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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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Pengembangan Formula Gel Ekstrak Teh Hijau (Camellia sinensis L.) sebagai Penyubur Rambut Novena Yety Lindawati; Lusia Murtisiwi; Crescentiana Emy Dhurhania
Jurnal Farmasi (Journal of Pharmacy) Vol 3, No 1 (2014): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v3i1.25

Abstract

Kerontokan rambut merupakan masalah yang dapat mengganggu penampilan. Ekstrak teh hijau dengan kadar 5 % terbukti menstimulasi pertumbuhan rambut (Sumakdjaja, dkk., 2008). Zat aktif dalam teh hijau (Camellia sinensis L) yang berkhasiat sebagai penyubur rambut adalah senyawa katekin dan turunannya. Senyawa flavonoid teh hijau terdiri dari epikatekin, (EC), epikatekin galat (ECG), dan epigalokatekin galat (EGCG). Selain itu juga terdapat asam galat, galokatekin galat (GCG), galokatekin (GC), katekin galat (CG) katekin (C), vitamin B dan vitamin C (Agus, 2007) yang mampu memperkuat akar rambut, mencegah kerontokan rambut, menghambat radikal bebas, menetralkan racun, dan melindungi kulit kepala dari infeksi. Formula sediaan kosmetik dan makanan berbahan aktif the hijau telah menyita perhatian masyarakat. Penyubur rambut berbahan aktif ekstrak teh hijau berbentuk gel belum dijumpai di kalangan masyarakat. Berdasarkan fenomena tersebut, penelitian ini bertujuan mengembangkan formula gel penyubur rambut berbahan aktif ekstrak teh hijau. Penelitian ini dilakukan dengan membuat empat formula, yaitu formula I (carbopol 1%, TEA 0,3%, gliserin 1 %), formula II (CMC Na 3%, gliserin 1%,), formula III (PEG 400 72 %, PEG 4000 8%, gliserin 1%) dan formula IV (carbopol 0,75%, TEA 2%, PEG 400 12 % gliserin 1 %. Masing-masing formula mengandung ekstrak teh hijau dengan kadar 5%, pengawet nipagin 0,1 %, dan natrium metabisulfit 0,1%, sediaan dibuat 100 gram. Keempat  gel yang diperoleh kemudian diuji kualitas sediaannya meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji daya proteksi, uji iritasi primer, uji aseptabilitas, serta uji aktivitas penyubur rambut. Dari penelitian diketahui bahwa formula gel yang paling optimal adalah formula I yang terdiri dari carbopol 1 %, TEA 0,3 %, dan gliserin 1%. Formula I menunjukkan konsistensi gel yang baik, mempunyai aktivitas penyubur rambut paling tinggi, tidak mengiritasi kulit, serta mempunyai sifat aseptabilitas yang baik.
TOTAL FLAVONOID DAN AKTIVITAS PENANGKAPAN RADIKAL BEBAS DARI EKSTRAK ETANOLIK DAUN DAN BUAH MENGKUDU Wigati, Dyan; Koko Pratoko, Dwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Morinda citrifolia L. is a plant widely used as a traditional medicine that rich of flavonoid contents. The aims of this study were to determined the total flavonoid content and free radical scavenging activity ethanolic extract of M. citrifolia L. leaves and fruits in order to find a new antioxidant sources. Total flavonoid contents were determined by aluminium chloride colorimetric method. The free radical scavenging activity of the extract ethanolic of M. citrifolia L. leaves and fruits were measured in vitro by 2,2-diphenyl-1-picrylhadrazyl (DPPH) assay. The total flavonoid contents of M. citrifolia L. leaves extract (23.05 ± 0.77 mg RE/g extract) were found significantly higher than fruits extract (18.81 ± 1.10 mg RE/g extract). Free radical scavenging activity of ethanolic extract of M. citrifolia L. leaves and fruits show that IC50 values of the leaves extract (49.09 ± 0.40 µg/mL) higher than IC50 values of the fruits extract (384.08 ± 2.29 µg/mL). The t-test result show a significant difference between fruits extract and leaves extract of the total flavonoid and free radical scavenging activity (p < 0,05). Data from present result revealed that both of M. citrifolia L. leaves and fruits extract act as an antioxidant agent due to its free radical scavenging activity.
Tingkat Kepatuhan Penggunaan Ramuan Jamu Saintifik Hiperglikemia pada Pasien Diabetes Melitus di Rumah Riset Jamu Hortus Medicus B2P2TOOT Tawangmangu Hartono; Ary Kusumastuti, Livia
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Diabetes mellitus is a degenerative disease caused by chronic metabolic disorders characterized by high blood sugar. The levels compliance with treatment therapy can improve the success of therapy. This research purpose to determine the level of patient compliance level of use of scientific herbal medicine hyperglycemia in diabetes mellitus in Hortus Medicus Herbal Medicine Research House B2P2TOOT Tawangmangu. This research is a descriptive research, using data collection namely purposive sampling. The instruments used for compliance testing using MMAS-8 questionnaire. Data studied inclued age, gender, type of medicine, education, occupation, duration of suffering, and level of patient compliance as well as factors related to compliance. Results research on 96 respondents showed that including the category levels of patient adherence to the use of scientific herbal medicine hyperglycemia was high 48%, moderate adherence rate of 43% and low adherence level of 9%. Based on the results of the study it can be concluded that compliance level of use of scientific herbal medicine hyperglycemia in diabetes mellitus in Hortus Medicus Herbal Medicine Research House B2P2TOOT Tawangmangu classified as high category 48%.
Pengaruh Metode Ekstraksi Terhadap Kadar Total Fenolik dan Kadar Total Flavonoid Daun Talas (Colocasia esculenta L.) Laksmi Ramayani , Septiana; Hildhania Nugraheni , Devi; Robertin Evan Wicaksono, Antonius
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Leaves taro ( colocasia esculenta i. Known ) can be used as an antidiabetic drug, due to the compound and flavonoid phenolic bioactive compound. Pharmacological activity an extract dependent on the active compounds contained, more compound higher the levels the more activity. Method extraction affecting concentration or loss of effect of simplicia therapy as some simplicia is relatively unstable and we. The purpose of this research is to know influence different calculation methods extraction to total levels phenolic compounds and total levels flavonoid compounds taro extract leaves. The extraction of leaves taro uses a solvent ethanol 96 % uses the method maceration, microwave-assisted extraction ( MAE), and soxhletasion . The determination of the total content of phenolic compounds uses the method Folin Ciocalteau by an exchange of a standard for comparison of gallic acid. The determination of the level of the total flavonoid uses the method colorimetry with reagent AlCl3 by an exchange of a standard for comparison of quercetin. A method of the extraction of significant impact on the level of the total flavonoid content of phenolic and total extract leaves taro with the value of p<0,05. The total content of phenolic and total flavonoid highest levels on the method the extraction of soxhletasion which is 10,39 mgGAE/g extract and 12,44 mgKE/g. extract.
Penurunan Kadar Air pada Minyak Goreng Bekas Pakai Menggunakan Arang Ampas Tebu Islamia Nanda Giovani, Kharisma; Purwati
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/htbh9k46

