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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 204 Documents
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The STUDI INTERAKSI OBAT ANTIHIPERLIPIDEMIA PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK Amal, Andi Nurzakiah; Agustini, Dewi Darwati; Amal, Surya
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1209

Abstract

Hyperlipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol levels in the blood, which is a risk factor for various cardiovascular diseases. Treatment of hyperlipidemia is often combined with other drugs, increasing the potential for drug interactions. This study aims to identify the severity of antihyperlipidemia drug interactions in outpatients in private hospitals in Cikampek during the period of June to December 2023. The research uses an analytical survey design with a retrospective approach. Data were obtained from 251 patient prescriptions that met the inclusion criteria and were analyzed univariably using the Stockley Drug Interaction and drugs.com application. The results showed that 67.65% of prescriptions had potential drug interactions, while 32.35% did not. Patients aged 50–59 years were the largest group (42.6%) receiving antihyperlipidemia, with simvastatin being the most frequently prescribed drug and causing drug interactions most often (51.11%). Of the 135 cases of drug interactions identified, moderate severity accounted for 57.03%, while major severity reached 46.97%. No cases with minor severity were found. This study highlights the importance of monitoring drug interactions to prevent more serious risks in hyperlipidemia patients.
POTENSI AKTIVITAS ANTIOKSIDAN SEDIAAN LIP BALM LIOFILISAT KULIT BUAH TERUNG UNGU PANJANG (Solanum melongena L.) DALAM MENANGKAL RADIKAL BEBAS Karim, Suhrah Febrina; Nadjamuddin, Mirfaidah; Ramadhani, Aulia Rezky
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1214

Abstract

Perubahan iklim mengakibatkan terjadinya peningkatan radiasi sinar ultraviolet (UV) yang menyebabkan kerusakan kulit akibat radikal bebas. Radikal bebas memberikan efek berupa pigmentasi pada Kulit, terutama pada kulit bibir sehingga warna bibir menjadi hitam serta pecah-pecah. Pigmentasi kulit bibir ini dapat dicegah dengan penggunaan tabir surya dalam bentuk lip balm. Lip balm merupakan salah satu produk lip care yang digunakan untuk mencegah serta mengatasi bibir kering dan pecah-pecah yang disebabkan oleh fungsi dari perlindungan pada bibir yang buruk. Kulit Terung Ungu panjang merupakan salah satu antioksidan alami yang mempunyai kandungan nasunin yang termasuk senyawa golongan flavonoid. Nasunin memiliki fungsi sebagai antioksidan alami yang 150 kali lebih kuat dari flavonoid. Penelitian ini bertujuan untuk mengetahui potensi aktivitas Antioksidan liofilisat kulit buah terung ungu panjang dalam menghambat radikal bebas dan memenuhi uji stabilitas fisik maupun kimia sediaan lip balm. Liofilisat kulit buah terung ungu panjang diformulasikan dengan variasi konsentrasi 2%, 4 % dan 6 % dilanjutkan dengan evaluasi sediaan secara fisik maupun kimia yang meliputi Uji Organoleptik, pH, Titik Lebur, Homogenitas, Daya Sebar dan Cycling Test. Setelah itu dilakukan Uji Potensi Aktivitas Antioksidan dari Liofilisat kulit buah terung ungu panjang melalui kemampuannya dalam mengangkal Radikal bebas dengan metode DPPH. Hasil penelitian yang didapatkan adalah Ekstrak kulit Buah Terung ungu panjang dapat dibuat dalam sediaan lip balm stabil secara fisik dan Kimia serta Sediaan lip balm ekstrak kulit Buah Terung ungu dapat memberikan aktivitas antioksidan paling efektif dengan metode DPPH pada konsentrasi ekstrak 6% dengan nilai IC50 sebesar 41,683 ppm dengan kategori sangat kuat
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN BODY SCRUB CREAM FRAKSI ETANOL DAUN JAMBU AIR (Syzygium aqueum) DENGAN METODE DPPH Mangago, Adventiani; Karim, Suhrah Febrina; Sirajuddin, Mutmainnah
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1216

