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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 193 Documents
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Gambaran Penggunaan Obat Pada Hepatitis A Pasien Rawat Inap di Rumah Sakit Umum Daerah dr. Soediran Mangun Sumarso Wonogiri Periode Januari 2017 – Juni 2019 Noor Hidayati, Listiana; Dian Anggraini, Truly
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hepatitis A is an infectious disease of the liver caused by the hepatitis A virus. Number of cases of hepatitis A inpatients at the Regional General Hospital dr. Soediran Mangun Sumarso Wonogiri during 2017 - June 2019 as many as 110 patients. The purpose of this study was to determine the description of drug use in hepatitis A patients including the characteristics and treatment of patients. This research is a non-experimental study with a descriptive analysis design, by collecting data information through medical records of hepatitis A patients diagnosed in the period January 2017 - June 2019. The parameters used are the percentage of the characteristics of hepatitis A patients calculated based on age, sex, type of comorbidities and description of treatment of hepatitis A patients including the type and amount of drug used, the type and amount of infusion fluid used. The results showed that the percentage based on the age of patients with the most age range ≥ 56 years (30.91%), the percentage based on the most sexes of men (55%), the percentage based on the types of comorbidities with most types of typhoid disease (53.33%) , the percentage based on the use of drugs that are widely used is curcuma (12.37%), and the percentage based on the use of most intravenous fluids is ringer acetate (58.78%).
Analisis Zat Pemanis Sakarin dan Siklamat Pada Minuman Bubble Drink Yang Dijual Di Kota Surakarta wimpy, wimpy; Harningsih, Tri
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1, Maret (2020)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1, Maret.95

Abstract

Zat pemanis ini merupakan suatu senyawa yang secara sengaja ditambahkan dan digunakan untuk meningkatkan cita rasa dan aroma, memperbaiki sifat-sifat fisik, sebagai pegawet, memperbaiki sifat-sifat kimia dan sumber kalori bagi tubuh. Zat pemanis ada dua jenis yaitu pemanis alami dan pemanis buatan. Produsen minuman dan pangan seperti produsen bubble drink lebih memilih untuk menggunakan pemanis buatan dibandingkan pemanis alami karena harga lebih murah dan tingkat kemanisan pemanis buatan lebih tinggi dibandingkan pemanis alami. Pemanis buatan seperti sakarin dan siklamat jika dikonsumsi secara berlebih dapat memicu terjadinya gangguan kesehatan seperti penyakit saraf, hipertensi, dan kanker otak.Jenis penelitian adalah  ekperimental dengan purposive sampling. 25 sampel diperoleh dari penjual bubble drink yang berada di 5 kecamatan yang dijual di kota Surakarta. Tempat penelitian dilaksanakan di Laboratorium Kimia STIKES Nasional. Uji kualitatif yang digunakan menggunakan rapid test kit sakarin dan siklamat. Hasil uji kualitatif pada 25 sampel menggunakan rapid test kit menunjukkkan hasil negatif,  tidak ditemukan adanya pemanis sakarin dan siklamat.
Efek Kemopreventif Ekstrak Metanol Kulit Kayu Nangka (Artocarpus heterophylla Lmk.) pada Karsinogenesis Kanker Payudara Tikus Betina yang Diinduksi DMBA Susilowati
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Chemopreventive compound discovery efforts that could inhibit and suppress the process need to be developed of carcinogenesis that is cancer prevention strategies. Jackfruit (Artocarpus heterophylla Lmk.) have been reported many chemical compounds that potent as anti-cancer properties. The aim of this research is to determine the potential anticarsinogenesis of methanolic extract of jackfruit bark to suppress 7,12-Dimethylbenz(a) antrhacene (DMBA) induced breast cancer female development during the initiation phase and post initiation of cancer. In this research 25 female Sprague-Dawley rats aged 47 days with 50-150 g body weight divided into 5 groups. Group I, II and III is a test group with extract dose of 200, 400 and 800 mg / kg BW. Group IV (comparison group) as a positive control (0.36 mg/200 g tamoxifen BB) and group V (the pain group) as a negative control (2 ml/200 g BB Na CMC 0.5%). DMBA (20 mg / kg) peroral given twice a week for five weeks. Extract and control treatment is given every day for 7 weeks with DMBA induction. Tumor development was examined by macroscopic and microscopic. The results showed that the potential of methanolic extract of jackfruit bark to suppress breast cancer development is unknown because still necessary to optimize the induction of breast cancer carcinogenesis models.
Pengaruh Kombinasi Emulgator CMC dan Tween 80 Terhadap Stabilitas Fisik Emulsi Minyak Ikan Retnowati Adiningsih
Jurnal Farmasi (Journal of Pharmacy) Vol 3, No 1 (2014): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v3i1.24

