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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 155 Documents
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Identifikasi Simultan Sildenafil Sitrat dan Tadalafil pada Kopi Herbal menggunakan Kromatografi Lapis Tipis – Densitometri Sofia Fatmawati; Almawati Situmorang; Berliana Hanifa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29735

Abstract

convenient use, herbs are currently packed as coffee or other powdered drinks. Because the transactions were more frequent and extensive, sildenafil and tadalafil were found in herbal coffee sold in internet retailers in this investigation. Thin-layer chromatography densitometry tests were conducted on samples of herbal coffee and the standard using ethyl acetate-methanol-ammonia as the mobile phase. The method's selectivity demonstrated that sildenafil and tadalafil in herbal beverages may be distinguished using this technique. Four samples from the ten herbal coffee samples tested positive for sildenafil, and four samples tested positive for tadalafil, according to the test results.Abstrak: Di Indonesia, masyarakat sering beralih ke pengobatan herbal sebagai alternatif pengobatan konvensional. Agar lebih nyaman digunakan, jamu saat ini dikemas dalam bentuk kopi atau minuman bubuk lainnya. Karena transaksi lebih sering dan luas, sildenafil dan tadalafil ditemukan dalam kopi herbal yang dijual di pengecer internet dalam penyelidikan ini. Uji densitometri kromatografi lapis tipis dilakukan pada sampel kopi herbal dan standar menggunakan etil asetat-metanol-amonia sebagai fase gerak. Selektivitas metode menunjukkan bahwa sildenafil dan tadalafil dalam minuman herbal dapat dibedakan dengan menggunakan teknik ini. Empat sampel dari sepuluh sampel kopi herbal dinyatakan positif sildenafil, dan empat sampel dinyatakan positif tadalafil, menurut hasil tes.                 
Efek Ekstrak Etanol 70% Daun Kemangi Ocimum americanum L.) Terhadap Perbaikan Sel Spermatogenik Tikus Sprague-Dawley Jantan Azrifitria Azrifitria; Eka Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.27787

Abstract

Kemangi is a strong aromatic herb with aphrodisiac activity. The content of secondary metabolites that are antioxidants in kemangi are thought to be able to overcome fertility disorders due to the work of free radicals.  The aim of this study was to screen for phytochemicals and to analyze the activity of 70% ethanol extract of kemangi leaves (Ocimum americanum L.) on the repair of spermatogenic cells in male sprague-dawley rats exposed to lead. The results of phytochemical screening showed that the basil leaf extract was positive for alkaloids, flavonoids, tannins, and saponins. The results of administration of 70% ethanol extract of kemangi leaves at a dose of 50 mg/KgBW, 100 mg/KgBW, and 200 mg/KgBW in rats that had been induced by lead acetate increased the diameter of the seminiferous tubules, the number of pachytene cells, and round spermatid cells compared to the negative control but not significantly different (p > 0.05). The highest increase in all parameters of the spermatogenic cell repair test was given the kemangi leaves extract at a dose of 200 mg/KgBW.
Aplikasi Natural Deep Eutectic Solvent (NADES) sebagai Green Solvent pada Ekstraksi Kafein dan Katekin dari Limbah Kulit Kopi Fitria Puspita; Isna Nurhidayati; Bella Mellisani; Fajar Amelia Rachmawati Putri; Anton Restu Prihadi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32256

Abstract

Various studies have been conducted to support green industry by developing green solvents to replace organic solvents that are generally toxic, volatile, and harmful to human health and the environment. Environmentally friendly solvents that have been successfully developed in the 21st century are eutectic solvents and natural deep eutectic solvents (NADES). NADES can be formed from primary metabolites such as amino acids, organic acids, sugars, or choline derivatives, and has a high ability to extract polar, non-polar compounds, and several other secondary metabolites. The amount of waste generated from the process of separating coffee from its seeds is abundant but has not been used optimally. Coffee husk waste has the potential to be used as a food product because it contains many active substances, especially phenolic compounds such as caffeine and catechins. In this study, an NADES solvent based on choline chloride-proline (1:1) was successfully synthesized and used to extract phenolic compounds from coffee husk waste in the form of caffeine and catechins. The results of the HPLC analysis showed that the levels of caffeine and catechins extracted were 14.5 ppm and 61 ppm, respectively. Based on these results, caffeine and catechins in coffee skin waste were successfully extracted using NADES based on choline chloride – proline (1:1). 
Uji Aktivitas Antibakteri Ekstrak Metanol Daun Paku Resam (Glechenia liearis Burm.) pada Tiga Bakteri Penyebab Akne Vulgaris Salmi Salmi; Monica Kharisma Swandi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.30474

