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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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Problem Kompatibilitas Pemberian Obat secara Intravena pada Pasien di Intensive Care Unit Haqoiroh; Rahmawati, Fita; Azhar Syed Sulaiman, Syed
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Intravenous administration of drugs is commonly used in hospitals patients who need rapid pharmacological effects or when patients can not take oral administration. Preparation for intravenous administration of drugs need special condition because there are some risks include incompatibilities. The aim of this study is to investigate the prevalence of intravenous drug incompatibilities such as drug incompatibilities in Intensive Care Units patients at RSUP Dr. Sardjito and UGM Hospital, and to find the risk factor that affect of drug incompatibilities such as length of hospital stay, number of drugs, and caused of hospitalization.This study was a cross-sectional, prospective, and multicenter in RSUP. Dr. Sardjito and Academic UGM Hospital, Yogyakarta. The location of this study were in ICU, ICCU, and HCU. The prevalence of potential drug incompatibility were analyzed with description statistics and the association between potential incompatibilities and risk factors will be investigated using student t test and ANOVA with 95% confidence interval. 65 patients were collected from this research. The prevalence of potential drug incompatibilities (PI) were found in 28 prescriptions with ratio PI 2.4 incompatibility/patient. The highest incompatibility type was precipitation of 42 (83,35%) and the most precipitating drug pairs are fentanyl and phenytoin; midazolam and phenytoin. The number of drugs were significantly related with PI.
Optimasi Karbopol dan Gliserin pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Wahyu Aji Pangestu, Rochmadani; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of the Non Steroid Anti-Inflamatory Drug (NSAID) that serves as the treatment of pain or inflammation. Ibuprofen is a part of biopharmaceutical classification system (BCS) class II drug with the characteristics of low solubility and high permeability. Solid dispersion may increase solubility. Ibuprofen has a variety of side effects so it need to be made into other routes of administration such as topical. This study was conducted to understand the effect of combinations of carbopol as the gelling agent and glycerin as a penetration enhancer compound to the physical quality and the release of active substances also to determine the optimum formula. This study used simplex lattice design method with two factors which is carbopol and glycerin in formula 1 ; formula 2 ; formula 3 in sequence 100%:0% ; 50%:50% ; 0%:100%. The solid dispersion was made by the melting method, then was tested with FTIR and then was made into a solid dispersion gel of ibuprofen-PEG 6000. The release of substance was tested using franz diffusion cell through a cellophane membrane, then the optimum formula was determined based on the counterplot from Design Expert 10.0.1 trial version with critical parameters of adhesion, viscosity, and penetration of substance. The result of the study showed that carbopol and glycerin affecting the physical quality and the release of a drug in a gel. Glycerin has more impact to the release of the drug. The proportion of carbopol 1,011% and glycerin 7,389% produce the optimum formula with the most excellent physical quality and the release of the drug.
UJI PENENTUAN NILAI SPF (Sun Protection Factor) FRAKSI BUNGA ROSELA (Hibiscus Sabdariffa L.) SEBAGAI ZAT AKTIF TABIR SURYA Vivin Nopiyanti; Siti Aisiyah
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1 (2020): Maret
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1.99

