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Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

jetromi
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Published by TALENTA PUBLISHER

ISSN : 26860872 EISSN : 26860856 DOI : 10.32734

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Journal of Endocrinology, Tropical Medicine and Infectious Diseases (JETROMI) is an international peer-reviewed journal (February, May, August and November) published by TALENTA Publisher, Universitas Sumatera Utara and managed by Faculty of Medicine, Universitas Sumatera Utara. It is dedicated to interchange for the articles of high quality research in the field of Medical Science. The journal publishes state-of-art papers in fundamental theory, case report, experiments and simulation, as well as applications, with a systematic proposed method, sufficient review on previous works, expanded discussion and concise conclusion. As our commitment to the advancement of science and technology, the JETROMI follows the open access policy that allows the published articles freely available online without any subscription. Each publication contains 6 (six) research articles which will be published online.

Arjuna Subject : Kedokteran - Endokrinologi, Diabetes dan Metabolisme

Articles 145 Documents

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C-Reactive Protein (CRP) Levels in Stadium 5 Chronic Kidney Disease with Hemodialysis Regularly and Covid-19 Alifa, Cut Safira; M. Feldi Gazaly Nasution
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 1 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i1.11928

Background: Chronic Kidney Disease (CKD) is kidney dysfunction that has occurred for more than 3 months. Patients with stage 5 CKD with hemodialysis (HD) regularly are prone to suffering from COVID-19 because hemodialysis patients can experience malnutrition, inflammation, and atherosclerosis. This study aims to determine CRP levels in stage 5 CKD with HD) regularly and COVID-19 at USU Hospital from June to October 2021. Method: One of the inflammatory biomarkers that can be used in assessing C-Reactive Protein (CRP) levels, by looking at these levels it is expected to know how severe the inflammation of the disease is. This is an observational descriptive study with a total sampling technique. Data were obtained secondarily from the medical records of stage 5 chronic kidney disease patients with COVID-19 with HD regularly. Result: Of the total 28 data, there were male 23 (82.1%) and female.5 (17.9%) patients. Most of them have aged 40-60 years old, and the clinical picture of patients was shortness of breath, with comorbid hypertension. In this study, the most HD duration was for 12-36 months and the highest level of CRP is > 200 mg/dl. Conclusion: The patients with CKD with HD regularly and covid-19 have increased inflammatory markers of CRP

Anxiety Levels of Severe COVID-19 Patients at Haji Adam Malik Hospital Medan in 2022 Nurul Citta Banu Putri; Tarigan, Amira Permatasari; Pendiaman Pandia; Andika Pradana; Putri Chairani Eyanoer; Elmeida Effendy
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 2 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i2.11941

Background: The COVID-19 pandemic is affecting the healthcare system and causing psychological changes, not only among healthcare professionals but also among citizens. These psychological changes are caused by depression, fear, anxiety, or insecurity. This study aims to investigate the anxiety level of severe COVID-19 patients who were treated at Haji Adam Malik General Hospital Medan in 2022 Method: This research is a descriptive observational study at the Department of Pulmonology and Respiratory Medicine Haji Adam Malik Hospital Medan from January 2022 until several samples were fulfilled. Sampling was done by consecutive sampling technique by filling Google Form questionnaire. The HospitalÂ Anxiety and Depression Scale (HADS) questionnaire consists of seven items which can breakdown into anxiety subscales. The detail scores for every item ranged from zero to three. Score three indicated the highest level of anxiety. A total subscale score of >8 points out of 21 indicates significant anxiety symptoms. Data were analyzed descriptively to find out the frequency distribution of research subjects based on research sample characteristics. Results: From 36 research samples, 23 samples (63.9%) were male, and 13 samples (36.1%) were female. On anxiety levels, it was found that HADS-A scores were severe inÂ 21 patients with severe COVID-19 (58.3%) and moderate levels in 15 patients (41.7%) with severe anxiety levels. Conclusion: Anxiety levels appear to be significantly increased in patients with severe COVID-19

Inflammatory Mediators as Predictors of Improved Functional Capacity after Phase 2 Cardiac Rehabilitation in Coronary Artery Bypass Surgery Patients Raynaldo, Abdul Halim; Sarastri, Yuke; Ilyas, Kamal Kharrazi; Tarigan, Stefanie
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 1 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i1.12145

