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All Journal Jurnal Mandala Pharmacon Indonesia Majalah Farmasetika Journal Borneo Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Nusantara (JPN) Lansau: Jurnal Ilmu Kefarmasian Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan
Astrid Indalifiany
Departemen Farmasi, Fakultas Farmasi, Universitas Halu Oleo, Sulawesi Tenggara, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulasi dan Karakterisasi Ekstrak Etanol Wualae (Etlingera elatior) dalam Sistem Penghantaran Vesikuler Fitofosfolipid Astrid Indalifiany; Sahidin Sahidin; Wahyuni Wahyuni; Mentarry Bafadal; Agung Wibawa Mahatva Yodha; Rina Andryani; La Ode Muhammad Fitrawan; Dian Munasari
Jurnal Mandala Pharmacon Indonesia Vol. 8 No. 1 (2022): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v8i1.152

Abstract

Etlingera elatior (Wualae) termasuk dalam tumbuhan famili zingiberaceae yang memiliki aktivitas antiinflamasi. Namun, bioavailabilitas dan permeabilitas zat aktif yang rendah sehingga diperlukan suatu sistem penghantaran dalam komplek lipid-bahan alam. Sistem yang dikenal dengan fitofosfolipid ini merupakan penghantaran fitokonstituen dalam matriks fosfolipid yang dapat meningkatkan permeabilitas dan bioavailabilitas zat aktif melalui karakteristik ampifilik dan aksi emulsifikasi oleh fosfolipid. Penelitian ini bertujuan untuk melakukan formulasi dan karakterisasi sistem vesikel sehingga diperoleh sistem yang optimum antara ekstrak etanol buah wualae dan fosfatidilkolin yang memiliki karakteristik vesikel terbaik. Preparasi dilakukan    menggunakan    teknik    hidrasi    lapis   tipis dengan adanya variasi komposisi ekstrak dan fosfatidilkolin, yakni 0,5:0,5 (Formula 1); 0,5:1 (Formula 2); 1:0,5 (Formula 3); 1:1 (Formula 4); 1:2 (Formula 5); dan 2:1 (Formula 6). Hasil yang diperoleh adalah komposisi formula optimum antara ekstrak dan fosfatidilkolin yaitu pada F4 dengan komposisi 1:1 dengan karakterisasi meliputi pengamatan morfologi berbentuk bulat (sferis) menggunakan mikroskop optic, efisiensi penjerapan vesikel diperoleh 99,20%, ukuran partikel 898,2 nm dan indeks polidispersitas 0,573 dengan kategori vesikel jenis LUV (Large Unilamellar Vesicle) menggunakan Particel Size Analyzer.
Pengembangan dan pengujian sifat fisik sediaan spray gel darı ekstrak etanol batang Etlıngera rubroloba menggunakan basıs gel Na-CMC WOS Zubaydah WOS Zubaydah; Rini Novianti; Astrid Indalifiany
Journal Borneo Vol. 2 No. 2 (2022): Volume 2 Issue 2 tahun 2022
Publisher : Politeknik Kaltara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.266 KB) | DOI: 10.57174/jborn.v2i2.27

Abstract

Tumbuhan Etlingera rubroloba merupakan tanaman yang memiliki aktivitas antioksidan karena mengandung senyawa polifenol. Manfaat batang Etlingera rubroloba sebagai antioksidan dapat formulasikan dalam bentuk sediaan topikal yaitu spray gel. Penggunaan Na-CMC sebagai basis gel memiliki keuntungan dengan menghasilkan basis gel yang jernih. Penelitian ini bertujuan untuk mengetahui formulasi, evaluasi fisik dan stabilitas fisik dari sediaan spray gel ekstrak etanol batang Etlingera rubroloba. Ekstrak yang diperoleh kemudian diformulasikan menjadi spray gel dengan variasi konsentrasi Na-CMC F1 (0,1%), F2 (0,2%), F3 (0,3%), F4 (0,4%) dan F5 (0,5%). Evaluasi fisik meliputi uji organoleptik, uji pH, uji viskositas, uji pola penyemprotan, uji waktu kering, uji homogenitas dan uji hedonik sedangkan stabilitas fisik meliputi pengujian sentrifugasi dan cycling test. Hasil evaluasi fisik didapatkan setiap formula masuk dalam rentang syarat sediaan spray gel yang baik. Hasil pengujian stabilitas fisik setelah cycling test menunjukkan adanya penurunan viskositas pada setiap formula dan tidak terjadi perubahan dari segi organoleptik maupun pH dari sediaan spray gel setelah cycling test. Hasil uji hedonik didapatkan formula 3 dan 4 lebih disukai. Berdasarkan penelitian ini didapatkan bahwa F3 dan F4 merupakan formula yang optimum berdasarkan evaluasi fisik, stabilitas fisik dan juga pengujian hedonik.
FORMULATION AND PHYSICAL STABILITY TEST OF NANOEMULGEL CONTAINING Petrosia Sp. ETHANOLIC EXTRACT Muhammad Hajrul Malaka; Astrid Indalifiany; Sahidin Sahidin; Adryan Fristiohady; Rina Andriani
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6080

