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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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Perbandingan Kadar Flavonoid Total Seduhan Daun Benalu Cengkeh (Dendrophthoe Petandra L.) pada Bahan Segar dan Kering Susilowati Susilowati; Iin Nurlinda Sari
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 2 (2020): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i2.108

Abstract

Benalu Cengkeh (Dendrophthoe petandra L.) adalah tanaman yang hidup menempel pada tanaman cengkeh. Tanaman ini sering dianggap hama oleh masyarakat, padahal tanaman benalu ini dapat dimanfaatkan sebagai tanaman obat karena memiliki kandungan fitokimia meliputi flavonoid, terpenoid, tannin, alkaloid dan saponin. Flavonoid merupakan senyawa penanda yang bertanggung jawab terhadap potensi antioksidan dan antikanker daun benalu cengkeh. Dalam penggunaan tanaman obat, masyarakat biasanya menggunakan teknik penyarian sederhana dengan seduhan. Tujuan dari penelitian ini adalah untuk mengetahui perbandingan kadar flavonoid total pada seduhan daun benalu cengkeh segar dan kering sehingga dapat memberikan informasi kepada masyarakat akan preparasi bahan yang tepat sebelum digunakan. Identifikasi awal flavonoid menggunakan uji alkali dengan pereaksi NaOH, uji asam dengan H2SO4 dan uji wilstatter. Penentuan kadar flavonoid total dilakukan secara spektrofotometri UV-Vis menggunakan pereaksi AlCl3 dan dinyatakan terhadap kuersetin (Quercetin Equivalent). Hasil penelitian menunjukkan daun benalu cengkeh mengandung flavonoid dengan kadar flavonoid total seduhan daun segar sebesar 8,1977 ppm QE dan seduhan daun kering sebesar 5,4407 ppm QE. Analisa perbandingan kadar dengan One Way Anova menunjukkan flavonoid total seduhan daun benalu cengkeh segar lebih besar secara signifikan dibandingkan daun kering.
Potensi Anti Hiperkolesterolemia Ekstrak Tumbuhan Sarang Semut (Myrmecodia Pendans Merr. & Perry) Hartono; Setiawan, Iwan; Saktiningsih, Hari
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hiperkolesterolemia adalah salah satu gangguan kadar lemak dalam darah (dislipidemia) yang mana kadar kolesterol dalam darah lebih dari 240 mg/dl. Hiperkolesterolemia merupakan salah satu faktor risiko penyebab terjadinya penyakit jantung koroner yang merupakan penyebab utama dan pertama dari seluruh kematian. Kandungan flavonoid Tumbuhan Sarang Semut (Myrmecodia pendens Merr. & Perry) memiliki potensi sebagai obat antihiperkolesterolemia, karena dapat menurunkan kolesterol total, Low Density Lipoprotein (LDL), dan dapat mencegah oksidasi LDL. Tujuan penelitian ini mempelajari potensi ekstrak tumbuhan sarang semut dalam menurunkan kadar kolesterol dan kadar Low Density Lipoprotein (LDL), serta kadar trigliserida serta peningkatan kadar HDL. Penelitian dilakukan dengan rancangan penelitian Pre and Post Randomized Controlled Group Design menggunakan binatang coba tikus putih (Rattus norvegicus) jantan, strain Wistar, dengan kriteria inklusi yaitu sehat dan mempunyai aktivitas normal, berumur kira-kira 12 -16 minggu dengan berat badan ± 200 gram sebagai objek penelitian. Penelitian dilakukan dengan 6 kelompok tikus yaitu kelompok normal, kontrol negatif, kontrol positif dan 3 perlakukan dengan mempergunakan pemberian ekstrak sarang semut dengan dosis 400 mg/KgBB, 600 mg/KbBB dan 800 mg/KgBB. Analisa data kadar kolesterol total, trigliserid, HDL dan Low Density Lipoprotein (LDL) menggunakan one way ANOVA α=0,05 dengan uji lanjutan uji Tukey. Hasil penelitian menunjukkan bahwa secara kualitatif ekstrak tumbuhan sarang semut positif menunjukkan adanya senyawa flavonoid. Ekstrak tumbuhan sarang semut memiliki potensi sebagai antihiperkolesterolemia untuk menurunkan kadar kolesterol total dan menaikkan kadar kolesterol HDL secara bermakna pada dosis 800 mg/KgBB. Uji one way ANOVA, ekstrak tumbuhan sarng semut memiliki probabilitas 0,004 lebih kecil daripada 0,05. Uji t test menunjukkan bahwa probabilitas 0,0046 < 0,025. Ekstrak tumbuhan sarang semut juga dapat menurunkan kadar trigliserid dan kolesterol LDL pada hewan uji namun tidak berbeda bermakna. Kesimpulan dari penelitian ini adalah ekstrak tumbuhan sarang semut memiliki potensi sebagai obat antihiperkolesterolemia menurunkan kadar kolesterol total dan meningkatkan kadar kolesterol HDL.
Analisis Pengaruh Pelaksanaan Standar Pelayanan Kefarmasian Terhadap Kepuasan Pasien Pada Program Rujuk Balik di Kota Yogyakarta Dwi R, Novi; Satibi; Ayu P, Diah
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

