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Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

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Published by TALENTA PUBLISHER

ISSN : 26860872 EISSN : 26860856 DOI : 10.32734

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an international peer-reviewed journal (February, May, August and November) published by TALENTA Publisher, Universitas Sumatera Utara and managed by Faculty of Medicine, Universitas Sumatera Utara. It is dedicated to interchange for the articles of high quality research in the field of Medical Science. The journal publishes state-of-art papers in fundamental theory, case report, experiments and simulation, as well as applications, with a systematic proposed method, sufficient review on previous works, expanded discussion and concise conclusion. As our commitment to the advancement of science and technology, the JETROMI follows the open access policy that allows the published articles freely available online without any subscription. Each publication contains 6 (six) research articles which will be published online.

Arjuna Subject : Kedokteran - Endokrinologi, Diabetes dan Metabolisme

Articles 145 Documents

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Measurement of Visceral Adipose Tissue using Abdomen CT scan As A Predictor of Type 2 Diabetes Mellitus at H. Adam Malik General Hospital Medan Nasution, Duma Ratna Sari; Putri Chairani Eyanoer; Pase, M Aron; Lubis, Netty Delvrita
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.15891

ABSTRACT Background: Obesity is a condition where the BMI is â‰¥ 25 kg/m2. Deposition of visceral adipose tissue (VAT) in obese conditions is a predictor of the incidence of type 2 diabetes mellitus. CT scan is an accurate measurement of VAT. A cut-off point value is needed to determine the stratification of VAT at risk for type 2 DM. Method: Cross-sectional study of patients undergoing CT scans of the abdominal area at the Radiology Installation of H. Adam Malik General Hospital, Medan during February 2024. Some of the data was taken from the Master of Clinical Medicine study in 2022. Data was collected in the form of examination BMI, waist circumference, DM risk score, and VAT volume in patients examined by abdominal CT scan at L4 level. The DM risk score was obtained using the ADA diabetes risk score questionnaire. VAT volume measurement using 3D segmentation tools. Results: Of the 116 patients studied, the number of samples was 53,4% male and 46,6% female. High DM risk score proportion of 59,5 %. The most frequent DM risk score was 5. Spearmanâ€™s correlation is used too. The best cut-off point between sensitivity 44.93% and specificity 80,85% is 1.311,9 cm3. The accuracy of CT scan as a predictor of type 2 DM is good (AUC 0.7). The positive predictive value (PPV) is 77,50%, and the negative predictive value (NPV) is 50%. The positive likelihood ratio value (LR +) is 2,34 and the negative likelihood ratio value (LR -) is 0,68. Conclusion: VAT measurement using abdominal CT scan as a predictor of type 2 DM has good accuracy. Keywords: Visceral adipose tissue, cut off, diabetes mellitus, body mass index, waist circumference, abdominal CT scan

Effect Of Administration Of Binahong Leaf Ethanol Extract On Reducing Blood Sugar Levels In Type 2 Diabetes Mellitus Model Rat Rusdiana, Rusdiana; Rina Amelia; Cut Putri Hazlianda
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.16587

ABSTRACT Background. Type 2 diabetes mellitus (T2DM) is characterized by elevated levels of blood glucose. Binahong leaves contain various metabolites such as flavonoids which are known to have antidiabetic effects. The research aims to determine the effect of administering ethanol extract of Anredera cordifolia (Ten.) Steenis leaves on reducing blood sugar levels in T2DM rats. Methods. This study is a true experimental in vivo with a pre-post test control group design. This study used 30 rats consisting of 6 groups: normal control, negative control, positive control (metformin), ethanol extract of binahong leaves dose 25 mg/kgBW, ethanol extract of binahong leaves dose 50 mg/kgBW, and ethanol extract of binahong leaves dose 100 mg/kgBW. The treatment group was induced by HFD for 14 days and injected with streptozotocin 30 mg/kgBW followed by ethanol extract of binahong leaves for 14 days. Rat blood sugar levels were evaluated 7 and 14 days after administration of binahong leaf ethanol extract. Data analysis used parametric and Wilcoxon non-parametric statistical tests. Results. Ethanol extract of binahong leaves doses of 25 mg/kgBB, 50 mg/kgBW, and 100 mg/kgBB affected reduced blood glucose significantly. Conclusion. Ethanol extract from binahong leaves can reduce the blood glucose in T2DM rats significantly. Keyword: Diabetes Mellitus, Hyperglycemia, Binahong Leaf Extract, Flavonoid, Streptozotocin