Abstract

Recycling technology processes used cooking oil into reusable oil using bagasse as an absorbent material, to determinate the decrease in water content in used cooking oil using bagasse chacoal. the reseach method is experimental. The sample used is used cooking oil. Water level before the addition of bagasse charcoal was 0,3%. This results after the additional of bagasse charchoal with variation of immersion time 1x24 hours, 2x24 hours and 3x24 hours was 0,1%, 0,03%, and 0,02%. There is reducing in water level after soaking using bagasse charcoal. Water level from used cooking oil more smaller after the addition of soaking time by bagasse charcoal.
Perbedaan Pengaruh Edukasi antara Film dan Ceramah Terhadap Pengetahuan dan Sikap Deteksi Dini Kanker Serviks Ibu-Ibu di Dusun Krodan Sleman Ratnaningrum, Paulina
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Cervical cancer is a malignant tumor that grows in the cervix are caused by Human Papillomavirus (HPV). Cervical cancer is the number one killer for women. According to data obtained from the Indonesian Cancer Foundation (2007) each year about 500.000 women diagnosed with cervical cancer and more than 250.000 died. Cervical cancer prevention can be done with papsmear. Papsmear can reduce cervical cancer mortality up to 50-60%. This research had pupose to know the difference influence education between movie and lecture to the knowledge and attitude on early detection of cervical cancer. This study was a quasi-experimental research with the design of pre-posttest intervention study with control group. The data was collected by using questionnaires and analyzed by using computer programs. The statistic analysis with Independent Sampels T-test showed significantly different increased of knowledge and attitude betwen movie and lecture on early detection of cervical cancer (p=0,002). Lecture was more effective than movie.
Perbandingan Kualitas Hidup Pasien yang Menjalani Hemodialisis dengan Terapi Epoetin Alfa dan Epoetin Beta di RS PKU Muhammadiyah Yogyakarta Murtisiwi, Lusia; Murti Andayani , Tri; Yuniarti, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

