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Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

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Published by TALENTA PUBLISHER

ISSN : 26860872 EISSN : 26860856 DOI : 10.32734

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an international peer-reviewed journal (February, May, August and November) published by TALENTA Publisher, Universitas Sumatera Utara and managed by Faculty of Medicine, Universitas Sumatera Utara. It is dedicated to interchange for the articles of high quality research in the field of Medical Science. The journal publishes state-of-art papers in fundamental theory, case report, experiments and simulation, as well as applications, with a systematic proposed method, sufficient review on previous works, expanded discussion and concise conclusion. As our commitment to the advancement of science and technology, the JETROMI follows the open access policy that allows the published articles freely available online without any subscription. Each publication contains 6 (six) research articles which will be published online.

Arjuna Subject : Kedokteran - Endokrinologi, Diabetes dan Metabolisme

Articles 151 Documents

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Factors Associated with Treatment Outcome of Shorter Treatment Regimen (STR) for MultiDrug-Resistant Tuberculosis (MDR-TB) Perangin-angin, Gwanita Nawariantina; Sinaga, Bintang Yinke Magdalena; Siagian, Parluhutan; Eyanoer, Putri Chairani
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.16123

ABSTRACT Background: Indonesia ranked 2nd around the world for TB cases with case population continue increasing. In 2018, Shorter Treatment Regimen (STR) was introduced as a new regimen for treating MDR-TB patient. The aim of this study is to determine factors associated with treatment outcome of MDR-TB patients treated with Shorter Treatment Regimen Methods: This is a descriptive-analytic study using cross sectional design which was conducted at Adam Malik Hospital Medan. Subject was 150 patients with drug-resistant Pulmonary TB at MDR-TB polyclinics according to inclusion and exclusion criteria Results: MDR-TB patients that treated with STR was mostly < 50 years old (65.2%) and 107 subjects (70.4%) were male. The majority of subjects with comorbidity were 94 subjects (61.8%); 43 subjects (28.3%) with DM, 5 subjects (3.3%) with CHF, 3 subjects (2.0%) with HIV, 1 subject (0.7%) with DM & CHF, and 1 subject (0.7%) with DM & HIV. When evaluated the patients treatment outcome, 47.4% were cured, 6.6% were failed, 34.8% were default and 11.2% were death. A chi square test was conducted to assess association between age with treatment outcome. Age was significantly associated with treatment outcome (p=0.038) but gender and comorbidity were not associated with treatment outcome with p-value 0.152 and 0.497 (p>0,05) respectively. Conclusions: There is a significant association between age and treatment outcome but no significant association between gender and comorbidity with treatment outcome. ABSTRAK Latar Belakang: Indonesia menduduki peringkat ke-2 dunia untuk kasus TBC dengan populasi kasus yang terus meningkat. Pada tahun 2018, Shorter Treatment Regimen (STR) diperkenalkan sebagai rejimen baru untuk mengobati pasien TB-MDR. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang berkorelasi dengan hasil pengobatan pasien TB-MDR yang diobati dengan Regimen STR. Metode: Penelitian ini merupakan penelitian deskriptif-analitik dengan desain cross-sectional yang dilakukan di Rumah Sakit Adam Malik Medan. Subyek penelitian adalah 150 pasien TB Paru Resisten Obat di poliklinik TB MDR sesuai kriteria inklusi dan eksklusi. Hasil: Pasien TB-MDR yang diobati dengan STR sebagian besar berusia <50 tahun (65,2%) dan berjenis kelamin laki-laki sebanyak 107 subjek (70,4%). Mayoritas subjek dengan penyakit penyerta sebanyak 94 orang (61,8%); 43 orang (28,3%) DM, 5 orang (3,3%) CHF, 3 orang (2,0%) HIV, 1 orang (0,7%) DM & CHF, dan 1 orang (0,7%) DM & HIV. Hasil pengobatan adalah 47,4% sembuh, 6,6% gagal, 34,8% putus berobat dan 11,2% meninggal. Uji chi square dilakukan untuk menilai hubungan antara usia dengan hasil pengobatan dan didapatkan nilai p = 0,038 yang menunjukkan adanya hubungan yang signifikan namun berdasarkan jenis kelamin dan penyakit penyerta ditemukan nilai p masing-masing 0,152 dan 0,497 (p>0,05) yang menunjukkan tidak ada hubungan antara jenis kelamin dan penyakit penyerta terhadap hasil pengobatan. Kesimpulan: Terdapat hubungan yang signifikan antara usia dan hasil pengobatan namun tidak ada hubungan yang signifikan antara jenis kelamin dan penyakit penyerta dengan hasil pengobatan.