Background: Inflammatory parameters correlate with the atherosclerotic acute coronary syndrome (ACS) process and can predict future cardiovascular events in healthy populations. Coronary heart disease (CHD) subjects who had undergone coronary artery bypass grafting (CABG) procedures and underwent cardiac rehabilitation must be prevented from increased cardiovascular events. The study aims to evaluate the effect of cardiac rehabilitation programs on marker inflammation of cardiovascular risk factors. Method: This study was conducted at Departement Cardiology and Vascular Diseases Integrated Heart Center H. Adam Malik Hospital Medan who had undergone CABG procedures and underwent phase I and II cardiac rehabilitation. All subjects were carried out to collect basic patient data based on anamnesis, physical examination, results of laboratory tests, and functional capacity of the heart. Result: The subjects of this study were male 26 (89.7%) subjects and female 3 (10.2%) subjects. The average BMI in this study was 26.4207Â±0.675 kg/m2, the most common CHD risk factor was smoking in 21 (72.4%) subjects, dyslipidemia in 20 (69%) subjects, hypertension in 18Â (62.1%) subjects, obesity 14 (48.3%) subjects and T2DM 13 (44.8%) subjects. Based on echocardiography results, the average ejection fraction was 47.931Â±2.17 %, and 18 (62.1%) subjects had cardiomegaly. After undergoing phase I and II cardiac rehabilitation, Â there was improved significantly of the 6-minute walk test to hsCRP, IL-6, neutrophil-lymphocyte ratio (NLR), and functional capacity (all, p <0.001). IL-6 value is correlated significantly with functional capacity improvement (p<0.05) in both phase I and II cardiac rehabilitation. Conclusion: Cardiac rehabilitation (CR) should be considered as a preventive plan in the treatment of CHD patients. Physical exercise is noteworthy and they reduce morbidity and mortality due to reduced inflammation.

Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients Lubis, Dian Anindita; Karina Sugih Arto; Heny Syahrini
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 1 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i1.12159

Background: Male hypogonadism is a clinical disorder of low testosterone and spermatozoa due to impaired production that can occur at one or more levels in the hypothalamic-pituitary-gonadal (HPG) axis. Apart from iron accumulation, hypogonadism can also occur due to other mechanisms in thalassemia patients, such as the influence of adipose tissue and leptin. The study aimed to assess the relationship between leptin with free testosterone levels and BMI in transfusion-dependent thalassemia. Method: The research design chosen was analytic cross-sectional. The study was conducted at the adult thalassemia polyclinic of Cipto Mangunkusumo General Hospital and Fatmawati General Hospital, during the period July - December 2022. The samples used were male transfusion-dependent thalassemia patients aged over 18 years who were under control at the Thalassemia Polyclinic during the study period. The diagnosis of Thalassemia had been previously established by high-performance liquid chromatography (HPLC) or microcapillary examination. Result: Most patients were major ÃŸ thalassemia (87.8%), while HbE ÃŸ thalassemia was only 12.1%. Age distribution was with a median of 23 years (minimum-maximum 18-42 years). The clinical symptoms of hypogonadism were erectile dysfunction and decreased libido (12.1% and 9%, respectively). From body mass index examination were underweight 18 (54,5%), normal weight 13 (39,5%), overweight 1 (3%), and obese 1 (3%). Of the 33 transfusion-dependent thalassemia patients, 95% did not reach puberty according to their age (Tanner stage V). Conclusion: There is an association significantly between leptin levels with free testosterone and body mass index in transfusion-dependent thalassemia men.

Pharmacotherapy of Hypertension in Chronic Dialysis Patients in USU Hospital Medan Panjaitan, Josep Henry; Gazaly, Feldi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 1 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i1.12193

Background: Hypertension is closely related to chronic kidney disease (CKD) patients because hypertension can be a cause or a result of hemodialysis (HD). The way that can be done to control blood pressure is the administration of antihypertensive drugs. The use of antihypertensive drugs in CKD on HD patients in hospitals is needed as an evaluation material in terms of the accuracy and optimization of drug administration. This study aims to know the administration pattern of antihypertensive drugs used by the HD unit in USU Hospital Medan. Method: Descriptive statistics were used to present the antihypertensive drug prescription pattern of CKD in HD patients. This study used data in the form of medical records and also direct interviews with patients and nurses of the HD Unit at USU Hospital in 2022. Results: The most common single drug antihypertensive used was Calcium Channel Blocker (CCB) as amlodipine 67.4% either alone or in combination. The most common 2 drugs antihypertensive combination were Angiotensin Receptor Blocker (ARB) as candesartan and CCB as amlodipine 19.5%. Conclusion: The most common single drug antihypertensive used was CCB, and the most common drugs antihypertensive in combination 2 drugs were CCB and ARB.

