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Sri Agus Sudjarwo
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Department of Basic Medical Veterinary of Faculty of Veterinary Medicine, Universitas Airlangga Kampus C, Mulyorejo, Kec. Mulyorejo, Kota SBY, Jawa Timur 60115 Phone: (031) 5992785 ext. 5993016
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INDONESIA
journal of Basic Medical Veterinary
Published by Universitas Airlangga
ISSN : 23026820     EISSN : 27749959     DOI : https://dx.doi.org/10.20473
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary
This journal published original articles, review articles, and case studies in Indonesian or English, in the scope of JBMV has a broad coverage of relevant topics across veterinary basic medical sciences which includes: preclinical and paraclinical disciplines like Anatomy, Physiology, Biochemistry, Pathology, Microbiology, Pharmacology and Medical Education.
Arjuna Subject : Kedokteran Hewan - Kedokteran Hewan (Lain-Lain)
Articles 136 Documents
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Biofilm-Mediated Survival of Leptospira spp.: A Comprehensive Review on Molecular Basis and Control Strategies Wijayanto, Robby; Zilfiarani, Chalida Nahendra; Fahlefi, Moch. Ilham Riza
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.81120

Abstract

Leptospirosis is a significant tropical zoonosis, with a considerable burden on morbidity and mortality in humans as well as animals. One of the possible explanations is biofilm formation, which is the accumulation of EPS, eDNA, and c-di-GMP signals that respond to various environmental, antibiotic, or host-immune challenges. This review focuses on the molecular mechanisms underlying biofilm formation, ecological significance, connection to antimicrobial resistance, and the public health implications. Elucidation of the c-di-GMP regulatory networks, adhesin gene and protein expression, and other metabolic shifts account for the survival of Leptospira biofilms in autochthonous populations of aquatic habitats and kidney colonization of reservoir hosts. In addition, biofilms have been associated with long-term bacterial colonization, chronic urine stream associated with persistent bacterial shedding, and failed antibiotics. This scenario, from an epidemiological perspective, facilitates the emergence of anthropogenic infections, and perpetuates the endemic nature of the disease. From a disease-control perspective, biofilms increase the burden associated with persistent infections. This review emphasizes that, as a survival strategy, biofilms represent several potential avenues for the implementation of novel control strategies, including the use of antibiofilm agents, quorum-sensing inhibitors, and multi-epitope vaccines. The functional and integrated dissection of biofilms positioned Leptospira spp. to novel One Health-based control strategies for the disease.
Effects of Nicotine-Containing E-Cigarette Smoke on Testicular Histopathology in Albino Rats Amalia, Nina; Zhafira, Farodina Azka; Yunita, Maya Nurwartanti; Sari, Shelly Oktania Nurvita; Herdiansyah, Akbar Dimas; Pratika, Selva; Wardana, Prasvita Rosa; Zahro, Fatimatus; Rahmadani, Aurel Aulia
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.82605

Abstract

This study aims to assess the level of damage from histopathology of seminiferous tubules of testicular organs of albino rats affected by exposure to e-cigarette vapor. The 20 albino rats used were divided into 5 groups, which are the control group (C) not given exposure to e-cigarette vapor and the treatment group given exposure to e-cigarette vapor at different doses. Treatment groups T1 (0.3 mg/ml), T2 (3 mg/ml), T3 (12 mg/ml), T4 (36 mg/ml). All treatment groups were given perinhaled and the treatment was carried out for 14 days. At the end of treatment, albino rats were euthanized and then necropsied and testicular organs were preserved to make histopathological preparations using Hematoxilin-Eosin staining. The results of the histopathological picture of the seminiferous tubules of the testes were observed at 400x magnification and the thickness of the epithelium and the diameter of the seminiferous tubules. The results showed a significant change in the thickness of the seminiferous tubule epithelium in each treatment which decreased, but there was no significant change in the diameter of the seminiferous tubules. This study states that exposure to e-cigarette vapor in rats can cause a decrease in spermatogenesis.
Front Cover, Editorial Board, Peer Reviewers, Acknowledgments Aisyafalah, S.Si, Salma
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

