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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
 524   525   526   527   528 
The Evaluation of 3-(2-Hydroxyphenyl)-1-Phenyl–Propenone as a Targeted Drug for Wound Healingin Sprague dawleyRats Summaya M. Dhiyaaldeen
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15975

Abstract

This study designed to evaluate the effects of 3-(2-Hydroxyphenyl)-1-phenyl–propenone (HPPP) as atargeted drug on enhancement the process of wound healing in Sprague dawley (SD) rats. A skin excisionwound was dissected from posterior neck area of each rat. Group 1 received no treatment, while group2 received Intrasite gel treatment. Wounds of groups 3 and 4 were dressed with HPPP 25 and 50 mg/kg, respectively. After 10 days, histological evaluation, immunohistochemistry and biochemical analysiswere investigated.Catalase (CAT), superoxide dismutase (SOD)enzymes and malondialdehyde (MDA)levels were determined in wound homogenates.Groups 3 and 4 showed remarkably a higher rate of woundhealing process when compared with the others. The microscopic results indicated increases in fibroblasts,collagen fibers and angiogenesis. Moreover, chalcone groups showed respectively an increase and reductionin antioxidant activity, and lipid peroxidation level. There were no signs of toxicity or mortality in the acutetoxicity experiment up to 1000 mg/kg.Our data provided an evidence for the first time that HPPP couldhasten significantly the wound healing process in rats.
Appropriate Technology of Organic Waste Composting with Activator Bioinokulen Rumen Cow Em4 and Em4 Sunaryo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15976

Abstract

Intruduction:The waste problem in Indonesia is the large amount of garbage waste, the lack of landfills andwaste processing facilities, resulting in a source of pollution and endangering health. In Ponorogo Regencyin the last three years, garbage has accumulated reaching 149 m3 / day with a percentage of the amountof organic waste amounting to 44.76%. Methods: This type of research is True Experimental, Posttest-Only Control design. The study used 80 ml cattle rumen activator, 80 ml EM4 activator, compost mixtureactivator with 60 ml EM4 + 20 ml livestock rumen activator mixture and 20 ml EM4 + 60 ml cattle rumenactivator, and without activator (control) assessed the level of compost maturity and for tested the NPKlevels and the C / N ratio. The raw material is 3 kg of organic waste with 5 times replication, so that 25fruit samples are needed and 75 kg of organic waste material. Results: The results showed that the compostconcentration was the same as the activator cattle rumen 80 ml, 80 ml EM4, and 60 ml EM4 + 20 ml cattlerumen ripened faster with an average time of 17 days. The results of the measurement of chemical qualitycompost have the best chemical content of SNI 19-7030-2004 compost activator 60 ml + 20 ml EM4 cattlerumen. Conclusions: The conclusion of research on the composting process of waste to be more effectiverequires an activator material. In addition to the activator material, it is necessary to pay attention to thequality of the activator material.
Implementation of Local Government Organizations According to the Adolescent Pregnancy Prevention and Solution Act 2016 : Case Study of Health Region 10, Thailand Sopapan Kaewhan; Saksit Sripa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15977