In patients with chronic kidney disease who undergo hemodialysis are anemic. Anemia in chronic kidney disease (CKD) can be treated by administration of epoetin. Quality of life is an important aspect evaluated as outcomes of intervention in hemodialysis patients. This study aims to determine differences in the quality of life for patients undergoing hemodialysis therapy with epoetin alfa and epoetin beta in PKU Muhammadiyah Yogyakarta Hospital. Cross-sectional study on regular hemodialysis patients in PKU Muhammadiyah Yogyakarta Hospital was conducted in November 2014- January 2015. Assessment of the quality of life of patients using questionnaires KDQOL-SF version 1.3. The subjects of this study consisted of two groups, the first group of patients using epoetin alfa for treatment anemia, while the second group is patients taking epoetin beta therapy for the treatment of anemia. Data were analyzed using Levene test, Chi-Square Goodness of Fit, Independent t-test, Mann-Whitney test and ANCOVA. The results showed that in general the overall quality of life for patients undergoing hemodialysis therapy with epoetin alfa and epoetin beta in RS PKU Muhammadiyah Yogyakarta showed different results was not significant (p> 0.05) in the amount of 60.25 ± 12.97, group epoetin alfa and 63.93 ± 15.53 in the epoetin beta group.
Hubungan Pengetahuan Remaja Tentang Kesehatan Reproduksi Dengan Tingkat Kecemasan Pada Remaja Di Desa Pandean Kabupaten Sukoharjo Tahun 2017 Amarseto, Binuko; Ariyanti, Lilik
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Reproductive health is a complete physical, mental and social welfare and not only the absence of a disease or weakness, in all matters relating to the reproductive system and its functions and processes. Knowledge about reproductive health is of course very important in relation to the development of the psychological life of adolescents who in this case often begin to deal with matters related to reproductive problems, in this case of course the matter of sexuality and orientation which will later result in self-confidence and anxiety self. This study aims to determine the relationship of adolescent knowledge about reproductive health to the level of anxiety in adolescents in the village of Pandean, Sukoharjo District 2017. This research is explanatory research with cross sectional design. Data collection is done by using questionnaires. The research sample was teenagers totaling 45 people from a population of 81 people using simple random sampling technique. Data analysis using Pearson Product Moment test with a significance level of 5%. The dependent variable in this study is adolescent anxiety, while the independent variable in this study is adolescent knowledge about reproductive health. The results of this study obtained a sample of 45 adolescents in Pandean village, with the highest number of sexes being men with 30 respondents (66.7%), the majority of respondents still attending school and taking high school education (69%). For the results of the research data description, the average value of knowledge is 15.16 while the average value of anxiety is 105.69. The results of the test data using Pearson Product Moment get the results of p = 0.007 (p <0.05) which means the relationship of adolescent knowledge about reproductive health with the level of anxiety in adolescents in Pandean Village, Sukoharjo Regency, with a coefficient of 0.396 which means the relationship of adolescent knowledge about reproductive health with anxiety has a low relationship strength.
Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Mengkudu (Morinda Citrifolia L.) Terhadap Bakteri Streptococcus Pyogenes secara In Vitro Retno Priamsari, Margareta; Rokhana, Almira
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Pharyngitis is a disease that is included in the Upper Respiratory Tract Infection (ISPA). The most common bacteria in acute pharyngitis is Streptococcus pyogenes. Plants that have antibacterial properties are noni (Morinda citrifolia L.). This study aims to determine the minimum inhibitory level (MIC) of S. pyogenes antibacterial activity in vitro. Extraction by remaceration method using ethanol 96% solvent. The Kirby-Bauer method for antibacterial testing used BAP media inoculated by means of a spread plate. The treatment group used a positive control (amoxicillin 25 µg); negative control (sterile distilled water); Noni leaf extract with a concentration of 1.25%, 2.5% and 5%. Replication was carried out 3 times. The parameters observed were the inhibition zone formed around the disc paper. The data obtained were analyzed statistically using Kruskall-Wallis followed by Mann-Whitney with a confidence level of 95%. The results showed that the noni leaf extract contained saponins, triterpenoids, tannins and phenols. Noni leaf extract had a significant effect (p≤0.05) on S. pyogenes. The 2.5% concentration had the smallest activity with an average inhibition zone diameter of 5.83 mm.
PENGARUH MATRIKS PEKTIN DAN HPMC K15M TERHADAP DAYA MENGAPUNG DAN MENGEMBANG SERTA DISOLUSI PADA TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN Valentina Ayuk Armadani; Siti Aisiyah; Ilham Kuncahyo
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1 (2020): Maret
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1.100

Abstract

Verapamil HCl merupakan penghambat kanal Ca2+ untuk terapi hipertensi dan angina pectoris. Verapamil HCl memiliki bioavabilitas 10-20% dan waktu paruh 4 jam sehingga dapat dibuat sediaan gastroretentive untuk mempertahankan kadar terapi obat. Penelitian ini bertujuan mengetahui pengaruh matriks pektin dan HPMC K15M terhadap kemampuan mengapung, mengembang dan pelepasan obat pada tablet floating verapamil HCl.Penelitian ini menggunakan empat formula variasi konsentrasi matriks pektin dan HPMC K15M dengan metode kempa langsung kemudian dilakukan pengujian terhadap sifat fisik serbuk dan tablet. Pengaruh dan interaksi antara pektin dan HPMC K15M ditentukan dengan metode factorial design menggunakan software Design Expert.Matriks pektin dan HPMC K15M memberikan pengaruh terhadap kemampuan mengapung, mengembang dan pelepasan obat dari tablet floating verapamil HCl. HPMC K15M berpengaruh dominan terhadap floating lag time yang lebih cepat dan floating time yang lebih lama. Peningkatan HPMC K15M dan pektin menurunkan jumlah pelepasan di awal   dan   kecepatan   pelepasan   obat,   serta   meningkatkan   kemampuan   mengembang. Kombinasi pektin dan HPMC K15 M (1,5:1) mempunyai floating lag time cepat, floating time lama, dan kemampuan mengembang paling besar serta mengikuti orde nol.

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