Role of Malondialdehyde Levels in The Occurrence of Hypogonadism in Transfusiondependent Thalassemia Male Patients Lubis, Dian Anindita; Nasution, Melati Silvanni; Lubis, Heny Syahrini; Pohan, Hafiza Humayra Prabisma
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.16485

Male hypogonadism is a clinical syndrome resulting from the failure of the testes to produce adequate testosterone. Thalassemia major is an autosomal recessive disorder characterized by the absence or severe deficiency of the synthesis of the ÃŸ-globulin chain of hemoglobin that causes severe anemia requiring lifelong transfusions. Chronic blood transfusion in patients with ÃŸ-thalassemia leads to the accumulation of transfusion-associated iron in the tissues. Iron accumulation in the testes and pituitary gland generally leads to a state of hypogonadism. In patients undergoing repeated transfusions, there can be increased oxidative stress which can be assessed by examining malondialdehyde (MDA) levels. Increased oxidative stress can also affect a person's reproductive process through damage to pituitary tissue and LH hormones, which ultimately results in a decrease in a person's testosterone levels. Our aim is to see the correlation between malondialdehyde levels and free testosterone in male patients with transfusion-dependent thalassemia. This study used a cross-sectional design conducted at the Thalassemia polyclinic of RSCM and Fatmawati from January to March 2023. The study samples were transfusion-dependent thalassemia patients who met the acceptance criteria of the study subjects. Each patient underwent venous blood collection and was examined for serum ferritin levels, transferrin saturation, FSH levels, LH levels, free testosterone levels and MDA. The data obtained will be recorded and processed using the SPSS 20 program. Forty-one male subjects with transfusion-dependent thalassemia had a median free testosterone of 14.53 pg/mL (minimum-maximum 0.1-35.78). Twelve subjects (29%) of them had low testosterone levels. The median MDA level was 2.22 uM (0.18-2.61). There was no significant correlation between free testosterone and MDA (r=-0.18, p=0.261). There were high MDA levels in men with transfusion-dependent thalassemia. High MDA levels had no correlation with free testosterone in men with transfusion-dependent thalassemia.

HYDROGEL-BASED WOUND DRESSING IN THE TREATMENT OF DIABETIC FOOT ULCERS: A NARRATIVE REVIEW Sembiring, Faisal Rozi; Sazli, Brama Ihsan
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.17208

ABSTRACTBackground: The aim of this case study is to determine the effectiveness of hydrogel-based wound dressing (HBWD) in the treatment of diabetic foot ulcer (DFU) in diabetic patients.Methods: Method in this case study is evidence-based case report. The clinical question used: Are HBWDs effective in the treatment of DFU, especially in the limited-resources healthcare facilities? To answer this question, we search the evidence from PubMed, Cochrane Database, Semantic Scholar, and Google Scholar with various keywords based on the clinical question. The studies were selected based on pre-determined inclusion and exclusion criterias and were critically appraised.Results: Four randomized controlled trials (RCTs) that met the inclusion and exclusion criterias were found. There are no significant difference in reduction of ulcer area (RUA) rate or complete wound closure (CWC) rate in all RCTs. When compared to control or non-hydrogel group, three studies reported some favoring aspect in HBWD group, such as less inflammatory signs and faster CWC mean time. Conclusion: HBWDs are recommended in the treatment of DFU because they are widely available, cost-effective, and relatively easy to use.