The Association Between Lipid Profiles and Atherogenic Index with Diabetic Foot Severity According to the Wagner-Meggitt Classification at Adam Malik Hospital Wilonna, Almira; Pase, M Aron; Lubis, Dian Anindita
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.18383

ABSTRACTIntroduction: Diabetic foot is a serious complication that leads to ulcers and amputations. Identifying risk factors, such as lipid profiles and atherogenic indices is crucial for prevention and treatment for cardiovascular disease and peripheral arterial disease. This study aims to investigate the relationship between lipid profiles and atherogenic indices with the severity of diabetic foot, categorized by the Wagner-Meggitt classification, at Adam Malik Hospital. Methods: This analytical observational study with cross-sectional design was conducted at Adam Malik Hospital, involving 70 diabetic foot patients. Data were collected from medical records, focusing on lipid profiles. Atherogenic indices were calculated as ratios: TC/HDL, TG/HDL, and LDL/HDL. The severity of diabetic foot was measured using the Wagner-Meggitt classification. Statistical analysis included Chi-square and Spearman's rho tests. Results: Of the 70 patients, most were aged 51-60 (41.4%), male (60%), and had normal BMI (57.1%). There was a significant correlation between diabetic foot severity and triglyceride levels (p=0.0002, r=0.358) as well as the TC/HDL ratio (p=0.02, r=-0.277). However, no significant relationships were found for total cholesterol (p=0.533), HDL (p=0.254), LDL (p=0.533), the TG/HDL ratio (p=0.158), or the LDL/HDL ratio (p=0.92). Discussion: In this study, 60% of the participants were male. The findings align with previous studies, demonstrating a correlation between elevated triglycerides and lipid profile abnormalities with the severity of diabetic foot ulcers. Conclusion: Triglycerides and the total cholesterol/HDL ratio are significantly associated with the severity of diabetic foot based on the Wagner-Meggitt classification. Keywords: diabetic foot; lipid profile; atherogenic index; Wagner-Meggitt

The Relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy KABAN, SRI MELINDA; Siti Syarifah; Pane, Yunita Sari; Tri Widyawati
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.18520

ABSTRACT Background Drug transporter polymorphisms are widely associated with the risk of toxicity in many chemotherapy drugs in cancer. This paper aims to assess the relationship of polymorphisms of this transporter, namely SLC22A16, which are associated with side effects of Doxorubicin-based chemotherapy drugs, namely hematological toxicity (anemia, neutropenia, leukopenia and thrombocytopenia) in breast cancer patients. Method This cross-sectional study will be conducted by testing polymorphism using the ARMS PCR method, which will assess the distribution of AA, AG, and GG genotypes. Result Most patient ages are under 50 years (55%), with overweight BMI (41,7%) and Batak ethnicity (43,3%). There is no relationship between SLC22A16 Gene Polymorphism and Hematological Toxicity in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy

Non-Contrast Head CT Features in HIV Patients with and without Antiretrovirals Therapy At Adam Malik General Hospital, Medan Wibowo, Tri Widi Wibowo; Sipahutar, Henny Maisara
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.18989

ABSTRACT Background: Human Immunodeficiency Virus (HIV) weakens the immune system and leads to Acquired Immune Deficiency Syndrome (AIDS). Patients may also developed cerebral toxoplasmosis. CT scans of the head without contrast can help diagnose opportunistic infections and monitor therapy response. Method: This descriptive, cross-sectional study was conducted from August 2021 to July 2022 at H. Adam Malik General Hospital, Medan. Data is presented in terms of numbers (n) and percentages (%) for variables such as age, gender, and non-contrast head CT scan images. Chi-square tests were used for bivariate analysis, with p-values <0.05 considered significant. Results: The mean age of patients receiving and not receiving ARVs was 35.0 Â± 12.83 years and 37.3 Â± 12.5 years, respectively. The majority were male. Most patients on ARVs showed no lesions on CT scans. Conclusion: Hypodense lesions were the most common findings in patients on ARVs, with multiple lesions observed in the majority of samples.