Abstract

Abstract: Acne vulgaris or acne is a skin disease caused by a bacterial infection. This study aimed to evaluate the antibacterial activity of methanol extract of paku resam leaves (Gleichenia linearis Burm.) on three different acne-causing bacteria Propionibacterium acnes ATCC 6919, Staphylococcus epidermidis ATCC 12228, and Staphylococcus aureus ATCC 25923. The research consisted of an antibacterial activity test using the disc diffusion method, a minimum inhibitory concentration (MIC) test, a minimum bactericidal concentration (MBC) test, and an equivalence test of antibacterial activity with clindamycin as a positive control. This study found that the methanol extract of paku resam leaves had a significant effect (p<0.05) on inhibiting the growth of the three bacteria at all concentrations tested, namely 2.5; 5; 10; 15; 20; 30%. The MIC value of the extract was lower for P. acnes ATCC 6919 and S. epidermidis ATCC 12228 by 1.63%, compared to S. aureus ATCC 25923 by 3.25%. The KBM value of methanol extract of paku resam leaves was lower for P. acnes ATCC 6919 and S. epidermidis ATCC 12228 (3.25%) compared to S. aureus ATCC 25923 (6.5%). The equivalence test showed that the antibacterial activity of the methanol extract of paku resam did not as strong as clindamycin inhibitory activity to the acne-causing bacteria. In conclusion, the methanolic extract of paku resam leaves has antibacterial activity toward three acne-causing bacteria based on the antibacterial test, MIC, and KBM tests, but its activity was still lessened than clindamycin. Abstrak: Akne vulgaris atau jerawat merupakan salah satu penyakit kulit yang dapat disebabkan oleh infeksi bakteri. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak metanol daun paku resam (Glechenia linearis Burm.) pada Propionibacterium acnes ATCC 6919, Staphylococcus epidermidis ATCC 12228 dan Staphylococcus aureus ATCC 25923 bakteri penyebab jerawat. Pengujian terdiri atas uji aktivitas antibakteri dilakukan dengan metode difusi cakram,  uji konsentrasi hambat minimum (KHM), uji konsentrasi bunuh minimum (KBM) dan uji kesetaraan aktivitas antibakteri dengan antibiotik klindamisin sebagai kontrol positif. Hasil penelitian menunjukkan bahwa ekstrak metanol daun paku resam berpengaruh nyata (p<0.05) menekan pertumbuhan ketiga bakteri pada semua konsentrasi yang diujikan yaitu 2.5; 5; 10; 15; 20; 30 %. Nilai KHM ekstrak lebih rendah terhadap P. acnes ATCC 6919 dan S. epidermidis ATCC 12228 sebesar 1.63%, dibandingkan pada S. aureus ATCC 25923 sebesar 3.25%. nilai KBM ekstrak metanol daun paku resam lebih rendah terhadap P. acnes ATCC 6919 dan S. epidermidis ATCC 12228 (3.25%) dibandingkan pada S. aureus ATCC 25923 (6.5%). Hasil uji kesetaraan menunjukkan bahwa aktivitas antibakteri ekstrak metanol paku resam masih lebih rendah dibandingkan klindamisin. Sebagai kesimpulan, ekstrak metanol daun paku resam mampu menghambat pertumbuhan 3 bakteri penyebab jerawat berdasarkan uji antibakteri, KHM dan KBM, namun aktivitasnya masih lebih rendah dibandingkan klindamisin.
Formulasi Sediaan Sampo Antiketombe Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm.f.) Alston) Neni Sri Gunarti; Himyatul Hidayah; Bintang Larasati; Putri Agustina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.29851

