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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 253 Documents
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PENGUJIAN AKTIVITAS DAYA ANALGETIK EKSTRAK n-HEKSANA, ETIL ASETAT DAN ETANOL DAUN KANGKUNG PAGAR (Ipomoea carnea Jacq) Qurotulaeni, Engkun; Setyahadi, Siswa; Simajuntak, Partomoan
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1135

Abstract

Pain is unpleasant symptom and feeling in of the organs, caused by tissue damage such as inflammatory conditions, infection, or related to muscle spasms. Previous research, is known that leaves Ipomoea carnea can inhibit prostaglandins which are pain mediators. This research aims to determine the activity of analgesic leaves Ipomoea carnea. The leaves Ipomoea carnea macerated with 96% ethanol and partitioned with n-hexane and ethyl acetate. The three extracts tested on male white mice (Mus musculus) with a weight of 25-30 g. The research method used is the writhing test. The test animals were divided into 11 groups. Group 1 (Na CMC 0.5% positive control), Group 2 (Paracetamol as a comparison), Group 3-5 (Ipomoea carnea ethanol extract doses of 50 mg, 100 mg and 200 mg/Kg BW), Groups 6-8 (ethyl acetate extract of Ipomoea carnea leaves doses of 50 mg, 100 mg and 200 mg/kb BW) and groups 9-11 (n-hexane extract of Ipomoea carnea leaves dose 50 mg, 100 mg and 200 mg/kb BW). The pain inducer 0.5% acetic acid intraperitoneally. Observations were carried out for 1 hour every 5 minutes and the percentage of analgesic power was calculated. Ethanol extract provides effect than ethyl acetate and n-hexane extracts, dose of 50 mg/Kg BW 62.4%; 100 mg/Kg BW 70.42% and 200 mg/Kg BW 69.15%. The significant value of the Mann-Whitney test is 0.008 from the test sample against the positive control so it can be concluded that there is analgesic activity from the ethanol extract of Ipomoea carnea leaves.
REVIEW : ANALISIS PENGGUNAAN ANTIBIOTIK PROFILAKSIS PADA PASIEN PASCA BEDAH SESAR DI BEBERAPA RUMAH SAKIT DI INDONESIA Shalsabina, Vina; Hermanto, Faizal
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1136

Abstract

Caesarean section shows an increase from year to year. The number of cesarean births every year also has an impact on the increase in post-surgical complications. The purpose of this article is to examine the effectiveness of the use of prophylactic antibiotics in patients after caesarean section. A systematic review of articles and publications published in the year 2014 to 2024 used 9 articles and used the search keyword, which is prophylactic antibiotics after caesarean section. The description of the use of prophylactic antibiotics that was seen includes the type, time of administration, method of administration, duration of treatment and dose of antibiotics, compared to the main guidelines of basic treatment of pharmacology and therapy according to Goodman & Gilman. It can be concluded that the most widely used antibiotics are the third generation cephalosporins, namely ceftriaxone and cefotaxime. These antibiotics are broad-spectrum, and target gram positive and gram negative bacteria, and are commonly used as prophylactic antibiotics in caesarean section patients.
PENGARUH METODE FERMENTASI TERHADAP PENINGKATAN KANDUNGAN KIMIA DAN AKTIVITAS FARMAKOLOGI PADA BEBERAPA TANAMAN: Artikel Review Puspitasari, Melisa; Riyanti, Soraya
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1138

Abstract

Fermentation is a process that involves the chemical transformation or breakdown of complex organic substances or other food components into simpler compounds through the action of natural enzymes and fermenting microorganisms. The purpose of this literature review is to explore the impact of fermentation methods on the enhancement of phytochemical content and pharmacological activity in various plants. Journal searches were conducted on Google Scholar, PubMed, and ScienceDirect. The results revealed that fermentation methods can increase the chemical content and pharmacological activity of a plant. Microorganisms that are frequently used in the fermentation process, such as Bacillus subtilis and actobacillus brevis, can increase the total phenol content and enhance antioxidant activity. Factors influencing the fermentation process in improving the chemical content and pharmacological activity of a plant include treatment methods, duration of fermentation (incubation), microorganisms used, and the concentration of inoculum used.
POTENSI TANAMAN HERBAL SEBAGAI STIMULAN SISTEM SARAF PUSAT: LITERATURE REVIEW ARTICLE Suri, Nurma; Oktoba, Zulpakor; Yulianti, Mega Intan
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.960