The Pharmaceutical services standards as an implementation reference of Pharmaceutical services in the pharmacy is intended to improve the quality of pharmaceutical services. Referral program is one BPJS health program for people with chronic diseases. The drugs for this program are taken in pharmacies outside the capitation fee system claims. The Quality of services affects patient satisfaction. Individual characteristics associated with satisfaction. This study aims to determine the effect of the implementation of the standard pharmaceutical services on the satisfaction and the relationship between the characteristics and the patient satisfaction in the pharmacies in the Referral Program. This research is descriptive analytic method of data collection is done by survey. Data obtained through a questionnaire which contains characteristics of respondents, respondents' perceptions of the implementation of pharmaceutical service standards and satisfaction. The research is supported with qualitative data as the results of interviews about opinions and input. The location of the research is in referral pharmacy in Yogyakarta with the samples as many as 101 respondents that were divided proportionally. There is the influence of the standard implementation of pharmaceutical services to the satisfaction of the patient in the pharmacy at Referral Program. Significant influence on the clinical aspects of pharmaceutical services (p = 0.000) and pharmaceutical esource (p=0.000) while the aspects of the supplies management were not significant (p = 0.436). Patient characteristics associated with the satisfaction were age and the distance between the residence and the pharmacy, while the characteristics of gender, education, employment, disease were not related with the patient satisfaction.
Pemanfaatan Limbah Minyak Goreng Bekas dan Bekatul Menjadi Sabun Antiaging Mita Susanti, Maria; Retno Priamsari, Margareta
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Used cooking oil and rice bran is waste that has less economic value. The use of cooking oil repeatedly causes the fatty acids contained in the oil to be more saturated. Changes in the nature of cooking oil make cooking oil unfit for use as food because it can cause health effects on the body. Meanwhile, the availability of rice bran which is very abundant and nutrition of rice bran that contains a high antioxidant has not been comparable with its limited utilization. The research objective is to treat used cooking oil waste and rice bran waste to be processed into anti-aging soap products. This was an experimental research with the independent variable is bran soap formula and the dependent variable is the quality characteristics of bran soap which includes organoleptic test, pH, foam power, free alkali and vitamin E. The data were analyzed descriptively by comparing the results of research with SNI 06-3532 -1994. The results showed rice bran soap that meets the quality requirements is formula II, which is obtained results that meet the soap quality requirements in theory which includes solid organoleptic tests, typical odorous rice bran and brown, pH 11 test, 2,28 cm foam power test, acid test 0,46% free fat, 0,1% free alkaline test and positive contain vitamin E.
Pengaruh Kombinasi Ekstrak Carica Papaya dan Propolis Terhadap Peningkatan Trombosit Widya Ningrum Lobang, Eka; Maharani Putri, Icha; Hanafi, Zidhan; Widhiyastuti, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

to tearing of the skin, causing bleeding. If a person's platelet level <150,000, it’s called thrombocytopenia. Papaya leaves have a content to increase platelets. Propolis can be used as an anti-inflammatory drug because of the presence of CAPE and quertecin which play a role in suppressing T cell activity. CAPE is able to inhibit NF-kB and stimulant IL-2 which stimulates the work of T cells. This study aims to determine whether there is an effect of giving a combination of papaya leaf extract and propolis in increasing platelets. This study used a literature study method where the data used come from research reports, theses or scientific journals both national and international in the last 10 years related to the effect of papaya leaf extract on increasing platelets. Previous research has shown there is an effect of papaya leaf extract on the increase in platelet count (p 0.00004). Previous research has also mentioned that propolis contains a variety of components, such as flavonoids and alkaloids. Flavonoids in propolis are able to support the performance of papaya leaf extract in increasing the number of platelets. The conclusion in this study was that the papaya leaf extract was effective enough to help increase the platelet count. The combination of papaya leaf extract and propolis extract can help reduce inflammation.
Sintesis Oktil Sinamat dengan Metode Sonokimia dan Potensinya sebagai Antikolesterol Verdia Mutiara, Erlita; Wildan, Achmad; Dian Advistasari, Yustisia; Indriyanti, Erwin
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/5wasds29

