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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Identifikasi Simultan Sildenafil Sitrat dan Tadalafil pada Kopi Herbal menggunakan Kromatografi Lapis Tipis – Densitometri Sofia Fatmawati; Almawati Situmorang; Berliana Hanifa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29735

Abstract

convenient use, herbs are currently packed as coffee or other powdered drinks. Because the transactions were more frequent and extensive, sildenafil and tadalafil were found in herbal coffee sold in internet retailers in this investigation. Thin-layer chromatography densitometry tests were conducted on samples of herbal coffee and the standard using ethyl acetate-methanol-ammonia as the mobile phase. The method's selectivity demonstrated that sildenafil and tadalafil in herbal beverages may be distinguished using this technique. Four samples from the ten herbal coffee samples tested positive for sildenafil, and four samples tested positive for tadalafil, according to the test results.Abstrak: Di Indonesia, masyarakat sering beralih ke pengobatan herbal sebagai alternatif pengobatan konvensional. Agar lebih nyaman digunakan, jamu saat ini dikemas dalam bentuk kopi atau minuman bubuk lainnya. Karena transaksi lebih sering dan luas, sildenafil dan tadalafil ditemukan dalam kopi herbal yang dijual di pengecer internet dalam penyelidikan ini. Uji densitometri kromatografi lapis tipis dilakukan pada sampel kopi herbal dan standar menggunakan etil asetat-metanol-amonia sebagai fase gerak. Selektivitas metode menunjukkan bahwa sildenafil dan tadalafil dalam minuman herbal dapat dibedakan dengan menggunakan teknik ini. Empat sampel dari sepuluh sampel kopi herbal dinyatakan positif sildenafil, dan empat sampel dinyatakan positif tadalafil, menurut hasil tes.                 
Uji Aktivitas Antibakteri Ekstrak Metanol Daun Paku Resam (Glechenia liearis Burm.) pada Tiga Bakteri Penyebab Akne Vulgaris Salmi Salmi; Monica Kharisma Swandi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.30474

Abstract

Abstract: Acne vulgaris or acne is a skin disease caused by a bacterial infection. This study aimed to evaluate the antibacterial activity of methanol extract of paku resam leaves (Gleichenia linearis Burm.) on three different acne-causing bacteria Propionibacterium acnes ATCC 6919, Staphylococcus epidermidis ATCC 12228, and Staphylococcus aureus ATCC 25923. The research consisted of an antibacterial activity test using the disc diffusion method, a minimum inhibitory concentration (MIC) test, a minimum bactericidal concentration (MBC) test, and an equivalence test of antibacterial activity with clindamycin as a positive control. This study found that the methanol extract of paku resam leaves had a significant effect (p<0.05) on inhibiting the growth of the three bacteria at all concentrations tested, namely 2.5; 5; 10; 15; 20; 30%. The MIC value of the extract was lower for P. acnes ATCC 6919 and S. epidermidis ATCC 12228 by 1.63%, compared to S. aureus ATCC 25923 by 3.25%. The KBM value of methanol extract of paku resam leaves was lower for P. acnes ATCC 6919 and S. epidermidis ATCC 12228 (3.25%) compared to S. aureus ATCC 25923 (6.5%). The equivalence test showed that the antibacterial activity of the methanol extract of paku resam did not as strong as clindamycin inhibitory activity to the acne-causing bacteria. In conclusion, the methanolic extract of paku resam leaves has antibacterial activity toward three acne-causing bacteria based on the antibacterial test, MIC, and KBM tests, but its activity was still lessened than clindamycin. Abstrak: Akne vulgaris atau jerawat merupakan salah satu penyakit kulit yang dapat disebabkan oleh infeksi bakteri. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak metanol daun paku resam (Glechenia linearis Burm.) pada Propionibacterium acnes ATCC 6919, Staphylococcus epidermidis ATCC 12228 dan Staphylococcus aureus ATCC 25923 bakteri penyebab jerawat. Pengujian terdiri atas uji aktivitas antibakteri dilakukan dengan metode difusi cakram,  uji konsentrasi hambat minimum (KHM), uji konsentrasi bunuh minimum (KBM) dan uji kesetaraan aktivitas antibakteri dengan antibiotik klindamisin sebagai kontrol positif. Hasil penelitian menunjukkan bahwa ekstrak metanol daun paku resam berpengaruh nyata (p<0.05) menekan pertumbuhan ketiga bakteri pada semua konsentrasi yang diujikan yaitu 2.5; 5; 10; 15; 20; 30 %. Nilai KHM ekstrak lebih rendah terhadap P. acnes ATCC 6919 dan S. epidermidis ATCC 12228 sebesar 1.63%, dibandingkan pada S. aureus ATCC 25923 sebesar 3.25%. nilai KBM ekstrak metanol daun paku resam lebih rendah terhadap P. acnes ATCC 6919 dan S. epidermidis ATCC 12228 (3.25%) dibandingkan pada S. aureus ATCC 25923 (6.5%). Hasil uji kesetaraan menunjukkan bahwa aktivitas antibakteri ekstrak metanol paku resam masih lebih rendah dibandingkan klindamisin. Sebagai kesimpulan, ekstrak metanol daun paku resam mampu menghambat pertumbuhan 3 bakteri penyebab jerawat berdasarkan uji antibakteri, KHM dan KBM, namun aktivitasnya masih lebih rendah dibandingkan klindamisin.
Analisis Senyawa Asam Mefenamat dalam Sediaan Jamu Pegal Linu di PasarSumber Kabupaten Cirebon Indri Dwi Rahasasti; Nabilah Nauli Jehan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.27812