Antimicrobial Activity of the Ethanolic Extract of Durio zibethinus Rind against ESBL-producing Escherichia coli and Klebsiella pneumoniae : Antimicrobial Activity of the Ethanolic Extract of Durian Rind against ESBL-producing E. coli and K. pneumoniae Kannady, Johnson; Mayasari, Evita; Mardiani, Tengku Helvi; Hutagalung, Sunna Vyatra; Alona, Ivana; Simatupang, Maria Magdalena
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 1 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i1.19027

Background: Durio zibethinus (durian) contains secondary metabolites with antibacterial potency, such as alkaloids, flavonoids, saponins, tannins, and glycosides. Indonesia is one of the worldâ€™s largest producing countries of durian, yet the thorny part of the fruit rind often ends up as waste. Investigations of durian rind for its antimicrobial activity will maximize the benefits and prevent waste accumulation. Objective: In this experimental study, we analyzed the antimicrobial activity of ethanolic extract of durian rind against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and K. pneumoniae in vitro. Methods: This study used a one-group posttest-only design. The disc diffusion method for antimicrobial susceptibility test was used to test the ethanolic extract of durian rind against ESBL-producing E. coli and K. pneumoniae, each with six experimental repetitions to observe the inhibition zone produced around discs containing the extracts at various concentrations (12.5%, 25%, 50%, 75%, 80%, and 100%). Results: Ethanolic extract of durian rind showed an inhibition zone against ESBL-producing E. coli at the extract concentration of 50%, with an average inhibition zone of 3.57 mm. The inhibition zone was also observed against ESBL-producing K. pneumoniae at the extract concentration of 75%, with an average inhibition zone of 3.73 mm. Conclusions: The ethanolic extract of durian rind showed inhibition zones against ESBL-producing E. coli and K. pneumoniae, showing its potential antimicrobial activity in vitro.

The Relationship Between The Habits Of Using Personal Protective Equipment And Personal Hygiene And The Incidence Of Intestine Parasite Infections In Waste Workers At TPA Terjun Medan Maria, Maria M.M Sitanggang; Steven Tandean; M. Oky Prabudi; Lambok Siahaan; Sinambela, Adelina Haryani; Panggabean, Yoan Carolina
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.15315

Background: Intestinal parasitic infections are quite a big problem and are still often found in society. Intestinal parasitic infections are caused by infections of intestinal protozoa and intestinal nematodes. Intestinal parasitic infections can result in a decline in an individual's health, nutrition, intelligence and productivity. Personal Protective Equipment (PPE) and good personal hygiene have an important role in reducing the transmission of parasites from soil to humans, both through eggs, larvae and adult parasites, especially for waste workers who have direct contact with infectious environments. In the city of Medan, the final disposal site used is TPA Terjun. Every day, TPA Terjun receives waste from various areas in the city of Medan. Workers are at high risk of being infected by intestinal parasites that spread through the soil. Objective: The purpose of this study is to determine the relationship between the habit of using PPE and personal hygiene with the incidence of intestinal parasite infections in waste workers at TPA Terjun Medan. Methods: This study included 121 subjects from TPA Terjun, Medan. This research used cross-sectional approach. Result: This study found that there was no correlation between the use of gloves, masks, protective clothing and protective shoes on the incidence of intestinal infections in waste workers at TPA Terjun Medan, also between personal hygiene and the incidence of intestinal parasite infections in waste workers at TPA Terjun Medan. Conclusion: The use of PPE is important to prevent the transmission of intestinal parasitic infections to workers at TPA Terjun, Medan.

Relationship Between Micronutrient Ferritin, Vitamin D, And Calcium With The Severity Of Diabetic Foot Based On The Wagner-Meggitt Criteria At Adam Malik Hospital Amalia Puspita Dewi; Mardianto; Nasution, Melati Silvanni
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Diabetic foot is a significant complication for Type 2 Diabetes Mellitusâ€™s (T2DM) patients. Previous studies have linked diabetic foot to micronutrients such as ferritin, vitamin D, and calcium, but there have been no follow-up studies in Medan. Objective: This study aimed to analyze the relationship between levels of ferritin, vitamin D, and calcium with the severity of diabetic foot, as measured by the Wagner-Meggit criteria, in T2DM patients at Adam Malik Hospital. Method: A cross-sectional study with 48 T2DM patients at Adam Malik Hospital from December 2022 to December 2023. Micronutrient levels were measured, and the severity of diabetic foot was assessed using the Wagner-Meggitt classification. Result: The majority of participants (64.6%) were female. High ferritin levels were observed in 91.6% of patients, while 93.75% had low levels of calcium and vitamin D. Bivariate analysis revealed no significant correlations between ferritin, corrected calcium, or vitamin D levels and Wagner grades 2-5 (p=0.515, p=0.646, p=0.377, respectively). Non-parametric correlation analysis showed significant relationships between corrected calcium (p=0.022) and vitamin D (p=0.027) with Wagner grades. Discussion: Among the 48 subjects, bivariate testing found that ferritin levels above 150 ng/ml were not linked to diabetic foot severity. Low calcium levels (below 8.5 ng/dl) were significantly associated with increased severity of diabetic foot (p < 0.03). 93.75% of participants had low vitamin D levels, which also correlated significantly with foot severity (p=0.027). Conclusion: The study concluded that calcium and vitamin D levels correlate with the severity of diabetic foot, whereas ferritin levels do not.