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Abstract

Guidelines for Author, Back Cover Aisyafalah, S.Si, Salma
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

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Abstract

Periodic Fasting Treatment on Growth Performance and Feed Efficiency of Nile Tilapia (Oreochromis niloticus, GIFT) Jacob Da Costa Pereira; Salustiano Zaret; Mateus Salvador; Kismiyati; Sapto Adriyono; Ahmad Shofy Mubarak; Mohammad Anam Al Arif
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.81125

Abstract

Fasting is a feed management strategy that reduces feeding frequency without inhibiting fish growth. This strategy involves specific intervals of feed deprivation, allowing fish to exhibit increased appetite once feeding resumes. This study aimed to evaluate the effects of periodic fasting on the growth performance and feed efficiency of GIFT Nile tilapia, as well as to identify the most effective fasting pattern for optimal results. The research used a completely randomized design (CRD) with four treatments, each replicated three times: continuous feeding without fasting (K, control); two days of feeding followed by one day of fasting (2E1F); three days of feeding followed by one day of fasting (3E1F); and four days of feeding followed by one day of fasting (4E1F). The primary parameters observed were absolute weight gain (g), absolute length growth (cm), and feed efficiency. Data were analyzed using the Kruskal–Wallis test (p < 0.05), followed by post hoc comparisons using independent samples tests to determine significant differences among treatments. The results showed that periodic fasting had a significant effect (p < 0.05) on absolute weight gain, absolute length growth, and feed efficiency of GIFT Nile tilapia. The best performance was observed in treatment 4E1F (four days of feeding followed by one day of fasting), while the lowest performance occurred in treatment 2E1F (two days of feeding followed by one day of fasting).
Essential Oils as Modulators of TRPV1: A Scoping Review of Mechanisms and Preclinical Evidence for Natural Analgesics Chaerul Fadly Mochtar; Andini Febriyanda; Andi Ainun Zulkiah Surur; Andi Sri Dewi Anggraeni; Ulfah Widyastuti Arsal; Nana Aulia Massakuta; Nita Magfirah Ilyas; Suriati
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.82224

Abstract

Essential oils contain diverse bioactive constituents capable of modulating ion channels involved in nociception, including the transient receptor potential vanilloid 1 (TRPV1) channel. Increasing evidence suggests that these volatile compounds may exert analgesic effects through TRPV1-mediated mechanisms; however, findings remain scattered across heterogeneous preclinical studies. This scoping review aimed to systematically map the current evidence on how essential oils and their isolated constituents interact with TRPV1 in the context of pain modulation. A comprehensive search of PubMed, Scopus, and Web of Science (up to October 2025) was conducted using predefined keywords related to essential oils, TRPV1, and pain. Eligible studies included in vitro or in vivo experiments evaluating the activation, inhibition, or modulation of TRPV1 alongside pain-related outcomes. Twenty studies met the inclusion criteria and were extracted for authorship, experimental models, compound types, TRPV1-specific findings, and nociceptive effects. Results demonstrated three dominant mechanisms of TRPV1 modulation: (i) direct inhibition of TRPV1 activity by compounds such as linalyl acetate and α-humulene; (ii) agonist-induced activation followed by desensitisation, as observed with myrcene, carvone, and citral; and (iii) multi-target modulation in which TRPV1 interacts with additional TRP channels and inflammatory pathways. Across models of acute, inflammatory, and neuropathic pain, these mechanisms consistently produced significant antinociceptive effects. Overall, essential oils show strong potential as natural TRPV1-targeted analgesic candidates. However, methodological heterogeneity, limited mechanistic depth, and the lack of clinical validation remain key limitations.
The Effect of Red Ginger (Zingiber officinale var. rubrum) Extract Administration on the Number of Spermatogenic Cells and Leydig Cells in White Rats (Rattus norvegicus) Exposed to Monosodium Glutamate Ahmad Fahrisa Sidharta; Kadek Rachmawati; Rimayanti; Budi Utomo; Nove Hidajati; Kuncoro Puguh Santoso; Rahmi Sugihartuti; Rochmah Kurnijasanti
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.82732