Abstract

Cinnamic acid derivatives play a very important role in the synthesis of other important compounds and as precursors for the synthesis of cinnamic esters. Cinnamate esters have diverse bioactivity. This group has antioxidant, hepatoprotective, anti-inflammatory, anxiolytic, insect repellent, antidiabetic and anticholesterol activities. Octyl cinnamate is a cinnamic acid derivative which is thought to be efficacious as a cholesterol lowering agent. Cholesterol has been known as the main cause of the process of atherosclerosis, namely the process of calcification and hardening of the arteries. As a result of this process the blood vessels, especially coronary arteries become narrow and block blood flow. Octylcinnamate has been successfully synthesized from the esterification reaction between cinnamic acid and n-octanol with a concentrated sulfuric acid catalyst. The sonochemical method is one of the methods developed in this synthesis process because it is very easy to do, efficient, with high yields, short time and environmentally friendly. From the results of the synthesis, identification of compounds was carried out through melting point and FTIR spectrophotometry. Based on the interpretation of data from FTIR that the synthesis product was n-octyl cinnamate. The synthesis was carried out at 600C with a sonication time of 7 hours. The anticholesterol activity of the optimally synthesized n-octyl cinnamate compound at a concentration of 5 ppm was 55.42%.
Optimasi Kapsul Bawang Putih (Allium sativum Linn) sebagai Terapi Alternatif Pengobatan TBC Yety Lindawati, Novena; Hartono
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Garlic (Allium Sativum Linn) proven inhibiting the Mycobacterium tuberculosis propagation. Alisin compound which implied in garlic (Allium Sativum Linn) functioning as wide spectrum antimikroba capable to pursue Tuberkulosis cause by bacterium. Garlic Capsule (Allium Sativum Linn) have to fulfill conditions as according to Decree Of The Minister For Public Health of Republic Indonesia No: 661/MENKES/SK/VII/1994 about traditional medicines. The results shows that garlic extract with 240 µg/ml medium (equivalent by 600 mg garlic extract per capsule) has better potency in pursuing growth of Mycobacterium tuberculosis (taken a from pure breeding colony from patient sputum culture which suffering Tuberkulosis BTA type + 2, positive culture 9, resisten to rifampisin) compared to 320 and 400 µg / ml media.Dry extract of garlic (Allium Sativum Linn) fulfilling conditions upon which fill traditional drug capsule, for example total plate number 1.5 (qualifying at the most 10); mould and khamir number 6x102 (qualifying at the most 104); negative result of patogen bacteries such as coliform bacteries, Eschericia Coli, Salmonella Sp, and Staphylococcus aureus; negatife result of of aflatoxin (qualify at the most 30 bpj); total water content equal to 1 - 2 % (qualifying at the most 10 %). Dry garlic extract (Allium Sativum Linn) capsule fulfilling conditions of pharmaceutical form of traditional capsule result disintegration time less than 13 minute (qualify at the most 15 minute) and fulfill uniformity of weight which qualify for the traditional capsule
Penelusuran Potensi Aktivitas Antibakteri dan Antioksidan Fraksi Kulit Pohon Faloak (Sterculia quadrifida R.Br) Rollando
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

People on Timor island use Faloak (Sterculia quadrifida R.Br.) bark as herbal remedy to cure diseases such as liver diseases, gastroenteritis and as stamina booster. Faloak bark contains fenol, flavonoid, and terpenoid. This study aims to analyze the ability of antibacterial and antioxidant of fraction of faloak bark ethanol extract. Fraction 3 showed the highest antibacterial activity (IC50) to the bacteria B. subtilis (90.51 µg/mL), E. coli (80.12µg/mL), S.aureus (77,87 μg/mL), and S.thypi (61.23 µg/mL). Antioxidant activity test showed that fraction 2 has highest phenol content (34,16 ± 0,76 mg GAE) and antioxidant activity.
LATIHAN SQUAT DENGAN PROGRESSIVE RESISTANCE EXERCISE (PRE) UNTUK PENDERITA OSTEOARTHRITIS (OA) Anjari Dyah K., Warih
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Osteoarthritis sufferers have a typical joint pain that is pain that increases weight when sustaining body weight or during activity, stiffness in the morning and feeling sore when the old joints are rested. On physical examination found tenderness, crepitations with or without restricted joint motion. Patients with lower extremity osteoarthritis may experience limitations in daily activities such as walking, bathing, dressing, using toilets, and doing household chores. Quadriceps muscle weakness is a common condition in patients with knee osteoarthritis which leads to disused atrophy due to the lack of use of the muscle on the sick side of the knee. The purpose of this study to determine the effect of both exercises on Osteoarthritis patients. The methodology used in this research is Pre and Post Test with Control Group Design. The results showed that the value of significance in both the squat exercise and progressive resistance exercise groups on the increase of functional activity in knee OA were all p <0.05 indicating that Close kinetic chain (p = 0.00) and Progressive Resistance Exercise (p = 0.001) similarly affects the increased functional activity in knee osteoarthritis. There is a difference in the effect of Squat exercise with progressive resistance exercise in improving functional activity in patients with knee osteoarthritis
Perbandingan Kualitas Air di Pulau Jawa dan Kalimantan (Review Jurnal) Yuliani, Rida; Imaningsih, Witiyasti
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

A review of water quality from the results of research on Java and Kalimantan has been carried out to get an illustration of water contamination level (refill drinking water, PDAM water, and well water) by Coliform bacteria. Data was obtained from secondary sources of research results from several regions in Java and Kalimantan. The results of water quality assessment of the two islands are presented as a percentage. Based on the results, the level of water contamination on Java island is higher than Kalimantan. The average percentage of Coliform contamination in water on Java is 61.42% and only 42.26% in Kalimantan. The high percentage of water contamination by Coliform bacteria in Java is due to the fact that Java has a higher source of contaminants. The existence of Coliform sources was influenced by the population, housing, and organic waste production.

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