Abstract

Energy drinks are consumed as supplement to increase energy and reduce fatigue. Herbal medicine has proven reduce fatigue in the body. This literature review aims to determine the types of herbal medicine that have properties as stimulants. This study used descriptive methode using the Population-Intervention-Controling-Outcome Framework. A literature search on studies published in the period 2012-2022 on the Google Scholar and Pub-Med using the keywords: stimulant, central nervous system, tonic, and herbal. Articles that cannot be accessed in full and herbal medicine that are not original from Indonesia will be excluded as samples. There were 1937 articles obtained based on the keywords used, a total of 91 articles met the inclusion criteria and 60 articles were excluded. Based on 30 articles reviewed, there are 31 types of herbal medicines that can increase stimulants with the most family is zingiberaceae and piperaceae. The combination of plant has a better stimulant effect than using the single plants. In vivo test method with the swimming endurance test as the most widely used. Flavonoid, alkaloid and terpenoid compounds are most likely to be effective as stimulants which have the same mechanism with caffeine through inhibition of Adenosine A1 receptors. This study shows there are 31 herbal medicine that have the potential to increase stimulants. Secondary metabolites which stimulant effects are flavonoids, alkaloids and terpenoids
Literature Review Artikel: MANFAAT MINYAK ATSIRI PADA BERBAGAI BAGIAN TUMBUHAN Fikayuniar, Lia; Audiny, Cindy; Ibrahim, Asshasyfa; Hidayat, Dhivira Azfari Pratama; Julianti, Dine; Ramadhani, Putri; Zaenudin, Rian Ahmad
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1078

Abstract

Essential oils are aromatic compounds naturally found in various parts and types of plants. This study aims to evaluate the benefits of essential oils extracted from different plant parts using various methods. The research was conducted through a literature review by analyzing data from multiple journal articles. The review revealed that essential oils extracted from different plant parts exhibit diverse compositions and benefits. Essential oil from the leaves of zodia (Evodia suaveolens), obtained through distillation, yielded 0.6471%, with 4(5H)-Benzofuranone identified as the main component through GC-MS analysis. Meanwhile, hydro-steam distillation of kaffir lime (Citrus hystrix) peel produced essential oil containing 25 components, primarily demonstrating antioxidant activity. Steam distillation of langsat (Lansium domesticum) fruit peel yielded essential oil with a 0.18% yield, comprising monoterpenoid and sesquiterpenoid compounds as its major components. This study highlights the potential of essential oils from various plant parts as sources of bioactive compounds with diverse benefits.
ANALISIS KANDUNGAN MINYAK ATSIRI EKSTRAK RIMPANG KENCUR (Kaemprefia galangan l.,) DENGAN MENGGUNAKAN METODE KLT Fikayuniar, Lia; Hanita, Icha; Aulia, M Azriel; Syarifah, Nadia Siti; Khairani, Risda Aulia; Pijriah, Sulis Salsa; Agrestia, Tasya
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1096

Abstract

Simplicia is a natural ingredient that is dried and used as medicine and has not undergone any processing involving any chemical processes. Simplicia is divided into three types, namely animal, pelican and vegetable simplicia. Drying simplicia must be done under appropriate conditions to avoid loss of active substance content. This research uses galangal (Kaempferia galanga) as the simplicia used. Galangal is used in various traditional treatments, such as rheumatism, asthma, stomach ulcers, malnutrition, diarrhea, coughs, fever, as a concoction to increase stamina and digestive tract disorders. The chemical ingredients in kencur simplicia, such as essential oils and curcuminoids, have good properties for the body. This research uses a thin layer chromatography method to identify the essential oil content in galangal rhizomes.
PENGGUNAAN METFORMIN PADA PASIEN POLYCYSTIC OVARY SYNDROME (PCOS) Salasanti, Citra Dewi; Agustini, Dewi Darwati; Ramdani, Amalia Dewi
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1139