Abstract

Syzygium aqueum (Burm.f) Alston) leaves have many ingredients that are beneficial to health, one of which is as an antifungal for fungi that cause anti dandruff. To optimize this content, an anti dandruff shampoo formulation was made with the active ingredient ethanol extract of Syzygium aqueum (Burm.f) Alston leaves against Malassezia furfur. The purpose of this study was to determine the effect of extract concentration on the quality of the preparation and to find out which formula had the best antidandruff activity. The research method used was quasi experimental. The results of the phytochemical screening of the ethanol extract of Syzygium aqueum positively contained alkaloids, flavonoids, saponins, tannins, quinones and steroids. The Minimum Inhibitory Concentration showed inhibitory activity at a concentration of 1.56% using the well diffusion method. In the preparation activity test on F1; F2; and F3 with an extract concentration of 1.5%; 2% and 2.5% showed the potential as a very strong anti-dandruff category with an average inhibition zone diameter of 23.41±1.60 mm; 28.11±3.66 mm and 30.21±0.92 mm. The results of the evaluation of the physical properties of the preparation are in the form of a viscous semi-liquid, with a distinctive aromatic odor with a white to brownish green color with an average pH of 5.28±0.02 ; 6.16±0.01 ; 6.18±0.00 and 6.23 ± 0.01 with an average viscosity of 3550.3±38.88 cPs ; 3279±68.94 cPs ; 2656.6±33.29 cPs and 2568.6±108.14 cPs and foam height of 23.11±1.57 mm ; 31.76±1.95mm ; 43.03±0.77 mm and 49.06±1.37 mm, which means that the results of the physical evaluation of the preparations met the criteria. From the research that has been done, it can be seen that F3 with an extract concentration of 2.5% showed the best anti-dandruff activity.
Penggunaan Tumbuhan Obat Sebagai Penunjang Kesehatan pada Masyarakat Betawi Hendri Aldrat; Winda Trya Wulandari; Mita Restinia
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32588

Abstract

Changes in land use from rice fields and plantations to residential areas, offices, and trading complexes will certainly result in changes in the biodiversity of the environment of the inhabitants of the capital city of Jakarta, including the Betawi community. The scarcity of certain species due to land conversion also affects people’s ethnobotanical knowledge. This study aimed to explore how the Betawi people, with the rapid flow of urbanization, use medicinal plants around them. A total of 25 respondents of the selected Betawi ethnicity were interviewed about the use of medicinal plants. Purposive sampling and snowball sampling were used. The data obtained from the respondents were collected and compared using triangulation techniques with previously published ethnobotanical reports. The results showed that as many as 61 species from 36 families were used by the Betawi people to support their health. Ginger, lemongrass, and jatropha are the most widely used plants. The most widely used species belong to the Zingiberaceae family. The most commonly used part is the leaves (55%), the most common processing method is boiling (48%), the most common way to administer the medicine is by drinking (49%), and as much as 61% of medicinal plants are used in the home. In conclusion, the Betawi people still maintain the tradition of using herbal medicine amidst the high rate of urbanization in the capital city of Jakarta. Furthermore, it is necessary to conduct further experiments in the laboratory to validate the safety, efficacy, and identification of the active ingredients in these plants. 
Analisis Senyawa Asam Mefenamat dalam Sediaan Jamu Pegal Linu di PasarSumber Kabupaten Cirebon Indri Dwi Rahasasti; Nabilah Nauli Jehan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.27812