Abstract

The purpose of this study was to examine the effect of red ginger extract (Zingiber officinale var. rubrum) on the number of spermatogenic cells and Leydig cells in white rats (Rattus norvegicus) exposed to monosodium glutamate (MSG). This study used 25 male white rats divided into five treatment groups. The K− group received 1% CMC-Na, the K+ group received MSG at a dose of 5 g/kg body weight (BW), and the P1 to P3 groups received MSG at 5 g/kg BW along with red ginger extract at doses of 50 mg/kg BW, 100 mg/kg BW, and 200 mg/kg BW, respectively, for 42 days. The rats’ testes were collected, processed into histopathological preparations, and observed under a microscope at 400× magnification. Data were analyzed using one-way ANOVA followed by Duncan’s test. The results showed significant differences (p < 0.05) in the number of spermatogenic cells and Leydig cells among the K−, K+, P1, and P2 groups, but no significant differences (p > 0.05) were observed between the K− group (57.60ᵈ ± 1.490 and 14.92ᵈ ± 1.487) and the P3 group (57.20ᵈ ± 1.208 and 14.84ᵈ ± 1.459). The optimal dose of red ginger extract was 200 mg/kg BW (P3). In conclusion, administration of red ginger extract can maintain the number of spermatogenic cells and Leydig cells in white rats (Rattus norvegicus) exposed to MSG.
Comparing the Effects of Different Diuretic Agents on Renal Function, Electrolyte Balance, and Survival in Rats: A Systematic Review Aulia Rahmawati; Belinda Ardelia Rahma Desyta; Kharisma Putri Utami; Yesi Kurnia Putri Maharani; Yuwanda Aulia Agustin
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.83003

Abstract

Diuretics alleviate fluid retention and electrolyte abnormalities; however, comparative preclinical animal studies remain limited. This systematic review evaluated the effects of loop diuretics (furosemide), thiazide diuretics (hydrochlorothiazide), and potassium-sparing agents (amiloride, triamterene) on renal function, electrolyte balance, and survival in rats. PRISMA 2020 guidelines were followed to search PubMed, Web of Science, and Google Scholar for comparative studies published between 2015 and 2025 investigating diuretic effects on glomerular filtration rate, creatinine clearance, urinary sodium/potassium/chloride excretion, plasma electrolytes, kidney injury biomarkers, and survival in rats. Dual screening and data extraction were performed independently by two reviewers, and risk of bias was assessed using the ARRIVE 2.0 checklist. Twelve studies (440 rats) were included. Thiazides (1.3–2.0-fold) and potassium-sparing agents (1.1–1.4-fold) increased urine volume less than loop diuretics (2.8–3.5-fold). Loop diuretics increased urinary potassium excretion and reduced plasma potassium to clinically dangerous levels (2.3–2.5 mmol/L), increasing the risk of hypokalemia by 2.3–3.2-fold. Thiazides showed moderate efficacy but also posed a significant risk of hypokalemia (1.5–1.9-fold K⁺ loss). Combination therapy with loop and potassium-sparing agents increased diuretic efficacy by 30–94% and reduced electrolyte disturbances by 30–50%. Diuretic resistance (approximately a 25% reduction in efficiency) was associated with aldosterone-mediated epithelial sodium channel overexpression during days 5–7 of chronic therapy. Aldosterone-deficient animals responded more favorably to diuretics. In disease models, furosemide promoted medullary damage in acute ischemia–reperfusion injury but improved survival in chronic renal failure (43–82% reduction in kidney injury biomarkers and 75–100% improvement with combination therapy). Metabolomic analyses indicated that outer medullary osmolyte depletion (betaine 89%, glycerophosphocholine 46–63%) contributed to impaired urine concentration. Prolonged furosemide use also resulted in significant micronutrient depletion (magnesium 16–33%, iron 52%, copper 31%). Effective loop diuretic therapy requires careful electrolyte monitoring. Combination therapy, particularly with loop and potassium-sparing diuretics, appears to be the most effective and safest strategy. Diuretic resistance caused by aldosterone-mediated sodium channel activation may be reduced through intermittent dosing, sodium restriction, or renin–angiotensin–aldosterone system antagonism. Future research should investigate long-term treatment protocols, combination regimens, disease-specific responses, and metabolomic standardization to optimize clinical diuretic therapy.
Analgesic Activity of A Transdermal Patch Containing Ethanol Extract of Piper nigrum L. Fructus with Various Penetration Enhancers in Mice Muhammad Nur Alawi; Zakky Nata Ardana; Radygta Pasha Putra; Raden Bagus Musa Dharma Tirta; Muhammad Adyaregha Asepputra
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.83260

