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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 155 Documents
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Studi In Silico Senyawa Bioaktif pada Daun Yakon (Smallanthus sonchifolius), Kayu Secang (Caesalpinia sappan L.), Daun Salam (Syzygium polyanthum) Sebagai Antidiabetes Mekanisme Kerja Inhibitor SGLT-2 Andri Prasetyo Prasetyo; Esti Mumpuni; Sekar Harsti Rahmadhani; Saeful Amin
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39508

Abstract

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia dimana pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Daun yakon, kayu secang dan daun salam memiliki beberapa yang berpotensi sebagai antidiabetes, namun belum diketahui senyawa spesifik mana yang terlibat dalam mekanisme inhibitor SGLT-2. Penelitian ini bertujuan untuk menganalisis potensi senyawa bioaktif yang terkandung dalam Daun yakon, kayu secang dan daun salam dalam menghambat enzim SGLT-2 secara in silico. Data senyawa aktif didapatkan dari laman PubChem. Kristal struktur dari Structure of human SGLT2-MAP17 complex bound with empagliflozin didapatkan dari Protein Data Bank dengan PDB ID: 7VSI. Molecular docking menggunakan Molegro Virtual Docker dan simulasi molecular dynamic menggunakan YASARA Dynamics. Hasil molecular docking didapatkan 4 senyawa memiliki nilai rerank score lebih negative dari senyawa pembanding (empagliflozi). Hasil visualisasi menunjukan residu asam amino yang berperan penting ialah PHE 98 dan VAL 157. Hasil molecular dynamics menunjukan kompleks ligan memiliki kestabilan ikatan paling baik dan stabil dari ligan uji lainnya. Dihasilkan senyawa yang stabil, yaitu 3,4-Dicaffeoyquinic acid.
Identifikasi DRPs Pasien Gagal Jantung di rawat Inap RSJPD Harapan Kita Tahun 2023 Zainul Islam; Desy Puspita Sari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 1 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.38486

Abstract

Identifikasi Drug Related Problems (DRPs) pada pengobatan sangat penting dalam rangka mengurangi angka morbiditas, mortalitas dan biaya pengobatan. Hal ini akan sangat membantu dalam meningkatkan efektivitas terapi obat terutama pada penyakit yang sifatnya kronis dan membutuhkan pengobatan jangka panjang, salah satunya adalah penyakit gagal jantung. Penelitian ini untuk mendapatkan gambaran jumlah kejadian DRPs pada pasien gagal jantung di rawat inap RSJPD Harapan Kita Maret – Mei 2023. Penelitian deskriptif noneksperimental dengan pengambilan data prospektif dari rekam medik pasien. Sampel sebanyak 81 pasien yang memenuhi kriteria inklusi. Data dianalisis menggunakan PCNE V9.1 tahun 2020. Pasien yang mengalami DRPs sebanyak 72 pasien (88,9%) dan yang tidak mengalami DRPs sebanyak 9 pasien (11,1%). Gambaran DRPs setiap kategori yang terjadi meliputi 7 pasien (8,05%) kejadian obat yang merugikan terjadi, 70 pasien (80,46%) interaksi obat, 9 pasien (10,34%) tidak ada pemberian terapi meskipun ada indikasi yang jelas dan 1 pasien (1,15%) regimen dosis tidak cukup sering. Kejadian DRPs terbanyak terjadi pada interaksi obat dengan angka kejadian moderate sebanyak 60,55%, minor sebanyak 23,59% dan major sebanyak 14,06%. Dengan melihat gambaran tersebut diharapkan dapat meningkatkan monitoring terhadap pasien untuk meminimalisir angka kejadian DRPs.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Annisa Larasati Putri; supandi supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24629

Abstract

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
Pemantauan Kadar Obat Antiepilepsi dalam Darah terhadap Clinical Outcome pada Pasien Epilepsi di RSPAD Gatot Soebroto dengan Pendekatan Farmakokinetika Dini Permata Sari; Winda Septyani Sianipar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.38924