Abstract

Abstract: Indonesia is a country where people are still productive in consuming herbal medicine. The number of consumers of herbal medicine resulted in some herbal medicine manufacturers adding medicinal chemicals in it. In accordance with BPOM rules that apply a herbal medicine may not contain the slightest BKO. This study aim to analyze the content of mefenamic acid in herbs that circulate around the Sumber Regency market in Cirebon. Mefenamic acid is one of the drugs used to treat various kinds of pain, especially toothache, muscle aches, joint pains and aches when or before menstruation. The method used in this research is descriptive qualitative test using Thin Layer Chromatography (TLC) and quantitative tests using UV-Vis spectrophotometry. In TLC, the initial identification of a compound is based on a comparison of the value of Rf versus standard Rf. Rf values are generally not the same from laboratory to laboratory even at different analysis times in the same laboratory, so it is necessary to consider the use of relative Rf, ie the Rf value of compound stains compared to other compound stains on the same plate. Five of the eight samples found on the market contained mefenamic acid compounds. The samples containing mefenamic acid of found in the code numbers B, C, F, G and H. The highest levels of mefenamic acid were found in the B-1 sample of 0.14%. According to the One Way ANOVA statistical test results obtained a sig value of 0.001 <0.05. This shows the data on the levels of mefenamic acid in a sample of aching rheumatic / rheumatic herbs there are significant differences circulating in the Sumber Regency Cirebon market.  
A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Suryani, Nelly; Anwar, Vidia Arliani; Saibi, Yardi; Dhilasari, Estu Mahanani; Dahlizar, Sabrina; Betha, Ofa Suzanti; Komala, Ismiarni; Azzahra, Afifah Nurnishrina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Abstract

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.
Penggunaan Obat Herbal pada Responden COVID-19 yang Menjalani Isolasi Mandiri Mita Restinia; Hendri Aldrat; Alia Dening Pangestuti; Ahmad Musir
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32294

Abstract

COVID-19 is an infectious disease caused by spreading the coronavirus worldwide. In Indonesia, COVID-19 patients with mild symptoms can undergo independent isolation at home. The public widely uses herbal medicines in the treatment of COVID-19. A non-experimental cross-sectional study was performed to identify the profile of the use of herbal medicines by COVID-19 respondents during independent isolation in South Tangerang. The sampling technique conducted purposive sampling on 96 respondents who met the inclusion criteria. The instrument used is a questionnaire with close-formatted and open-ended questions. Questionnaires were distributed online from March to May 2022. The most used herbal medicines were honey (85.4%), ginger (52.1%), propolis (35.4%), turmeric (32.3%) and garlic (26%). The reason respondents used herbs because they were made from natural ingredients (84.4%), the method of use was boiled or brewed (58.3%), information on the use of herbal medicines was obtained from the family (63.5%), the source of obtaining herbal medicines was sent by relatives/family/friends (69.8%), the duration of using herbal medicines is 1-7 days (39.6%), the time to use herbal medicines was generally in the morning (49%), and the cost of herbal medicines is IDR 100,000 - 500,000 (44.8%). Through this research, it can be concluded that South Tangerang City's people still use herbal medicines as an alternative treatment while infected with COVID-19. Therefore, further education on the safety and maximum use of herbal medicines is required.
Penetapan Kadar Fenol Total dengan Spektrofotometer UV-Vis dan Uji Sitotoksisitas Ekstrak Air Daun Lidah Mertua (Sansevieria masoniana C.) Terhadap Sel Kanker Paru A-549 Lilis Febriyanti; Ayu Nala El Muna Haerussana
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.30080

Abstract

Cancer is the second most common cause of mortality globally, following cardiovascular disease, according to the World Health Organization (WHO). Leading the list of fatal cancers annually are lung, breast, stomach, liver, and colorectal cancers. Hence, the discovery and development of effective agents to treat various types of cancer is urgently needed. Mother-in-law tongue (Sansevieria masoniana Chahin) leaves contain flavonoids and saponins. However, information regarding the total phenolic content of the aqueous extract of the S. masoniana Chahin leaves is currently unavailable. Hence, this research aims to determine the total phenol content using a UV-Vis spectrophotometer and assess the invitro anticancer activity of the water extract of S. masoniana Chahin through the MTT Assay. From the results of measuring the total phenolic content, the water extract of the leaves contained a phenol content of 3.3061 mgGAE/g. Meanwhile, the results of the cytotoxicity assay on lung cancer cells A-549 showed that the IC50 value of the aqueous extract of S. masoniana Chahin leaves was above 100 ppm, indicating that the extract has less potential as an anti-lung cancer agent.

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