Abstract

Sun Protection Factor atau SPF didefinisikan sebagai perbandingan antara banyaknya energi sinar surya (dalam hal ini UV-B) yang dibutuhkan untuk menimbulkan eritema minimal pada kulit yang dilindungi tabir surya dengan yang tidak dilindungi tabir surya. Bunga rosela mengandung flavonoid, antosian, dan polifenol. Senyawa flavonoid mempunyai potensi sebagai tabir surya karena memiliki gugus kromofor (ikatan rangkap tunggal terkonjugasi) yang mampu menyerap sinar UV-A maupun UV-B sehingga mengurangi intensitas pada kulit. Penelitian ini dilakukan untuk mengetahui berapa nilai SPF dari fraksi n-heksana, fraksi etil asetat dan fraksi air dari bunga rosela. Dan diketahui fraksi yang mempunyai nilai SPF tertinggi yang bisa dimanfaatkan sebagai tabir surya. Bunga rosela dibuat ekstrak kemudian difraksinasi dengan pelarut n-heksana, etil asetat dan air. Fraksi yang dihasilkan berupa fraksi n-heksana, fraksi etil asetat dan fraksi air serta ekstrak tersebut diukur nilai SPF nya. Pengukuran SPF dapat dilakukan secara in vitro dengan menggunakan spektrofotometri UV- Vis. Pengujian secara in vitro berguna untuk tes pendahuluan dalam proses pengembangan produk tabir surya.Nilai SPF dari ekstrak etanol 70%, fraksi n-heksana, fraksi etil asetat dan fraksi air dari ekstrak bunga rosela yaitu berturut-turut 6,63±0,23; 10,11±0,61; 13,83±1,50; 11,15±0,47. Fraksi etil asetat adalah fraksi yang mempunyai nilai SPF tertinggi yang bisa dimanfaatkan sebagai tabir surya.
ANALISIS TINGKAT PENGETAHUAN DAN PERSEPSI SWAMEDIKASI OBAT ANALGETIK PADA SISWA DI SMAN 3 CIREBON Nurrahma Berlian, Febia; Azrul Zuniarto, Ahmad; Pandanwangi, Siti; Rubihatlan, Encis; Minhatul Maula, Ajni; Farhan Alfawwaz, Azriel; Salafi, Akil; Sri Virgianti, Deby
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/qz9tq825