Correlation between Low-Density Lipoprotein Cholesterol and Certain Lipid Profiles in The Treatment of Bay Leaf Extract (Syzgium Polyanthum (Wight) Walp) to Dyslipidemia Patients Nasution, Melati Silvanni; Brama Ihsan Sazli; Santi Syafril
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 2 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i2.12244

Background: The use of herbal medicine has long been practiced throughout the world, and the production and processing of herbal medicines are constantly being improved to treat various diseases. The aim of this study was to assess the correlation between low density lipoprotein cholesterol and certain lipid profiles in the treatment of bay leaf extract (syzgium polyanthum (wight) walp) to dyslipidemia patients. Method: We recruit dyslipidemia patients, and the search project was given an explanation and asked to give written consent (informed consent) to participate in the research. Then anamnes is carried out and examination:measurement of BMI, measurement of weist circumference, after being satisfied for 10-12 hours, the patient then took blood samples by the laboratory, to examine hs-CRP levels, lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides), routine blood, kidney function (ureum, creatinine). Blood samples is taken before and after 30 days study. Bay leaf extract 150 mg is taken two times perday . Result: Subjects who participate of the study were 15 peoples as a treatment group and ages 47.47Â±11,507 years old. There is signifikant differences in cholesterol total, LDL-C and Apo=B (all, p < 0,01). There is a correlation between LDL-C and Total Cholesrerol, Triglyceride, FPG and Apo-B (all, p < 0.05). Conclusion: In this study, bay leaf administration 2x150 mg for 30 days, improved lipid profiles of total cholesterol, LDL, and ApoB in dyslipidemic patients. Bay leaf extract administration has the potential to prevent and improve cardiovascular disease in dyslipidemic patients

Six Months of Bedaquiline-Pretomanid-Linezolid (BPaL) Regimen in Patients with Drug-Resistant Tuberculosis: A Narrative Review Oki Nugraha Putra; Ana Khusnul Faizah; Nani Wijayanti D.N
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 2 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i2.12373

Background: Drug-resistant tuberculosis (DR-TB) is more difficult to treat with multiple therapies and a longer duration than drug-sensitive tuberculosis. Pre-XDR and XDR-TB are highly DR-TB with a lower success treatment than MDR-TB. Therapy for high DR-TB with fewer drugs and shorter treatment is required to increase the success of treatment. We comprehensively reviewed the risk factors for unfavorable outcomes (death, treatment failure, and loss of follow-up) related to all oral regimens containing bedaquiline and or delamanid in patients with MDR-TB. Method: This was a narrative review to summarize the role of the BPaL regimen to manage highly DR-TB patients. Results: The six months of BPaL regimen was reported to provide treatment success in two previous trials, Nix and Zenix TB. BPaL offers treatment success, especially in highly DR-TB compared to standard regimens containing bedaquiline. However, several adverse effects, such as myelosuppression, peripheral neuropathy, and optic neuritis were more common in BPaL regimens than in standard regimens. In addition, the incidence of QTc interval prolongation was lower in BPaL regimens compared with standard regimens. It is mandatory to monitor adverse effects associated with linezolid in the BPaL regimen and how to manage them. Conclusion: This review concludes that the BPaL regimen provides treatment success over six months of treatment. Health facilities should prepare for the implementation of BPaL to manage DR-TB patients.

Cardiovascular Risk Assessment in Type 2 Diabetic Patients at Universitas Sumatera Utara Hospital Faza Ulya Putri; Naomi Niari Dalimunthe; Ginting, Andi Raga; Isti Ilmiati Fujiati
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 2 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i2.12406

Background. Diabetes is a major health problem worldwide including in Indonesia. There is a close relationship between diabetes and cardiovascular disease, with cardiovascular events being the most prevalent cause of morbidity and mortality in diabetic patients. Therefore, it is important to assess cardiovascular risk in patients with diabetes in order to conduct appropriate preventive strategies. Various methods have been developed to assess the degree of cardiovascular risk, one of which is the Jakarta Cardiovascular Score, a scoring method that has been adapted for the Indonesian community. This study aims to describe the profile of cardiovascular risk in diabetes patients at Universitas Sumatera Utara Hospital. Methods. A descriptive, cross-sectional study was conducted in the internal medicine outpatient clinic at Universitas Sumatera Utara Hospital. All subjects were diabetic patients who had not developed any cardiovascular complications. The risk of cardiovascular disorders was assessed using the Jakarta Cardiovascular Score. Data were collected through medical records, interviews, and physical examinations. Results. There were 64 subjects in this study. The majority of subjects (81.3%) were classified as high risk for cardiovascular disease. Conclusion. Most patients with diabetes have a high degree of risk of cardiovascular disease.