THE RELATIONSHIP BETWEEN CD4 LEVELS AND FEATURES TOXOPLASMOSIS ENCEPHALITIS FROM NON-CONTRAST HEAD CT-SCAN HIV PATIENTS
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.17288

Background: HIV/AIDS is known to cause central nervous system disorders, including opportunistic infections such as toxoplasmosis, triggered by Toxoplasma gondii. The activation of T. gondii is particularly prevalent in immunocompromised individuals, especially those with CD4 counts below 50. CT scans are commonly used for diagnosing cerebral toxoplasmosis. Methods: This analytical research employs a cross-sectional design starting from February 2023 at H. Adam Malik General Hospital, Medan. Descriptive data analysis includes variables like age, gender, and CD4 levels. Bivariate analysis was conducted using Chi-square and Fisher Exact tests. Results: The majority of subjects were male (66.7%), with an average age of 36.43 years. Sixty percent of patients had CD4 levels < 200 cells/mm3, while 40% had CD4 levels > 200 cells/mm3. Conclusion: HIV patients with toxoplasmosis encephalitis typically exhibit clinical symptoms such as headaches and altered consciousness. CD4 levels are associated with the localization of lesions in brain lobes (frontal, occipital, temporal, parietal) and perifocal edema.

ASSOCIATION OF TRIGLYCERIDE / HIGH-DENSITY LIPOPROTEIN RATIO (TG/HDL RATIO) TO SPECIFIC RISK FACTORS OF DIABETES AND PREDIABETES Nasution, Melati Silvanni; Pase, Muhammad Aron; Nasution, Ali Nafiah
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 4 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i4.17394

Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. Prediabetes is a precursor before the diagnosis of diabetes. Patients with prediabetes and diabetes have several risk factors, one of which is dyslipidemia. The TG/HDL ratio is found to be positively associated with insulin resistance and CVD. This study was conducted to determine whether there is a relationship between TG/HDL ratio and the incidence of prediabetes and diabetes. Method: This analytic cross-sectional study was conducted on July-December 2023. The study samples were prediabetic and diabetic patients who met the acceptance criteria of the study subjects. They were tested for BMI, BG, HbA1C and lipid profile. Data analysis used paired t test and Pearson correlation Result: In this study, BMI was greater in the prediabetes group than the diabetes group. There was a negative correlation between age, BG and HDL levels on TG/HDL ratio in prediabetic and diabetic patients. There was a significant relationship between fasting BG, 2 hours after meals BG, HbA1C and TG/HDL ratio when compared between the prediabetes and the diabetes group. Conclusion: In this study, there was no association between TG/HDL ratio in prediabetes and diabetes. Keywords: Prediabetes, diabetes, TG, HDL, HbA1c

The Relationship Between Asymmetric Dimethylarginine and Ankle-Brachial Index With the Severity of Diabetic Foot Ulcers Mardia, Indra Kusuma; Santi Syafril; Brama Ihsan Sazli
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.19466