Abstract

Self-medication is the selection and use of drugs by individuals or family members without doctor's instructions, to treat conditions that are recognized or self-diagnosed. Analgesics or what is often referred to as pain-blocking drugs without losing consciousness. This study aims to determine the level of students' knowledge about self-medication of analgesic drugs at SMAN 3 Cirebon, to determine students' perceptions of self-medication of analgesic drugs at SMAN 3 Cirebon, to determine the level of knowledge and perceptions of students towards self-medication of analgesic drugs based on student characteristics, and to determine the level of knowledge and students' perceptions of self-medication of analgesic drugs based on the indicators of the questions assessed. This research method is a quantitative research using a descriptive design. The sampling technique used purposive sampling technique. Data collection used an e-questionnaire (google form) which was given to 82 respondents who met the inclusion and exclusion criteria. The data analysis technique of this research uses descriptive analysis. The results of the research on the level of knowledge and students' perceptions about self-medication of analgesic drugs at SMAN 3 Cirebon found that the level of knowledge obtained an average value of 78.96% was included in the good category. Students' perceptions obtained an average score of 83.63% included in the very good category. Based on the characteristics of respondents who have good knowledge and very good perception, most are at the age of 16 years, female gender, parents work as private employees, pain experienced by respondents in the last 1 month, namely body/muscle pain, history of drug use, namely paracetamol and places get medicine namely Pharmacy. The level of students' knowledge about self-medication of analgesic drugs based on the indicators of questions that were assessed correctly, namely: 78.66% on the indicator of the level of safety and accuracy of drug use, 74.39% on the indicator of drug dosage, 93.9% on the indicator of drug use, 64, 63% on the indicator of how to use the drug 74.39% on the indicator of drug side effects, 89.02% on the indicator of how to store it, 97.56% on the indicator of drug expiry time, and 64.63% on the indicator of drug destruction.
Hubungan Usia dan Konsumsi Makanan Berlemak dengan Kolesterol Total Pada Lansia Kelurahan Serengan Surakarta Adhiyani, Cisillia
Jurnal Farmasi (Journal of Pharmacy) Vol. 2 No. 1 (2013): Jurnal Farmasi (Journal of Pharmacy), October 2013
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Aging brings physical decline and increases morbidity trend, out of many is coronary heart disease(CHD). This disease is the leading cause in Indonesian’s total death number and one of the risk factors is hypercholesterolemia. Hypercholesterolemia is influenced by diet, heredity, age, sex, obesity, stress, alcohol, and physical activity. To identify the relationship of age and consumption of fatty food by total cholesterol. It is a descriptive analytical research by applying cross sectional approach. Purposive sampling method is conducted. Data are analyzed using SPSS version 16.0 Result of taking 101 elderly as samples, 13 are male and 88 are female, 28 elderly female tend to have cholesterol increase. The age range of 55 – 64 years old has got the highest cholesterol level than the other age range. Elderly who like to consume fatty food are 21 compared to people who don’t like fatty food are only 8. Total cholesterol test result of 101 blood samples obtains 107 mg /dl for lowest level and 301 mg /dl for highest level with 184 mg /dl for average. Elderly with CHD risk are 19 people and high risk of CHD are 10 people based on the total cholesterol result. The result of the statistical analysis is concluded that there is significant association of age with total cholesterol (p=0.067,α=0.05), there is no significant association with the consumption of fatty foods in total cholesterol ( p=0.057 ; α=0.05 ), and there are no significant relationships of age, consumption of fatty foods with total cholesterol (p=0.185; α=0.05)
Pengaruh Kombinasi Emulgator CMC dan Tween 80 Terhadap Stabilitas Fisik Emulsi Minyak Ikan Adiningsih, Retnowati
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Cod-liver oil emulsion in standard formula using gum arabic as emulsifying agent is considered to be “true” emulsifier. The disadvantage of gum arabic is it cannot be stored in along time because the emulsifier effect will vanish, so it has to be combined with other emulsifying agent such as CMC and Tween 80. The aim of the experiment was to study the influence of CMC and Tween 80 emulsifiers combination on physical stability of cod liver oil emulsion and the optimal concentration of CMC and Tween 80 emulsifiers to prepare a stable cod liver oil emulsion, indicated by there was no significant damage of the emulsion during the experiment. The experiment used 4 formulas which contain emulsifiers combinations: 0,25% CMC; 0,25% CMC : 10% Tween 80; 0,25% CMC : 20% Tween 80; 20% Tween 80. The observation of emultion stability includes emulsion type, separation percentage at room temperature, at 40° - 50°C temperature, at 3000 rpm centrifugally, viscosity and particle size determination. The result of the experiment indicated there was various stability of cod liver oil emulsion in each emulsifier combination. The statistic result indicated that CMC 0,25% had significant influence on separation percentage at room temperature, at 40° - 50°C, 3000 rpm centrifugally, viscosity and particle size of cod liver oil. Emulsion with emulsifiers combination of 0,25% CMC : 20% Tween 80 was the most stable emulsion because at the separation percentage examination, the viscosity and particle size had the best physical stability compared with other formula.
OPTIMASI PROPORSI CAMPURAN POLIVINIL PIROLIDON DAN AVICEL PH 101 DALAM FORMULASI TABLET ASAM MEFENAMAT SECARA SIMPLEX LATTICE DESIGN Puspitasari, Dian; Kuncahyo, Ilham
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Mefenamic acid is used as an analgesic and non-steroidal anti-inflammatory drugs. The problem that often occurs in the process of compressing is that mefenamic acid tends to stick on the surface of punch and die-compressing machine, so that it often experiences sticking and within a sustainable manner can cause capping process. The other problems of Mefenamic acid are hydrophobic and having low solubility, so that the dissolution becomes a problem. The combination of Avicel PH101 and PVP is expected to fix the problems, so that well-qualified Mefenamic acid tablets can be obtained. This study was aimed at obtaining the optimum formula of mixed Avicel PH101 and PVP in the manufacture of mefenamic acid tablets by wet granulation, based on the method of simplex lattice design (SLD) with two components, namely: Avicel PH101 (A) and PVP (B). Three formulas of mefenamic acid tablets (F1 (100% A), F2 (50% A: 50% B), F3 (100% B)) are made by wet granulation. The granules are tested for the fluidity, compactibility and dissolution. The result is to obtain SLD equation. The equation is used to determine the optimum formula which is the formula with the total response of the most optimal physical properties of granules. The result of the experiment shows that optimum formula was obtained from Avicel PH 101 30% - PVP 70% mixture at granules’ physical properties, and the obtained tablets of Mefenamic acid fulfills tablet physical property test.
Analisis Zat Pemanis Sakarin dan Siklamat Pada Minuman Bubble Drink yang Dijual di Kota Surakarta Wimpy; Harningsih, Tri; Siska Wardani, Tatiana
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Sweetener known as a compound that is intentionally added and used to improve it’s taste and aroma,it also used to improve physical and chemical properties. It also used as the source of calories for the body. There are two types of sweetener : natural sweeteners and artificial sweeteners. Beverage and food producers such as bubble drink producer prefer to use artificial sweeteners rather than natural sweeteners because it is cheaper and sweeter than natural sweeteners. If we use excessive amounts of saccharin and cyclamate, they can lead to many health problems such as neurological diseases, hypertension, and brain cancer.This is an experimental research with purposive sampling method. Samples were collected from bubble drink sellers in 5 sub-districts of the Surakarta City. The experiment was conducted at the National STIKES Chemistry Laboratory. Saccharin and cyclamate were determined by rapid test kits. Qualitative test results on 25 buble drinks did not show the presence of saccharin and cyclamate sweetener.
KESESUAIAN ASEPTIK DISPENSING INJEKSI ANTIBIOTIK PADA PASIEN ANAK RUMAH SAKIT UMUM DAERAH DR. SOEDIRAN MANGUN SUMARSO WONOGIRI Rusmiyati, Eny; Dian Anggraini, Truly
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/hvvtre46