Abstract

Petrosia sp. is one of the sponges from the demospongia class that has biological activity as anti-inflammatory, antimalarial, cytotoxic agent, and can be used in nanoemulgel formulation. Nanoemulsion system is thermodynamically stable and produces globule size that can increase the permeability and diffusibility of Petrosia sp. The presence of gelling agent in the nanoemulgel gives the viscosity and spreadability of Petrosia sp nanoemulsion optimally to increase the effectiveness of the active substances on the skin. This study aims to determine the formulation, characterization, and physical stability of nanoemulgel ethanol extract of sponge Petrosia sp. with carbopol 940 as the gel base. Nanoemulsion characterization included transmittance value, particle size, polydispersity index, and type of emulsion formed. The physical stability test of nanoemulgel included centrifugation and freeze thaw tests with organoleptic, pH, viscosity, and dispersibility evaluation. Nanoemulsion of Petrosia sp ethanolic extract with a composition of 1% VCO, 7% Tween-80, and 2% PEG-400 produced an oil-in-water (O/W) nanoemulsion, transmittance value of 94.84%, droplet size of 23.9 nm and particle size distribution of 0.176. The optimum formula for nanoemulgel is F1 with a nanoemulsion concentration of 75 mL and 25 g of gel base produced a clear and transparent nanoemulgel, semi-solid, soft texture, distinctive aroma, pH value of 5, viscosity of 28,000, dispersibility of 5.7 cm and the shape/color did not change after freeze thaw stability test. Based on the data above, it can be concluded that the F1 nanoemulgel formula with carbopol 940 as the base gel produced an optimal nanoemulgel.
ISOLATION AND IDENTIFICATION OF ANTIOXIDANT COMPOUNDS FROM METHANOL EXTRACT OF SAPPAN WOOD (Caesalpinia sappan) Agung Wibawa Mahatva Yodha; Muamar Abdillah; Astrid Indalifiany; Elfahmi Elfahmi; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6096

Abstract

Sappan wood extract (Caesalpinia sappan) provides better antioxidant properties than ascorbic acid. Empirically, Sappan wood is often used as traditional medicine. To support the utilization of Sappan wood, the isolation and identification of active antioxidant compounds from the methanol extract of Sappan wood had been conducted from this study. Extraction was performed with maceration and evaporation methods. The spots of active antioxidant compounds in TLC-DPPH observations were isolated using liquid vacuum chromatography to obtain two pure compounds. The results of the LC-MS/MS identification of the two compounds, respectively, exhibited peak fragmentation of molecular ions at m/z 271.09, 257.15, 167.03, 151.06, 123.12, and 104.06 at the retention time of 6.35 minutes which were translated as Alpinetine and peak fragmentation of molecular ion at m/z 287.09, 177.06, 164.05, 123.04 and 110.04 at a retention time of 5.75. minutes which were translated as 3-Deoxysappanone B. The antioxidant activity quantitatively showed that Alpinetine and 3-Deoxysappanone B were capable of scavenging DPPH radicals with IC50 values ​​of 20.11 M and 15.28 M, respectively.
Formulasi dan Uji Karakteristik Self –Nanoemulsifying Drug Delivery System (SNEDDS) Ekstrak Etanol Sponge Xestospongia sp. Menggunakan Tween 80 Sebagai Surfaktan WOS Zubaydah; Listha Magistia; Astrid Indalifiany
Majalah Farmasetika Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i2.41779