Abstract

The use of antiepileptic drugs requires monitoring of blood drug levels because antiepileptics are drugs with a narrow therapeutic index. This study was conducted to determine the relationship between the accuracy of blood antiepileptic drug levels and clinical outcomes in epilepsy patients at RSPAD Gatot Soebroto using a pharmacokinetic approach. This study is an analytical observational study with a retrospective cross-sectional study of epilepsy patients using antiepileptic drugs from January 2023 to January 2024 at RSPAD Gatot Soebroto Jakarta. The results of this study showed that the most antiepileptic drug was valproic acid (38.55%). Of the 32 patients using valproic acid, there were 22 uses of valproic acid below the therapeutic range (<50 mg/L), 10 uses of valproic acid within the therapeutic range (50–100 mg/L). Of the 22 uses of phenytoin, there were 4 uses of phenytoin below the therapeutic range (<10 mg/L), 17 uses of phenytoin within the therapeutic range (10–20 mg/L), and 1 use of phenytoin above the therapeutic range (>20 mg/L). Of the 10 uses of carbamazepine, 1 use of carbamazepine was below the therapeutic range (<4 mg/L), and 9 uses of carbamazepine were within the therapeutic range (4-12 mg/L). Of the 4 uses of levetiracetam, there were 4 uses of levetiracetam below the therapeutic range (12-46 mg/L), and 1 use of oxcarbazepine had a therapeutic range below the therapeutic range (3-35 mg/L). In clinical outcomes within 6 months, 18.07% of patients experienced seizures after receiving antiepileptic drug therapy, and 81.93% of patients experienced seizure-free for up to 6 months. The conclusion of this study is that a p-value of >0.05 is obtained, which means that there is no relationship between clinical outcomes and the accuracy of antiepileptic drug levels in the blood of epilepsy patients. This is because there are other pharmacokinetic parameters that cannot be predicted, so it is necessary to monitor antiepileptic drug levels directly on patients to improve the desired clinical outcomes.
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Arini Khaerunnisa; Ratna Djamil; Lilik Sulastri; Tarso Rudiana; Partomuan Simanjuntak
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Efek Antinyeri Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi L) pada Mencit yang Diinduksi Asam Asetat Mira Kemila; Edy Suprasetya; ,Arifson Umbu Laga
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.31287

Abstract

Pain is an unpleasant combination of sensory and emotional experience linked to the potential or actual of tissue damage. Typically, pain arises from stimulation of peripheral receptors, which send impulses through pain pathways to the brain. Starfruit is a medicinal plant that is used empirically as an analgesic. This study aims to determine the analgesic effect of starfruit extract on the stretch index and pain protection ratio against acetic acid-induced mice. This study used 25 mice divided into three test groups: one control group (Na-CMC) and one comparison group (Mefenamic acid). The results showed that starfruit can reduce the pain stretch index and have a pain protection ratio compared to the control group. A dose of 250 mg/kg has an analgesic protection ratio of 75.75%, and a dose of 500 mg/kg has a protection ratio of 85.14%. Thus, based on the results of this study, it can be seen that starfruit has the ability to act as an anti-pain.
Studi In Silico Senyawa Kimia Zingiber Montanum J.König sebagai Antidiabetes terhadap Reseptor α-Glukosidase Ninu Eltriya; Rosa Adelina; Ismiarni Komala
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39136

Abstract

Diabetes Mellitus (DM) is a metabolic disorder resulting from the impaired secretion of insulin, glucagon, and other hormones, leading to elevated blood sugar levels. Bangle (Zingiber montanum) is recognized for its potent antidiabetic compounds. This study sought to evaluate the potential and interaction of chemical compounds from bangle on the α-glucosidase receptor as an antidiabetic using molecular docking studies. The molecular docking analyses were conducted using Autodock Vina software and Biovia Discovery Studio Visualizer for 2D and 3D visualization. Fifteen chemical compounds from the bangle plant were subjected to molecular docking studies against the α-glucosidase receptor, with the comparative ligand acarbose. Results indicated that acarbose demonstrated a bond energy (ΔGbind) of -6.9 cal/mol. Conversely, six test compounds, including cassumunarin A (-7.7 kcal/mol), cassumunarin B (-7.5 kcal/mol), cassumunarin C (-8.0 kcal/mol), cassumunin A (-7.0 kcal/mol), cassumunin C (-7.0 kcal/mol), and banglenol A (-6.9 kcal/mol), exhibited lower binding energy than acarbose, signifying a more stable bond conformation and a stronger effect. These compounds formed hydrogen bonds with the amino acids Asp327, Asp203, Arg526, and Asp542, hydrophobic bonds with Tyr299, Thr406, and Phe575, and electrostatic bonds with Asp327, Asp203, Met444, and Asp542. In conclusion, this research indicates that several chemical compounds from the rhizome of bangle have the potential to interact with the α-glucosidase receptor as antidiabetic agents.
Pengaruh Penambahan Enhancer Isopropil Miristat dan dan Propilen Glikol terhadap Penetrasi Krim Asiklovir Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.25859

Abstract

Acyclovir, a BCS class III drug, has a high ability to fight the herpes virus but has low permeability and is poorly soluble in water. In order to obtain the expected effect of viral infection on the skin, the penetration of the active ingredients becomes a critical factor for a topical treatment to achieve the desired concentration. This study was to see the effect of adding isopropyl myristate and propylene glycol as enhancers that help diffuse the drug through the stratum corneum. The formulation is made by adding enhancer propylene glycol 8% (F1), isopropyl myristate 8% (F2), and without enhancers (F3). Physical stability of acyclovir cream, including homogeneity, organoleptic, pH, viscosity, type of emulsion and power spread, and in vitro cream penetration test with Franz diffusion cells will be observed. The result of acyclovir cream preparations F1, F2, and F3 had a homogeneous preparation of white semisolid and odorless with pH between 7,30-7,60, emulsion type o/w, and a viscosity between 35000-47000 cPS. The cumulative amount of acyclovir penetrated at F3 was 226,008± 8,462  μg/cm2, while the cream containing the enhancers F1 258,059±1,730 μg/cm2 and F2 268,336±0,740 μg/cm2, respectively. The presence of enhancers will increase the penetration ability of acyclovir cream, with more penetration using isopropyl myristate than propylene glycol.
Profil Pelayanan Informasi Obat pada Pelayanan Swamedikasi Obat Allopurinol di Apotek Kabupaten Bekasi Clarisya Pramirusanti Putri; Ainun Wulandari; Tahoma Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 1 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.35167

