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Ilil Maidatuz Zulfa
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Akademi Farmasi Surabaya Jl. Ketintang Madya No. 81 Surabaya, Jawa Timur, Indonesia.
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Journal Pharmasci (Journal of Pharmacy and Science)
Published by Akademi Farmasi Surabaya
ISSN : 25276328     EISSN : 25493558     DOI : https://doi.org/10.53342/pharmasci
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. Pharmacology and Toxicology 3. Community pharmacy 4. Dosage forms formulation 5. Pharmaceutics 6. Pharmacognosy 7. Natural product 8. Biology and Microbiology 9. Pharmaceutical Chemistry 10. Applied physics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 135 Documents
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In silico Approach Revealed α-amylase Inhibitor of Sappanon Compounds From Caesalpinia sappan In Carbohydrate Metabolism : Kajian in silico Senyawa Sappanon Caesalpinia sappan Sebagai Inhibitor α-amylase Pada Metabolisme Karbohidrat Dewi Ratih Tirto Sari; Siti Zamilatul Azkiyah; M. Eko Pranoto; Yohanes Bare; Lailatus Sarifah
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.335

Abstract

Human salivary amylase is a hydrolase enzyme that hydrolyze polysaccharides to small sugar. The α- amylase inhibition is an alternative strategy for reducing hyperglycemia. Caesalpinia sappan heartwood contains several bioactive compounds, as sappanon and derivates. Those compounds have been reported for promoting PDE4 inhibitor and anti-inflammatory. This study compared the α- amylase antagonist effect of sappanone A, Sappanone B, 3′-Deoxysappanone A, 3-Deoxysappanone B, and Neosappanone A compounds through molecular docking. In silico approach was used to identified the potential activity of those compounds. Five sappanone compound and their derivates were taken out the 3D structure at PubChem NCBI database. Then the α- amylase structure also was downloaded from Protein Data Bank with PDB ID 1smd. Among five sappanon compounds, L-peptide linking (control) and α- amylase were redocked using Molegro virtual docker and then visualized by Discovery studio version 5.50. The 3D complex structure of five sappanone compounds and their derivates showed inhibition activity of α- amylase at the same site of L-peptide linking. LYS227 was identifies in five sappanon - α-amilase complex. The ILE230 also showed in the complex of Neosappanone A, Sappanone B, and 3-Deoxysappanone B. interestingly, the ASN250 performed at Sappanone A and Sappanone B. in conclusion, this study suggests that five sappanone compounds and derivates potentially as antihyperglycemic and prevent the diabetes mellitus type 2 syndrome.
Evaluation of Prescription and Non-Prescription Services in Pharmaceutical Facilities: A Patient Simulation Study in the Lamongan Region: Evaluasi Pelayanan Resep dan Non Resep di Fasilitas Kefarmasian: Studi Simulasi Pasien di Wilayah Lamongan Cici Sayyidatul Adhimi; Primanitha Ria Utami; Enggar Ayu Fifianti; Erika Cindiana Pramudia Putri; Heru Setiawan; Lailya Eka; Muhammad Hadi Ma'ruf
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.342

Abstract

Pharmaceutical Services is an activity in identifying, preventing and resolving drug problems related to health. A new paradigm that is currently (patient oriented) with the aim of improving the quality of life of patients with an understanding of a drug or drug prescription from a doctor. This study aims to describe the implementation of prescription and non-prescription services based on Pharmaceutical Service Standards by pharmacists and pharmacists in the Lamongan area. This research is a descriptive research conducted by observation using patient simulation techniques. The location in the Lamongan area. The time of the study was November - December 2022. The sample consisted of 34 pharmacists who provide self-medication services at the Lamongan pharmaceutical facility, which were using the simple random sampling technique. The instruments used for data collection were scenarios of self-medication patients (for cases of fever, cough, runny nose), observation sheets, standard checklists for pharmaceutical services. The results of the study indicate that prescription and non-prescription services carried out by pharmacists in Lamongan have not fully complied with regulatory standards regarding pharmaceutical services. A total of 70.23% met pharmaceutical service standards. Special attention is needed in developing pharmaceutical competence, especially in providing effective patient education.
Formulation and Activity Test of Cold Shake Noni Fruit Extract (Morinda citrifolia L.): Formulasi dan Uji Aktivitas Antioksidan Bedak Dingin Kocok Ekstrak Buah Mengkudu (Morinda citrifolia L.) Rasdawati; Nurisyah; Sisilia Teresia Rosmala Dewi
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.347