Abstract

The use of injection preparations in hospitalized patients has a high prevalence rate so that dispensing injections needs attention because there are many risks that can arise during the mixing process. The purpose of the study was to determine the suitability of the aseptic procedure for dispensing antibiotics in pediatric patients with standard operating procedures applicable at the dr. Sudirman Mangun Sumarso Wonogiri. This study used a retrospective method with descriptive analysis of the data for August – October 2021. Conformity was measured using a checklist form and the percentage of conformity was calculated. The results showed that from 106 antibiotic mixtures consisting of Cefotaxim inj (46%), Ceftriaxon inj (12%), Chloramphenicol inj (3%), and Gentamicin inj (39%) obtained 85.71% according to standard operating procedures. Compliance that has met the standard includes reviewing prescriptions, doing 5 correct, calculating dosage suitability, choosing solvents, calculating solvent volumes, making delivery forms and those that are not appropriate, namely checking the condition of the drug when it is received. Examination of the condition of the drug when it is received should be carried out accompanied by a form so that there is a record that can be used for tracing when a medication error occurs.
Pengaruh Kombinasi Ekstrak Etanolik Temulawak (Curcuma canthorrizha Roxb) Rendah Minyak Atsiri dan Ekstrak Etanolik Sambung Nyawa (Gynura procumbens (Lour.) Merr) Terhadap Kadar Trigliserida Tikus Putih Jantan Galur Wistar Serta Gambaran Histopatologinya Novianto, Agil
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hyperlipidemia is factor affected to coronary hearth disease, allow with increase of serum level cholesterol and tryglycerida. This research is to know effect combination of ethanolic extract of Curcuma xanthorrizha Roxb with low content of volletile oil and ethanolic extract Gynura procumbens (Lour.) on triglyceride level serum and its hyperlipidemia manifestation atherosclerosis. Forty eight male albino rat devide into 8 groups. Positive group receive gemfibrozil, CMC-Na 0,5 % (negatif) and treatment group combination of temulawak and sambung nyawa 100:0, 75:25, 50:50, 25:75, 0:100. Dose of ethanolic extract temulawak is 225 mg/kg BB and dose of ethanolic exstrac sambung nyawa 150 Methode of this research by give diet lipid and yolk egg for about 30 day on treatment group except normal group after this give sample test for about 30 day. Trygliceride level serum measure on day 0 (baseline), 30 and 60 with Trigliserida FS Diasys®. Hypotrigliceride activity describe into % of change triglyceride level and analyse with Mann-whitney with level of significane 95 %. Histopatology analyze used cardiac aorta. Hypotriglyceride activity combination of extract temulawak and extract sambung nyawa showing no significance difference both combination (p>0,05). Combination of temulawak:sambung nyawa (75:25) give the highest hypotrigliceride activity with decrease on triglyceride level serum for about 56,77 %. Combination both extract effective to avoid atherosclerosis

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