Abstract

Emulsi minyak ikan dalam formula standar menggunakan emulgator gom arab yang mempunyai sifat emulgator sejati. Gom ini mempunyai kerugian yaitu penyimpanan yang lama dapat menyebabkan hilangnya daya mengemulsinya, sehingga berdasarkan hal tersebut tidak menutup kemungkinan untuk menggunakan emulgator lain yaitu CMC dan Tween 80. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi emulgator CMC dan Tween 80 terhadap stabilitas fisik minyak ikan dan konsentrasi emulgator CMC dan Tween 80 yang optimal untuk membuat emulsi minyak ikan yang stabil, ditunjukkan dengan tidak adanya kerusakan yang berarti dari emulsi selama penelitian. Penelitian ini menggunakan 4 formula dengan kandungan kombinasi emulgator yang bervariasi yaitu CMC 0,25% ; CMC 0,25% : Tween 80 10% ; CMC 0,25% : Tween 80 20% ; Tween 80 20%. Pengamatan stabilitas emulsi meliputi tipe emulsi, persen pemisahan pada suhu kamar, pada suhu 40° - 50°C, pada sentrifugasi 3000 rpm, viskositas dan penentuan ukuran patikel. Hasil yang didapat pada penelitian ini menunjukkan adanya variasi stabilitas emulsi minyak ikan dari tiap-tiap kombinasi emulgator. Hasil statistik menunjukkan bahwa emulgator CMC 0,25% berpengaruh nyata terhadap persen pemisahan pada suhu kamar, suhu 40° - 50°C, sentrifugasi 3000 rpm, viskositas dan ukuran partakel emulsi minyak ikan. Emulsi dengan kombinasi emulgator CMC 0,25% : Tween 80 20% merupakan emulsi yang paling stabil karena pada pemeriksaan persen pemisahan, viskositas dan ukuran partikel mempunyai stabilitas fisik yang lebih baik dibanding formula lain.
DETEKSI VIRUS DEN3 PADA SEMUA STADIUM Aedes aegypti (TRANSOVARIAL) DENGAN TEKNIK IMUNOSITOKIMIA SECARA INVITRO Kumoro Setya, Adhi; Dharmawan, Ruben
Jurnal Farmasi (Journal of Pharmacy) Vol. 5 No. 1 (2016): Jurnal Farmasi (Journal of Pharmacy), October 2016
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Many dangerous parasites transmitted by the mosquito, one of which is dengue virus which causes dengue fever. The previous study said that in immunocytochemistry, dengue virus can be found in A. aegypti that does not suck blood. The basic principle of this examination was done by a technique of determining the existence (location) of antigen in cells in a tissue using antigen-antibody reaction. The purpose of this study was to determine the result of positive value of A. aegypti breeding stages in laboratory scale. DEN3 virus was mixed into the blood for trial then infected orally on the A. aegypti for breeding. All stages of breeding results was tested for DEN3 virus from the body tissue. DEN3 antigen in the body of the vector will bind with specific antibody from reagent and by the presence of the enzyme and chromogen substrate, it will give a brown color to the cells and granule surrounding the cells. Such color reaction was checked using a light microscope with 400x magnification with the positive control of DEN3 breed and the negative control of normal blood as a comparison. The findings showed that immunocytochemistry with SBPC method was capable of detecting DEN3 at all stages of metamorphosis of A. aegypti with the results of the stage respectively; egg: 82%, larva: 89%, pupa: 94% and adult: 100%. These results showed how immunocytochemistry technique as an alternative method which is relatively cheaper than molecular technique can be used for surveillance on dengue will appear.
Skrining Fitokimia dan Aktivitas Penyembuhan Luka Bakar Ekstrak Etanolik Morinda Citrifolia L. pada Kulit Kelinci (Oryctolagus Cuniculus) Retno Priamsari, Margareta; Auly Yuniawati, Noor