Abstract

Noni fruit (Morinda citrifolia L.) is known to contain flavonoids, alkaloids and saponins. Flavonoid compounds function as antioxidants. This study aims to determine the antioxidant activity and stability of whipped cold powder extract of Noni Fruit (Morinda citrifolia L.). Noni fruit (Morinda citrifolia L.) was extracted using the maceration method using 96% ethanol, then evaporated using a rotary evaporator. The preparation of whipped cold powder Noni Fruit extract was made in 3 formulas with various concentrations, F I (3%), F II (6%) and F III (9%). The cold whipped powder formula is made without using extract as a base (F 0). Test the antioxidant activity of the DPPH solution as measured by a UV-Vis spectrophotometer at a maximum wavelength of 519 nm, the results of the analysis showed the average % inhibition of F I was 76.43%, F II was 81.69%, F III was 81.81% while the chilled powder base (F 0) was 9.21%. Of all the formulas that have the most effective antioxidant activity is F II with a concentration of 6%. Next, an evaluation of the whipped cold powder preparations was carried out, namely organoleptic testing, homogeneity, pH, viscosity, and adhesion of all the cold whipped powder preparations that met the requirements.
Standardization of Kesambi Leaf Extract (Schleichera oleosa) from The Selayar Area: Standardisasi Ekstrak Daun Kesambi (Schleichera oleosa) yang Berasal dari Daerah Selayar Afra Azisah Azisah; Alfrida Monica Salasa; St. Ratnah
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.348

Abstract

Kesambi leaves are part of plant that’s commonly used as medicine, at Selayar district. In general, the monograph of a medicinal plant is listed in Indonesian Herbal Pharmacopoeia, but kesambi leaves haven’t been included in the book so standardization needs to be carried out. The purpose of this study is to determine the standard values of specific and non-specific parameters of Kesambi (Schleichera oleosa) leaf extract originating from the Selayar. The majority of testing methods refer to the standardization book issued by the Indonesian Ministry of Health. The results of the specific parameters of Kesambi Leaf extract are blackish brown, characteristic odor and thick taste. The total level of flavonoids was 1.2918% b/b and polyphenols were 9.738% b/b. Compounds dissolved in ethanol were 13.1866 ± 1.5894 and in water were 13.9474 ± 0.1561. Testing non-specific parameters obtained drying shrinkage of 33.4307 ± 5.7692, water content 5.1797 ± 0.5462, total ash content 2.5178 ± 0.2559, acid insoluble ash content 0.4394 ± 0.2906, as well as microbial contamination and heavy metal contamination that comply with the requirements.
Analysis Of Drug Use Patterns Towards Total Costs Hypertensive Inpatients at Panembahan Senopati Hospital: Analisis Pola Penggunakan Obat Terhadap Biaya Total Pasien Hipertensi Rawat Inap di RSUD Panembahan Senopati Anis Febri Nilansari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.349