Nutritional Status of Kindergarten Children in Medan Helvetia Subdistrict and the Factors Affecting It Pasaribu, Ira Nurhasanah; Wijaya, Hendri; Sinaga, Bintang Yinke Magdalena; Yunita, Rina
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.18618

Background: During childhood, especially from toddlerhood to school age, children experience significant body growth. Therefore, children require an adequate concentration of nutrients per kilogram of body weight. Low nutritional status affects the quality of human resources because it affects intelligence and resistance to disease. The aim of the study was to analyse the factors that contribute to the nutritional status of kindergartens in Medan Helvetia Sub-district. Methods. This study was a quantitative analytic study using a cross sectional approach. The study population was kindergartens in Medan Helvetia Subdistrict with a sample of 100 people. The sampling technique in this study used a stratified random sampling method. Data collection method was questionnaire method using questionnaire and 24-hour food recall and anthropometric measurement using weighing tool and microtoise. Data analysis using chi square and fisherâ€™s exact test. Results. Of 100 children, it was known that 58 was female, 42 children was male, 29 children was < 60 months old, 64 children was 60 to 72 months old, 7 children is > 72 months old. 1 child has poor nutritional status, 29 children was found with malnutrition, 57 had good nutritional status, 9 had an overnutrition status, while 4 children was obese. Bivariate analysis of food intake with a p value = 0.004; family income with a p value = 0.672; maternal insight with a p value = 0.234; infectious diseases with a p value = 0.030; immunization status with a p value = 0.399; maternal education level with a p value = 0.092. Conclusion. Factors that influence the nutritional status of kindergarten children in Medan Helvetia Sub-district are food intake and infectious diseases.

Correlation Of Serum 25-Hydroxyvitamin D Levels With Glycemic Control In Type 2 Diabetes Mellitus Patients Putri, Septia Harma; Aprilia, Dinda; Decroli, Eva
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.18731

ABSTRACT Background: Type 2 diabetes mellitus (T2DM) is caused by reduced insulin sensitivity, which can lead to insulin shortage. Several recent investigations have found that vitamin D is connected with insulin secretion and sensitivity. Vitamin D insufficiency is linked to poor glucose regulation. Aim: To determine the correlation between serum 25-hydroxyvitamin D levels and glycemic control in Type 2 DM patients. Method: T2DM patients' serum levels of 25-Hydroxyvitamin D, Fasting Blood Glucose (FBG), 2-hours postprandial blood glucose (2-h PBG), and HbA1c were examined in this cross-sectional analytical observational study. Statistical analysis was also performed. Result: From 49 samples included, the number of male subjects was almost the same as female, mean age was 58 years. There was a decrease in serum 25-Hydroxyvitamin D levels with a median of 27.87 ng/ml (12,626 -94,367). Glycemic control was found to be poor, the median of FBG levels was 134 mg/dl (61-339), 2-h PBG levels was 208 mg/dl (93-488) and HbA1c levels was 7.5% (5.6-12.8). Analysis using Spearman correlation between serum 25-Hydroxyvitamin D levels with levels of FBG, 2-h PBG and HbA1c showed values of r = -0.538 and p = 0.000, r = -0.354 and p 0.013, r = -0.501 and p 0.000. Conclusion: There was a statistically significant negative correlation between serum 25-Hydroxyvitamin D levels and levels of FBP, 2h-PBG and HbA1c in T2DM patients. Keywords: 25-Hydroxyvitamin D serum, glycemic control, fasting blood glucose, two-hour postprandial blood glucose, HbA1c.

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Contact Name Dharma Lindarto

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Editorial Address Jalan Dr T Mansur No 9 Padang Bulan, Kecamatan Medan Baru, Kota Medan, Sumatera Utara, Indonesia

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Contact Name
Dharma Lindarto

Contact Email
jetromi@usu.ac.id

Phone
+6282168842564

Journal Mail Official
jetromi@usu.ac.id

Editorial Address
Jalan Dr T Mansur No 9 Padang Bulan, Kecamatan Medan Baru, Kota Medan, Sumatera Utara, Indonesia

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Unknown,

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INDONESIA