Eka Fitri; Sayakti, Putri Indah; Ramadhan, Hafiz
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.785

Abstract

Permintaan terhadap minyak atsiri terus meningkat setiap tahun sejalan dengan kemajuan industry modern di bidang kosmetik, pangan, farmaso, parfum, hingga aromaterapi. Minyak atsiri diperoleh dari tanaman beraroma yang salah satunya dapat berasal dari genus Mangifera. Salah satu spesies Mangifera yang merupakan tanaman endemic Kalimantan yang perlu dieksplorasi komponen minyak atsirinya adalah Binjai (Mangifera caesia). Riset ini dilaksanakan guna mengidentifikasi profil senyawa minyak atsiri pada daun binjai, baik dalam keadaan segar maupun yang telah layu. Metode analisis menggunakan Headspace Gas Chromatography Mass Spektrofotometry (HS-GC-MS) yang memungkinkan analisis senyawa volatile pada pelarut yang bersifat polar. Temuan penelitian menunjukkan bahwa pada sampel daun segar terdapat 6 senyawa minyak atsiri dengan tiga konstituen utama yaitu Benzoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy- (44,68%), 4,6-Heptadiyn-3-one (30,84%), serta 5-Heptenal, 2,6-dimethyl- (17,66%). Sementara itu, pada sampel daun yang layu ditemukan 4 senyawa dengan tiga komponen dominan berupa 6-Hepten-3-one, 5-hydroxy-4-methyl- (24,5%), Benzoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy (22,67%), dan (1-Ethyl-2-methylpropyl)methylamine (15,73%). Hasil ini mengindikasikan adanya variasi kompisisi senyawa minyak atsiri pada daun binjai tergantung pada kondisi kesegaran bahan bakuny
Formulasi Sediaan Masker Stick Clay Dengan Kombinasi Ekstrak Daun Kelor (Moringa Oleifera Lamk) Dan Daun Sagu (Metroxylon Sagu Rottb) Serta Aktivitas Antioksidan Putri, Risky Juliansyah; Halid, Nur Hatidjah Awaliyah; Himaniarwati, Himaniarwati; Nasir, Nur Herlina; Pusmarani, Jastria; Jannah, Nisa Fil
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.792

Abstract

Antioxidants are beneficial for skin health, and they help to neutralize free radicals. These antioxidants are present in various plants, including Moringa and sago leaves. To enable easier application, these antioxidant properties are incorporated into cosmetic products, such as stick clay masks. The purpose of this research is to assess the formula's stability and the antioxidant effectiveness of stick clay mask formulations that combine extracts from Moringa and sago leaves. The study utilized a laboratory experimental design, and the samples were collected from Wolulu Village, Watubangga District, Southeast Sulawesi.. Stick clay mask containing extracts of sago and moringa leaves at 0.5%, 1%, and 1.5% concentrations. The formulation underwent a stability test, and the IC50 value was used to determine the antioxidant activity test using DPPH methods. In addition to having antioxidant activity at F0 263.51 µg/mL in the weak category, Formula FI 73.80 µg/mL in the strong category, F II 54.74 µg/mL in the strong category, and F III 30.11 µg/mL in the very strong category, the results of the stability test of the Stick clay mask have satisfied the requirements, which include organoleptic test, homogeneity test, spreadability test, adhesion test, and drying time test.
Formulasi Sediaan Lip Balm Kombinasi Ekstrak Etanol Bunga Kecombrang (Etlingera elatior (Jack) R.M.Sm.) Dan Madu (Mel depuratum) Sebagai Antioksidan Alami Halid, Nur Hatidjah Awaliyah; Mannassai, Siti Nur Azigha Awaliya; Kasih, Ridia Utami; Putri , Risky Juliansyah; Himaniarwati , Himaniarwati; Mus Ifaya
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.793

Abstract

Kecombrang flower (Etlingera elatior (Jack) R.M.Sm.) contains flavonoids and anthocyanins that have potential as antioxidants and natural colorants, and honey (Mel depuratum) has humectant, anti-inflammatory, and antioxidant properties. This study aims to formulate, evaluate the physical stability and test the antioxidant activity of lip balm preparations combined with kecombrang flower extract and honey. This type of research is experimental with a formulation design of three variations in the concentration of a combination of ethanol extracts of kecombrang flowers 10%, 15%, 20% and honey as much as 6%. Physical stability test was conducted through cycling test method and storage at room temperature, including organoleptic observation, homogeneity, pH, spreadability, adhesiveness, melting point, and humidity. The antioxidant activity test was carried out using the DPPH method which was measured using the UV-Vis spectrophotometry method and the positive control was vitamin C. The results showed that all lip balm preparations met the physical quality requirements that were stable in storage and cycling tests. F0 has an IC50 value of 95.5 μg/mL in the medium category, F1 (10:6) with an IC50 value of 25.88 μg/mL, F2 (15:6) with an IC50 value of 20.79 μg/mL, and F3 (20:6) with an IC50 value of 17.83 μg/mL. The IC50 results of formulas F1, F2 and F3 are in the very strong category, with moisture reaching 82.5%.The combination of kecombrang flower extract and honey can be effectively formulated into a lip balm with stable physical quality and strong antioxidant activity. Further research can be conducted on pharmacological and toxicity tests of the preparation.

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