Abstract

Infertility in women of reproductive age with Polycystic Ovary Syndrome (PCOS) in Indonesia is increasing. Insulin resistance occurs in some PCOS patients, so the use of insulin sensitivity-enhancing drugs such as metformin is recommended. This study was conducted to determine the use of metformin in PCOS patients at independent doctor's practices in Bandung City. The study was conducted as an observational descriptive study with data collected retrospectively using purposive sampling. Data were taken from patient medical records and interviews with the doctor in charge. The sample in this study consisted of patients who met the inclusion and exclusion criteria. The data obtained were then summarized and displayed in table form. The results showed that the majority of PCOS patients were 26-30 years old with marriages that had lasted for 3 years. Ovulation and pregnancy in PCOS patients who used oral metformin treatment occurred in 15% of cases. The metformin used had a dose of 500-850 mg, which was given twice a day for 4-9 months.
REVIEW: POTENSI KETIDAKTEPATAN PENGGUNAAN OBAT PADA PASIEN GERIATRI DI BEBERAPA RUMAH SAKIT DI INDONESIA Pratama, Gumilar; Wahyuningsih, Sri; Hermanto, Faizal
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1144

Abstract

Inappropriate medication use in geriatric patients, particularly related to Potentially Inappropriate Medications (PIMs), is a major concern in elderly healthcare management. This study aims to explore the prevalence and types of PIMs found in several hospitals in Indonesia. A narrative review method was employed, with journal data searched using the query: “Potentially Inappropriate Medications” OR “Potentially Inappropriate Prescribing”, “identification of PIMs”, “evaluation of PIMs”, “Beers Criteria” OR “Beers Criteria”, “STOPP Criteria”, “PRISCUS PIMs” in Google Scholar, Garuda, and PubMed databases. Articles selected met the inclusion criteria, including national and international journals published within the last 10 years and available in full text. The results showed that the prevalence of PIMs in a hospital in Semarang was 487 medication items, with sodium diclofenac being the most frequently found medication (12.96%). At RSUD Arjawinangun, the occurrence of PIMs reached 56.82%, with furosemide being the most dominant medication (22.73%). A study in Jakarta showed that prescription review by pharmacists successfully reduced the occurrence of PIMs to 18.89%. Inappropriate medication use in geriatric patients remains high, and it is essential to improve patient education and enhance collaboration between pharmacists and doctors to reduce PIMs risks. The use of Beers, STOPP, and PRISCUS criteria can help assess and prevent PIMs in geriatric patients.
REVIEW: GAMBARAN TINGKAT KESALAHAN PENGOBATAN PADA BEBERAPA RUMAH SAKIT DI INDONESIA Adiningsih, Martha; Hermanto, Faizal
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1148

Abstract

A medication error is any preventable event that can cause or result in inappropriate medication use or harm to the patient. Medication errors can occur in several phases or stages, namely prescribing errors, errors in translating prescriptions, errors in preparing and dispensing drugs, and errors in administering drugs. The aim of this article is to review and identify various levels of medication errors in several hospitals in Indonesia which are obtained from the percentage of medication errors. Based on a literature review conducted on 10 journals, article searches were carried out using two databases, namely Google Schollar and PubMed, the results obtained were that the most common medication errors occurring in several hospitals in Indonesia were the prescribing phase with a total distribution of levels of 7, then dispensing with a count of 2 and copying with a count of 1. Although medication errors remain a major challenge, with appropriate improvement efforts, patient safety in hospitals can be significantly improved)
FORMULASI OBAT KUMUR EKSTRAK KULIT PISANG KEPOK KUNING (Musa paradisiaca L.) SEBAGAI ANTIBAKTERI Julyanti, Ai Rian; Genatrika, Erza; Annissya, Widia Primi; Setyaningrum, Nenden; Ferliati, Rosi Eka; Pratama, Okta Nurandi
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1151

Abstract

Yellow kepok banana peel (Musa paradisiaca L.) contains alkaloid, flavonoid, and tannin compounds that are known to have antibacterial activity. This study was conducted to determine the antibacterial activity of mouthwash from yellow kepok banana peel in inhibiting the growth of Streptococcus mutans. The yellow kepok banana peel used the maceration method with 96% ethanol solvent, then mouthwash preparation formulations with the extract concentrations of 2%, 4%, and 8%. The antibacterial activity of the mouthwash preparation was tested against Streptococcus mutans using the disc diffusion method. The results showed that the mouthwash formula of yellow kepok banana peel extract had inhibitory power on Streptococcus mutans bacteria with an inhibition zone of 9.52 mm in formula I, formula II 10.67 mm, and formula III 12.36 mm. Formulas I and II are classified as moderate antibacterial activity categories, while formula III is classified as having strong antibacterial activity. The results showed a p <0.05, meaning each test group has a significant difference. Formula III is the best formula because the resulting preparation is homogeneous, PH is 5, viscosity is 2.4 cP, the preparation is stable and formula III has the best antibacterial activity.

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