Abstract

Background: Pregnancy in adolescence is a global problem. Around the world gives attention and attempts tofind a solution in prevention and resolution of the problem. The purpose of this research is to learn the process ofthe local authorities in complying act for prevention and solution of the adolescent pregnancy problem, B.E. 2559(2016) : case studies of Health Region 10. Methods: The study was divided into 2 parts is Quantitative research.It is a cross-sectional survey study by questionnaire and interviewingwhich are methods to collect data, analyzinginformation, using descriptive statistics including frequency, percentage, mean, standard deviation to describe theinformation of the personal factor, knowledge, comprehensive, attitude, point of views, problems and berriers tothe process of act for prevention and solution of the adolescent pregnancy problem, B.E. 2559 (2016). The sampleand using Pearson correlation coefficient analyze the relationships between variables Operate between August andOctober 2020.Results: The result of the research found that in phase 1 the general information of people who workin reproductive health, the local authorities in complying act for prevention and solution of the adolescent pregnancyproblem, B.E. 2559 (2016) : case studies of Health Region 10 doing survey is women 66.80 percentage, age 36 –45 years 51.60 percentage, mostly working in Subdistrict Administrative Organization 64.80 percentage, years ofworking mean 10.74 years the score of knowledge personnel about act for prevention and solution of the adolescentpregnancy problem, B.E. 2559 (2016) is high level ( X = 8.38 score, S.D. = 2.10) and the score of Comprehensivemedium level ( X =7.42 score, S.D. = 1.32). The people who work in reproductive health the local authoritiescomplying pay attention in pregnancy in adolescent 54.30 percentage, comprehensive and attitude is high level ( X=3.70 score, S.D. = 0.50). In the Phase 2, the analysis of Pearson Correlation Coefficient) analyzed to the relationshipbetween variables found that the knowledge of the act for prevention and solution of the adolescent pregnancyproblem, B.E. 2559 (2016) (X1) (r=0.164*), the attitude and emphasis about act for prevention and solution of theadolescent pregnancy problem, B.E. 2559 (2016) (X3) (r=0.214*) and the point of views in people who work in thelocal authorities complying act for prevention and solution of the adolescent pregnancy problem, B.E. 2559 (2016)(X4) (r=0.369*) have positive relationship with the result of the process in a problem and a barrier in operations ofthe relevant departments according to act for prevention and solution of the adolescent pregnancy problem, B.E.2559 (2016), statistically significant at a level of 0.05. The understanding of act for prevention and solution of theadolescent pregnancy problem, B.E. 2559 (2016) (X2) (r=-0.108) does not have any relationship with the results ofthe process in a problem and a barrier in the operations of the relevant departments according to act for preventionand solution of the adolescent pregnancy problem, B.E. 2559 (2016), statistically significant at a level of 0.05.Conclusion: In conclusion, this research shows the highest score in Yasothorn province that using strategy of Acttheprevention and resolving of pregnancy in adolescence B.E. 2559 following 5 strategies and added strategy number 6which are religious and culture. Building a family culture of conduct living in adolescents based on traditions in dailylife under the supervision of their parents has been operating models that are suitable for the local. Therefore, thesuccess factor of the operation of Health Region 10 and institution relevant should be given priority by formulatinga policy to lead to further action.
Diaphragmatic Hernia in an Adult: An Autopsy Case Report Sudipta Ranjan Singh; Mukul Sharma; Afsar Jahan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15978

Abstract

Non-traumatic diaphragmatic hernia in adult is anuncommon condition. Abrought dead case of 27-year-oldmale for medico-legal autopsy was foundto be suffering from a massive left sided diaphragmatic hernia.The patient was suffering from repeated bouts of abdominal discomfort and constipation from last coupleof months. Though he had sought medical care at different health care facilities but his condition wasnever suspected nor diagnosed till he was brought dead to the tertiary health care institute and autopsyconducted. The gross autopsy findings, histopathology and patho-physiology are discussed in detail alongwith emphasis on clinical diagnosis of this preventable cause of death.
Mepiquat Poisoning – Report of a Patient with Mepiquat Poisoning Presenting with Bradycardia and Hypoglycemia Smitesh Gutta; Ramya I; Karthik Gunasekaran; Arun Jose
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15979

Abstract

Mepiquat chloride is a quaternary ammonium salt which is used as a plant growth regulator. We reportthe case of 18 year old tribal girl who had consumed Mepiquat chloride (5%) in an attempt of deliberateself-harm. The patient had symptomatic bradycardia and hypoglycaemia at presentation both resolved withsupportive treatment. Unlike Chlormequat which can be fatal in humans when ingested mepiquat whichlacks the choline subunit and has only a weak effect on the muscarinic and nicotinic receptors in the humanbody causing only mild bradycardia and hypoglycemia. Patient has been followed up for 1 year and shedoing well with no sequelae.
Type 2 Diabetes Prediction using Gray Wolf Optimization Algorithm Aliakbar Tajari Siahmarzkooh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15980

Abstract

Background: Increasing the number of diabetic patients and the ignorance of most of these patients aboutthe dangers arising from it is a challenge that threatens human lives.Materials and Method: In this paper, a new solution based on the Gray Wolf Optimization (GWO) algorithmfor predicting type 2 diabetes is presented. The main purpose of the proposed method is to increase theaccuracy of prediction and also to reduce the probability of getting stuck in local optimal points. In moredetail, the proposed method consists of two parts: 1- data preprocessing including data preparation andnoise cancellation and 2- data classification using gray wolf algorithm. The Pima Indians Diabetes dataset inMATLAB simulation environment was used to analyze the data and compare the research results.Results: The simulation results show that by adjusting the parameters of the gray wolf algorithm, about 6%better prediction accuracy is obtained than other researches.Conclusion: Also, for a more accurate evaluation of the proposed method, two other datasets have beenused for testing. The results of experiments show that the proposed model for health management in diabetesis effective.
Rationale and Dose Regimen for Sitagliptin/ Glimepiride Combination Therapy in Type 2 Diabetes Treatment Mohammed Hamid Mohammed; Orooba Mohammed Saeed Ibrahim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15981