Correlation between Erythropoietin Resistance Index and Mortality in Regular Hemodialysis Patients at Haji Adam Malik General Hospital Medan Nasution, Fakhri Amin; Nasution, Alwi Thamrin; Nasution, Feldy G
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 2 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i2.12550

Introduction: One of the functions of the kidneys is the production of erythropoietin, a signaling molecule that stimulates the production of red blood cells, in response to reduced oxygen levels in the blood. In chronic kidney disease, there is a disturbance in the production of erythropoietin. Several previous studies have linked the index of erythropoietin resistance to mortality in patients with chronic kidney disease. The study aimed to correlate between erythropoietin resistance index (ERI) and Mortality in regular hemodialysis patients. Method: Observational analytic study with a cross-sectional method to assess the relationship between ERI and mortality in all regular hemodialysis patients at H Adam Malik Medan. The ERI was used to evaluate erythropoietin EPO by comparing the dose of EPO to the hemoglobin level. The data were tested statistically with the Chi-Square method. Results: The average study subjects suffered from anemia with Hb levels of 8.21 g/dL, serum iron levels of 63.22 mcg/dL, and increased total iron-binding capacity (TIBC) levels with an average value of 190.2 mcg/dL, low ferritin levels of 195.59 mcg/L and serum transferrin (TSAT) 19.2%, and of 2.94 g/dL. Albumin levels, transferrin saturation, and ERI were associated with the mortality rate of patients undergoing regular hemodialysis (p=0.021; p=0.011; p=0.012). Conclusion: There is a relationship between the index of erythropoietin resistance and the mortality rate of patients undergoing regular hemodialysis

Relationship between Degrees of Severity Gastroesophageal Reflux Disease (Gerd) with Quality of Life Bulqaini, Alul Azmi; Darmadi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 3 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i3.10884

Background. Gastroesophageal reflux disease (GERD) is a pathological condition caused by the reflux of gastric contents into the esophagus, with symptoms that appear inside and outside the esophagus which can reduce the patient's quality of life. The aim study is to analyze the relationship between the severity of GERD and the quality of life of students Faculty of Medicine at Universitas Sumatera Utara (USU) in 2019 and 2020. Method. Cross-sectional research with a sampling technique in the form of total sampling. Data collection was carried out using an online questionnaire in the form of a Google form with an assessment using the GERD Questionnaire (GerdQ), Frequency scale for the symptoms of GERD (FSSG), Gastroesophageal reflux disease-health related quality of life questionnaire (GERD-HRQL), and the 20-item self-reporting questionnaire (SRQ-20). After that, the data that has been collected will be tabulated. This study used bivariate analysis, with the Chi-square test and the Fisher Exact Test. Results. The total number of samples that met the inclusion and exclusion criteria of the study was 225 people with 41 people with GERD (18.2%) suffering from GERD. Of the 41 Students of the Faculty of Medicine from USU in 2019 and 2020 with GERD, 29 people (70.7%) had a good quality of life, and the remaining 12 people (29.3%) had a bad quality of life. There is a relationship between GERD and gender and psychological stress. In addition, there is a relationship between quality of life and the severity of GERD, psychological stress, and drinking alcohol, but there is no relationship between quality of life and gender, smoking habits, and BMI. Conclusion. Most Medical School Students have a good quality of life, and there is a significant relationship between the severity of GERD and the quality of life.

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Editorial Address Jalan Dr T Mansur No 9 Padang Bulan, Kecamatan Medan Baru, Kota Medan, Sumatera Utara, Indonesia

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Contact Name
Dharma Lindarto

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jetromi@usu.ac.id

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+6282168842564

Journal Mail Official
jetromi@usu.ac.id

Editorial Address
Jalan Dr T Mansur No 9 Padang Bulan, Kecamatan Medan Baru, Kota Medan, Sumatera Utara, Indonesia

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INDONESIA