Abstract

Antioksidan adalah substansi yang diperlukan tubuh untuk menetralisir radikal bebas dan mencegah kerusakan sel normal, protein, dan lemak oleh radikal bebas. Daun jambu air (Syzygium aqueum) merupakan salah satu tanaman yang mempunyai aktivitas antioksidan karena memiliki kandungan flavonoid. Penelitian ini bertujuan untuk mengetahui formulasi body scrub cream fraksi etanol daun jambu air (Syzygium aqueum) sebagai antioksidan dan untuk mengetahui aktivitas antioksidan body scrub cream fraksi etanol daun jambu air (Syzygium aqueum). Metode penelitian ini secara eksperimental, dimulai dengan daun jambu air (Syzygium aqueum) diekstraksi menggunakan pelarut etanol 96% dengan metode maserasi, dilanjutkan dengan fraksinasi menggunakan pelarut etanol, n-heksan dan etil asetat lalu dibuat sediaan body scrub cream dengan konsentrasi ekstrak formula I, II, III berturut-turut 1%, 2% dan 3%. Pada penelitian ini uji stabilitas fisik body scrub cream meliputi uji organoleptis diperoleh hasil beraroma jambu dan tekstur semi padat, uji homogenitas diperoleh hasil homogen, uji pH diperoleh hasil sesuai dengan standar pH yaitu 4,5-7, uji daya sebar diperoleh hasil sesuai dengan persyaratan yaitu 5-7 cm dan cycling test yang dilakukan secara 6 siklus 12 hari. Berdasarkan hasil pengukuran aktivitas antioksidan maka didapatkan hasil nilai IC50 pada formula I, formula II, formula III, vitamin C secara berturut-turut yaitu 46,7602 µg/mL, 21,1618 µg/mL, 6,1973 µg/mL, 4,1727 µg/mL. Hasil penelitian dapat disimpulkan bahwa fraksi etanol daun jambu air (Syzygium aqueum) dapat diformulasikan sebagai sediaan body scrub cream yang stabil secara fisika dan kimia serta memiliki aktivitas antioksidan paling efektif pada formula III dengan nilai IC50 sebesar 6,1973µg/mL.
FORMULASI HAND AND BODY LOTION BERBASIS EKSTRAK JAMUR LINGZHI (GANODERMA LUCIDUM) SEBAGAI SEDIAAN FOTOPROTEKTIF Hidayat, Fahmi; Rosanti, Aulia Dewi; Sa’diyah, Asvikatu
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1222

Abstract

Ultraviolet (UV) radiation can induce various health problems, particularly on the skin as the body's protective organ. This study aimed to enhance skin protection against free radical damage by utilizing the antioxidant potential of lingzhi mushroom (Ganoderma lucidum) extract. Through the formulation of hand and body lotion, various concentrations of lingzhi mushroom extract (0%, 0.25%, 0.50%, and 0.75%) were incorporated. In vitro testing was conducted to measure the Sun Protection Factor (SPF) value as an indicator of the product's ability to protect the skin from ultraviolet radiation. The results showed an increase in SPF value with increasing concentrations of lingzhi mushroom extract. The formulation with 0.75% lingzhi mushroom extract yielded the highest SPF value of 4.4. These findings indicate that lingzhi mushroom extract has the potential to be an active ingredient in skincare products, not only providing hydration but also offering optimal protection against free radical damage and UV radiation.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SHEET MASK BIOSELULOSA MENGANDUNG MINYAK ATSIRI BUNGA KENANGA (Cananga odorata) Farhamzah, Farhamzah; Yuniarsih, Nia; Mursal, Iin Lidia Putama; Anggraeni, Fera
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1224