Abstract

Abstract: Indonesia is a country where people are still productive in consuming herbal medicine. The number of consumers of herbal medicine resulted in some herbal medicine manufacturers adding medicinal chemicals in it. In accordance with BPOM rules that apply a herbal medicine may not contain the slightest BKO. This study aim to analyze the content of mefenamic acid in herbs that circulate around the Sumber Regency market in Cirebon. Mefenamic acid is one of the drugs used to treat various kinds of pain, especially toothache, muscle aches, joint pains and aches when or before menstruation. The method used in this research is descriptive qualitative test using Thin Layer Chromatography (TLC) and quantitative tests using UV-Vis spectrophotometry. In TLC, the initial identification of a compound is based on a comparison of the value of Rf versus standard Rf. Rf values are generally not the same from laboratory to laboratory even at different analysis times in the same laboratory, so it is necessary to consider the use of relative Rf, ie the Rf value of compound stains compared to other compound stains on the same plate. Five of the eight samples found on the market contained mefenamic acid compounds. The samples containing mefenamic acid of found in the code numbers B, C, F, G and H. The highest levels of mefenamic acid were found in the B-1 sample of 0.14%. According to the One Way ANOVA statistical test results obtained a sig value of 0.001 <0.05. This shows the data on the levels of mefenamic acid in a sample of aching rheumatic / rheumatic herbs there are significant differences circulating in the Sumber Regency Cirebon market.  
Review: Potensi Resin Kemenyan (Styrax benzoin) dan Senyawa Aktifnya Dalam Pengobatan Penyakit Erlia Anggrainy Sianipar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30202

Abstract

Studies on drug discovery from natural ingredients are important to determine the pharmacological effects of the compound’s content so that it can be used to treat diseases. Kemenyan (Styrax benzoin) resin has been widely used by the local community for various purposes, including medicine. This review article aims to provide a comprehensive view of the potency of Kemenyan resin and its active compounds so that they could be used and developed to treat diseases in the future. The method used was based on searching for scientific literature in national and international journals. The results showed that the Kemenyan resin contains active compounds, including cinnamic acid, benzoic acid, benzaldehyde, benzyl benzoate, vanillin, styrene, styracin, coniferyl benzoate, benziresinol resin, resinotannol, sterols, phthalic acid, and sumaresorcinol. These compounds are known to have various pharmacological effects, including antibacterial, anesthetic, anti-inflammatory, antispasmodic, antimutagenic, fungicidal, herbicidal, tyrosinase inhibitory, and LDL synthesis inhibitory effects. Based on these studies, it can be concluded that the Kemenyan resin has great potential for the treatment of various diseases.
Kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi Chytra Bertdiana Ersa; Najmiatul Fitria; Dedy Almasdy
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32264