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Burns are damage to the unit or network components caused by changes in temperature, chemicals, electricity, and radiation. Alkaloid, flavonoid, saponin, and tannin compounds in Noni leaves (Morinda citrifolia. L) have the potential to heal burns. The aim of this study was to determine phytochemical screening and the activity of noni leaf extract to the healing of burns on rabbit skin. This type of research is experimental with a randomized pattern design in one direction. Noni leaf ethanolic extract was obtained by remaseration method using 96% ethanol solvent and phytochemical screening tests. Tests of burns were carried out on 5 male New Zealand strain rabbits. Each part of the rabbit's back skin was divided into 5 treatments, namely positive control (Bioplacenton gel), negative control (vaselin flavum), and ethanolic extract of noni leaf concentrations of 10%, 15%, and 20%. The skin of the back is induced by a 2 cm diameter hot metal plate for 10 seconds until a shallow second degree burn occurs. Burn wound healing parameters include visual observation of physiological mean and reduction in wound diameter for 21 days. The average percentage of wound healing was analyzed by non-parametric statistics with Kruskal-Wallis, followed by Mann-Whitney with a confidence level of 95%. The results showed that the ethanolic extract of noni leaves contained alkaloids, flavonoids, saponins and tannins as well as having burn healing activities. The variation in the concentration of ethanolic extract of noni leaves is 10%; 15% and 20% have no significant effect on the healing of burns.
Optimasi Tween 80 dan Etanol pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Jonathan Suneidesis Alpons, Gabriel; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of Non Steroid Anti-Inflamatory Drug (NSAID) that used as treatment of pain or inflammatory. Solid dispersion method may improve the solubility of ibuprofen. Ibuprofen was made into a gel product to overcome the side effect. Addition of an enhancer in a gel may increase the penetration of an active substance. The purpose of this study is to understand the effect of tween 80 and ethanol as an enhancer to penetration and drug release of ibuprofen in gel, the effect to physical quality of gel, and to obtain the optimum formula of the combination of enhancer. This study used simplex lattice design with two factor which is tween 80 and ethanol in gel product formula 1; formula 2; and formula 3 in sequence 100%:0%; 50%:50%; 0%:100%. Solid dispersion of ibuprofen-PEG 6000 was made with melting method and tested with FT-IR before made into gel product. Penetration test is done by using Franz diffusion cell with selofan membrane and the determination of the optimum formula obtained based on counterplot from optimization with design expert 10.0.01 trial version with the parameters of the critical level is viscosity and penetration substanced. The results showed the combination of tween 80 and ethanol could affect viscosity and penetration of active substance, tween 80 had a greater effect than ethanol. The proportion of tween 80 4.681% and ethanol 16.319% produces the optimum formula with the most optimum viscosity, adhesion, and drug penetration
Aktivitas Antioksidan Fraksi Air dan Etil Asetat dari Ekstrak Sarang Semut (Myrmecodia pendens Merr. & Perry) Suprijono, Agus; Hesti Wulan S, A. Ariani; Dyah Pratiwi, Arini
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/ne6xb653