Abstract

Tenaga kefarmasian merupakan tenaga kesehatan yang memberikan pelayanan kefarmasian kepada masyarakat, salah satunya Pelayanan Informasi Obat khususnya dalam memberikan pelayanan pengobatan mandiri. Peran apoteker di apotek dapat dikatakan belum maksimal, baik dalam penggalian informasi maupun teknis pelayanan informasi obat. Penelitian ini bertujuan untuk mengetahui layanan informasi obat pada layanan pengobatan mandiri allopurinol di apotek di Kabupaten Bekasi. Jenis penelitian ini menggunakan penelitian deskriptif. Penelitian ini dilakukan secara observasional dengan menggunakan metode simulasi pasien, yaitu simulasi pasien yang telah dilatih. Pemilihan sampel apotek menggunakan metode Probability Sampling dan Cluster Random Sampling dengan jumlah apotek yang ada di Kabupaten Bekasi sebanyak 76 buah yang terbagi dalam 21 kecamatan. Subyek penelitian dalam penelitian ini adalah petugas di bagian apotek yaitu apoteker, asisten apoteker, dan petugas non apotek. Instrumen penelitian yang digunakan adalah checklist yang berisi kriteria informasi yang harus disediakan oleh tenaga farmasi dalam pelayanan informasi obat sesuai Peraturan Menteri Kesehatan Republik Indonesia Nomor 73 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Apotek. Hasil penelitian menunjukkan bahwa penggalian informasi dari pasien dikategorikan buruk dengan nilai 0,16% (≤70%), pemberian informasi obat allopurinol dikategorikan buruk dengan nilai 14,11% (≤70%), sehingga kualitas pelayanan kesehatan baik. pelayanan informasi obat yang dilakukan oleh apoteker (7,57%), oleh asisten apoteker (7,18%), dan oleh petugas non apotek (6,56%), dimana ketiganya termasuk dalam kategori buruk (≤70%). Dari penelitian ini disimpulkan bahwa peran petugas apotek dalam memberikan pelayanan informasi obat allopurinol masih rendah dan perlu ditingkatkan.
Formulasi dan Karakterisasi Nanopartikel Ekstrak Biji Carica (Carica pubescens) dengan Variasi Konsentrasi Kitosan menggunakan Metode Gelasi Ionik Fania Putri Luhurningtyas; Prashinta Nita Damayanti; Suzan Astyamalia; Mir-a Kemila; Evi Novitasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39161

Abstract

Carica seeds (Carica pubescens) contain alkaloid, saponin, and flavonoid compounds, which have pharmacological activities such as antibacterial, anti-inflammatory, immunomodulatory, and antihyperlipidemic properties, but their bioavailability is low. Nanotechnology has significantly advanced in drug delivery systems because it can enhance absorption in the gastrointestinal tract, allowing entry into the bloodstream. This study aims to create and evaluate the characteristics of carica seed extract nanoparticles with varying concentrations of chitosan. The carica seed extract was obtained using the maceration method with 70% ethanol as the solvent. The Carica seed extract was then formulated into nanoparticles using the ionic gelation method with varying concentrations of chitosan: NaTPP, specifically formulas FA (0.3:1), FB (0.2:1), and FC (0.1:1). The resulting nanoparticle colloids were characterized for particle size, polydispersity index (PDI), percent transmittance (%T), and specific functional groups. The results showed that the particle sizes for formulas FA, FB, and FC were 243.7 nm, 47.96 nm, and 116.6 nm, respectively. The PDI values for formulas FA, FB, and FC were 0.378, 0.357, and 0.52, respectively. The percent transmittance for all three formulas ranged from 99.5% to 99.6%. The characterization of functional groups indicated interactions between the carica seed extract, chitosan, and NaTPP, with the presence of OH, N-H, aliphatic CH, P=O, and PO3 groups. These interactions were observed based on the shift in wavenumbers in the FTIR results for each sample. All carica seed nanoparticle formulas showed particle sizes within the nanometer range (<1000 nm), polydispersity indices less than 1, percent transmittance close to 100%, and specific functional groups indicating interactions between the extract and the coating polymer. Formula FB was the optimal formula, with the smallest nanoparticle size (<100 nm), a PDI value of <0.5, and a percent transmittance of >99%.

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