Abstract

Transdermal drug delivery has emerged as an effective alternative to conventional analgesic administration, offering controlled release, improved bioavailability, and reduced systemic side effects. This literature review evaluates the analgesic potential of Piper nigrum L. fructus ethanol extract formulated into transdermal patches using various penetration enhancers. A total of ten peer-reviewed studies published between 2015 and 2025 were examined to identify trends in formulation strategies, enhancer mechanisms, and analgesic outcomes in animal models. The findings reveal that Piper nigrum extract demonstrates consistent analgesic activity through modulation of nociceptive pathways involving piperine, its primary bioactive constituent. The incorporation of enhancers such as oleic acid, propylene glycol, menthol, and DMSO significantly improves transdermal permeation, leading to higher therapeutic efficacy compared to formulations without enhancers. Most studies report increased inhibition of the writhing response, prolonged latency in hot-plate tests, and enhanced anti-inflammatory activity. However, variations in enhancer concentration, polymer composition, and evaluation methods contribute to heterogeneity in outcomes. Despite these differences, current evidence supports the potential of Piper nigrum-based transdermal patches as a promising analgesic modality. Further standardized in vivo studies and clinical investigations are required to validate optimal enhancer combinations, safety profiles, and dosage parameters.
Towards a Micro-Circular Economy in Poultry Production: Integrating Probiotic Substitution and Waste Valorization to Mitigate Environmental Impact Bodhi Agustono; Maya Nurwartanti Yunita; Zhaza Afililla; Ragil Angga Prastiya; Suciyono; Faizal Ulhaq; Mirza Atikah Madarina Hisyam; Widya Paramita Lokapirnasari
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.83263

Abstract

The intensification of the global poultry sector is currently challenged by the need to balance productivity with the mitigation of antimicrobial resistance (AMR) and environmental pollution. This study addresses the technological gap among smallholder farmers in Banyuwangi, Indonesia, by implementing a comprehensive technology transfer program focused on the functional substitution of antibiotic growth promoters (AGPs) with probiotics and the development of waste management cycles. Employing a Participatory Action Research (PAR) framework, the intervention integrated cognitive coaching, technical demonstrations, and longitudinal field applications to bridge the divide between biotechnological innovation and grassroots practice. Data were obtained from 27 broiler farmers through pre- and post-test evaluations and Focus Group Discussions (FGDs) to measure literacy shifts and technical adoption. Quantitative analysis revealed a significant transformation in biotechnology literacy, with understanding of probiotic mechanisms increasing from 37.0% (baseline) to 85.2% post-intervention. Furthermore, technical competence in functional feed formulation improved by 33.4% (p < 0.05), while the intention to adopt sustainable practices increased to 96.3%. These findings indicate that barriers to adoption among smallholders are primarily driven by limited access to applied science rather than cultural resistance. The study concludes that this hybrid extension model successfully establishes a viable micro-circular economy, offering a replicable strategy for upstream AMR mitigation in developing agropolitan regions.

Page 12 of 14 | Total Record : 136

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