Abstract

Implementasi terapi Antiretroviral (ARV) dikatakan berhasil apabila kualitas hidup Orang dengan HIV/AIDS (ODHA) menjadi lebih baik (Wu, 2000). Tujuan penelitian ini adalah untuk memberikan gambaran tentang kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi berdasarkan lama penggunaan terapi ARV dan rejimen yang digunakan. Penelitian ini dilakukan secara prospektif mulai Januari hingga April 2023 di klinik VCT RSUD Raden Mattaher Jambi. Kami mengumpulkan data dari pasien klinik VCT RSUD Raden Mattaher Jambi yang memenuhi kriteria inkllusi dan eksklusi sebagai responden. Kuesioner terstruktur, instrument EQ-5D-5L dan EQ-VAS digunakan sebagai instrumen pengumpulan data. Data dianalisis menggunakan Uji Mann Whitney, Kruskall Wallis, Korelasi Spearman. Dari 349 populasi ODHA usia dewasa (≥ 18 tahun) yang terdata di klinik VCT RSUD Raden Mattaher Jambi, 152 (43,55%) diantaranya bersedia menjadi Responden penelitian dan sejumlah 143 (94%) dari total sampel yang dapat dianalisis. Hasil penelitian ini menunjukkan secara sosiodemografi tidak terdapat perbedaan bermakna nilai kualitas hidup pada variabel usia, jenis kelamin, domisili, pekerjaan, pendidikan dan status pernikahan (p<0,05) akan tetapi terdapat perbedaan bermakna nilai kualitas hidup pada faktor resiko penularan dan ada tidaknya penyakit lain (p<0,05). Ditemukan perbedaan bermakna nilai kualitas hidup pada lama penggunaan terapi ARV dimana kelompok responden yang menggunakan terapi ARV ≤ 2 tahun memiliki perbedaan bermakna dibandingkan dengan responden yang telah menggunakan terapi ARV >2 tahun (p<0,05). Tidak terdapat perbedaan bermakna pada kelompok yang menggunakan terapi ARV >2 – 5 tahun,  >5 – 10 tahun maupun > 10 tahun (p>0,05). Tidak ada perbedaan nilai kualitas hidup secara bermakna pada 8 kelompok rejimen terapi ARV (p>0,05). Analisis korelasi menunjukkan terdapat hubungan positif antara nilai UEQ-5D dan UEQ-VAS dengan dengan tingkat cukup (koefisien korelasi 0,348). 
Optimization of Reaction Condition for Synthesis of 4-Methoxychalcone from Ethyl p-methoxycinnamate Ismiarni Komala; Muhamad Beny Setiawan; Yardi Yardi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.30028

Abstract

Ethyl p-methoxycinnamate (1) is the main secondary metabolite found in Kaempferia galanga Linn and has various interesting pharmacological activities, including anti-inflammatory, sedative, vasorelaxant, and antiangiogenic activities. This study aimed to optimize the conditions for the conversion of 1 to 4-methoxychalcone (2) using a conventional synthetic reaction. The conversion was initiated by the hydrolysis of 1 to p-methoxycinnamic acid (3) and 3 to 4-methoxybenzaldehyde (4), and continued with the Claisen-Schmidt reaction of 4 with acetophenone (5). The temperature (room temperature and 45 °C) and ratio of 4 to 5 (1:1 and 1:2) were varied to determine the optimal conditions for the reaction. The results suggested that the reaction of 4 with 5 gave the best yield (42.1 %) when conducted at room temperature in a ratio of 4 to 5 (1:1). The structure of the reaction product was elucidated by spectroscopic analysis and compared with previously published data
Korelasi Tingkat Pengetahuan Terhadap Keberhasilan Terapi Pasien Hipertensi di Puskemas Tuti Wiyati; Vera Rahayu; Septianita Hastuti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30231