Abstract

This study explores how glimepiride, alone or in combination with sitagliptin, affected glycemic control inType 2 diabetes patients. Type 2 diabetes was induced in rats by feeding them a high-fat diet and injectingthem with Alloxan and nicotinamide. Forty-two rats were divided equally into seven groups. Negativecontrol and group 2-7: rats fed with the HFD Positive control (diabetic non-treated) Group (T1, T2, T3, T4and T5) were treated with monotherapy and combination. All the treatment regimen reduces fasting bloodglucose and enhanced GLP-1 and insulin level as indicated by an increase in the area under the curve.Additionally, as opposed to monotherapies, the combination category had better glycemic regulation. As aresult, we assume that sitagliptin/glimepiride combined therapy has a synergistic effect.
Underweight among Children under TwoYears in Indonesia Zahrotu Romadhon; Hario Megatsari; AgungDwi Laksono; Mursyidul Ibad
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15982

Abstract

Underweight, have an impact on low cognitive, productivity, and intellectual abilities in children. Thisstudy aimed to analyze ecologically the factors related to underweight among children under two years inIndonesia.The study conducted using secondary data from the Indonesia Ministry of Health official report.Apart from the prevalence of underweight in children under two years, four other variables analyzed asindependent variables were the percentage of population passing Junior High School, poor population,exclusive breastfeeding, and prevalence of low birth weight.Data were analyzed using cross-tabulation.The results showed there was no relationship between the prevalence of underweight in children under twoyears with the percentage of population passing Junior High School and the percentage of poor population.Meanwhile, there is a positive relationship between the prevalence of low birth weight with the prevalenceof underweight in children under two years. The higher the prevalence of low birth weight, the higher theprevalence of underweight in children under two years. Moreover, the study found the higher the percentageof exclusive breastfeeding, the lower the prevalence of underweight in children under two years in a region.The study concluded that ecologically two variables have an ecological relationship with the prevalence ofunderweight in children under two years, namely the prevalence of low birth weight and the percentage ofexclusive breastfeeding.
PAX2 Expression in Endometrial Intraepithelial Neoplasia Zahra Abbas Fadhil; Sazan Abdulwahab Mirza; Sahira Abood Ali
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15983

Abstract

Endometrial intraepithelial neoplasia (EIN) is a clonal growth of glands of the endometrium, regardedas a precancerous condition because of its highcorrelation with endometrioid adenocarcinoma of theendometrium of uterus.Objective: To evaluate the expression of PAX2 in EIN and to correlate the expression with clinicalparameters.Materials and Methods: - This is a retrospective study for (57)totalcasesof D&C and endometrial pipplebiopsies, (21) cases where diagnosed as hormonal imbalance, (26) cases where diagnosed as EIN and (10)cases where diagnosed as endometrioid endometrial adenocarcinoma.Results: -Total number of cases that showed completely loss of PAX2 expression in all this study groups25/57 and cases that showed partial loss 10/57. In hormonal imbalance group: all the cases showed normalexpression of PAX2. In EIN: (65.4%) of cases were with complete loss of PAX2, (30.4%) with partial loss.In endometrial endometrioid cancer group:80% of cases with complete PAX2 expression, while partialloss or decrease PAX2 expression did occur in only (20%) ofcases.The association between study groupsand PAX2 expression:decrease and complete loss of PAX2 staining were significantly (P= 0.001) occurredin cases of EIN and endometrial endometroid adenocarcinoma, while there was insignificant association(P=0.635) between study groups (EIN and endometrial endometroid adenocarcinoma), and results of PAX2expression.Conclusion: -Loss of PAX2 immunomarkerexpressionhappens early and during of EIN using the WHOdiagnostic categories.
Effect of Fucusvesiculosus Algae on the Growth of Some Types of Fungi Isolated from the Mouth of Children with Oral Thrush Lesion Zahraa Ali; Meethaq S. Abood
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15984

Abstract

Oral swab samples were collected from 120 children(ages between new born and 12 years). Samples werecollected from the pediatric department of Al-Rifai General HospitalAnd Al-Shatrah General Hospital andMuhammad Al-Mousawi Children’s Hospital in Nasiriyah For the period from 24/2/2020 to 7/5/2020.Thenumber of samples that are positive for culture80 samples at a percentage of 66.67% Males 60% and females40% ,Then, this study show that there were Four types of Candida. They are Candidaalbicans,C.krusei,C.parapsilosis ,C.tropicalis .C. albicans was the most common type, with a percentage of 77.5%.The resultsof the study showed that the highest incidence of oral thrush was among newborns. Whose age was less thanone year, and the incidence of this disease was among this age group. % 83.75.The study included testingthe inhibitory efficacy of the aqueous and alcoholic extracts of FucusvesiculosusAgainst four species, allbelonging to the genus Candida, using the Agar well Diffusion Method.It was found that the alcoholicextract better than aqueous extract in effect on the isolated yeasts.

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