Abstract

The use of antioxidants can be administered orally or topically. Antioxidants are known to be better if given topically in topical dosage forms such as sheet masks, so it is necessary to make masks from natural ingredients that have high antioxidant activity such as Cananga odorata because they contain benzyl benzoate which has anti-free radical properties. This study aims to prove the preparation of biocellulose essence sheet mask containing Cananga odorata has antioxidant activity with concentrations of F1, F2 and F3. Antioxidant testing using the DPPH method. Evaluation of biocellulose sheet mask preparations includes the mask sheet weight test and the mask sheet thickness test. Evaluation of essence preparations includes organoleptic, pH, viscosity, irritation, and hedonic tests. The positive phytochemical screening results contained alkaloids, flavonoids, tannins, and saponins. The results of testing the antioxidant activity of Cananga odorata obtained an IC50 value of 4.027 ppm. Evaluation of essence preparations obtained homogeneous, pH (5.01-6.43), viscosity (400-600 cPs), no irritation occurred in volunteers. Cananga odorata has antioxidant activity in the weak to moderate category, IC50 results for each formula F1 184.212 ppm, F2 150.175 ppm, and F3 72.448 ppm. Based on these results it can be concluded that Cananga odorata can be formulated as an essence with strong antioxidant potential with an IC50 value of 4.027 ppm.
EFEKTIVITAS BIOETANOL DARI LIMBAH BIJI MANGGA SEBAGAI HAND SANITIZER TERHADAP BAKTERI Staphylococcus aureus Gunawan, Leo Van; Ghozali, Muhamad; Supriatun, Evi; Simanjuntak, Naomi Margaretha; Zainuddin, Zainuddin
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1225

Abstract

Indramayu is a mango producing area in West Java Province. There are many varieties of mango types cultivated in Indramayu, including gedong gincu, gajah, harum manis, cengkir, golek, lali jiwa, agrimania and manalagi. In Indramayu, mangoes are sold as fruit and dodol. Mango seeds are simply thrown away or used as seeds. Mango seeds contain 81.3% starch per 100 grams. The starch in mango seeds can be made into flour as a raw material for making bioethanol. Bioethanol with a content of 70% can be used as an antiseptic to kill bacteria, viruses and fungi so that it can be used as a basic ingredient for making hand sanitizer. The method for making hand sanitizer from mango seed bioethanol goes through the Liquification Process, Saccharification Process, Fermentation Process, Distillation Process, Testing Bioethanol Content, Making Hand Sanitizer and Testing the Effectiveness of Hand Sanitizer on Staphylococcus aureus Bacteria using the disk diffusion method. The results of testing the bioethanol content after the multistage distillation process is 74%. Then bioethanol is mixed with Glycerin 99,7%, H2O2 3% and Sterile Aquadest to make hand sanitizer. The results of testing the effectiveness of hand sanitizers on Staphylococcus aureus bacteria showed that the diameter of the inhibition zone was 6 mm. Based on the Davis and Stout criteria, the effectiveness of hand sanitizer from mango seed waste bioethanol in inhibiting the growth of Staphylococcus aureus bacteria is medium.
A Fikayuniar, Lia; Yuniarsih, Nia; Abriyani, Ermi; Ayesha, Adinda
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1226

Abstract

Temulawak (Curcuma xanthorrhiza Roxb) is a rhizome plant that has long been used in traditional medicine in Indonesia. The active compounds in temulawak function as antioxidants, which are essential in combating free radicals and preventing cell damage. This study aims to compare the antioxidant activity of ethanol extracts of temulawak obtained through maceration and ultrasonic extraction methods. The research method applied is pre-experimental, with testing conducted in triplicate to ensure result validity. Antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results show that the ethanol extract of temulawak obtained via maceration method has an IC50 value of 33.379 µg/ml. In contrast, the ultrasonic extraction method showed a lower IC50 value of 9.454 µg/ml, indicating stronger antioxidant activity. Temulawak, as an antioxidant source, has significant potential in the development of herbal products. The comparison of the two extraction methods shows that the ultrasonic method is more effective in enhancing antioxidant activity. This study emphasizes that the extraction method influences the antioxidant activity of temulawak. These results could serve as an important reference for the development of herbal-based products in the future.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN CLEANSING BALM EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) Farhamzah, Farhamzah; Warsito, Ainun Mar’atus Putri; Yuniarsih, Nia
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1227