Abstract

Sarang Semut (Myrmecodia pendens Merr. & Perry) is a medicinal herbal contains of flavonoids, tannins, phenolic compounds, polyphenols, and vitamin E. Those substances are potent antioxidants. This research refers to previous research that the ethanol extract of Sarang Semut (Myrmecodia pendens Merr. & Perry) provided antioxidant activity with a mean EC50 of 3.8021 µg/ml. The purpose of this research was to determine the antioxidant activity of the fracti ons of ethanolic extract of Sarang Semut (Myrmecodia pendens Merr. & Perry) and to determine the highest antioxidant activity of them expressed by EC50. The ethanol extract of Sarang Semut (Myrmecodia pendens Merr. & Perry) was obtained by filtration using the soxletation method with 96% ethanol as solvent, then the ethanolic extract partitioned by liquid-liquid fractionation with water and ethyl acetate. Each fraction at a concentration of 0.9 µg/ml, 1.0 µg/ml, 2.0 µg/ml, 3.0 µg/ml, 4.0 µg/ml, and 5.0 µg/ml were tested by the DPPH method (1,1-diphenyl-2-picrylhidrazyl 2) using a spectrophotometer at λ 515 nm and operating time 35 minutes. The result shows the fraction of ethyl acetate has the highest antioxidant activity with a mean EC50 of 2.8821+ 0.1361 µg/ml. While the average EC50 fraction of water is 3.8830 + 0.2205 µg/ml. From the statistical t test is known that the fraction of water and ethyl acetate have significantly different rates of EC50.
Tinjauan Pola Penggunaan Antibiotik Pada Pasien Anak Demam Tifoid di Instalasi Rawat Inap RSUP dr. Kariadi Semarang Tahun 2009 Truly Dian Anggraini
Jurnal Farmasi (Journal of Pharmacy) Vol 2, No 1 (2013): Oktober
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v2i1.19

Abstract

Demam tifoid termasuk salah satu penyakit infeksi yang banyak ditemukan di negara berkembang dengan kepadatan penduduk tinggi serta kesehatan lingkungan yang rendah. Berdasarkan laporan WHO disebutkan bahwa Indonesia merupakan salah satu Negara dengan angka kejadian demam tifoid yang tinggi, yaitu >100 per 100.000 penduduk per tahun. Studi epidemiologi baru-baru ini menunjukkan mulai adanya resiko multi drug resisten (MDR) pada penggunaan antibiotik untuk pengobatan demam tifoid sehingga penelitian ini dilakukan untuk mengetahui pola penggunaan antibiotik pada pasien anak demam tifoid di instalasi rawat inap RSUP Dr. Kariadi Semarang pada tahun 2009. Penelitian ini merupakan penelitian non eksperimental. Pengumpulan data dilakukan secara retrospektif dari data rekam medik pasien. Sebanyak 100 sampel diperoleh, dan hasil penelitian dianalisis menggunakan metode deskriptif non analitik. Pola penggunaan antibiotik untuk demam tifoid dilihat melalui golongan antibiotik yang digunakan, ada tidaknya penggantian antibiotik selama terapi, kombinasi antibiotik yang diberikan, cara pemberian, lama pemberian antibiotik, efek samping antibiotik, dan interaksi obat yang terjadi akibat penggunaan antibiotik. Hasil penelitian menunjukkan bahwa pada periode tahun 2009 di instalasi rawat inap RSUP Dr. Kariadi demam tifoid didominasi oleh pasien laki-laki pada rentang usia 6-10 tahun. Golongan antibiotik yang paling banyak digunakan adalah dari golongan sefalosporin sebesar 55,22%, dari 100 kasus 35 diantaranya mengalami penggantian antibiotik, penggunaan kombinasi antibiotik sebesar 50%, sediaan antibiotik lebih banyak diberikan dalam bentuk injeksi dan untuk lama pemberian antibiotik terdapat ketidaksesuaian lama pemberian antibiotik pada pasien dengan yang tercantum pada Standar Prosedur Operasional yaitu jauh lebih singkat.
Metode Ekstraksi Sarang Semut (Myrmecodia Pendans) dengan Teknik Maserasi untuk Menghasilkan Obat Alternatif Kanker Paru Suharyanto; Purwono, Bambang
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Cancer is a growing cells of any type of cell and tissue in the body anywhere, a large number of diseases are characterized by tissue and cell type of origin. Each year found nearly 6 million new patients known to have cancer, and more than 4 million of them died. Until now cancer treatment is done by 3 ways: surgery, radiation, and drug delivery of anti -neoplastic or anti- cancer. However, all three treatments over a lot of side effects to the patient. This study aims to conduct a series of pre-clinical trials to determine the optimal dose of Sarangsemut plant ( Myrmecodia pendens ) can be used as a drug to cure lung cancer. The specific objective of this research is to extract Sarangsemut plant ( Myrmecodia pendens ) and soursop leaves to produce drugs alterlatif cancer disease. Benefits of this research can be used.

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