Abstract

Knowledge can affect the success of therapeutic outcomes in hypertensive patients. Blood pressure must be controlled to prevent risk factors for other cardiovascular diseases. The purpose of this study was to analyze the relationship between knowledge of patients with hypertension and the success of therapy outcomes that showed controlled blood pressure. This observational cross-sectional study was conducted from March to June 2021 at Tangerang District Health Centers. A sample of 85 outpatients with hypertension was administered the HK-LS questionnaire to measure their level of knowledge, while the results of therapeutic outcomes were measured using blood pressure. The results showed that 60% of patients had intermediate knowledge and only 28.24% of the subjects had well-controlled blood pressure. There was a correlation between knowledge and therapy outcomes (p<0.05) with coef. correlation was -0.336, means a weak and inverse correlation. Comorbidity and sex were significantly correlated with knowledge (p<0,05). The level of knowledge needs to be improved to decrease the number of comorbidities or risk of complications to raise the goal of therapy. 
Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Azhoma Gumala; Henny Lucida; Salman Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic.  A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur  07.12 - 17.17 menit dan penetapan kadar  94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan  USP memenuhi persyaratan T90 min  (Q ≥ 75%) dan memiliki profil disolusi mengikuti  persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika
Review Kandungan Metabolit Sekunder Tanaman Berkhasiat terhadap Tulang dan Sendi menurut Al-Qanun Fi’l Tibb II Barita Juliano Siregar; Sarah Nahdah Zhaafirah Sangadji; Ofa Suzanti Betha; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.25611

Abstract

Al-Qanun Fi’l Tibb II merupakan buku materia medica karya Ibnu Sina yang terkenal di dunia. Buku tersebut menjelaskan secara rinci mengenai monografi tanaman berkhasiat terhadap organ tubuh, salah satunya terhadap tulang dan sendi. Akan tetapi dalam buku tersebut belum memuat komponen major metabolit sekunder yang diduga berperan penting dalam memberikan efek farmakologis. Penelitian ini ditujukan untuk menginventarisasi tumbuhan yang terdapat di dalam buku Al-Qanun Fi’l Tibb II dan melakukan literatur review terkait kandungan metabolit sekunder yang terdapat dalam tanaman tersebut. Metode penelitian dilakukan dengan literature review melalui studi kepustakaan. Hasil pengambilan data menunjukan terdapat 74 tanaman yang berkhasiat terhadap tulang dan sendi diantaranya memiliki komponen major metabolit sekunder seperti senyawa terpen, flavonoid, alkaloid, tanin, alil isotiosianat, saponin, glikosida, alkohol lemak, asam fenolat, benzofenon, kuinon, sekoiridoid, kumarin, stilbene, anthrone, naftalen, benzaldehida dan asam karboksilat. Terpen merupakan metabolit sekunder yang paling banyak ditemukan dalam tanaman yang berkhasiat terhadap tulang dan sendi. Bioaktivitas yang ditemukan pada tanaman diantaranya antigout, antioksidan, osteoprotektif, antiosteoporosis, antibakteri, antiinflamasi dan analgesik.
Kajian Penerapan Cara Pembuatan Obat Tradisional yang Baik pada Industri Ekstrak Bahan Alam di Indonesia Purnama Dwi Tistiyanto; Sukrasno Sukrasno; Budiastuti Budiastuti; Lydia Prima
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32090

Abstract

 Good Manufacturing Practices for Traditional Medicine (GMP for TM) must be applied by Traditional Medicine Businesses in Indonesia, namely Traditional Medicine Small Businesses (TMSB), Traditional Medicine Micro Businesses (TMMB), Traditional Medicine Industry (TMI) and Active Traditional Medicine Ingredients Industries (ATMII), to ensure the quality of the products produced. At the end of 2021, the Indonesian FDA established the most recent GMP for TM standards, which follow the PIC / PE 009-015 standard that must be applied by TMI and ATMII, with an appendix related to GMP for Active Ingredients Traditional Medicine (ATMI) for ATMII. This study aims to determine the GMP profile for TM implementation, specifically in 17 ATMII in Indonesia, and to provide recommendations to the Indonesian FDA in supervising and assisting ATMII. The method was carried out by creating a list of questions from 17 aspects of GMP for Active Ingredients TM, including aspects of product development and technology transfer, to be filled out independently by 17 IEBA, followed by verification and assessment of compliance with the implementation of GMP for TM with the conclusion of the assessment results of the categories are very good, good, sufficient, and poor. According to the findings of the current GMP for TM application, 6 ATMII (35.3%) received a very good assessment result, 6 ATMII (35.3%) received a good assessment result, 3 ATMII (17.6%) received sufficient assessment results, and 2 ATMII (11.8%) received poor assessment results. The current GMP for TM implementation by ATMII that requires attention are Contract Manufacturers (Including Laboratories), product development and technology transfer, personnel, quality control, and validation, whose average level of fulfilment is still less than 80%. These aspects are critical because they significantly influence the consistency of the quality.

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