ABSTRACT Introduction: Approximately 50% of inpatient cases for diabetic complications are diabetic foot ulcers (DFU). Peripheral artery defect is one of the mechanisms that is characterized by increased asymmetric dimethylarginine (ADMA). Severe diabetic foot ulcers are found in populations with low ankle-brachial index (ABI) values. This study aims to find the relationship between ADMA and ABI in predicting risk for DFU. Methods: An Observational study with a cross-sectional method was conducted at Adam Malik Hospital, Medan collaboration with the Clinical Laboratory from the Faculty of Medicine, Universitas Sumatera Utara. Forty-two patients with DFU from September 2023 to April 2024 were registered with the following information: anthropometric, gender, history of drug use, comorbidities, ABI, ADMA, complete blood count, lipid profile, and fasting blood glucose. Results: In grade II DFU, the average ADMA value was 87.6 ng/dl, grade III 231.3 ng/dl, grade IV 444.9 ng/dl, and grade V 652.3 ng/dl. ABI value using Sokoye classification shows grade II DFU has an average ABI value of 1.08 (Normal), grade III 0.74 (Mild), Grade IV 0.61 (Moderate), and grade V 0.5 (Moderate). There is a significant relationship between the severity of DFU (Wagner scale) and ADMA levels (P = 0.001) and ABI values (P = 0.001). There is a relationship between ADMA and ABI values with DFU (P = 0.001). Conclusion: There is a significant relationship between the severity of DFU (Wagner scale) and ADMA levels (P = 0.001) and ABI values (P = 0.001). There is a relationship between ADMA and ABI values with DFU (P = 0.001). Keywords: Diabetic foot ulcer, Asymmetric dimethylarginine, Ankle-brachial index ABSTRAK Pendahuluan: Sekitar 50% kasus rawat inap untuk komplikasi diabetes adalah diabetic foot ulcers (DFU). Cacat arteri perifer adalah salah satu mekanisme yang ditandai dengan peningkatan asymmetric dimethylarginine (ADMA). Ulkus kaki diabetes parah ditemukan pada populasi dengan ankle-brachial index (ABI) values. Penelitian ini bertujuan untuk mengetahui hubungan antara ADMA dan ABI dalam memprediksi risiko untuk DFU. Metode: Studi Observasional dengan metode cross-sectional dilakukan di Rumah Sakit Adam Malik Medan bekerja sama dengan Laboratorium Klinik dari Fakultas Kedokteran, Universitas Sumatera Utara. Empat puluh dua pasien DFU dari September 2023 hingga April 2024 terdaftar dengan informasi dari antropometri, jenis kelamin, riwayat penggunaan narkoba, komorbiditas, ABI, ADMA, hitung darah lengkap, profil lipid, dan glukosa darah puasa sebagai berikut.. Hasil: Nilai ADMA rata-rata DFU kelas II: 87,6 ng/dl, grade III: 231,3 ng/dl, grade IV: 444,9 ng/dl, dan grade V: 652,3 ng/dl. Nilai ABI menggunakan klasifikasi Sokoye menunjukkan DFU grade II memiliki nilai ABI rata-rata 1,08 (Normal), grade III 0,74 (Mild), Grade IV 0,61 (Moderate), dan grade V 0,5 (Moderate). Terdapat hubungan antara tingkat keparahan DFU (skala Wagner) dengan kadar ADMA (P = 0,001) dan nilai ABI (P = 0,001). Ada hubungan antara nilai ADMA dan ABI dengan DFU (P = 0,001). Kesimpulan: Ada hubungan antara tingkat keparahan DFU (skala Wagner) dengan kadar ADMA (P = 0,001) dan nilai ABI (P = 0,001). Ada hubungan antara nilai ADMA dan ABI dengan DFU (P = 0,001). Kata kunci: Ulkus kaki diabetik, Asimetris Dimetilarginin, ABI

FACTORS AFFECTING SUCCESSFUL PULMONARY TUBERCULOSIS TREATMENT AT STABAT HEALTH CENTER IN LANGKAT DISTRICT Nahdhia; Sinaga, Bintang Yinke Magdalena; Adriztina, Indri; Saragih, Rina Amalia Caromina; Nasution, Tetty Aman
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.21244

Background: Pulmonary Tuberculosis (TB) is a significant global public health problem, mainly affecting the lungs. Many factors are associated with the successful treatment of pulmonary TB patients. This study aims to analyze factors affecting the successful treatment of pulmonary TB at Stabat Health Center, Langkat District. Method: This observational analytic study used a cross-sectional design and was conducted from October 2024 to January 2025 at Stabat Health Center. All pulmonary TB patients diagnosed between 2022 and 2023 who met the inclusion and exclusion criteria were included using a total sampling approach. Data were collected from the Tuberculosis Information System and analyzed using univariate, bivariate, and multivariate analyses. Results: Comorbid diabetes mellitus (DM) (p=0.003; OR=7.01) and distance to health facility (p=0.022; OR=4.44) were significantly associated with treatment success. In contrast, age, sex, occupation, comorbid HIV infection, and treatment status did not show a statistically significant association with treatment outcomes. Conclusion: Comorbid DM had the greatest effect on successful of pulmonary TB treatment at Stabat Health Center. TB patients with Diabetes Mellitus comorbid need special attention. Further research is needed to analyze other potential factors.