Abstract

Skin is the outermost layer of the human body that protects the organs inside and skin is the layer that adapts most to the external environment, weather or climate. Facial cleansing is the first step to remove dead skin cells, dirt, sebum and cosmetic residue, which causes acne, redness, irritation and can be made worse by the presence of free radicals. Compounds that are able to ward off free radicals are antioxidants, so this research will make Cleansing Balm with butterfly pea flower extract (Clitoria ternatea L.) as an antioxidant and find out the best formula and storage stability from experimental research by testing antioxidant activity using the DPPH method. The Cleansing Balm preparation was made with three additional concentrations of butterfly pea flower extract (Clitoria ternatea L.), namely F1 (0.1%), F2 (0.2%), and F3 (0.3%). In this research, the results showed that telang flower extract contains alkaloids, flavonoids, quinones, tannins and saponins. The antioxidant activity of Cleansing Balm of butterfly pea flower (Clitoria ternatea L.) shows an IC50 F1 of 95,732 ppm, F2 of 51,368 ppm, F3 of 10,213 ppm. From the research, it can be concluded that Cleansing Balm Formula 3 which contains 0.3% butterfly pea flower extract (Clitoria ternatea L.) is the most effective formula for antioxidant activity
GAMBARAN PENGGUNAAN OBAT TRADISIONAL DI DESA CIKERIS PURWAKARTA Lina Aliyani, Lina Aliyani Mardiana; Fatwa, Dini Noer; Ramadhina, Aisyah Salsabila
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1228

Abstract

The use of traditional medicine as an alternative treatment is widely practiced in various regions in Indonesia, including Cikeris Village, Purwakarta. This study aims to determine the description of the use of traditional medicine in Cikeris Village, including the characteristics of respondents, types of traditional medicine used, and the level of community knowledge about traditional medicine. The study used a quantitative descriptive method by distributing questionnaires to 97 respondents. The results showed that 52.6% of respondents were male, the majority were aged 25-44 years (56.7%), had a high school education (67.0%), and worked as farmers (28.9%). A total of 64.9% of respondents used traditional medicine based on information passed down from their parents. The most frequently used traditional medicines were ginger (23.7%), turmeric (20.6%), and beras kencur (10.3%). Packaged products such as Tolak Angin (4.1%) and Kiranti (2.1%) were also found to be used. The level of community knowledge about traditional medicine is quite good, with 82.43% of respondents giving correct answers to the eight statements asked. This study shows that the people of Cikeris Village have good habits and knowledge related to the use of traditional medicine as part of daily treatment.
PENGEMBANGAN SEDIAAN BODY LOTION EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) Sugiharta, Sudrajat; Septiani, Putri; Fikayuniar, Lia
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1231

Abstract

An alternative to synthetic ingredients with a focus on reducing the sticky effect upon application. Given the belief in natural ingredients being safer than synthetic chemicals, this body lotion was designed to utilise the antioxidant potential of telang flower. This study aims to develop a body lotion based on telang flower extract (Clitoria ternatea L.). This study used a quasi-experimental laboratory method with a completely randomised design (CRD) with a 3 x 2 factorial pattern, testing variations in the concentration of stearic acid (2.5%, 5.0%, 7.5%) and liquid paraffin (5.0%, 15%) on the quality of the Body lotion formulation. Organoleptic test results showed that all Body lotion formulas had a characteristic aroma and colour of bay flower, with varying colours depending on the concentration of ingredients. Homogeneity test showed that all formulas were homogeneous without coarse particles. The pH, viscosity, adhesion, and spreadability parameters of the Body lotion met the requirements of good cosmetics, with pH values between 6.68-7.47, viscosity between 2033-2459 cps, adhesion between 22-43 seconds, and spreadability between 5-6.9 cm. The acceptability test showed that all panelists liked the colour, aroma, and texture of the body lotion, and did not feel the sticky effect after application. This study concludes that variations in the concentration of stearic acid and liquid paraffin affect the quality of Body lotion, with the optimal formulation being able to reduce the sticky effect and increase the comfort of use on the skin.

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