Abstract

Xestospongia sp. merupakan salah satu sponge dari kelas Demospongiae yang digunakkan sebagai bahan baku obat yang dapat dikembangkan salah satunya dengan metode SNEDDS. Penelitian ini bertujuan untuk mengetahui formulasi dan karakteristik SNEDDS ekstrak etanol sponge Xestospongia sp., Formulasi SNEDDS estrak etanol sponge Xestospongia sp. dengan metode SNEDDS menggunakan VCO sebagai fase minyak, Tween 80 sebagai surfaktan dan PEG 400 sebagai ko-surfaktan. Formula terbaik yang didapatkan adalah Formula 8 dengan komposisi  yaitu 1 mL VCO, 8 mL Tween 80 dan 1 mL PEG 400. Formula 8 menunjukkan waktu emulsifikasi 19 detik, % Transmitan 99,2 %, ukuran partikel 15,67 nm, indeks polidispersitas (PI) 0,213 dan Zeta Potensial -1,86 dan stabil pada pengujian stabilitas dengan uji sentrifugasi, Heating-cooling pada suhu 40oC dan suhu 4oC. berdasarkan data diatas, dapat disimpulkan bahwa SNEDDS ekstrak etanol sponge Xestospongia sp. menghasilkan SNEDDS yang baik.
PENCEGAHAN DEMAM BERDARAH PADA LINGKUNGAN SEKOLAH TAMBOSUPA MELALUI PERILAKU HIDUP BERSIH-SEHAT Astrid Indalifiany; Sabarudin Sabarudin; Halik Halik; Nurull Hikmah; La Ode Nggawu; Fifi Nirmala
Jurnal Pengabdian NUSANTARA Vol 3, No 1 (2023): Januari- Juni
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jpnus.v3i1.35298

Abstract

Dengue fever is an infectious disease spread by the bite of the Aedes mosquito, especially Aedes aegypti. The fact that the Aedes aegypti mosquito often bites during the day during school activities, makes schools a potential location for the spread of DHF. To stop the spread of dengue fever, clean and healthy living behavior (PHBS) can be implemented by washing hands properly, keeping classrooms clean, eating healthy food, exercising regularly, and getting enough sleep. Other efforts are wearing a mask when in crowds, maintaining a safe distance, and using 3M-plus to prevent dengue, such as draining, covering, and burying. The purpose of this service is to educate junior high school students in Tambosupa Konawe Selatan Village about maintaining a clean school environment and avoiding various diseases, especially DHF, to increase their knowledge and skills regarding clean and healthy behavior (PHBS). 
Formulasi Sistem Vesikel Elastik Surfaktan Nonionik Ekstrak Etanol Rimpang Etlingera alba dalam Sediaan Gel: Formulation of Nonionic Surfactant Elastic Vesicle System of Etlingera alba Rhizome Ethanolic Extract in Gel Preparation Astrid Indalifiany; Suryani; Wahyuni; Sahidin; Wa Ode Erna Fitriani
Lansau: Jurnal Ilmu Kefarmasian Vol. 1 No. 1 (2023): Lansau: Edisi April 2023
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v1i1.1

Abstract

Etlingera alba is a plant in Southeast Sulawesi that has antioxidant activity. Natural ingredients such as herbal medicine require a delivery system that facilitates them to reach the site of drug action, especially for transdermal delivery. The elastic vesicle system is a transdermal delivery system that can increase the penetration of active substances at the skin through the act of phospholipids on the skin's lipid bilayer and the deformability of the vesicles. This study aims to formulate and evaluate Etlingera alba rhizome ethanolic extract's elastic vesicle gel to obtain the optimal concentration of Tween 60 as a vesicle former and carbopol as a gel base. Preparation of elastic vesicles of Etlingera alba ethanolic extract using the heat method through variations Tween 60's concentration, namely 5%(F1); 10%(F2); 15%(F3); and 20%(F4). Meanwhile, elastic vesicle gel formulation of the ethanol extract of Etlingera alba rhizome used various concentrations of 0.5% carbopol gel base (FGel 1); 1% (FGel 2); 1.5% (FGel 3); and 2% (FGel 4). The results obtained were the optimum concentration of Tween 60 as a constituent of elastic vesicles of 15% (F4) with spherical morphology using an optical microscope, vesicle size of 10.45 nm, and polydispersity index of 0.280 using a Particle Size Analyzer. In addition, the optimal concentration of carbopol as a base for elastic vesicle gel is a concentration of 0.5% (GGel 1) with white color, distinctive aroma, and thick texture, and has a pH of 6, a viscosity of 2,366 cPs, spread of 6.8 cm, and physically stable through cycling test.
Formulasi dan Karakterisasi Nanoemulsi Ekstrak Etanol Buah Wualae (Etlingera Elatior (Jack) R.M. Smith): Formulation and Characterization of Nanoemulsion Ethanol Extract of Wualae (Etlingera Elatior (Jack) R.M. Smith) Wa Ode Sitti Zubaydah; Astrid Indalifiany; Yamin; Suryani; Dian Munasari; Muhammad Handoyo Sahumena; Sitti Raodah Nurul Jannah
Lansau: Jurnal Ilmu Kefarmasian Vol. 1 No. 1 (2023): Lansau: Edisi April 2023
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v1i1.4