Abstract

The National Health Insurance System imposes health service tariffs by way of the INA-CBGS tariff. Payment using the INA-CBGS system is based on the diagnosis issued to the patient. The difference in costs between class 1, 2, and 3 patients in the same code is the cost of accommodation. This study aims to compare the cost of inpatient treatment of hypertensive patients between class 1, 2, and 3 patients and to determine patterns of drug use. The research data was taken retrospectively from hospital financial data and patient medical records. The study was conducted for 10 months (October 2016 to July 2017) with a total of 53 patients who met the inclusion criteria. The results showed that the total hospital costs exceeded the INA-CBGs claim rates. The cost of using drugs per day for class 1 is Rp. 166,550, class 2 Rp. 161,659 and class 3 Rp. 99,285 with statistical test results obtained p value> 0.05. The pattern of drug use in patients class 1 (generic = 55.4%, patent 44.5%), class 2 (generic = 56%, patent 44%), and class 3 (generic = 60%, patent = 40%). The mean drug items received by class 1 patients = 12.16 items, class 2 = 12.75 items, and class 3 = 9.45 items. Based on the Post Hoc test, the results showed that the average drug prescribed for class 3 inpatient hypertension was significantly different from class 1 and 2 patients.
Profile of Drug Adherence in Elderly Patients with Oral Antidiabetes And Antihipertensive Therapy Using Pill Count Method: Profil Kepatuhan Minum Obat Pasien Lansia Dengan Terapi Oral Antidiabetes Dan Antihipertensi Metode Pill Count Ninik Mas Ulfa
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.352

Abstract

Medication adherance is a problem by the elderly. This study was conducted to evaluate adherence to taking oral antidiabetic drugs and oral antihypertensive drugs in elderly patients using the pill count method at one of the health centers in South Surabaya. The pill count method in this study was chosen because it can provide an overview of the profile of medication adherence for elderly patients who receive oral antidiabetic and oral antihypertensive drugs by calculating the remaining medication based on the dosage and the rules for taking the drug when the patient returns to control. This study was observational with prospective observations and data were analyzed descriptively. The number of samples in this study were 30 elderly patients. The results obtained were that the most oral antidiabates drugs were given the Sulfonylurea combination Biguanida drug class, namely Glibenclamide 5 mg combination Metformin 500 mg (66.7%), while for oral antidiabates therapy the single administration was the calcium channel blocker is Amlodipine 5 mg (76 %). In the results of medication adherence, it was found that 63.3% of patients adherance to taking oral antidiabetic drugs and not adherance is 36,7%. While 70.0% of patients were adherence to taking oral antihypertension drugs and not adherance is 30%. Patients who consumed 2 drug combinations were 53.3% more adherent than those who consumed 3 to 5 drug combinations of 46.7%.
Antioxidan Activity from Methanol Extract of Kratom Leaves (Mitragyna speciosa) Maseration Result Using The DPPH Method: Aktivitas Antioksidan Ekstrak Metanol Daun Kratom (Mitragyna speciosa) Hasil Maserasi Menggunakan Metode DPPH Andhika Dwi Aristyawan; Anggi Ayu Windari; Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.357

Abstract

Antioxidants are compounds that can prevent the formation of free radicals. Kratom is a typical plant from South Putussibau area, in West Kalimantan. The kratom plant contains alkaloids, triterpenoid-steroids, saponins, tannins and flavonoids. The main component of kratom leaves is an indole alkaloid that is efficacious as an antioxidant. The goal is to determine the antioxidant activity of kratom leaf extract (Mitragyna speciosa). The method used is the measurement of the reduced amount of DPPH from an antioxidant compound UV-Vis spectrophotometrically at a wavelength of 517nm using Vitamin C as a comparison. The extraction method used is maceration. The test was sampled 10 mg of kratom leaf extract (Mitragyna speciosa) with 10 ppm, 20 ppm, 30 ppm, 40 ppm, and 50ppm concentrations, then repeated 3 times. The results of the antioxidant activity of kratom leaves (Mitragyna speciosa) were expressed with IC50 values of 44,169 ± 0.5313 with an RSD value of 1.202%. Then it can be concluded that kratom leaf methanol extract (Mitragyna speciosa) has a very strong antioxidant activity with an IC50 value of 44,169 ± 0.5313 with an RSD value of 1.202%.
Physical and Chemical Study of Manalagi Apple Peel (Malus sylvestris) Kombucha on 7 Days Fermentation Time: Studi Fisik dan Kimia Kombucha Kulit Apel Manalagi (Malus sylvestris) dengan Waktu Fermentasi 7 hari Kinanti Ayu Puji Lestari; Floreta Fiska Yuliarni; Widya Dara Anindya
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.358