Corelation Between Level of Knowledge and Antibiotic Use Behaviour in Kelurahan Sei Putih Timur, Medan KABAN, SRI MELINDA; Kumar, Ajith; Hafaz Zakky Abdillah; Anggrreiny; Siti Syarifah
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.20830

Background: Antibiotics are one of the great discoveries in the world of health that have saved many lives since their invention by Sir Henry Flaming in 1928. Not long after its discovery, antibiotic usage faced a new issue, which is antibiotic resistance that caused antibiotic effectivity to decrease and caused millions of deaths ever since. Until now, antibiotics have become a global threat that has to be solved. This research aims to determine the community’s knowledge level about antibiotics, if their use of antibiotics is rational, and if knowledge about antibiotics in the community will affect their usage of antibiotics. Method: A cross-sectional strategy is used in this descriptive-analytical study. The population and sample of this study were the community of Kelurahan Sei Putih Timur 2 Medan that met the criteria of respondents of 120 people.T Results and Discussion: The results obtained were 38 respondent (31.7%) has insufficient level of knowledge about antibiotics, 56 respondent (46.7%) has sufficient knowledge and 26 respondent (21.7%) has good knowledge about antibiotics. The number of respondent who has rational usage of antibiotics was 69 (57.5%) and the other 51 respondent (42.5%) has irrational usage of antibiotics. From analysis, 63 respondent, has sufficient to good knowledge about antibiotics and rational usage of it. Conclusion: Most of the antibiotic use behaviour of the East Sei Putih 2 Community is classified as rational, and has sufficient knowledge about antibiotics

Factors influencing general practitioners' knowledge of asthma management in primary health facilities in Medan City Vinda Sari Ermiza Nasution; Amira Permatasari Tarigan; Andika Pradana; Rina Amelia
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.20831

Asthma is a chronic respiratory disease caused by inflammation, making the airways hypersensitive to triggers and leading to recurrent symptoms. Adequate knowledge of asthma management among general practitioners is essential to improve patient care, reduce disease severity, and prevent mortality. This study aimed to identify factors influencing general practitioners’ knowledge of asthma management in primary health facilities in Medan City. A cross-sectional study was conducted involving 90 general practitioners selected through consecutive sampling. Data collected included respondent characteristics such as age, length of service, number of asthma patients treated monthly, source of knowledge, history of asthma management training, and level of knowledge. A validated and reliable questionnaire was used (Guttman scale r = 0.489; Cronbach’s alpha = 0.93). Statistical analysis using SPSS included chi-square and Fisher’s exact tests to assess relationships between variables. Results showed that most general practitioners had enough knowledge (54.4%) about asthma management. Significant associations were found between age (p = 0.034) and source of knowledge (p = 0.048) with the level of knowledge. Other variables showed no significant relationship. In conclusion, age and source of knowledge significantly influence general practitioners' knowledge of asthma management in primary health facilities, highlighting the need for targeted educational interventions.

Association of Neutrophil-to-Lymphocyte Ratio with One-Year Mortality in Maintenance Hemodialysis Patients Amini, Sri Rahmania; Nasution, Alwi Thamrin; Tarigan, Radar Radius
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 4 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i4.22478

Chronic kidney disease (CKD) carries a high morbidity and mortality rate, particularly among patients undergoing maintenance hemodialysis (MHD). Inflammation is a key mechanism affecting prognosis, and the neutrophil-to-lymphocyte ratio (NLR) is a simple, accessible marker of systemic inflammation. This retrospective cohort study aimed to evaluate the association between NLR and one-year mortality in MHD patients. A total of 65 adult CKD patients at Adam Malik General Hospital, Medan, from January to December 2024 were included. Demographic, clinical, and laboratory data were obtained from medical records, and NLR was calculated as the neutrophil count divided by the lymphocyte count, categorized as <3.5 and ≥3.5. Associations were analyzed using Chi-square or Fisher’s exact test, with odds ratios (OR) and 95% confidence intervals (CI). The mean age was 48.35 ± 13.43 years, and 66.2% were male. The median NLR was 2.93 (IQR 2.25), with 46.2% ≥3.5. One-year mortality was 30.8%. Elevated NLR (≥3.5) was significantly associated with higher mortality (46.7% vs. 17.1%; p=0.01) and a 4.229-fold higher risk of death (95% CI: 1.36–13.15). High NLR is significantly associated with increased one-year mortality in MHD patients. Routine NLR monitoring may help identify high-risk patients for earlier intervention.

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Dharma Lindarto

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+6282168842564

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