Abstract

Wualae (Etlingera elatior (Jack) R.M. Smith) has a high flavonoid content, so it has the potential as an antioxidant and can be used in drug delivery systems, namely nanoemulsions. Nanoemulsions can improve absorption, help dissolve lipophilic drugs and increase bioavailability. This study aims to determine the formulation and characterization of wualae nanoemulsion. The research method used is a low-energy emulsification method. The nanoemulsion is formulated into four formulas with a concentration ratio of tween 80 and PEG 400, namely 50%: 30% (F1), 50%: 10% (F2), 10%: 30% (F3), and 10%: 10% (F4). The characterizations included organoleptic tests, nanoemulsion type tests, viscosity tests, transmittance tests, particle size tests, polydispersity index tests, potential zeta and physical tests, and centrifugation and cycling tests. The results obtained sequentially are F1 has a characteristic odour of clear yellow, type of oil-in-water nanoemulsion, 150 cPa.s, 99%, 14.56 ± 0.666 nm, 0.061 ± 0.017, 1.453 ± 1.23 mV and is stable in the test. F2 has a characteristic odour of clear yellow colour, oil-in-water nanoemulsion type, 900 cPa.s, 97.2%, 13.8 ± 0.781 nm, 0.126 ± 0.066, -5.503 ± 0.57 mV and is stable in difficult tests. F3 has a dirty white type of nanoemulsion oil in 9.5 cPa and is unstable in typical tests. F4 has a characteristic odour of cloudy white colour, oil-in-water nanoemulsion type, 6 cPa.s and is inconsistent in stability testing. Based on the data above, the best wualae fruit extract nanoemulsion formulation is formula 1.
Sosialisasi Pemanfaatan Potensi Tanaman Desa di Desa Laimeo Adryan Fristiohadi; Muhammad Hajrul Malaka; Wahyuni Wahyuni; Muhammad Israwan Aziz; La Ode Muh. Fitrawan; Astrid Indalifiany; Sahidin Sahidin; Agung Wibawa Mahatva Yodha; Rahmat Muliadi; Fadhliyah Malik
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 2 (2023): NADIKAMI: Juli 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Laimeo merupakan sebuah wilayah yang ada di pesisir laut. dikarenakan hal tersebut, mayoritas mata pencaharian masyarakat setempat adalah nelayan. Sementara itu, terdapat kekayaan alam lain yang dapat dimanfaatakan potensinya dalam bidang kesehatan dan inovasi usaha lainnya. Obat-obatan tradisional Indonesia umumnya memiliki peranan yang sangat besar terutama dalam kaitannya dengan pelayanan kesehatan masyarakat. Namun demikian tampaknya pemanfaatan tanaman obat di Indonesia masih belum dilakukan secara optimal untuk kesehatan. Padahal saat ini biaya pengobatan modern cukup mahal di tambah lagi dengan krisis ekonomi yang belum sepenuhnya berakhir. Tujuan pengabdian ini untuk memberikan meningkatkan pemahaman terhadap potensi tanaman desa dalam bidang kesehatan dan beragam inovasi usaha. Metode Pengabdian dilakukan dengan memberi sosiaisasi (ceramah dan tanya jawab) pada kelompok masyarakat di desa Laimeo, Kecamatan Sawa, Kabupaten Konawe Utara. Hasil pengabdian yang dilakukan mampu meningkatkan pemahaman masyarakat desa laimeo tentang tanaman obat yang ada disekitarnya.
Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Wa Ode Sitti Zubaydah; Wahyuni Wahyuni; Sahidin Sahidin; Tian Amalia Halik; Rina Andriani; Astrid Indalifiany; Adryan Fristiohady
Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Co-Authors ,, Suryani Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Asriullah Jabbar Bafadal, Mentarry Bahari Bahari Dian Munasari Dian Munasari Doddy Ismunandar Bahari Elfahmi Elfahmi, Elfahmi Elvira Riskiyani Kasim Fadhliyah Malik Fifi Nirmala Fitrawan, La Ode Muhammad Halik Halik Husnaeni Husnaeni La Ode Muh. Fitrawan La Ode Nggawu Listha Magistia Muamar Abdillah Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Handoyo Sahumena Muhammad Ilyas Y Muhammad Israwan Azis Norma Arif Nurull Hikmah Rahmat Muliadi Rahmat Muliadi Rezki Annisa Rifa’atul Mahmudah Rina Andriani Rina Andriani Rina Andryani Rini Novianti Sabarudin Sabarudin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sitti Raodah Nurul Jannah Suriana Suriana Tian Amalia Halik Tjandra Buana Vica Aspadiah Vica Aspadiah W. Wahyuni Wa Ode Erna Fitriani Wa Ode Sitti Zubaydah Wahyuni Wahyuni WOS Zubaydah WOS Zubaydah WOS Zubaydah Yamin Yodha, Agung Wibawa Mahatva