Abstract

KKombucha was one of the millennial beverage with a lot of benefits. Kombucha was a subject of research that was always interesting to discuss because of the various indicators of its subject. One of them was the Manalagi apple peel kombucha which was very rare on reviewed. This research focuses on the physical and chemical aspects of Manalagi apple peel kombucha. Manalagi apple peel kombucha is made in three different formulations namely FKA, FKB and FKC and fermented for 7 days. Each kombucha then went through a physical test which included thickness, wet weight, dry weight, moisture content and chemical evaluation as seen from changes in the pH of the kombucha using universal pH paper. The results showed that the physical evaluation of Manalagi apple peel kombucha with the FKC formulation had the highest thickness, wet weight, dry weight and yield, while the FKB formulation had the highest water content. While the pH of each formulation of kombucha apple skin Manalagi decreased and there were differences in values on the surface, middle and bottom of each formulation from pH 5 to pH 4 and 3.
Effect of Orange Peel Waste Adsorbent Mass on Lead (Pb) Metal Biosorption in Artificial Liquid Waste: Pengaruh Massa Adsorben Limbah Kulit Jeruk terhadap Biosorpsi Logam Timbal (Pb) dalam Limbah Cair Buatan Djamilah Arifiyana; Ratih Kusuma Wardani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.359

Abstract

In this study, orange peel was used as an adsorbent to determine the adsorption properties of lead metal. The orange peel used in this study came from waste generated by a fruit juice shop. The mass variation of the adsorbent was studied to determine its effect on the adsorption of lead metal. Mass variations used include 0.25-1.5 gram. The operating conditions used in this study included the preparation of 50 mL of 50 mg/L Lead solution, the pH of the mixture was adjusted to pH 4, the stirring speed was 100 rpm for 180 minutes and at 25℃. The results showed that the highest % adsorption was achieved at an adsorbent mass of 0.75 grams, which was 92.9% (2.5 mg/g), while the highest adsorption capacity was obtained at the use of an adsorbent mass of 0.25 grams (7.27 mg/g). Both the decrease in % adsorption and adsorption capacity that occurred in the use of the mass variation of the adsorbent were mostly caused by the aggregation process.
The Relationship between Medication Adherence and The Quality of Life of Tuberculosis Patients at the Health Center in Lamongan Regency: Hubungan Kepatuhan Minum Obat dengan Kualitas Hidup Pasien Tuberkulosis di Puskesmas Kabupaten Lamongan Dewi Indah Ayu Ardiyanti Fistalia; Devi Ristian Octavia; Sri Bintang Sahara M.K.N
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.363

Abstract

Tuberculosis (TBC) is one of the deadliest infectious diseases in the world. Adherence to TB therapy is critical in achieving successful treatment outcomes, controlling transmission, and preventing the development of TB drug resistance. Compliance with taking antituberculosis drugs is closely related to the patient's quality of life, but the number of cases of recurrence should be a source of thought whether the patient's adherence to taking the drug will have a significant impact on the patient's quality of life. This study aims to analyze the relationship between medication adherence and the quality of life of tuberculosis patients in Lamongan. The research design is a descriptive collaborative with a cross-sectional approach. Sampling by purposive sampling with a total sample of 60 respondents. Compliance with taking medication was obtained through the MARS-5 questionnaire and quality of life using the SGRQ questionnaire. The data obtained were then analyzed with the Chi-Square test. The results showed that 70.0% of respondents had high medication adherence, and 60.0% experienced a good quality of life category. The results of the Chi-Square test showed that there was a relationship between medication adherence and the quality of life of tuberculosis patients at the Lamongan District Health Center. The more obedient the patient is in taking the drug, the better the quality of life.

Page 13 of 14 | Total Record : 135

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